Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury

Journal of Gastroenterology

Volumn 39, Issue 1, 2004, Pages 41-49

  Yamagiwa, Tetsuya ^a   Shimosegawa, Tooru ^a   Satoh, Akihiko ^a   Kimura, Kenji ^a   Sakai, Yoshitaka ^a   Masamune, Atsushi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute pancreatitis; Adenosine; Cytokine; Inosine

Indexed keywords

AMYLASE; CERULETIDE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; INOSINE; MYELOPEROXIDASE;

ACINAR CELL; ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CELL VACUOLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOMODULATION; LUNG ALVEOLUS CELL; LUNG INJURY; MALE; NONHUMAN; PANCREAS BLOOD FLOW; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ACUTE DISEASE; AMYLASES; ANIMALS; CAERULEIN; CHEMOKINES, CXC; ENZYME-LINKED IMMUNOSORBENT ASSAY; INOSINE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; LUNG DISEASES; MALE; PANCREAS; PANCREATITIS; PEROXIDASE; RATS; RATS, WISTAR;

EID: 1142263174     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00535-003-1243-3     Document Type: Article

References (43)

1. Relevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 1998;50:413-92.
2. Sawynok J. Adenosine receptor activation and nociception. Eur J Pharmacol 1998;17:1-11.
3. Barankiewicz J, Cohen A. Purine nucleotide metabolism in resident and activated rat macrophages in vitro. Eur J Immunol 1985;15:627-31.
4. Bell MJ, Kochanek PM, Carcillo JA, Mi Z, Schiding JK, Wisniewski SR, et al. Interstitial adenosine, inosine, and hypoxanthine are increased after experimental traumatic brain injury in the rat. J Neurotrauma 1998;15:163-70.
5. Wang T, Sodhi J, Mentzer RM Jr, Van Wylen DG. Changes in interstitial adenosine during hypoxia: relationship to oxygen supply:demand imbalance, and effects of adenosine deaminase. Cardiovasc Res 1994;28:1320-5.
6. Rego AC, Santos MS, Oliveira CR. Adenosine triphosphate degradation products after oxidative stress and metabolic dysfunction in cultured retinal cells. J Neurochem 1997;69:1228-35.
7. Fredholm BB, Sollevi A. The release of adenosine and inosine from canine subcutaneous adipose tissue by nerve stimulation and noradrenaline. J Physiol 1981;313:351-67.
8. Juhasz-Nagy A, Aviado DM. Inosine as a cardiotonic agent that reverses adrenergic beta blockade. J Pharmacol Exp Ther 1977; 202:683-95.
9. Jabs CM, Neglen P, Eklof B. Breakdown of adenine nucleotides, formation of oxygen free radicals, and early markers of cellular injury in endotoxic shock. Eur J Surg 1995;161:147-55.
10. Grum CM, Simon RH, Dantzker DR, Fox IH. Evidence for adenosine triphosphate degradation in critically ill patients. Chest 1985;88:763-7.
11. Hasko G, Kuhel DG, Nemeth ZH, Mabley JG, Stachlewitz RF, Virag L, et al. Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol 2000;164:1013-9.
12. Liaudet L, Mabley JG, Pacher P, Virag L, Soriano FG, Marton A, et al. Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury. Ann Surg 2002;235:568-78.
13. Liaudet L, Mabley JG, Soriano FG, Pacher P, Marton A, Hasko G, et al. Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture. Am J Resp Crit Care Med 2001;164:1213-20.
14. Mabley JG, Pacher P, Liaudet L, Soriano FG, Hasko G, Marton A, et al. Inosine reduces inflammation and improves survival in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol 2003;284:G138-44.
15. Banks PA. Medical management of acute pancreatitis and complications. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, editors. The pancreas: biology, pathobiology, and disease. New York: Raven; 1993. p. 593-611.
16. Pitchumoni CS, Agarwal N, Jain NK. Systemic complications of acute pancreatitis. Am J Gastroenterol 1988;83:597-606.
17. Kingsnorth A. A role of cytokines and their inhibitors in acute pancreatitis. Gut 1997;40:1-4.
