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Volumn 100, Issue 4, 2007, Pages 905-914

Dynamics of immediate early gene and neuropeptide gene response to prolonged immobilization stress: Evidence against a critical role of the termination of exposure to the stressor

Author keywords

Activity regulated cytoskeleton associated protein; c fos; CRF; Immobilization; Poststress dynamics; Prolonged stress

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; NEUROPEPTIDE;

EID: 33846834149     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04278.x     Document Type: Article
Times cited : (17)

References (46)
  • 1
    • 0024532638 scopus 로고
    • Influence of intensity and duration of exposure to various stressors on serum TSH and GH levels in adult male rats
    • Armario A. and Jolin T. (1989) Influence of intensity and duration of exposure to various stressors on serum TSH and GH levels in adult male rats. Life Sci. 44, 215-221.
    • (1989) Life Sci , vol.44 , pp. 215-221
    • Armario, A.1    Jolin, T.2
  • 2
    • 0031794193 scopus 로고    scopus 로고
    • Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain
    • Bonaz B. and Rivest S. (1998) Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain. Am. J. Physiol. 275, R1438-R1449.
    • (1998) Am. J. Physiol , vol.275
    • Bonaz, B.1    Rivest, S.2
  • 3
    • 0030936486 scopus 로고    scopus 로고
    • Hypophysiotropic CRF neurons display a sustained immediate-early gene response to chronic stress but not to adrenalectomy
    • Brown E. R. and Sawchenko P. E. (1997) Hypophysiotropic CRF neurons display a sustained immediate-early gene response to chronic stress but not to adrenalectomy. J. Neuroendocrinol. 9, 307-316.
    • (1997) J. Neuroendocrinol , vol.9 , pp. 307-316
    • Brown, E.R.1    Sawchenko, P.E.2
  • 4
    • 0027131719 scopus 로고
    • A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry
    • Chan R. K., Brown E. R., Ericsson A., Kovacs K. J. and Sawchenko P. E. (1993) A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J. Neurosci. 13, 5126-5138.
    • (1993) J. Neurosci , vol.13 , pp. 5126-5138
    • Chan, R.K.1    Brown, E.R.2    Ericsson, A.3    Kovacs, K.J.4    Sawchenko, P.E.5
  • 5
    • 0028894469 scopus 로고
    • Pattern and time course of immediate early gene expression in rat brain following acute stress
    • Cullinan W. E., Herman J. P., Battaglia D. F., Akil H. and Watson S. J. (1995) Pattern and time course of immediate early gene expression in rat brain following acute stress. Neuroscience 64, 477-505.
    • (1995) Neuroscience , vol.64 , pp. 477-505
    • Cullinan, W.E.1    Herman, J.P.2    Battaglia, D.F.3    Akil, H.4    Watson, S.J.5
  • 6
    • 0033832205 scopus 로고    scopus 로고
    • Recovery of the hypothalamic-pituitary-adrenal response to stress. Effect of stress intensity, stress duration and previous stress exposure
    • Garcia A., Marti O., Valles A., Dal-Zotto S. and Armario A. (2000) Recovery of the hypothalamic-pituitary-adrenal response to stress. Effect of stress intensity, stress duration and previous stress exposure. Neuroendocrinology 72, 114-125.
    • (2000) Neuroendocrinology , vol.72 , pp. 114-125
    • Garcia, A.1    Marti, O.2    Valles, A.3    Dal-Zotto, S.4    Armario, A.5
  • 7
    • 0035819859 scopus 로고    scopus 로고
    • Regulation of mRNA stability in mammalian cells
    • Guhaniyogi J. and Brewer G. (2001) Regulation of mRNA stability in mammalian cells. Gene 265, 11-23.
