Proteomics in renal research

American Journal of Physiology - Renal Physiology

Volumn 292, Issue 2, 2007, Pages

  Janech, Michael G ^a   Raymond, John R ^a   Arthur, John M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

DIGE; Glomerulus; Mass spectrometry; Nephron; Renal tubule; Two dimensional gel electrophoresis

Indexed keywords

ALBUMIN; ALPHA2 GLYCOPROTEIN; APOLIPOPROTEIN A4; BETA 2 MICROGLOBULIN; CARBONATE DEHYDRATASE; CONNEXIN 43; GENTAMICIN; GLUTATHIONE TRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; LEAD; LITHOSTATHINE; PREALBUMIN; SNARE PROTEIN; STREPTOZOCIN; TOXIN; VITAMIN D BINDING PROTEIN;

AMINO ACID SEQUENCE; CELL LYSATE; CELL STRAIN; CLINICAL RESEARCH; COLON CANCER; DIALYSIS; GEL ELECTROPHORESIS; GLOMERULUS; HEMOFILTRATION; HENLE LOOP; HUMAN; IMMUNOHISTOCHEMISTRY; ISOTOPE ANALYSIS; KIDNEY CANCER; KIDNEY CORTEX; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY MEDULLA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE; LEAD POISONING; MASS SPECTROMETRY; NEPHROLITHIASIS; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN URINE LEVEL; PROTEOMICS; REVERSED PHASE LIQUID CHROMATOGRAPHY; REVIEW; SENSITIVITY ANALYSIS; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; TISSUE MICROARRAY; TWO DIMENSIONAL GEL ELECTROPHORESIS; URINALYSIS; URINARY TRACT CANCER; WHOLE CELL;

EID: 33846869763     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00298.2006     Document Type: Review

References (140)

1. Afjehi-Sadat L, Krapfenbauer K, Slavc I, Fountoulakis M, Lubec G. Hypothetical proteins with putative enzyme activity in human amnion, lymphocyte, bronchial epithelial and kidney cell lines. Biochim Biophys Acta 1700: 65-74, 2004.
2. Ahola H, Heikkila E, Astrom E, Inagaki M, Izawa I, Pavenstadt H, Kerjaschki D, Holthofer H. A novel protein, densin, expressed by glomerular podocytes. J Am Soc Nephrol 14: 1731-1737, 2003.
3. Anderson L, Hunter CL. Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol Cell Proteomics 5: 573-588, 2006.
4. Anderson NG, Anderson NL, Tollaksen SL. Proteins of human urine. I. Concentration and analysis by two-dimensional electrophoresis. Clin Chem 25: 1199-1210, 1979.
5. Anderson L, Seilhamer J. A comparison of selected mRNA and protein abundances in human liver. Electrophoresis 18: 533-537, 1997.
6. Aoki Y, Lipsky MM, Fowler BA. Alteration in protein synthesis in primary cultures of rat kidney proximal tubule epithelial cells by exposure to gallium, indium, and arsenite. Toxicol Appl Pharmacol 106: 462-468, 1990.
7. Arthur JM. The MDCK cell line is made up of populations of cells with diverse resistive and transport properties. Tissue Cell 32: 446-450, 2000.
8. Arthur JM. Proteomics. Curr Opin Nephrol Hypertens 12: 423-430, 2003.
9. Arthur JM, Thongboonkerd V, Scherzer JA, Cai J, Pierce WM, Klein JB. Differential expression of proteins in renal cortex and medulla: a proteomic approach. Kidney Int 62: 1314-1321, 2002.
10. Balabanov S, Zimmermann U, Protzel C, Scharf C, Klebingat KJ, Walther R. Tumour-related enzyme alterations in the clear cell type of human renal cell carcinoma identified by two-dimensional gel electrophoresis. Eur J Biochem 268: 5977-5980, 2001.
11. Banks RE, Dunn MJ, Forbes MA, Stanley A, Pappin D, Naven T, Gough M, Harnden P, Selby PJ. The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis-preliminary findings. Electrophoresis 20: 689-700, 1999.