18. Grewal HP, Mohey el Din AM, Gaber L, Kotb M, Gaber O. Amelioration of the physiologic and biochemical changes of acute pancreatitis using anti-TNF-alpha polyclonal antibody. Am J Surg 1994;167:214-9.
19. Sakai Y, Masamune A, Satoh A, Nishihira J, Yamagiwa T, Shimosegawa T. Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. Gastroenterology 2003;124:725-36.
20. Niederau C, Niederau M, Lüthen R, Strohmeyer G, Ferrell L. Pancreatic exocrine secretion in acute experimental pancreatitis. Gastroenterology 1990;99:1120-7.
21. Satoh A, Satoh K, Masamune A, Yamagiwa T, Shimosegawa T. Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis. Pancreas 2002;24:75-82.
22. Satoh A, Shimosegawa T, Abe T, Kikuchi Y, Abe R, Koizumi M, et al. Role of nitric oxide in the pancreatic blood flow: response to caerulein. Pancreas 1994;9:574-9.
23. 3 adenosine receptors and stimulates mast cell degranulation. J Clin Invest 1997;100:2849-57.
24. 3 receptors on mast cells. J Clin Invest 2000;105:361-7.
25. 1-receptor pathway induces edema formation in the pancreas of rats. Gastroenterology 2000;119:829-36.
26. 3 receptors on macrophages inhibits tumor necrosis factor-alpha. Eur J Pharmacol 1996;310:209-16.
27. 3 adenosine receptors. J Immunol 1996;156:3435-42.
28. 3 receptors: Pharmacological properties, species differences and receptor functions. Trends Pharmacol Sci 1994;15:298-306.
29. Watanabe K, Konishi K, Fujioka M, Kinoshita S, Nakagawa H. The neutrophil chemoattractant produced by the rat kidney epithelioid cell line NRK-52E is a protein related to the KC/gro protein. J Biol Chem 1989;264:19559-63.
30. Brady M, Bhatia M, Christmas S, Boyd MT, Neoptolemos JP, Slavin J. Expression of the chemokines MCP-1/JE and cytokine-induced neutrophil chemoattractant in early acute pancreatitis. Pancreas 2002;25:260-9.
31. Bhatia M, Brady M, Zagorski J, Christmas SE, Campbell F, Neoptolemos JP, et al. Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury. Gut 2000;47:838-44.
32. Wu X, Dolecki GJ, Lefkowith JB. GRO chemokines: a transduction, integration, and amplification mechanism in acute renal inflammation. Am J Physiol 1995;269:F248-56.
33. Norman JG, Fink GW, Messina J, Carter G, Franz MG. Timing of tumor necrosis factor antagonism is critical in determining outcome in murine lethal acute pancreatitis. Surgery 1996;120:515-21.
34. Tang X, Fenton MJ, Amar S. Identification and functional characterization of a novel binding site on TNF-α promoter. Proc Natl Acad Sci U S A 2003;1100:4096-101.
35. Anisowicz A, Messineo M, Lee SW, Sager R. An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha induction of gro in human fibroblasts. J Immunol 1991;147:520-7.
36. Majumdar S, Aggarwal BB. Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types. Oncogene 2003;22:1206-18.
37. Schulz HU, Niederau C, Klonowski-Stumpe H, Halangk W, Luthen R, Lippert H. Oxidative stress in acute pancreatitis. Hepatogastroenterology 1999;46:2736-50.
38. Virag L, Szabo C. Purines inhibit poly (ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J 2001;15:99-107.
39. Szabo C, Dawson VL. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 1998;19:287-98.
40. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 1981;78:6858-62.
41. McNaughton L, Dalton B, Tarr J. Inosine supplementation has no effect on aerobic or anaerobic cycling performance. Int J Sport Nutr 1999;9:333-44.
42. Reid PG, Watt AH, Routledge PA, Smith AP. Intravenous infusion of adenosine but not inosine stimulates respiration in man. Br J Clin Pharmacol 1987;23:331-8.
43. Williams MH, Kreider RB, Hunter DW, Somma CT, Shall LM, Woodhouse ML, et al. Effect of inosine supplementation on 3-mile treadmill run performance and VO2 peak. Med Sci Sports Exerc 1990;22:517-22.