-
1
-
-
0038299000
-
Sirolimus: its discovery, biological properties, and mechanism of action
-
Sehgal S.N. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc 35 (2003) 7S
-
(2003)
Transplant Proc
, vol.35
-
-
Sehgal, S.N.1
-
2
-
-
16644385561
-
The pleiotropic effects of mTor inhibitors
-
Ponticelli C. The pleiotropic effects of mTor inhibitors. J Nephrol 17 (2004) 762
-
(2004)
J Nephrol
, vol.17
, pp. 762
-
-
Ponticelli, C.1
-
3
-
-
13844308657
-
Drug-eluting stents: results, promises and problems
-
van der Hoeven B.L., Pires N.M., Warda H.M., et al. Drug-eluting stents: results, promises and problems. Int J Cardiol 99 (2005) 9
-
(2005)
Int J Cardiol
, vol.99
, pp. 9
-
-
van der Hoeven, B.L.1
Pires, N.M.2
Warda, H.M.3
-
4
-
-
0025775062
-
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
-
Monks A., Scudiero D., Skehan P., et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 83 (1991) 757
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 757
-
-
Monks, A.1
Scudiero, D.2
Skehan, P.3
-
5
-
-
0036817880
-
Clinical development of mammalian target of rapamycin inhibitors
-
Dancey J.E. Clinical development of mammalian target of rapamycin inhibitors. Hematol Oncol Clin North Am 16 (2002) 1101
-
(2002)
Hematol Oncol Clin North Am
, vol.16
, pp. 1101
-
-
Dancey, J.E.1
-
6
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
Jacinto E., and Hall M.N. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 4 (2003) 117
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 117
-
-
Jacinto, E.1
Hall, M.N.2
-
7
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
-
Hidalgo M., and Rowinsky E.K. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19 (2000) 6680
-
(2000)
Oncogene
, vol.19
, pp. 6680
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
8
-
-
14844363721
-
Signaling by target of rapamycin proteins in cell growth control
-
Inoki K., Ouyang H., Li Y., et al. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev 69 (2005) 79
-
(2005)
Microbiol Mol Biol Rev
, vol.69
, pp. 79
-
-
Inoki, K.1
Ouyang, H.2
Li, Y.3
-
9
-
-
33846881897
-
-
2005 Cancer Facts and Figures. American Cancer Society.
-
-
-
-
10
-
-
0026724699
-
Towards a molecular basis for tamoxifen resistance in breast cancer
-
Johnston S.R., Dowsett M., and Smith I.E. Towards a molecular basis for tamoxifen resistance in breast cancer. Ann Oncol 3 (1992) 503
-
(1992)
Ann Oncol
, vol.3
, pp. 503
-
-
Johnston, S.R.1
Dowsett, M.2
Smith, I.E.3
-
11
-
-
0034790016
-
mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
Yu K., Toral-Barza L., Discafani C., et al. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 8 (2001) 249
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 249
-
-
Yu, K.1
Toral-Barza, L.2
Discafani, C.3
-
12
-
-
0034727094
-
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
-
Simoncini T., Hafezi-Moghadam A., Brazil D.P., et al. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 407 (2000) 538
-
(2000)
Nature
, vol.407
, pp. 538
-
-
Simoncini, T.1
Hafezi-Moghadam, A.2
Brazil, D.P.3
-
13
-
-
0035881568
-
Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K
-
Sun M., Paciga J.E., Feldman R.I., et al. Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer Res 61 (2001) 5985
-
(2001)
Cancer Res
, vol.61
, pp. 5985
-
-
Sun, M.1
Paciga, J.E.2
Feldman, R.I.3
-
14
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
-
Chou T.C., and Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22 (1984) 27
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27
-
-
Chou, T.C.1
Talalay, P.2
-
15
-
-
15444368857
-
Mechanisms of estrogen receptor signaling: convergence of genomic and non-genomic actions on target genes
-
Bjornstrom L., and Sjoberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and non-genomic actions on target genes. Mol Endocrinol 19 (2005) 833
-
(2005)
Mol Endocrinol
, vol.19
, pp. 833
-
-
Bjornstrom, L.1
Sjoberg, M.2
-
16
-
-
0037884924
-
Estradiol rapidly activates Akt via the ErbB2 signaling pathway
-
Stoica G.E., Franke T.F., Wellstein A., et al. Estradiol rapidly activates Akt via the ErbB2 signaling pathway. Mol Endocrinol 17 (2003) 818
-
(2003)
Mol Endocrinol
, vol.17
, pp. 818
-
-
Stoica, G.E.1
Franke, T.F.2
Wellstein, A.3
-
17
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder P.K., Febbo P.G., Bikoff R., et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10 (2004) 594
-
(2004)
Nat Med
, vol.10
, pp. 594
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
-
18
-
-
1042267229
-
Determinants of rapamycin sensitivity in breast cancer cells
-
Noh W.C., Mondesire W.H., Peng J., et al. Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res 10 (2004) 1013
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1013
-
-
Noh, W.C.1
Mondesire, W.H.2
Peng, J.3
-
19
-
-
17944368972
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
-
Podsypanina K., Lee R.T., Politis C., et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci USA 98 (2001) 10320
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10320
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
-
20
-
-
0034489181
-
Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity
-
Lobenhofer E.K., and Marks J.R. Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity. J Steroid Biochem Mol Biol 75 (2000) 11
-
(2000)
J Steroid Biochem Mol Biol
, vol.75
, pp. 11
-
-
Lobenhofer, E.K.1
Marks, J.R.2
-
21
-
-
6944235337
-
Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity
-
deGraffenried L.A., Friedrichs W.E., Russell D.H., et al. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. Clin Cancer Res 10 (2004) 8059
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8059
-
-
deGraffenried, L.A.1
Friedrichs, W.E.2
Russell, D.H.3
-
22
-
-
0346362997
-
Rapamycins: mechanism of action and cellular resistance
-
Huang S., Bjornsti M.A., and Houghton P.J. Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2 (2003) 222
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 222
-
-
Huang, S.1
Bjornsti, M.A.2
Houghton, P.J.3
-
24
-
-
27344455530
-
A phase Ib study of the mTOR inhibitor RAD001 (everolimus) in combination with letrozole (Femara), investigating safety and pharmacokinetics in patients with advanced breast cancer stable or slowly progressing on letrozole [Abstract]
-
Awada A., Cardosa F., Fontaine C., et al. A phase Ib study of the mTOR inhibitor RAD001 (everolimus) in combination with letrozole (Femara), investigating safety and pharmacokinetics in patients with advanced breast cancer stable or slowly progressing on letrozole [Abstract]. Breast Cancer Res Treat 88 (2004) S234
-
(2004)
Breast Cancer Res Treat
, vol.88
-
-
Awada, A.1
Cardosa, F.2
Fontaine, C.3
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