Serum leptin and ghrelin levels in response to methylprednisolone injection in healthy dogs

Research in Veterinary Science

Volumn 82, Issue 2, 2007, Pages 187-194

  Yilmaz, Zeki ^a   Ilcol, Yesim Ozarda ^a   Golcu, Esin ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

Dog; Ghrelin; Glucocorticoid; Leptin; Methylprednisolone

Indexed keywords

GHRELIN; HYDROCORTISONE; LEPTIN; METHYLPREDNISOLONE; PREDNOL L; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CLINICAL OBSERVATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DOG; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; LOW DRUG DOSE; MALE; NONHUMAN; RADIOIMMUNOASSAY; TIME;

ANIMALS; DOGS; FEMALE; GLUCOCORTICOIDS; HYDROCORTISONE; LEPTIN; MALE; METHYLPREDNISOLONE; PEPTIDE HORMONES; REGRESSION ANALYSIS;

CANIS FAMILIARIS;

EID: 33846815495     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2006.07.005     Document Type: Article

References (62)

1. Ahima R.S., Prabakaran D., and Flier J.S. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Journal of Clinical Investigation 101 (1998) 1020-1027
2. Ariyasu H., Takaya K., Hosoda H., Iwakura H., Ebihara K., Mori K., Ogawa Y., Hosoda K., Akamizu T., Kojima M., Kangawa K., and Nakao K. Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology 143 (2002) 3341-3350
3. Arvad E., Broglio F., Aimaretti G., Benso A., Giordano R., Deghenghi R., and Ghigo E. Ghrelin and synthetic GH secretagogues. Best Practice and Research Clinical Endocrinology and Metabolism 16 (2002) 505-517
4. Barazzoni R., Zanetti M., Stebel M., Biolo G., Cattin L., and Guarnieri G. Hyperleptinemia prevents increased plasma ghrelin concentration during short-term moderate caloric restriction in rats. Gastroenterology 124 (2003) 1188-1192
5. Berneis K., Vosmeer S., and Keller U. Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man. European Journal of Endocrinology 135 (1996) 663-665
6. Bhatti S.F., De Vliegher S.P., Van Ham L., and Kooistra H.S. Effects of growth hormone-releasing peptides in healthy dogs and in dogs with pituitary-dependent hyperadrenocorticism. Molecular and Cellular Endocrinology 197 (2002) 97-103
7. Bruder E.D., Jacobson L., and Raff H. Plasma leptin and ghrelin in the neonatal rat: interaction of dexamethasone and hypoxia. Journal of Endocrinology 185 (2005) 477-484
8. Campfield L.A., Smith F.J., Guisez Y., Devos R., and Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269 (1995) 546-554
9. Chan J.L., Bullen J., Lee J.H., Yiannakouris N., and Mantzoros C.S. Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects. The Journal of Clinical Endocrinology and Metabolism 89 (2004) 335-343
10. De Ambrogi M., Volpe S., and Tamanini C. Ghrelin: central and peripheral effects of a novel peptydil hormone. Medical Science Monitor 9 (2003) 217-224
11. Engeland W.C., Miller P., and Gann D.S. Pituitary-adrenal and adrenomedullary responses to noise in awake dogs. American Journal of Physiology 258 (1990) 672-677
12. Espelund U., Hansen T.K., Hojlund K., Beck-Nielsen H., Clausen J.T., Hansen B.S., Orskov H., Jorgensen J.O., and Frystyk J. Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. The Journal of Clinical Endocrinology and Metabolism 90 (2005) 741-746
13. Fogteloo A.J., Pijl H., Roelfsema F., Frolich M., and Meinders A.E. Impact of meal timing and frequency on the twenty-four-hour leptin rhythm. Hormone Research 21 (2004) 71-78
14. Franchimont D., Roland S., Gustot T., Quertinmont E., Toubouti Y., Gervy M.C., Deviere J., and Van Gossum A. Impact of infliximab on serum leptin levels in patients with Crohn's disease. The Journal of Clinical Endocrinology and Metabolism 90 (2005) 3510-3516
15. Frieboes R.C., Antonijevic I.A., Held K., Murck H., Polmacher T., Uhr M., and Steiger A. Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers. Psychoneuroendocrinology 29 (2004) 851-860
16. Gavrila A., Peng C.K., Chan J.L., Mietus J.E., Goldberger A.L., and Mantzoros C.S. Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. The Journal of Clinical Endocrinology and Metabolism 88 (2003) 2838-2843
17. Herpertz S., Albers N., and Wagner R. Longitudinal changes of circadian leptin, insulin and cortisol plasma levels and their correlation during refeeding in patients with anorexia nervosa. European Journal of Endocrinology 142 (2000) 373-379