12. Barati MT, Powell DW, McLeish KR. Proteomic approach to identification of novel kinase substrates in mesangial cells. Contrib Nephrol 141: 231-244, 2004.
13. Barile M, Pisitkun T, Yu MJ, Chou CL, Verbalis MJ, Shen RF, Knepper MA. Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Mol Cell Proteomics 4: 1095-1106, 2005.
14. Bickel CA, Knepper MA, Verbalis JG, Ecelbarger CA. Dysregulation of renal salt and water transport proteins in diabetic Zucker rats. Kidney Int 61: 2099-2110, 2002.
15. Binette JP, Binette MB. Sequencing of proteins extracted from stones. Scanning Microsc 8: 233-239, 1994.
16. Bonventre JV. The kidney proteome: a hint of things to come. Kidney Int 62: 1470-1471, 2002.
17. + transporter and channel abundances in angiotensin II type 1a receptor knockout mice. Hypertension 39: 470-473, 2002.
18. + transporter abundances in NHE3 and NCC null mice using targeted proteomics. J Physiol 530: 359-366, 2001.
19. Bueler MR, Wiederkehr F, Vonderschmitt DJ. Electrophoretic, chromatographic and immunological studies of human urinary proteins. Electrophoresis 16: 124-134, 1995.
20. Cadieux PA, Beiko DT, Watterson JD, Burton JP, Howard JC, Knudsen BE, Gan BS, McCormick JK, Chambers AF, Denstedt JD, Reid G. Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS): a new proteomic urinary test for patients with urolithiasis. J Clin Lab Anal 18: 170-175, 2004.
21. Charlwood J, Skehel JM, King N, Camilleri P, Lord P, Bugelski P, Atif U. Proteomic analysis of rat kidney cortex following treatment with gentamicin. J Proteome Res 1: 73-82, 2002.
22. Cheung PY, Lai WP, Lau HY, Lo SC, Wong MS. Acute and chronic effect of dietary phosphorus restriction on protein expression in young rat renal proximal tubules. Proteomics 2: 1211-1219, 2002.
23. Chutipongtanate S, Nakagawa Y, Sritippayawan S, Pittayamateekul J, Parichatikanond P, Westley BR, May FE, Malasit P, Thongboonkerd V. Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor. J Clin Invest 115: 3613-3622, 2005.
24. Craven RA, Totty N, Harnden P, Selby PJ, Banks RE. Laser capture microdissection and two-dimensional polyacrylamide gel electrophoresis: evaluation of tissue preparation and sample limitations. Am J Pathol 160: 815-822, 2002.
25. Curthoys NP, Taylor L, Hoffert JD, Knepper MA. Proteomic analysis of the adaptive response of rat renal proximal tubules to metabolic acidosis. Am J Physiol Renal Physiol 291: F140-F147, 2006.
26. Cutillas P, Burlingame A, Unwin R. Proteomic strategies and their application in studies of renal function. News Physiol Sci 19: 114-119, 2004.
27. Cutillas PR, Biber J, Marks J, Jacob R, Stieger B, Cramer R, Waterfield M, Burlingame AL, Unwin RJ. Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex. Proteomics 5: 101-112, 2005.
28. D'Ambrosio C, Arena S, Talamo F, Ledda L, Renzone G, Ferrara L, Scaloni A. Comparative proteomic analysis of mammalian animal tissues and body fluids: bovine proteome database. J Chromatogr B Analyt Technol Biomed Life Sci 815: 157-168, 2005.
29. Davis MT, Spahr CS, McGinley MD, Robinson JH, Bures EJ, Beierle J, Mort J, Yu W, Luethy R, Patterson SD. Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry. II. Limitations of complex mixture analyses. Proteomics 1: 108-117, 2001.
30. Dihazi H, Rahman AA, Agarwal NK, Doncheva Y, Muller GA. Proteomics analysis of cellular response to osmotic stress in TALH-cells. Mol Cell Proteomics 4: 1445-1458, 2005.
