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Volumn 3, Issue 5, 1993, Pages 803-808

The free energy change of restricting a bond rotation in the binding of peptide analogues to vancomycin group antibiotics

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; N FUMARYL DEXTRO ALANINE; N SUCCINYL DEXTRO ALANINE; RISTOCETIN A; UNCLASSIFIED DRUG; VANCOMYCIN DERIVATIVE;

EID: 0027241298     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)80670-8     Document Type: Article
Times cited : (25)

References (20)
  • 8
    • 84913182091 scopus 로고    scopus 로고
    • N-succinyl-D-alanine (NSDA) and N-fumaryl-D-alanine (NFDA) were both prepared from D-alanine methyl ester, and mono-methyl succinate or mono-methyl fumarate, respectively. The N-succinyl-D-alanine dimethyl ester (N-fumaryl-D-alanine dimethyl ester) was prepared by stirring a 1:1 mixture of D-lanine methyl ester and mono-methyl succinate (mono-methyl fumarate) with N-methylmorpholine, hydroxybenzotriazole and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (8:1:2) in dichloromethane for 10 hours at room temperature. The solvent was evaporated and the residue dissolved in ethyl acetate. The solution was washed with water, sodium hydrogen carbonate solution, citric acid solution, and again with water, dried over potassium carbonate, filtered, and the solvent then evaporated under vacuum. Final purification by flash column chromatography using silica gel/ethyl acetate gave pure N-succinyl-D-alanine dimethyl ester (N-fumaryl-D-alanine dimethyl ester), typical yields [[Truncated]]
  • 9
    • 84913182090 scopus 로고    scopus 로고
    • Gerhard, U.; Williams D.H.; University of Cambridge, unpublished results.
  • 11
    • 34250653849 scopus 로고
    • max for both ligands was determined to be 286nm. Titration was carried out at the previously determined wavelength in a 2-cell arrangement, where buffer and ristocetin A solutions were placed in the reference and sample beam respectively. Equal [[Truncated]]
    • (1989) Numerical Recipes in Pascal
    • Press1    Flannery2    Tenkolsky3    Vetterling4
  • 19
    • 84913182089 scopus 로고    scopus 로고
    • Searle, M. S.; Williams, D. H.; J. Am. Chem. Soc. submitted.
  • 20
    • 84913182088 scopus 로고    scopus 로고
    • −1.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.