    • (2001) Gene , vol.265 , pp. 11-23
    • Guhaniyogi, J.1    Brewer, G.2
  • 8
    • 0028351274 scopus 로고
    • Double immunofluorescence staining of Fos and Jun in the hypothalamus of the rat
    • Guldenaar S. E., Wang K. and McCabe J. T. (1994) Double immunofluorescence staining of Fos and Jun in the hypothalamus of the rat. Cell Tissue Res. 276, 1-6.
    • (1994) Cell Tissue Res , vol.276 , pp. 1-6
    • Guldenaar, S.E.1    Wang, K.2    McCabe, J.T.3
  • 9
    • 0034213297 scopus 로고    scopus 로고
    • Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory
    • Guzowski J. F., Lyford G. L., Stevenson G. D., Houston F. P., McGaugh J. L., Worley P. F. and Barnes C. A. (2000) Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J. Neurosci. 20, 3993-4001.
    • (2000) J. Neurosci , vol.20 , pp. 3993-4001
    • Guzowski, J.F.1    Lyford, G.L.2    Stevenson, G.D.3    Houston, F.P.4    McGaugh, J.L.5    Worley, P.F.6    Barnes, C.A.7
  • 10
    • 0035879067 scopus 로고    scopus 로고
    • Experience-dependent gene expression in the rat hippocampus after spatial learning: A comparison of the immediate-early genes Arc, c-fos, and zif268
    • Guzowski J. F., Setlow B., Wagner E. K. and McGaugh J. L. (2001) Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268. J. Neurosci. 21, 5089-5098.
    • (2001) J. Neurosci , vol.21 , pp. 5089-5098
    • Guzowski, J.F.1    Setlow, B.2    Wagner, E.K.3    McGaugh, J.L.4
  • 11
    • 0242352373 scopus 로고    scopus 로고
    • Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary- adrenocortical responsiveness
    • Herman J. P., Figueiredo H., Mueller N. K., Ulrich-Lai Y., Ostrander M. M., Choi D. C. and Cullinan W. E. (2003) Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary- adrenocortical responsiveness. Front. Neuroendocrinol. 24, 151-180.
    • (2003) Front. Neuroendocrinol , vol.24 , pp. 151-180
    • Herman, J.P.1    Figueiredo, H.2    Mueller, N.K.3    Ulrich-Lai, Y.4    Ostrander, M.M.5    Choi, D.C.6    Cullinan, W.E.7
  • 12
    • 0033946468 scopus 로고    scopus 로고
    • Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
    • Husi H., Ward M. A., Choudhary J. S., Blackstock W. P. and Grant S. G. (2000) Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat. Neurosci. 3, 661-669.
    • (2000) Nat. Neurosci , vol.3 , pp. 661-669
    • Husi, H.1    Ward, M.A.2    Choudhary, J.S.3    Blackstock, W.P.4    Grant, S.G.5
  • 13
    • 0030342450 scopus 로고    scopus 로고
    • Different expression of immediate-early genes in the rat paraventricular nucleus induced by stress: Relation to corticotropin-releasing factor gene transcription
    • Imaki T., Shibasaki T., Chikada N., Harada S., Naruse M. and Demura H. (1996) Different expression of immediate-early genes in the rat paraventricular nucleus induced by stress: relation to corticotropin-releasing factor gene transcription. Endocr. J. 43, 629-638.
    • (1996) Endocr. J , vol.43 , pp. 629-638
    • Imaki, T.1    Shibasaki, T.2    Chikada, N.3    Harada, S.4    Naruse, M.5    Demura, H.6
  • 14
    • 0026753964 scopus 로고
    • Early induction of c-fos precedes increased expression of corticotropin-releasing factor messenger ribonucleic acid in the paraventricular nucleus after immobilization stress
    • Imaki T., Shibasaki T., Hotta M. and Demura H. (1992) Early induction of c-fos precedes increased expression of corticotropin-releasing factor messenger ribonucleic acid in the paraventricular nucleus after immobilization stress. Endocrinology 131, 240-246.