31. Ecelbarger CA. Proteomics and sodium transport. Contrib Nephrol 141: 124-141, 2004.
32. Ecelbarger CA. Targeted proteomics using immunoblotting technique for studying dysregulation of ion transporters in renal disorders. Expert Rev Proteomics 1: 219-227, 2004.
33. Emmert-Buck MR, Bonner RF, Smith PD, Chuaqui RF, Zhuang Z, Goldstein SR, Weiss RA, Liotta LA. Laser capture microdissection. Science 274: 998-1001, 1996.
34. Fiedler K, Kellner R, Simons K. Mapping the protein composition of trans-Golgi network (TGN)-derived carrier vesicles from polarized MDCK cells. Electrophoresis 18: 2613-2619, 1997.
35. Fiedler K, Kobayashi T, Kurzchalia TV, Simons K. Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells. Biochemistry 32: 6365-6373, 1993.
36. Fliser D, Wittke S, Mischak H. Capillary electrophoresis coupled to mass spectrometry for clinical diagnostic purposes. Electrophoresis 26: 2708-2716, 2005.
37. Ford DM, Molitoris BA. Abnormal proximal tubule apical membrane protein composition in X-linked hypophosphatemic mice. Am J Physiol Renal Fluid Electrolyte Physiol 260: F317-F322, 1991.
38. Fung E, Diamond D, Simonsesn AH, Weinberger SR. The use of SELDI ProteinChip array technology in renal disease research. Methods Mol Med 86: 295-312, 2003.
39. Grover PK, Resnick MI. Evidence for the presence of abnormal proteins in the urine of recurrent stone formers. J Urol 153: 1716-1721, 1995.
40. Gygi SP, Rist B, Aebersold R. Measuring gene expression by quantitative proteome analysis. Curr Opin Biotechnol 11: 396-401, 2000.
41. Gygi SP, Rist B, Gerber SA, Turecek F, Gelb MH, Aebersold R. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol 17: 994-999, 1999.
42. Gygi SP, Rochon Y, Franza BR, Aebersold R. Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19: 1720-1730, 1999.
43. Hempel G. Biomedical applications of capillary electrophoresis. Clin Chem Lab Med 41: 720-723, 2003.
44. Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci USA 103: 7159-7164, 2006.
45. Hoffert JD, van Balkom BW, Chou CL, Knepper MA. Application of difference gel electrophoresis to the identification of inner medullary collecting duct proteins. Am J Physiol Renal Physiol 286: F170-F179, 2004.
46. Hoorn EJ, Hoffert JD, Knepper MA. Combined proteomics and pathways analysis of collecting duct reveals a protein regulatory network activated in vasopressin escape. J Am Soc Nephrol 16: 2852-2863, 2005.
47. Hoorn EJ, Pisitkun T, Zietse R, Gross P, Frokiaer J, Wang NS, Gonzales PA, Star RA, Knepper MA. Prospects for urinary proteomics: exosomes as a source of urinary biomarkers. Nephrology 10: 283-290, 2005.
48. Huber LA, Pasquali C, Gagescu R, Zuk A, Gruenberg J, Matlin KS. Endosomal fractions from viral K-ras-transformed MDCK cells reveal transformation specific changes on two-dimensional gel maps. Electrophoresis 17: 1734-1740, 1996.
49. Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K. Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J Cell Biol 123: 35-45, 1993.
50. Huber LA, Ullrich O, Takai Y, Lutcke A, Dupree P, Olkkonen V, Virta H, de Hoop MJ, Alexandrov K, Peter M. Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis. Proc Natl Acad Sci USA 91: 7874-7878, 1994.
51. Hwa JS, Park HJ, Jung JH, Kam SC, Park HC, Kim CW, Kang KR, Hyun JS, Chung KH. Identification of proteins differentially expressed in the conventional renal cell carcinoma by proteomic analysis. J Korean Med Sci 20: 450-455, 2005.
