Influence of aminoguanidine on parameters of liver injury and regeneration induced in rats by a necrogenic dose of thioacetamide

British Journal of Pharmacology

Volumn 125, Issue 1, 1998, Pages 102-108

  Díez Fernández, Carmen ^a   Sanz, Nuria ^a   Alvarez, Alberto M ^b   Zaragoza, Asunción ^a   Cascales, María ^a  

^a Instituto de Bioquimica   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Aminoguanidine; Hepatic necrosis; Hepatic regeneration; Nitric oxide synthase; Oxidative stress; Thioacetamide

Indexed keywords

AMINOGUANIDINE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDRAZINE DERIVATIVE; MALONALDEHYDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; THIOACETAMIDE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL CULTURE; CELL POPULATION; CONTROLLED STUDY; DISEASE SEVERITY; DNA SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; LIVER LEVEL; LIVER NECROSIS; LIVER REGENERATION; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; POLYPLOIDY; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOGENS; ENZYME INHIBITORS; GLUTATHIONE; GUANIDINES; LIVER; LIVER REGENERATION; MACROPHAGES, PERITONEAL; MALE; MALONDIALDEHYDE; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGENASES; PLOIDIES; RATS; RATS, WISTAR; THIOACETAMIDE; TIME FACTORS;

EID: 0031659724     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702014     Document Type: Article

References (41)

