Inhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase

Archives of Biochemistry and Biophysics

Volumn 458, Issue 2, 2007, Pages 202-212

  Oz Gleenberg, Iris ^a   Herschhorn, Alon ^a   Goldgur, Yehuda ^b   Hizi, Amnon ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

DNA polymerase; HIV 1; Inhibition; Integrase; Modeling; Peptides; Reverse transcriptase

Indexed keywords

ALANYLGLUTAMYLVALYLISOLEUCYLPROLYLALANYLGLUTAMYLTHREONYLGLYCYL GLUTAMINYLGLUTAMYLTHREONYLALANYLTYROSYLPHENYLALANYLLEUCYLLEUCYLLYSYLLEUCYL ALANINE; ALANYLGLYCYLGLUTAMYLARGINYLISOLEUCYLVALYLASPARTYLISOLEUCYL ISOLEUCYLALANYLTHREONYLASPARTYLISOLEUCYLGLUTAMINYLTHREONYLLYSYL GLUTAMYLLEUCYLGLUTAMINYLLYSINE; ALANYLVALYLHISTIDYLVALYLALANYLSERYLGLYCYLTYROSYLISOLEUCYL GLUTAMYLALANYLGLUTAMYLVALYLISOLEUCYLPROLYLALANYLGLUTAMYLTHREONYLGLYCYLGLUTAMINE; ARGINYLASPARTYLGLUTAMINYLALANYLGLUTAMYLHISTIDYLLEUCYLLYSYL THREONYLALANYLVALYLGLUTAMINYLMETHIONYLALANYLVALYLPHENYLALANYLISOLEUCYL HISTIDYLASPARAGINYLPHENYLALANINE; ASPARTYLASPARAGINYLGLYCYLSERYLASPARAGINYLPHENYLALANYL THREONYLGLYCYLALANYLTHREONYLVALYLARGINYLALANYLALANYLCYSTEINYLTRYPTOPHANYL TRYPTOPHANYLALANYLGLYCYLISOLEUCINE; ASPARTYLLYSYLALANYLGLUTAMINYLASPARTYLGLUTAMYLHISTIDYL GLUTAMYLLYSYLTYROSYLHISTIDYLSERYLASPARAGINYLTRYPTOPHANYLARGINYLALANYL METHIONYLALANYLSERYLASPARTIC ACID; CYSTEINYLSERYLPROLYLGLYCYLISOLEUCYLTRYPTOPHANYL GLUTAMINYLLEUCYLASPARTYLCYSTEINYLTHREONYLHISTIDYLLEUCYL GLUTAMYLGLYCYLLYSYLVALYLISOLEUCYLLEUCYLVALINE; DNA POLYMERASE; GLUTAMINYLISOLEUCYLTHREONYLLYSYLISOLEUCYLGLUTAMINYL ASPARAGINYLPHENYLALANYLARGINYLVALYLTYROSYLTYROSYLARGINYLASPARTYLSERYL ARGINYLASPARAGINYLPROLYLLEUCYLTRYPTOPHAN; GLUTAMINYLSERYLGLUTAMINYLGLYCYLVALYLVALYLGLUTAMYLSERYL METHIONYLASPARAGINYLLYSYLGLUTAMYLLEUCYLLYSYLLYSYLISOLEUCYLISOLEUCYLGLYCYL GLUTAMINYLVALINE; GLUTAMYLTHREONYLALANYLTYROSYLPHENYLALANYLLEUCYLLEUCYLLYSYLLEUCYL ALANYLGLYCYLARGINYLTRYPTOPHANYLPROLYLVALYLLYSYLTHREONYLISOLEUCYL HISTIDYLTHREONINE; GLYCYLARGINYLTRYPTOPHANYLPROLYLVALYLLYSYLTHREONYLISOLEUCYL HISTIDYLTHREONYLASPARTYLASPARAGINYLGLYCYLSERYLASPARAGINYLPHENYLALANYL THREONYLGLYCYLALANYLTHREONINE; HISTIDYLSERYLASPARAGINYLTRYPTOPHANYLARGINYLALANYL METHIONYLALANYLSERYLASPARTYLPHENYLALANYLASPARAGINYLLEUCYL PROLYLPROLYLVALYLVALYLALANYLLYSYLGLUTAMIC ACID; INTEGRASE; ISOLEUCYLARGINYLLYSYLVALYLLEUCYLPHENYLALANYLLEUCYLASPARTYL