52. Jia Z, Person MD, Dong J, Shen J, Hensley SC, Stevens JL, Monks TJ, Lau SS. Grp78 is essential for 11-deoxy-16,16-dimethyl PGE2-mediated cytoprotection in renal epithelial cells. Am J Physiol Renal Physiol 287: F1113-F1122, 2004.
53. Jones WT, Resnick MI. The characterization of soluble matrix proteins in selected human renal calculi using two-dimensional polyacrylamide gel electrophoresis. J Urol 144: 1010-1014, 1990.
54. Kaiser T, Hermann A, Kielstein JT, Wittke S, Bartel S, Krebs R, Hausadel F, Hillmann M, Golovko I, Koester P, Haller H, Weissinger EM, Fliser D, Mischak H. Capillary electrophoresis coupled to mass spectrometry to establish polypeptide patterns in dialysis fluids. J Chromatogr A 1013: 157-171, 2003.
55. Kaneko K, Yamanobe T, Nakagomi K, Mawatari K, Onoda M, Fujimori S. Detection of protein Z in a renal calculus composed of calcium oxalate monohydrate with the use of liquid chromatographymass spectrometry/mass spectrometry following two-dimensional polyacrylamide gel electrophoresis separation. Anal Biochem 324: 191-196, 2004.
56. Kanitz MH, Witzmann FA, Zhu H, Fultz CD, Skaggs S, Moorman WJ, Savage RE Jr. Alterations in rabbit kidney protein expression following lead exposure as analyzed by two-dimensional gel electrophoresis. Electrophoresis 20: 2977-2985, 1999.
57. Keller T, Pleskova M, McDonald MC, Thiemermann C, Pfeilschifter J, Beck KF. Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis. Nitric Oxide 9: 183-193, 2003.
58. Kennedy S. The role of proteomics in toxicology: identification of biomarkers of toxicity by protein expression analysis. Biomarkers 7: 269-290, 2002.
59. Kim CH, Park DU, Chung AS, Zou Y, Jung KJ, Sung BK, Yu BP, Chung HY. Proteomic analysis of post-mitochondrial fractions of young and old rat kidney. Exp Gerontol 39: 1155-1168, 2004.
60. Kirby R, Cho EJ, Gehrke B, Bayer T, Park YS, Neikirk DP, McDevitt JT, Ellington AD. Aptamer-based sensor arrays for the detection and quantitation of proteins. Anal Chem 76: 4066-4075, 2004.
61. Klade CS, Voss T, Krystek E, Ahorn H, Zatloukal K, Pummer K, Adolf GR. Identification of tumor antigens in renal cell carcinoma by serological proteome analysis. Proteomics 1: 890-898, 2001.
62. Klein E, Klein JB, Thongboonkerd V. Two-dimensional gel electrophoresis: a fundamental tool for expression proteomics studies. Contrib Nephrol 141: 25-39, 2004.
63. Klose J. Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues. Humangenetik 26: 231-243, 1975.
64. Knepper MA. Proteomics and the kidney. J Am Soc Nephrol 13: 1398-1408, 2002.
65. Knepper MA, Masilamani S. Targeted proteomics in the kidney using ensembles of antibodies. Acta Physiol Scand 173: 11-21, 2001.
66. Kodadek T, Reddy MM, Olivos HJ, Bachhawat-Sikder K, Alluri PG. Synthetic molecules as antibody replacements. Acc Chem Res 37: 711-718, 2004.
67. Kolch W, Neususs C, Pelzing M, Mischak H. Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery. Mass Spectrom Rev 24: 959-977, 2005.
68. Kuncewicz T, Sheta EA, Goldknopf IL, Kone BC. Proteomic analysis reveals novel protein targets of S-nitrosylation in mesangial cells. Contrib Nephrol 141: 221-230, 2004.
69. Ladarola P, Cetta G, Luisetti M, Annovazzi L, Casado B, Baraniuk J, Zanone C, Viglio S. Micellar electrokinetic chromatographic and capillary zone electrophoretic methods for screening urinary biomarkers of human disorders: a critical review of the state-of-the-art. Electrophoresis 26: 752-766, 2005.
