Proteomics and mesangial cell: Serpin, megsin and plasmin

Contributions to Nephrology

Volumn 141, Issue , 2004, Pages 212-220

  Onogi, Hiroshi ^a   Inagi, Reiko ^a   Miyata, Toshio ^a   Nangaku, Masaomi ^b   Kurokawa, Kiyoshi ^a  

^a TOKAI UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33747043751     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (29)

1. Shimizu F, Kawachi H, Orikasa M: Role of mesangial cell damage in progressive renal disease. Kidney Blood Press Res 1999;22:5-12.
2. Yasuda Y, Miyata T, Nangaku M, lida Y, Maeda K, Okubo K, Kurokawa K: Functional quantitative analysis of the genome in cultured human mesangial cells. Kidney Int 1998;53:154-158.
3. Wada T, Miyata T, Inagi R, Nangaku M, Wagatsuma M, Suzuki D, Wadzinski BE, Okubo K, Kurokawa K: Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells. J Am Soc Nephrol 2001;12:2601-2608.
4. Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC: The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem 2001;276:33293-33296.
5. Miyata T, Nangaku M, Suzuki D, Inagi R, Uragami K, Sakai H, Okubo K, Kurokawa K: A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy. J Clin Invest 1998;102:828-836.
6. Inagi R, Nangaku M, Miyata T, Kurokawa K: Mesangial cell-predominant functional gene, megsin. Clin Exp Nephrol 2003;7:87-92.
7. Schick C, Kamachi Y, Bartuski AJ, Cataltepe S, Schechter NM, Pemberton PA, Silverman GA: Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase. J Biol Chem 1997;272:1849-1855.
8. Inagi R, Miyata T, Nangaku M, Ueyama H, Takeyama K, Kato S, Kurokawa K: Transcriptional regulation of a mesangium-predominant gene, megsin. J Am Soc Nephrol 2002; 13:2715-2722.
9. Ye RD, Ahern SM, LeBeau MM, Lebo RV Sadler JE: Structure of the gene from human plasminogen activator inhibitor-2. J Biol Chem 1989;264:5495-5502.
10. Kruithof EK, Baker MS, Bunn C: Biological and clinical aspects of plasminogen activator inhibitor type 2. Blood 1995;86:4007-4024.
11. Bachmann F: The enigma PAI-2: Gene expression, evolutionary and functional aspects. Thromb Haemost 1995;74:172-179.
12. Bird PI: Serpins and regulation of cell death. Results Probl Cell Differ 1998;24:63-89.
13. Scott FL, Eyre HJ, Lioumi M, Ragoussis J, Irving JA, Sutherland GA, Bird PI: Human ovalbumin serpin evolution: Phylogenic analysis, gene organization and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25. Genomics 1999;62:490-499.
14. Inagi R, Miyata T, Suzuki D, Toyoda M, Wada T, Ueda Y, Izuhara Y, Sakai H, Nangaku M, Kurokawa K: Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy. Biochem Biophys Res Commun 2001;286:1098-1106.
15. Nangaku M, Miyata T, Suzuki D, Umezono T, Hashimoto T, Wada T, Yagi M, Nagano N, Inagi R, Kurokawa K: Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis. Kidney Int 2001;60:641-652.
16. Suzuki D, Miyata T, Nangaku M, Takano H, Saotome N, Inagi R, Endoh M, Kurokawa K, Sakai H: Expression of megsin mRNA, a novel mesangium-predominant gene, in the renal tissues of various glomerular diseases. J Am Soc Nephrol 1999;10:2606-2613.
17. Inagi R, Miyata T, Imasawa T, Nangaku M, Kurokawa K: Mesangial cell-predominant gene, megsin. Nephrol Dial Transplant 2002; 17:32-33.
18. Miyata T, Inagi R, Nangaku M, Imasawa T, Sato M, Izuhara Y, Suzuki D, Yoshino A, Onogi H, Kimura M, Sugiyama S, Kurokawa K: Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion. J Clin Invest 2002;109:585-593.
19. Mclennan SV, Fisher E, Martell SY, Death AK, Williams PF, Lyons JG, Yue DK: Effects of glucose on matrix metalloproteinase and plasmin activities in mesangial cells: Possible role in diabetic nephropathy. Kidney Int 2000;58(suppl 77):81-87.
20. Brown NJ, Vaughan DE, Fogo AB: The renin-angiotensin-aldosterone system and fibrinolysis in progressive renal disease. Semin Nephrol 2002;22:399-3406.
21. Baricos WH, Cortez SL, el-Dahr SS, Schnaper HW: ECM degradation by cultured human mesangial cells is mediated by a PA/plasmin/MMP-2 cascade. Kidney Int 1995;47:1039-1047.
22. Eitzman DT, McCoy RD, Zheng X, Fay WP, Shen T, Ginsburg D, Simon RH: Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996;97:232-237.
23. Johnson RJ, Lovett D, Lehrer RI, Couser WG, Klebanoff SJ: Role of oxidants and proteases in glomerular injury. Kidney Int 1994;45:352-359.
24. Davie M, Martin J, Thomas GJ, Lovett DH: Proteinases and glomerular matrix turnover. Kidney Int 1992;41:671-678.
25. Baricos WH, Shah SV: Proteolytic enzymes as mediators of glomerular injury. Kidney Int 1991; 40:161-173.
26. Davies M, Coles GA, Thomas GJ, Martin J, Lovett DH: Proteinases and the glomerulus: Their role in glomerular diseases. Klin Wochenschr 1990;68:1145-1149.
27. Fogo AB: The role of angiotensin II and plasminogen activator inhibitor-1 in progressive glomeru-losclerosis. Am J Kidney Dis 2000;35:179-188.
28. Loskutoff DJ: A slice of PAL J Clin Invest 1993;92:2563.
29. Nakamura S, Nakamura I, Ma L, Vaughan DE, Fogo AB: Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo. Kidney Int 2000;58:251-259.