GLYCYLISOLEUCYLASPARTYLLYSYLALANYLGLUTAMINYLASPARTYLGLUTAMYLHISTIDYL GLUTAMYLLYSYLTYROSINE; ISOLEUCYLVALYLALANYLSERYLCYSTEINYLASPARTYLLYSYLCYSTEINYL GLUTAMINYLLEUCYLLYSYLGLYCYLGLUTAMYLALANYLMETHIONYLHISTIDYLGLYCYL GLUTAMINYLVALYLASPARTIC ACID; LYSYLARGINYLLYSYLGLYCYLGLYCYLISOLEUCYLGLYCYLGLYCYLTYROSYLSERYL ALANYLGLYCYLGLUTAMYLARGINYLISOLEUCYLVALYLASPARTYLISOLEUCYLISOLEUCYLALANINE; LYSYLGLUTAMINYLGLUTAMYLPHENYLALANYLGLYCYLISOLEUCYLPROLYLTYROSYL ASPARAGINYLPROLYLGLUTAMINYLSERYLGLUTAMINYLGLYCYLVALYLVALYLGLUTAMYLSERYL METHIONYLASPARAGINE; LYSYLGLUTAMYLLEUCYLLYSYLLYSYLISOLEUCYLISOLEUCYLGLYCYL GLUTAMINYLVALYLARGINYLASPARTYLGLUTAMINYLALANYLGLUTAMYL HISTIDYLLEUCYLLYSYLTHREONYLALANINE; LYSYLGLYCYLGLUTAMYLALANYLMETHIONYLHISTIDYLGLYCYL GLUTAMINYLVALYLASPARTYLCYSTEINYLSERYLPROLYLGLYCYLISOLEUCYLTRYPTOPHANYL GLUTAMINYLLEUCYLASPARTYLCYSTEINE; PHENYLALANYLASPARAGINYLLEUCYLPROLYLPROLYLVALYLVALYLALANYLLYSYL GLUTAMYLISOLEUCYLVALYLALANYLSERYLCYSTEINYLASPARTYLLYSYLCYSTEINYL GLUTAMINYLLEUCINE; RECOMBINANT DNA; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE INHIBITOR; THREONYLASPARTYLISOLEUCYLGLUTAMINYLTHREONYLLYSYLGLUTAMYLLEUCYL GLUTAMINYLLYSYLGLUTAMINYLISOLEUCYLTHREONYLLYSYLISOLEUCYLGLUTAMINYL ASPARAGINYLPHENYLALANYLARGINYLVALINE; THREONYLHISTIDYLLEUCYLGLUTAMYLGLYCYLLYSYLVALYLISOLEUCYLLEUCYL VALYLALANYLVALYLHISTIDYLVALYLALANYLSERYLGLYCYLTYROSYLISOLEUCYLGLUTAMIC ACID; TYROSYLTYROSYLARGINYLASPARTYLSERYLARGINYLASPARAGINYL PROLYLLEUCYLTRYPTOPHANYLLYSYLGLYCYLPROLYLALANYLLYSYLLEUCYLLEUCYL TRYPTOPHANYLLYSYLGLYCINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALYLARGINYLALANYLALANYLCYSTEINYLTRYPTOPHANYLTRYPTOPHANYLALANYL GLYCYLISOLEUCYLLYSYLGLUTAMINYLGLUTAMYLPHENYLALANYLGLYCYLISOLEUCYLPROLYL TYROSYLASPARAGINYLPROLINE; VALYLGLUTAMINYLMETHIONYLALANYLVALYLPHENYLALANYLISOLEUCYL HISTIDYLASPARAGINYLPHENYLALANYLLYSYLARGINYLLYSYLGLYCYLGLYCYLISOLEUCYL GLYCYLGLYCYLTYROSYLSERINE;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG SCREENING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; STEREOSPECIFICITY;

AMINO ACID SEQUENCE; DNA; HIV INTEGRASE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33846841959     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.12.007     Document Type: Article

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