70. Langlois RG, Trebes JE, Dalmasso EA, Ying Y, Davies RW, Curzi MP, Colston BW Jr, Turteltaub KW, Perkins J, Chromy BA, Choi MW, Murphy GA, Fitch JP, McCutchen-Maloney SL. Serum protein profile alterations in hemodialysis patients. Am J Nephrol 24: 268-274, 2004.
71. Lefler DM, Pafford RG, Black NA, Raymond JR, Arthur JM. Identification of proteins in slow continuous ultrafiltrate by reversed-phase chromatography and proteomics. J Proteome Res 3: 1254-1260, 2004.
72. Legato J, Knepper MA, Star RA, Mejia R. Database for renal collecting duct regulatory and transporter proteins. Physiol Genomics 13: 179-181, 2003.
73. Lehtonen S, Lehtonen E, Kudlicka K, Holthofer H, Farquhar MG. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am J Pathol 165: 923-936, 2004.
74. Leong PK, Devillez A, Sandberg MB, Yang LE, Yip KP, Klein JB, McDonough AA. Effects of ACE inhibition on proximal tubule sodium transport. Am J Physiol Renal Physiol 290: F854-F863, 2006.
75. Li G, Chu J, Liu X, Yuan Z. Separation, identification of uremic middle molecules, and preliminary study on their toxicity. Clin Chim Acta 350: 89-98, 2004.
76. Merrick BA, Bruno ME. Genomic and proteomic profiling for biomarkers and signature profiles of toxicity. Curr Opin Mol Ther 6: 600-607, 2004.
77. Mijalski T, Harder A, Halder T, Kersten M, Horsch M, Strom TM, Liebscher HV, Lottspeich F, de Angelis MH, Beckers J. Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues. Proc Natl Acad Sci USA 102: 8621-8626, 2005.
78. Molina H, Bunkenborg J, Reddy GH, Muthusamy B, Scheel PJ, Pandey A. A proteomic analysis of human hemodialysis fluid. Mol Cell Proteomics 4: 637-650, 2005.
79. Myung JK, Afjehi-Sadat L, Felizardo-Cabatic M, Slavc I, Lubec G. Expressional patterns of chaperones in ten human tumor cell lines. Proteome Sci 2: 1-21, 2004.
80. Nedelkov D, Nelson RW. Analysis of human urine protein biomarkers via biomolecular interaction analysis mass spectrometry. Am J Kidney Dis 38: 481-487, 2001.
81. Neuhoff N, Kaiser T, Wittke S, Krebs R, Pitt A, Burchard A, Sundmacher A, Schlegelberger B, Kolch W, Mischak H. Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry. Rapid Commun Mass Spectrom 18: 149-156, 2004.
82. O'Farrell PH. High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250: 4007-4021, 1975.
83. Oates JC, Varghese SA, Bland AM, Taylor TP, Self SE, Stanislaus R, Almeida JS, Arthur JM. Prediction of urinary protein markers in lupus nephritis. Kidney Int 65: 2588-2592, 2005.
84. Obelchuk LI, Tsomartova DA, Kovalyov LI, Khasigov PZ, Rubachev PG, Grachev SV, Shishkin SS, Berezov TT. Standardized and extended catalog of major proteins of the human kidney. Biochemistry (Mosc) 62: 191-199, 1997.
85. Oh JE, Krapfenbauer K, Fountoulakis M, Frischer T, Lubec G. Evidence for the existence of hypothetical proteins in human bronchial epithelial, fibroblast, amnion, lymphocyte, mesothelial and kidney cell lines. Amino Acids 26: 9-18, 2004.
86. Onogi H, Inagi R, Miyata T, Nangaku M, Kurokawa K. Proteomics and mesangial cell: serpin, megsin and plasmin. Contrib Nephrol 141: 212-220, 2004.
87. Parker CE, Mocanu V, Warren MR, Greer SF, Borchers CH. Mass spectrometric determination of protein ubiquitination. Methods Mol Biol 301: 153-173, 2005.