18. Hosoda H., Kojima M., Matsuo H., and Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochemisty Biophysic Research Communication 29 (2000) 909-913
19. Hotta M., Ohwada R., Katakami H., Shibasaki T., Hizuka N., and Takano K. Plasma levels of intact and degraded ghrelin an their responses to glucose infusion in anorexia nervosa. The Journal of Clinical Endocrinology and Metabolism 89 (2004) 5707-5712
20. Ilcol Y.O., Yilmaz Z., and Ulus I.H. Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs. Neuroscience Letters 339 (2003) 195-198
21. Ilcol Y.O., Yilmaz Z., and Ulus I.H. Endotoxin alters serum free choline and phospholipid-bound choline concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs. Shock 24 (2005) 288-293
22. Ishioka K., Soliman M.M., Honjoh T., Shibata H., Kimura K., and Saito M. Dexamethasone increases serum leptin concentration in dogs. The Veterinary Journal 164 (2002) 295-297
23. Ishioka K., Hatai H., Komabayashi K., Soliman M.M., Shibata H., Honjoh T., Kimura K., and Saito M. Diurnal variations of serum leptin in dogs: effects of fasting and re-feeding. The Veterinary Journal 169 (2005) 85-90
24. Iwase M., Kimura K., Komagome R., Sasaki N., Ishioka K., Honjoh T., and Saito M. Sandwich enzyme-linked immunosorbent assay of canine leptin. Journal of Veterinary Medical Science 62 (2000) 207-209
25. Jeusette I.C., Detilleux J., Shibata H., Saito M., Honjoh T., Delobel A., Istasse L., and Diez M. Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Research in Veterinary Science 79 (2005) 169-175
26. Kamegai J., Tamura H., Shimizu T., Ishii S., Sugihara H., and Oikawa S. Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach. Regulatory Peptides 119 (2004) 77-81
27. Keller-Wood M.E., Shinsako J., and Dallman M.F. Integral as well as proportional adrenal responses to ACTH. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 245 (1983) 53-59
28. Kojima M., Hosoda H., Date Y., Nakazato M., Matsua H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
29. Korbonits M., and Grossman A.B. Ghrelin: update on a novel hormonal system. European Journal of Endocrinology 151 (2004) 67-70
30. Korbonits M., Goldstone A.P., Gueorguiev M., and Grossman A.B. Ghrelin-a hormone with multiple functions. Frontiers in Neuroendocrinology 25 (2004) 27-68
31. Laferrere B., Caixas A., Fried S.K., Bashore C., Kim J., and Pi-Sunyer F.X. A pulse of insulin and dexamethasone stimulates serum leptin in fasting human subjects. European Journal of Endocrinology 146 (2002) 839-845
32. Lewandowski K., Randeva H.S., O'Callaghan C.J., Horn R., Medley G.F., Hillhouse E.W., Brabant G., and O'Hare P. Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin. Clinical Endocrinology 54 (2001) 533-539
33. Miell J.P., Englaro P., and Blum W.F. Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Hormone and Metabolic Research 28 (1996) 704-707
34. Nakai Y., Hosoda H., Nin K., Ooya C., Hayashi H., Akamizu T., and Kangawa K. Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa. European Journal of Endocrinology 149 (2003) 1-3
35. Nakai Y., Hosoda H., Nin K., Ooya C., Hayashi H., Akamizu T., and Kangawa K. Short-term secretory regulation of the active form of ghrelin and total ghrelin during an oral glucose tolerance test in patients with anorexia nervosa. European Journal of Endocrinology 150 (2004) 913-914
36. Nørrelund H., Hansen T.K., Ørskov H., Hosoda H., Kojima M., Kangawa K., Weeke J., Møller N., Christiansen J.S., and Jørgensen J.O. Ghrelin immunoreactivity in human plasma is suppressed by somatostatin. Clinical Endocrinology 57 (2002) 539-546
37. Orth D.N. Corticotropin-releasing hormone in humans. Endocrine Reviews 13 (1992) 164-191
38. Otto B., Tschop M., Heldwein W., Pfeiffer A.F., and Diederich S. Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. European Journal of Endocrinology 151 (2004) 113-117
39. Otto B., Tschop M., Frühauf E., Heldwein W., Fichter M., Otto C., and Cuntz U. Postprandial ghrelin release in anorectic patients before and after weight gain. Psychoneuroendocrinology 30 (2005) 577-581
40. Papanek PE., and Raff H. Chronic physiological increases in cortisol inhibit the vasopressin response to hypertonicity in conscious dogs. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 267 (1994) 1342-1349
41. Pellymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., and Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 (1995) 540-543
42. Prolo P., Wong M.L., and Licinio J. Leptin. The International Journal of Biochemistry and Cell Biology 30 (1998) 1285-1290
43. Russell C.D., Petersen R.N., and Rao S.P. Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone. The American Journal of Physiology 275 (1998) 507-515
44. Sanchez J., Oliver P., Pico C., and Palou A. Diurnal rhythms of leptin and ghrelin in the systemic circulation and in the gastric mucosa are related to food intake in rats. European Journal of Physiology 4 (2004) 1283-1284
45. Schmid D.A., Held K., Ising M., Uhr M., Weikel J.C., and Steiger A. Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls. Neuropsychopharmacology 30 (2005) 1187-1892
46. Schoeller D.A., Cella L.K., Sinha M.K., and Caro J.F. Entrainment of the rhythm of plasma leptin to meal timing. Journal of Clinical Investigation 100 (1997) 1882-1887
47. Shibata H., Akahane R., Honjoh T., Asano M., Mominoki K., Fujii K., Suzuki M., Ohtaishi N., Ishioka K., Ahmed M., Soliman M., Kimura K., and Saito M. Seasonal changes in serum leptin of the feral raccoon (Procyon lotor) determined by canine-leptin-specific ELISA. Journal of Experimental Zoology Part A-Comparative Experimental Biology 303 (2005) 527-533
48. Shintani M., Ogawa Y., Ebihara K., Aizawa-Abe M., Miyanaga F., Takaya K., Hayashi T., Inoue G., Hosoda K., Kojima M., Kangawa K., and Nakao K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50 (2001) 227-232
49. Song Y.M., Lee W.J., Chen M.D., Kao C.H., and Sheu W.H. Methylprednisolone increases plasma leptin levels in Graves' hyperthroidism patients with active Graves' ophthalmopathy. Hormone and Metabolic Research 32 (2000) 277-282
50. Tataranni P.A., Larson D.E., Snitker S., Young J.B., Flatt J.P., and Ravussin E. Effects of glucocorticoids on energy metabolism and food intake in humans. American Journal of Physiology 271 (1996) 317-325
51. Tataranni P.A., Pratley R., Maffei M., and Ravussin E. Acute and prolonged administration of glucocorticoids (methylprednisolone) does not affect plasma leptin concentration in humans. International Journal of Obesity Related Metabolic Disorders 21 (1997) 327-330
52. Tentolouris N., Kokkinos A., Tsigos C., Kyriaki D., Doupis J., Raptis S.A., and Katsilambros N. Differential effects of high-fat and high-carbohydrate content isoenergetic meals on plasma active ghrelin concentrations in lean and obese women. Hormone and Metabolic Research 36 (2004) 559-563
53. Tomasetto C., Karam S.M., Ribieras S., Masson R., Lefebvre O., Staub A., Alexander G., Chenard M.P., and Rio M.C. Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 119 (2000) 395-405
54. Tschop M., Smiley D.L., and Heiman H.L. Ghrelin induces adiposity in rodents. Nature 407 (2000) 908-913
55. Tschop M., Weyer C., Tataranni P.A., Devanarayan V., Ravussin E., and Heiman M.L. Circulating ghrelin levels are decreased in human obesity. Diabetes 50 (2001) 707-709
56. Tung Y.L., Hewson A.K., and Dickson S.L. Glucocorticoid-dependent stimulation of adiposity and appetite by a ghrelin mimetic in the rat. European Journal of Endocrinology 150 (2004) 905-911
57. Wabitsch M., Jensen P.B., and Blum W.F. Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 45 (1996) 1435-1438
58. Weikel J.C., Winhniak A., Ising H., Brunner H., Friess E., Held K., Mathias S., Schmid D.A., Uhr M., and Steiger A. Ghrelin promotes slow-wave sleep in humans. American Journal of Physiology, Endocrinology and Metabolism 284 (2003) 407-415
59. Williams J., and Mobarhan S. A critical interaction: leptin and ghrelin. Nutrition Reviews 61 (2003) 391-393
60. Wood C.E., Shinsako J., and Dallman M.F. Comparison of canine corticosteroid responses to mean and phasic increases in ACTH. American Journal Physiology 242 (1982) 102-108
61. Wren A.M., Seal L.J., Cohen M.A., Brynes A.E., Frost G.S., Murphy K.G., Dhillo W.S., Ghatei M.A., and Blood S.R. Ghrelin enhances appetite and increases food intake in humans. The Journal of Endocrinology and Metabolism 86 (2001) 5992-5995
62. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432