    • (1992) Endocrinology , vol.131 , pp. 240-246
    • Imaki, T.1    Shibasaki, T.2    Hotta, M.3    Demura, H.4
  • 15
    • 0041342036 scopus 로고    scopus 로고
    • Experience-dependent regulation of the immediate-early gene arc differs across brain regions
    • Kelly M. P. and Deadwyler S. A. (2003) Experience-dependent regulation of the immediate-early gene arc differs across brain regions. J. Neurosci. 23, 6443-6451.
    • (2003) J. Neurosci , vol.23 , pp. 6443-6451
    • Kelly, M.P.1    Deadwyler, S.A.2
  • 16
    • 0032191915 scopus 로고    scopus 로고
    • c-Fos as a transcription factor: A stressful (re)view from a functional map
    • Kovacs K. J. (1998) c-Fos as a transcription factor: a stressful (re)view from a functional map. Neurochem. Int. 33, 287-297.
    • (1998) Neurochem. Int , vol.33 , pp. 287-297
    • Kovacs, K.J.1
  • 17
    • 0030070524 scopus 로고    scopus 로고
    • Sequence of stress-induced alterations in indices of synaptic and transcriptional activation in parvocellular neurosecretory neurons
    • Kovacs K. J. and Sawchenko P. E. (1996) Sequence of stress-induced alterations in indices of synaptic and transcriptional activation in parvocellular neurosecretory neurons. J. Neurosci. 16, 262-273.
    • (1996) J. Neurosci , vol.16 , pp. 262-273
    • Kovacs, K.J.1    Sawchenko, P.E.2
  • 20
    • 0033305122 scopus 로고    scopus 로고
    • Vasopressin and corticotropin-releasing hormone gene responses to novel stress in rats adapted to repeated restraint
    • Ma X. M., Lightman S. L. and Aguilera G. (1999) Vasopressin and corticotropin-releasing hormone gene responses to novel stress in rats adapted to repeated restraint. Endocrinology 140, 3623-3632.
    • (1999) Endocrinology , vol.140 , pp. 3623-3632
    • Ma, X.M.1    Lightman, S.L.2    Aguilera, G.3
  • 21
    • 0036468936 scopus 로고    scopus 로고
    • Post-stress recovery of pituitary-adrenal hormones and glucose, but not the response during exposure to the stressor, is a marker of stress intensity in highly stressful situations
    • Marquez C., Belda X. and Armario A. (2002) Post-stress recovery of pituitary-adrenal hormones and glucose, but not the response during exposure to the stressor, is a marker of stress intensity in highly stressful situations. Brain Res. 926, 181-185.
    • (2002) Brain Res , vol.926 , pp. 181-185
    • Marquez, C.1    Belda, X.2    Armario, A.3
  • 22
    • 0035181863 scopus 로고    scopus 로고
    • Evidence that a single exposure to aversive stimuli triggers longlasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time
    • Marti O., Garcia A., Valles A., Harbuz M. S. and Armario A. (2001) Evidence that a single exposure to aversive stimuli triggers longlasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time. Eur. J. Neurosci. 13, 129-136.
    • (2001) Eur. J. Neurosci , vol.13 , pp. 129-136
    • Marti, O.1    Garcia, A.2    Valles, A.3    Harbuz, M.S.4    Armario, A.5
  • 23
    • 1642462381 scopus 로고    scopus 로고
    • Activity-regulated cytoskeletal-associated protein is localized to recently activated excitatory synapses
    • Moga D. E., Calhoun M. E., Chowdhury A., Worley P., Morrison J. H. and Shapiro M. L. (2004) Activity-regulated cytoskeletal-associated protein is localized to recently activated excitatory synapses. Neuroscience 125, 7-11.