88. Person MD, Lo HH, Towndrow KM, Jia Z, Monks TJ, Lau SS. Comparative identification of prostanoid inducible proteins by LC-ESIMS/MS and MALDI-TOF mass spectrometry. Chem Res Toxicol 16: 757-767, 2003.
89. Pieper R, Gatlin CL, McGrath AM, Makusky AJ, Mondal M, Seonarain M, Field E, Schatz CR, Estock MA, Ahmed N, Anderson NG, Steiner S. Characterization of the human urinary proteome: a method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots. Proteomics 4: 1159-1174, 2004.
90. Pinet F, Poirier F, Fuchs S, Tharaux PL, Caron M, Corvol P, Michel JB, Joubert-Caron R. Troponin T as a marker of differentiation revealed by proteomic analysis in renal arterioles. FASEB J 18: 585-586, 2004.
91. Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA 101: 13368-13373, 2004.
92. Pizzonia JH, Gesek FA, Kennedy SM, Coutermarsh BA, Backsai BJ, Friedman PA. Immunomagnetic separation, primary culture, and characterization of cortical thick ascending limb plus distal convoluted tubule cells from mouse kidney. In Vitro Cell Dev Biol 27A: 409-416, 1991.
93. Praetorius J, Backlund P, Yergey AL, Spring KR. Specific lectin binding to beta1 integrin and fibronectin on the apical membrane of Madin-Darby canine kidney cells. J Membr Biol 184: 273-281, 2001.
94. Ransom RF. Podocyte proteomics. Contrib Nephrol 141: 189-211, 2004.
95. Ransom RF, Vega-Warner V, Smoyer WE, Klein J. Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes. Kidney Int 67: 1275-1285, 2005.
96. Reshkin SJ, Wuarin F, Biber J, Murer H. Parathyroid hormone-induced alterations of protein content and phosphorylation in enriched apical membranes of opossum kidney cells. J Biol Chem 265: 15261-15266, 1990.
97. Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, Szweda LI, Brownlee M, Monnier VM, Weiss MF. Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol 289: F420-F430, 2005.
98. Rowe PS. The role of the PHEX gene (PEX) in families with X-linked hypophosphataemic rickets. Curr Opin Nephrol Hypertens 7: 367-376, 1998.
99. Sanchez-Fructuoso AI, Torralbo A, Arroyo M, Luque M, Ruilope LM, Santos JL, Cruceyra A, Barrientos A. Occult lead intoxication as a cause of hypertension and renal failure. Nephrol Dial Transplant 11: 1775-1780, 1996.
100. Sarto C, Marocchi A, Sanchez JC, Giannone D, Frutiger S, Golaz O, Wilkins MR, Doro G, Cappellano F, Hughes G, Hochstrasser DF, Mocarelli P. Renal cell carcinoma and normal kidney protein expression. Electrophoresis 18: 599-604, 1997.
101. Sarto C, Valsecchi C, Magni F, Tremolada L, Arizzi C, Cordani N, Casellato S, Doro G, Favini P, Perego RA, Raimondo F, Ferrero S, Mocarelli P, Galli-Kienle M. Expression of heat shock protein 27 in human renal cell carcinoma. Proteomics 4: 2252-2260, 2004.
102. Schaub S, Rush D, Wilkins J, Gibson IW, Weiler T, Sangster K, Nicolle L, Karpinski M, Jeffery J, Nickerson P. Proteomic-based detection of urine proteins associated with acute renal allograft rejection. J Am Soc Nephrol 15: 219-227, 2004.
103. Schaub S, Wilkins JA, Antonovici M, Krokhin O, Weiler T, Rush D, Nickerson P. Proteomic-based identification of cleaved urinary beta2-microglobulin as a potential marker for acute tubular injury in renal allografts. Am J Transplant 5: 729-738, 2005.
104. Shi T, Dong F, Liou LS, Duan ZH, Novick AC, DiDonato JA. Differential protein profiling in renal-cell carcinoma. Mol Carcinog 40: 47-61, 2004.
