Protective effects of inosine on mice subjected to lethal total-body ionizing irradiation

Journal of Radiation Research

Volumn 48, Issue 1, 2007, Pages 57-62

  Hou, Bing ^a   Xu, Zhi Wei ^a   Yang, Chao Wen ^a   Gao, Yan ^a   Zhao, Shi Fu ^a   Zhang, Cheng Gang ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Inosine; Spatial memory; Total body irradiation

Indexed keywords

ANTHROPOMETRY; GAMMA RAYS; IRRADIATION;

BALB/C MICE; EXPOSED TO; IN-VITRO; INOSINE; IONIZING IRRADIATION; PROTECTIVE EFFECTS; SPATIAL MEMORY; SURVIVAL TIME; TOTAL BODY IRRADIATION; VITRO AND IN VIVO;

MAMMALS;

MAMMALIA; MUS;

EID: 33846869096     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.06067     Document Type: Article

References (27)

1. Dubois, A. and Walker, R. I. (1988) Prospects for management of gastrointestinal injury associated with the acute radiation syndrome. Gastroenterology 95: 500-507.
2. Devous, M. D., Sr. and Lewandowski, E. D. (1987) Inosine preserves ATP during ischemia and enhances recovery during reperfusion. Am. J. Physiol 253: H1224-H1233.
3. Harmsen, E., de Tombe, P. P., de Jong, J. W., and Achterberg, P. W. (1984) Enhanced ATP and GTP synthesis from hypoxanthine or inosine after myocardial ischemia. Am. J. Physiol 246: H37-H43.
4. Dowdall, J. F., Winter, D. C., and Bouchier-Hayes, D. J. (2002) Inosine modulates gut barrier dysfunction and end organ damage in a model of ischemia-reperfusion injury. J. Surg. Res. 108: 61-68.
5. Litsky, M. L., Hohl, C. M., Lucas, J. H., and Jurkowitz, M. S. (1999) Inosine and guanosine preserve neuronal and glial cell viability in mouse spinal cord cultures during chemical hypoxia. Brain Res. 821: 426-432.
6. Shi, M., You, S. W., Meng, J. H., and Ju, G. (2002) Direct protection of inosine on PC12 cells against zinc-induced injury. Neuroreport 13: 477-479.
7. Hou, B., You, S. W., Wu, M. M., Kuang, F., Liu, H. L., Jiao, X. Y., and Ju, G. (2004) Neuroprotective effect of inosine on axotomized retinal ganglion cells in adult rats. Invest Ophthalmol. Vis. Sci. 45: 662-667.
8. Hasko, G., Kuhel, D. G., Nemeth, Z. H., Mabley, J. G., Stachlewitz, R. F., Virag, L., Lohinai, Z., Southan, G. J., Salzman, A. L., and Szabo, C. (2000) Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J. Immunol. 164: 1013-1019.
9. Yamagiwa, T., Shimosegawa, T., Satoh, A., Kimura, K., Sakai, Y., and Masamune, A. (2004) Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury. J. Gastroenterol. 39: 41-49.
10. Mabley, J. G., Rabinovitch, A., Suarez-Pinzon, W., Hasko, G., Pacher, P., Power, R., Southan, G., Salzman, A., and Szabo, C. (2003) Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes. Mol. Med. 9: 96-104.
11. Pospisil, M., Netikova, J., Pipalova, I., and Volenec, K. (1991) Radioprotective effect of inosine and its enhancement by magnesium and global hypoxia. Physiol Res. 40: 445-452.
12. Mizumatsu, S., Monje, M. L., Morhardt, D. R., Rola, R., Palmer, T. D., and Fike, J. R. (2003) Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 63: 4021-4027.
13. Rola, R., Raber, J., Rizk, A., Otsuka, S., VandenBerg, S. R., Morhardt, D. R., and Fike, J. R. (2004) Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp. Neurol. 188: 316-330.
14. Goel, H. C., Prasad, J., Singh, S., Sagar, R. K., Agrawala, P. K., Bala, M., Sinha, A. K., and Dogra, R. (2004) Radioprotective potential of an herbal extract of Tinospora cordifolia. J. Radiat. Res. (Tokyo) 45: 61-68.
15. Singh, I., Sharma, A., Nunia, V., and Goyal, P. K. (2005) Radioprotection of Swiss albino mice by Emblica officinalis. Phytother. Res. 19: 444-446.
16. Hofer, M., Mazur, L., Pospisil, M., Weiterova, L., and Znojil, V. (2000) Radioprotective action of extracellular adenosine on bone marrow cells in mice exposed to gamma rays as assayed by the micronucleus test. Radiat. Res. 154: 217-221.
17. Tikhomirova, M. V., Iashkin, P. N., Fedorenko, B. S., and Chertkov, K. S. (1984) [Radiation-protective effectiveness of ATP and adenosine against high-energy protons]. Kosm. Biol. Aviakosm. Med. 18: 75-77.
18. Pospisil, M., Hofer, M., Netikova, J., Pipalova, I., Vacek, A., Bartonickova, A., and Volenec, K. (1993) Elevation of extracellular adenosine induces radioprotective effects in mice. Radiat. Res. 134: 323-330.
19. Barankiewicz, J. and Cohen, A. (1985) Purine nucleotide metabolism in resident and activated rat macrophages in vitro. Eur. J. Immunol. 15: 627-631.
20. Jin, X., Shepherd, R. K., Duling, B. R., and Linden, J. (1997) Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J. Clin. Invest 100: 2849-2857.
21. Benowitz, L. I., Jing, Y., Tabibiazar, R., Jo, S. A., Petrausch, B., Stuermer, C. A., Rosenberg, P. A., and Irwin, N. (1998) Axon outgrowth is regulated by an intracellular purine-sensitive mechanism in retinal ganglion cells. J. Biol. Chem. 273: 29626-29634.
22. Jurkowitz, M. S., Litsky, M. L., Browning, M. J., and Hohl, C. M. (1998) Adenosine, inosine, and guanosine protect glial cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation. J. Neurochem. 71: 535-548.
23. Haun, S. E., Segeleon, J. E., Trapp, V. L., Clotz, M. A., and Horrocks, L. A. (1996) Inosine mediates the protective effect of adenosine in rat astrocyte cultures subjected to combined glucose-oxygen deprivation. J. Neurochem. 67: 2051-2059.
24. Keller, J. N., Kindy, M. S., Holtsberg, F. W., St Clair, D. K., Yen, H. C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., and Mattson, M. P. (1998) Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J. Neurosci. 18: 687-697.
25. Normile, H. J. and Barraco, R. A. (1991) N6-cyclopentyladenosine impairs passive avoidance retention by selective action at A1 receptors. Brain Res. Bull. 27: 101-104.
26. Hauber, W. and Bareiss, A. (2001) Facilitative effects of an adenosine A1/A2 receptor blockade on spatial memory performance of rats: selective enhancement of reference memory retention during the light period. Behav. Brain Res. 118: 43-52.
27. Chen, P., Goldberg, D. E., Kolb, B., Lanser, M., and Benowitz, L. I. (2002) Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc. Natl. Acad. Sci. U. S. A 99: 9031-9036.