    • (2004) Neuroscience , vol.125 , pp. 7-11
    • Moga, D.E.1    Calhoun, M.E.2    Chowdhury, A.3    Worley, P.4    Morrison, J.H.5    Shapiro, M.L.6
  • 24
    • 0032101285 scopus 로고    scopus 로고
    • Divergence in the expression of molecular markers of neuronal activation in the parvocellular paraventricular nucleus of the hypothalamus evoked by alcohol administration via different routes
    • Ogilvie K. M., Lee S. and Rivier C. (1998) Divergence in the expression of molecular markers of neuronal activation in the parvocellular paraventricular nucleus of the hypothalamus evoked by alcohol administration via different routes. J. Neurosci. 18, 4344-4352.
    • (1998) J. Neurosci , vol.18 , pp. 4344-4352
    • Ogilvie, K.M.1    Lee, S.2    Rivier, C.3
  • 25
    • 2642540798 scopus 로고    scopus 로고
    • Stress-induced activation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is restricted to telencephalic areas in the rat brain: Relationship to c-fos mRNA
    • Ons S., Marti O. and Armario A. (2004) Stress-induced activation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is restricted to telencephalic areas in the rat brain: relationship to c-fos mRNA. J. Neurochem. 89, 1111-1118.
    • (2004) J. Neurochem , vol.89 , pp. 1111-1118
    • Ons, S.1    Marti, O.2    Armario, A.3
  • 26
    • 0034887389 scopus 로고    scopus 로고
    • Stressor specificity of central neuro-endocrine responses: Implications for stress-related disorders
    • Pacak K. and Palkovits M. (2001) Stressor specificity of central neuro-endocrine responses: implications for stress-related disorders. Endocr. Rev. 22, 502-548.
    • (2001) Endocr. Rev , vol.22 , pp. 502-548
    • Pacak, K.1    Palkovits, M.2
  • 27
    • 0027205322 scopus 로고
    • Distributed changes in c-Fos and c-Jun immunoreactivity in the rat brain associated with arousal and habituation to novelty
    • Papa M., Pellicano M. P., Welzl H. and Sadile A. G. (1993) Distributed changes in c-Fos and c-Jun immunoreactivity in the rat brain associated with arousal and habituation to novelty. Brain Res. Bull. 32, 509-515.
    • (1993) Brain Res. Bull , vol.32 , pp. 509-515
    • Papa, M.1    Pellicano, M.P.2    Welzl, H.3    Sadile, A.G.4
  • 28
    • 0029113915 scopus 로고
    • Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats
    • Rivest S. and Laflamme N. (1995) Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats. J. Neuroendocrinol. 7, 501-525.
    • (1995) J. Neuroendocrinol , vol.7 , pp. 501-525
    • Rivest, S.1    Laflamme, N.2
  • 29
    • 0030575304 scopus 로고    scopus 로고
    • Acute alcohol administration stimulates the activity of hypothalamic neurons that express corticotropin-releasing factor and vasopressin
    • Rivier C. and Lee S. (1996) Acute alcohol administration stimulates the activity of hypothalamic neurons that express corticotropin-releasing factor and vasopressin. Brain Res. 726, 1-10.
    • (1996) Brain Res , vol.726 , pp. 1-10
    • Rivier, C.1    Lee, S.2
  • 30
    • 0023619045 scopus 로고
    • Diminished responsiveness of the hypothalamic-pituitary-adrenal axis of the rat during exposure to prolonged stress: A pituitary-mediated mechanism
    • Rivier C. and Vale W. (1987) Diminished responsiveness of the hypothalamic-pituitary-adrenal axis of the rat during exposure to prolonged stress: a pituitary-mediated mechanism. Endocrinology 121, 1320-1328.
    • (1987) Endocrinology , vol.121 , pp. 1320-1328
    • Rivier, C.1    Vale, W.2
  • 31
    • 0023748761 scopus 로고
    • Transcriptional autoregulation of the proto-oncogene fos
    • Sassone-Corsi P., Sisson J. C. and Verma I. M. (1988) Transcriptional autoregulation of the proto-oncogene fos. Nature 334, 314-319.