105. Singh D, Lampe PD. Identification of connexin-43 interacting proteins. Cell Commun Adhes 10: 215-220, 2003.
106. Sitek B, Potthoff S, Schulenborg T, Stegbauer J, Vinke T, Rump LC, Meyer HE, Vonend O, Stuhler K. Novel approaches to analyse glomerular proteins from smallest scale murine and human samples using DIGE saturation labelling. Proteomics 6: 4337-4345, 2006.
107. Smith AH, Vrtis JM, Kodadek T. The potential of protein-detecting microarrays for clinical diagnostics. Adv Clin Chem 38: 217-238, 2004.
108. Spahr CS, Davis MT, McGinley MD, Robinson JH, Bures EJ, Beierle J, Mort J, Courchesne PL, Chen K, Wahl RC, Yu W, Luethy R, Patterson SD. Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry. I. Profiling an unfractionated tryptic digest. Proteomics 1: 93-107, 2001.
109. Thongboonkerd V. Proteomics in nephrology: current status and future directions. Am J Nephrol 24: 360-378, 2004.
110. Thongboonkerd V, Barati MT, McLeish KR, Benarafa C, Remold-O'Donnell E, Zheng S, Rovin BH, Pierce WM, Epstein PN, Klein JB. Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis. J Am Soc Nephrol 15: 650-662, 2004.
111. Thongboonkerd V, Chutipongtanate S, Kanlaya R, Songtawee N, Sinchaikul S, Parichatikanond P, Chen ST, Malasit P. Proteomic identification of alterations in metabolic enzymes and signaling proteins in hypokalemic nephropathy. Proteomics 6: 2273-2285, 2006.
112. Thongboonkerd V, Gozal E, Sachleben LR Jr, Arthur JM, Pierce WM, Cai J, Chao J, Bader M, Pesquero JB, Gozal D, Klein JB. Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension. J Biol Chem 277: 34708-34716, 2002.
113. Thongboonkerd V, Klein JB, Arthur JM. Proteomic identification of a large complement of rat urinary proteins. Nephron Exp Nephrol 95: e69-e78, 2003.
114. Thongboonkerd V, Klein JB, Pierce WM, Jevans AW, Arthur JM. Sodium loading changes urinary protein excretion: a proteomic analysis. Am J Physiol Renal Physiol 284: F1155-F1163, 2003.
115. Thongboonkerd V, Malasit P. Renal and urinary proteomics: current applications and challenges. Proteomics 5: 1033-1042, 2005.
116. Tonge R, Shaw J, Middleton B, Rowlinson R, Rayner S, Young J, Pognan F, Hawkins E, Currie I, Davison M. Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology. Proteomics 1: 377-396, 2001.
117. Towndrow KM, Jia Z, Lo HH, Person MD, Monks TJ, Lau SS. 11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. Chem Res Toxicol 16: 312-319, 2003.
118. Unlu M, Morgan ME, Minden JS. Difference gel electrophoresis: a single gel method for detecting changes in protein extracts. Electrophoresis 18: 2071-2077, 1997.
119. Unwin RD, Knowles MA, Selby PJ, Banks RE. Urological malignancies and the proteomic-genomic interface. Electrophoresis 20: 3629-3637, 1999.
120. Unwin RD, Pierce A, Watson RB, Sternberg DW, Whetton AD. Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol Cell Proteomics 4: 924-935, 2005.
121. Valkova N, Yunis R, Mak SK, Kang K, Kultz D. Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice. Mol Cell Proteomics 4: 1009-1018, 2005.
122. van Balkom BW, Hoffert JD, Chou CL, Knepper MA. Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat. Am J Physiol Renal Physiol 286: F216-F224, 2004.
123. Vosseller K, Trinidad JC, Chalkley RJ, Specht CG, Thalhammer A, Lynn AJ, Snedecor JO, Guan S, Medzihradszky KF, Maltby DA, Schoepfer R, Burlingame AL. O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry. Mol Cell Proteomics 5: 923-934, 2006.