1. BILLIAR, T.R. & HARBRECHT, B.G. (1977). Resolving the nitric oxide paradox in acute tissue damage. Gastroenterology, 113, 1405-1407.
2. BRADFORD, M.M. (1975). A rapid and sensitive method for the quantification of micrograms quantities of protein utilizing the principle of protein-dye-binding. Anal. Biochem., 72, 248-254.
3. BROWNLEE, M., VLASSARA, H., KOONEY, A., ULRICH, P. & CERAMI, A. (1986). Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science, 232, 1629-1632.
4. CASCALES, M., MARTÍN-SANZ, P., ALVAREZ, A., SANCHEZ, M., DÍEZ-FERNÁNDEZ, C. & BOSCÁ. L. (1992). Isoenzymes of carbohydrate metabolism in primary cultures of hepatocytes from thioacetamide-induced rat liver necrosis. Responses to growth factors. Hepatology, 16, 232-240.
5. CASCALES, M., MARTÍN-SANZ, P., CRACIUNESCU, D.C., MAYO, I., AGUILAR, A., ROBLES-CHILLIDA, E.M. & CASCALES, C. (1991). Alterations in hepatic peroxidation mechanisms in thioacetamide-induced tumors in rats. Effect of a rhodium complex. Carcinogenesis, 12, 233-240.
6. CHIELI, E. & MAVALDI, G. (1984). Role of microsomal FAD-containing monooxygenase in liver toxicity of thioacetamide-S-oxide. Toxicology, 31, 45-52.
7. CROSS, A.H., MISKO, T.P., LIN, R.F., HICKEY, W.F., TROTTER, J.L. & TILTON, R.G. (1994). Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest., 93, 2684-2690.
8. DÍEZ-FERNÁNDEZ, C., BOSCÁ, L., FERNÁNDEZ-SIMÓN, L., ALVAREZ, A. & CASCALES, M. (1993). Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide. Hepatology, 18, 912-918.
9. DÍEZ-FERNÁNDEZ, C., SANZ, N., BOSCÁ, L., HORTELANO, S. & CASCALES M. (1997). Involvement of nitric oxide synthesis in hepatic perturbations induced in rats by a necrogenic dose of thioacetamide. Br. J. Pharmacol., 121, 820-826.
10. DÍEZ FERNÁNDEZ, C., SANZ, N. & CASCALES, M. (1996a). Changes in Glucose-6-phosphate dehydrogenase and malic enzyme gene expression in acute hepatic injury induced by thioacetamide. Biochem. Pharmacol., 51, 1159-1163.
11. 2+-dependent enzymes. J. Hepatol., 24, 460-467.
12. FAUSTO, N., LAIRD, A.D. & WEBBER, E.M. (1995). Role of growth factors and cytokines in hepatic regeneration. FASEB J., 9, 1527-1536.
13. GARDNER, C.R., HECK, DE., YANG, C.S., THOMAS, P.E., ZHANG, X-J., DEGEORGE, G.L., LASKIN, J.D. & LASKIN, D.L. (1998), Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. Hepatology, 27, 748-754.
14. GOLDBERG, D.M. & SPOONER, R.J. (1987). Glutathione Reductase. NAD(P)H: oxidized glutathione oxidoreductase. In Methods of Enzymatic Analysis, 3rd edn. vol III, ed. H.U. Bergmeyer, pp. 258-265. Weinheim: Verlag Chemie.
15. 15N] nitrate in biological fluids. Anal. Biochem., 126, 131-138.
16. GRIFFITH, O.W. (1980). Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpiridine. Anal. Biochem., 106, 207-212.
17. GUNZLER, W.A., KRAMERS, H. & FLOHÉ, L. (1974). An improved coupled test procedure for glutathione peroxidase in blood. Klin. Chem. Klin. Biochem., 12, 444-452.
18. HAMES, H., MARTIN, S., FEDERLIN, K., GEISEN, K. & BROWNLEE, M. (1991). Aminoguanidine inhibits the development of experimental diabetic retinopathy. Proc. Natl. Acad. Sci. U.S.A., 88, 11555-11558.
19. JOSHI, P.C., GROGAN, J.B. & THOMAE, K.R. (1996). Effect of aminoguanidine on in vivo expression of cytokines and inducible nitric oxide synthase in the lungs of endotoxemic rats. Res. Cummun. Mol. Pathol. Pharmacol., 91, 339-346.
20. KALLIO, E.A., KOSKINEN, P.K., AAVIK, E., VAALI, K. & LEMSTOM, K.B. (1997). Role of nitric oxide in experimental obliterative bronchiolitis (chronic rejection) in the rat. J. Clin. Invest., 100, 2984-2994.
21. LASKIN, D.L. (1992). Role of macrophages and endothelial cells in hepatotoxicity. In Kupffer hepatocyte interactions, ed. T. Billiar and R. Curran, pp. 147-168. Boca Ratón, FL:CRC Press.
22. LASKIN, D.I., GARDNER, C.R., PRICE, V.F. & FOLLOW, D.J. (1995). Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology, 21, 1045-1050.
23. LASKIN, D.L. & PENDINO, K.J. (1995). Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol., 35, 655-677.
24. MANGIPUDY, R.S., CHANDA, S. & MEHENDALE, H.M. (1995). Hepatocellular regeneration. Key to thioacetamide autoprotection. Pharmacol. Toxicol., 77, 182-188.
25. MEHENDALE, H.M. (1991). Role of hepatocellular regeneration and hepatocellular healing in final outcome of liver injury. A two stage model of toxicity. Biochem. Pharmacol., 42, 1155-1162.
26. MEHENDALE, H.M., ROTH, R.A., GANDOLFO, A.J., KLAUNING, J.E., LEMASTERS, J.J. & CURTIS, R.L. (1994). Novel mechanisms in chemical induced hepatotoxicity. FASEB J., 8, 1285-1295.
27. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide, physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
28. NIEAUS, W.G., SAMUELSON, J.R. & WILL, E.D. (1969). Lipid peroxide formation in microsomes. Biochem. J., 113, 315-341.
29. OU, P., & WOLFF, S.P. (1993). Aminoguanidine, a drug proposed for prophylaxis in diabetes, inhibits catalase and generates hydrogen peroxide in vitro. Biochem. Pharmacol., 46, 1139-1144.
30. SANZ, N., DÍEZ-FERNÁNDEZ, C. & CASCALES, M. (1997). Age-dependent modifications in rat hepatocyte antioxidant defense systems. J. Hepatol., 27, 525-534.
31. SANZ, N., DÍEZ-FERNÁNDEZ, C., FERNÁNDEZ-SIMÓN, L., ALVAREZ, A. & CASCALES, M. (1998a). Necrogenic and regenerative responses of liver of newly weaned rats against a sublethal dose of thioacetamide. Biochim. Biophys. Acta., 1384, 66-78.
32. SANZ N., DÍEZ-FERNÁNDEZ, C. & CASCALES, M. (1998b). Aging delays the post-necrotic restoration of liver function. BioFactors, 00, 1-7 (in press).
33. SCHLEICHER, E., WAGNER, E. & NERLICH, G. (1997). Increased accumulation of the glycoxidation product N∈-(carboxymethyl) lysine in human tissues in diabetic and aging. J. Clin. Invest., 99, 457-468.
34. SEGLEN, P.O. (1993). Isolation of hepatocytes by collagenase perfussion. In Methods in Toxicology. In vitro biological systems, ed. C.A. Tyson & J.M. Frazier, pp. 231-243. New York, London: Academic Press.
35. SHIOMI, M., WAKABAYASHI, Y., SANO, T., SHINODA, Y., NIMURA, Y., ISHIMURA, Y. & SUEMATSU, M. (1998). Nitric oxide suppression reversibly attenuates mitochondrial dysfunction and cholestasis in endotoxemic rat liver. Hepatology, 27, 108-115.
36. STEER, C.J. (1995). Liver regeneration. FASEB J., 9, 1396-1400.
37. SUM, C.Y. & KASPER, C.B. (1982). Mixed-function amine oxidase on the rat hepatocyte nuclear envelope. Demonstration and effects of phenobarbital and 3-methylcholanthrene, Biochem. Pharmacol., 31, 69-72.
38. SZABÓ, C., FERRER-SUETA, G., ZINGARELLI, B., SOUTHAN, G.J., SALMAN, A.L. & RADI, R. (1997). Mercaptoethylguanine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J. Biol. Chem., 272, 9030-9036.
39. VINDELOV, L.L., CHRISTENSEN, I.J. & NISSEN, N.I. (1983). A detergent trypsin method for the preparation of nuclei for flow cytometry. Cytometry, 3, 323-327.
40. VOS, T.A., GOUW, A.S., KLOK, P.A., HAVINGA, R., VAN-GOOR, H., HUITEMA, S., ROELOFSEN, H., KUIPERS, F., JANSEN, P.L. & MOSHAGE, H. (1997). Differential effects of nitric oxide synthase inhibitors on endotoxic-induced liver damage in rats Gastroenterology, 113, 1323-1333.
41. WEBBER, E.M., GODOWSKI, P.J. & FAUSTO, N. (1994). In vivo response of hepatocyte to growth factors requires an initial priming stimulus. Hepatology, 19, 1521-1527.