    • (1988) Nature , vol.334 , pp. 314-319
    • Sassone-Corsi, P.1    Sisson, J.C.2    Verma, I.M.3
  • 32
    • 0028232485 scopus 로고
    • Differential expression of fos family and jun family mRNAs in the rat hypothalamo-pituitary- adrenal axis after immobilization stress
    • Senba E., Umemoto S., Kawai Y. and Noguchi K. (1994) Differential expression of fos family and jun family mRNAs in the rat hypothalamo-pituitary- adrenal axis after immobilization stress. Brain Res. Mol. Brain Res. 24, 283-294.
    • (1994) Brain Res. Mol. Brain Res , vol.24 , pp. 283-294
    • Senba, E.1    Umemoto, S.2    Kawai, Y.3    Noguchi, K.4
  • 33
    • 0025267015 scopus 로고
    • The regulation and function of c-fos and other immediate early genes in the nervous system
    • Sheng M. and Greenberg M. E. (1990) The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4, 477-485.
    • (1990) Neuron , vol.4 , pp. 477-485
    • Sheng, M.1    Greenberg, M.E.2
  • 34
    • 17644367481 scopus 로고    scopus 로고
    • Role of glucocorticoids and cAMP-mediated repression in limiting corticotropin-releasing hormone transcription during stress
    • Shepard J. D., Liu Y., Sassone-Corsi P. and Aguilera G. (2005) Role of glucocorticoids and cAMP-mediated repression in limiting corticotropin-releasing hormone transcription during stress. J. Neurosci. 25, 4073-4081.
    • (2005) J. Neurosci , vol.25 , pp. 4073-4081
    • Shepard, J.D.1    Liu, Y.2    Sassone-Corsi, P.3    Aguilera, G.4
  • 35
    • 0024463970 scopus 로고
    • A complete protocol for in situ hybridization of messeger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes
    • Simmons D., Arriza J. and Swanson L. (1989) A complete protocol for in situ hybridization of messeger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes. J. Histotechnol. 12, 169-181.
    • (1989) J. Histotechnol , vol.12 , pp. 169-181
    • Simmons, D.1    Arriza, J.2    Swanson, L.3
  • 36
    • 0035036344 scopus 로고    scopus 로고
    • Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation
    • Steward O. and Worley P. F. (2001) Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30, 227-240.
    • (2001) Neuron , vol.30 , pp. 227-240
    • Steward, O.1    Worley, P.F.2
  • 37
    • 0036881893 scopus 로고    scopus 로고
    • Local synthesis of proteins at synaptic sites on dendrites: Role in synaptic plasticity and memory consolidation?
    • Steward O. and Worley P. (2002) Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory consolidation? Neurobiol. Learn Mem. 78, 508-527.
    • (2002) Neurobiol. Learn Mem , vol.78 , pp. 508-527
    • Steward, O.1    Worley, P.2
  • 38
    • 0032191909 scopus 로고    scopus 로고
    • Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites
    • Steward O., Wallace C. S., Lyford G. L. and Worley P. F. (1998) Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. Neuron 21, 741-751.
    • (1998) Neuron , vol.21 , pp. 741-751
    • Steward, O.1    Wallace, C.S.2    Lyford, G.L.3    Worley, P.F.4
  • 39
    • 0033607584 scopus 로고    scopus 로고
    • Coordinate regulation of Fos and Jun proteins in mouse brain by LiCl
    • Swank M. W. (1999) Coordinate regulation of Fos and Jun proteins in mouse brain by LiCl. Neuroreport 10, 3685-3689.