124. Wang G, Wu WW, Pisitkun T, Hoffert JD, Knepper MA, Shen RF. Automated quantification tool for high-throughput proteomics using stable isotope labeling and LC-MSn. Anal Chem 78: 5752-5761, 2006.
125. Wang XY, Masilamani S, Nielsen J, Kwon TH, Brooks HL, Nielsen S, Knepper MA. The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest 108: 215-222, 2001.
126. Ward RA, Brinkley KA. A proteomic analysis of proteins removed by ultrafiltration during extracorporeal renal replacement therapy. Contrib Nephrol 141: 280-291, 2004.
127. Warren MR, Parker CE, Mocanu V, Klapper D, Borchers CH. Electrospray ionization tandem mass spectrometry of model peptides reveals diagnostic fragment ions for protein ubiquitination. Rapid Commun Mass Spectrom 19: 429-437, 2005.
128. Watzig H, Gunter S. Capillary electrophoresis-a high performance analytical separation technique. Clin Chem Lab Med 41: 724-738, 2003.
129. Weissinger EM, Kaiser T, Meert N, De Smet R, Walden M, Mischak H, Vanholder RC. Proteomics: a novel tool to unravel the patho-physiology of uraemia. Nephrol Dial Transplant 19: 3068-3077, 2004.
130. Wittke S, Haubitz M, Walden M, Rohde F, Schwarz A, Mengel M, Mischak H, Haller H, Gwinner W. Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients. Am J Transplant 5: 2479-2488, 2005.
131. Witzmann FA, Bauer MD, Fieno AM, Grant RA, Keough TW, Lacey MP, Sun Y, Witten ML, Young RS. Proteomic analysis of the renal effects of simulated occupational jet fuel exposure. Electrophoresis 21: 976-984, 2000.
132. Witzmann FA, Carpenter RL, Ritchie GD, Wilson CL, Nordholm AF, Rossi J III. Toxicity of chemical mixtures: proteomic analysis of persisting liver and kidney protein alterations induced by repeated exposure of rats to JP-8 jet fuel vapor. Electrophoresis 21: 2138-2147, 2000.
133. Witzmann FA, Daggett DA, Fultz CD, Nelson SA, Wright LS, Kornguth SE, Siegel FL. Glutathione S-transferases: two-dimensional electrophoretic protein markers of lead exposure. Electrophoresis 19: 1332-1335, 1998.
134. Witzmann FA, Fultz CD, Grant RA, Wright LS, Kornguth SE, Siegel FL. Differential expression of cytosolic proteins in the rat kidney cortex and medulla: preliminary proteomics. Electrophoresis 19: 2491-2497, 1998.
135. Witzmann FA, Fultz CD, Grant RA, Wright LS, Kornguth SE, Siegel FL. Regional protein alterations in rat kidneys induced by lead exposure. Electrophoresis 20: 943-951, 1999.
136. Witzmann FA, Fultz CD, Lipscomb JC. Toxicant-induced alterations in two-dimensional electrophoretic patterns of hepatic and renal stress proteins. Electrophoresis 17: 198-202, 1996.
137. Xu H, Hu LS, Chang M, Jing L, Zhang XY, Li GS. Proteomic analysis of kidney in fluoride-treated rat. Toxicol Lett 160: 69-75, 2005.
138. Yoshida Y, Miyazaki K, Kamiie J, Sato M, Okuizumi S, Kenmochi A, Kamijo K, Nabetani T, Tsugita A, Xu B, Zhang Y, Yaoita E, Osawa T, Yamamoto T. Two-dimensional electrophoretic profiling of normal human kidney glomerulus proteome and construction of an extensible markup language (XML)-based database. Proteomics 5: 1083-1096, 2005.
139. Zhou H, Pisitkun T, Aponte A, Yuen PS, Hoffert JD, Yasuda H, Hu X, Chawla L, Shen RF, Knepper MA, Star RA. Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury. Kidney Int 70: 1847-1857, 2006.
140. Zhou H, Yuen PS, Pisitkun T, Gonzales PA, Yasuda H, Dear JW, Gross P, Knepper MA, Star RA. Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int 69: 1471-1476, 2006.