    • (1999) Neuroreport , vol.10 , pp. 3685-3689
    • Swank, M.W.1
  • 40
    • 0031758238 scopus 로고    scopus 로고
    • Peptide gene activation, secretion, and steroid feedback during stimulation of rat neuroendocrine corticotropin-releasing hormone neurons
    • Tanimura S. M., Sanchez-Watts G. and Watts A. G. (1998) Peptide gene activation, secretion, and steroid feedback during stimulation of rat neuroendocrine corticotropin-releasing hormone neurons. Endocrinology 139, 3822-3829.
    • (1998) Endocrinology , vol.139 , pp. 3822-3829
    • Tanimura, S.M.1    Sanchez-Watts, G.2    Watts, A.G.3
  • 41
    • 0030737398 scopus 로고    scopus 로고
    • Chronic glucocorticoid administration as well as repeated stress affects the subsequent acute immobilization stress-induced expression of immediate early genes but not that of NGFI-A
    • Umemoto S., Kawai Y., Ueyama T. and Senba E. (1997) Chronic glucocorticoid administration as well as repeated stress affects the subsequent acute immobilization stress-induced expression of immediate early genes but not that of NGFI-A. Neuroscience 80, 763-773.
    • (1997) Neuroscience , vol.80 , pp. 763-773
    • Umemoto, S.1    Kawai, Y.2    Ueyama, T.3    Senba, E.4
  • 42
    • 0141593528 scopus 로고    scopus 로고
    • Long-term effects of a single exposure to immobilization stress on the hypothalamic-pituitary-adrenal axis: Transcriptional evidence for a progressive desensitization process
    • Valles A., Marti O. and Armario A. (2003) Long-term effects of a single exposure to immobilization stress on the hypothalamic-pituitary-adrenal axis: transcriptional evidence for a progressive desensitization process. Eur. J. Neurosci. 18, 1353-1361.
    • (2003) Eur. J. Neurosci , vol.18 , pp. 1353-1361
    • Valles, A.1    Marti, O.2    Armario, A.3
  • 43
    • 33846826482 scopus 로고    scopus 로고
    • Long-term effects of a single exposure to immobilization: A c-Fos mRNA study of the response to the homotypic stressor in the rat brain
    • Vallès A., Martí O. and Armario A. (2006) Long-term effects of a single exposure to immobilization: a c-Fos mRNA study of the response to the homotypic stressor in the rat brain. J. Neurobiol. 66, 591-602.
    • (2006) J. Neurobiol , vol.66 , pp. 591-602
    • Vallès, A.1    Martí, O.2    Armario, A.3
  • 44
    • 0031038423 scopus 로고    scopus 로고
    • Fos and Jun expression in rat supraoptic nucleus neurons after acute vs. repeated osmotic stimulation
    • Wang K., Guldenaar S. E. and McCabe J. T. (1997) Fos and Jun expression in rat supraoptic nucleus neurons after acute vs. repeated osmotic stimulation. Brain Res. 746, 117-125.
    • (1997) Brain Res , vol.746 , pp. 117-125
    • Wang, K.1    Guldenaar, S.E.2    McCabe, J.T.3
  • 45
    • 0028343088 scopus 로고
    • Induction and habituation of c-fos and zif/268 by acute and repeated stressors
    • Watanabe Y., Stone E. and McEwen B. S. (1994) Induction and habituation of c-fos and zif/268 by acute and repeated stressors. Neuroreport 5, 1321-1324.
    • (1994) Neuroreport , vol.5 , pp. 1321-1324
    • Watanabe, Y.1    Stone, E.2    McEwen, B.S.3
  • 46
    • 0037203327 scopus 로고    scopus 로고
    • Differential induction and decay curves of c-fos and zif268 revealed through dual activity maps
    • Zangenehpour S. and Chaudhuri A. (2002) Differential induction and decay curves of c-fos and zif268 revealed through dual activity maps. Brain Res. Mol Brain Res. 109, 221-225.
    • (2002) Brain Res. Mol Brain Res , vol.109 , pp. 221-225
    • Zangenehpour, S.1    Chaudhuri, A.2


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