The biomechanics of arterial aneurysms

Annual Review of Fluid Mechanics

Volumn 39, Issue , 2007, Pages 293-319

  Lasheras, Juan C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Abdominal aortic aneurysms; Cerebral aneurysms; Enlargemnt; Flow structure interaction; Rupture

Indexed keywords

BODY FLUIDS; DISEASES; FLOW OF FLUIDS; FLUID STRUCTURE INTERACTION; HEMODYNAMICS; PRESSURE; SHEAR STRESS;

ABDOMINAL AORTIC ANEURYSMS; CEREBRAL ANEURYSMS; ENLARGEMENT;

BIOMECHANICS;

BIOMECHANICS; BODY FLUIDS; DISEASES; FLOW OF FLUIDS; FLUID STRUCTURE INTERACTION; HEMODYNAMICS; PRESSURE; SHEAR STRESS;

BIOMECHANICS; CARDIOVASCULAR SYSTEM; FLUID-STRUCTURE INTERACTION; RUPTURE;

EID: 33846786892     PISSN: 00664189     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.fluid.39.050905.110128     Document Type: Review

References (136)

1. Asbury CL, Ruberd JW, Bluth EI, Peattie RA. 1995. Experimental investigation of steady flow in rigid models of abdominal aortic aneurysms. Ann. Biomed. Eng. 23:23-39
2. Auerbach O, Garfinkel L. 1980. Atherosclerosis and aneurysm of the aorta in relation to smoking habits and age. Cbest 78:805-9
3. Bao X, Lu C, Frangos JA. 1999. Temporal gradients in shear but not steady shear stresses induces PDGF-A and MCP-1 expressions in enthelial cells. Atheroscler. Thromb. Vasc. Biol. 19:996-1003
4. Ben Driss A, Benessiano J, Poitevin P, Levy BI, Michel JB. 1997. Arterial expansive remodeling induced by high flow rates. Am. J. Physiol. Heart Circ. Physiol. 272:H851-58
5. Best A, Price JF, Fowkes FGR. 2003. Persistent increase in the incidence of abdominal aortic aneurysm in Scotland. J. Biomech. Eng. 122:274-82
6. Blackman BR, García-Cardeña G, Gimbrone MA. 2002. A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms. J. Biomech. Eng. 124:397-407
7. Blackman BR, Thibault LE, Barbee KA. 2000. Selective modulation of endothelial cell [Ca2+]i response to flow by the onset rate of shear stress. J. Biomech. Eng. 122:274-82
8. Bonita R. 1986. Cigarette smoking, hypertension and the risk of subarachnoid hemorrhage: a population-based case-control study. Stroke 17(5):831-35
9. Braunwald E, ed. 1988. Heart Diseases. Philadelphia: Saunders
10. Brown PM, Zelt DT, Sobolev B. 2003. The risk of rupture in untreated aneurysms: The impact of size, gender, and expansion rate. J. Vasc. Surg. 37:280-84
11. Buchanan JR Jr, Kleinstreuer C, Truskey GA, Lei M. 1999. Relation between nonuniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction. Atherosclerosis 143:27-40
12. Budwig R, Elger D, Hooper H, Slippy J. 1993. Steady flow in abdominal aortic aneurysm models. J. Biomech. Eng. 115:418-23
13. Burleson AC, Strother CM, Turitto VT. 1995. Computer modeling of intracranial saccular and lateral aneurysms for the study of their hemodynamics. Neurosurgery 37(4):774-84
14. Cameron J. 1999. Estimation of arterial mechanics in clinical practice and as research technique. Clin. Exp. Pharmacol. Physiol. 26:285-94
15. Cantón G. 2004. Hemodynamics of intracranial aneurysms. PhD thesis. Univ. Calif., San Diego
16. Cantón G, Levy DI, Lasheras JC. 2005a. Changes in the intra-aneurysmal pressure due to hydrocoil embolic system. Am. J. Neuroradiol. 26:904-7
17. Cantón G, Levy DI, Lasheras JC. 2005b. Hemodynamical changes in bifurcating intracranial aneurysms due to stent placement.J. Neurosurg. 103:146-55
18. Cantón G, Levy DI, Nelson PK, Lasheras JC. 2005c. Flow changes caused by the sequential placement of stents across the neck of sidewall cerebral aneurysms. J. Neurosurg. 103:891-902
19. Carlson RG, Lillehei CW, Edwards J. 1970. Cystic medical necrosis of ascending aorta in relation to age and hypertension. Am. J. Cardiol. 25:411-15
20. Cebral JR, Castro MA, Burgess JE, Pergolizzi RS, Sheridan MJ, Putman CM. 2005. Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models. Am. J. Neuroradiol. 26:2550-59
21. Chang LJ, Tarbell JM. 1988. A numerical study of flow in curved tubes simulating coronary arteries. J. Biomech. 21(11):927-37
22. Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW. 1998. Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ. Res. 82:532-39
23. Chiu JJ, Chen Q, Chen CN, Lee PL, Lee CI. 2004. A model for studying the effect of shear stress on interactions between vascular endothelial cells and smooth muscle cells. J. Biomech. 37:531-39
24. Chiu JJ, Chen LJ, Lee PL, Lee CI, Lo LW, et al. 2003. Shear stress inhibits adhesion molecule expression in vascular endothelial cells induce by coculture with smooth muscle cells. Blood 1:2667-74
25. Collin J. 1988. The epidemiology of abdominal aortic aneurysm. Br. J. Hosp. Med. 40:64-67
26. Davies PF, Dewey CF, Bussolari S, Gordon E, Gibrone MA. 1984. Influence of hemodynamic forces on vascular endothelial function. J. Clin. Invest. 73:112-29
27. Davies PF, Mundel T, Barbee KA. 1995. A mechanism for heterogeneous endothelial responses to flow in vivo and in vitro. J. Biomech. 28:1553-60
28. Davies PF, Remuzzi A, Gordon EJ, Dewey CF, Gibrone MA. 1986. Turbulent fluid shear stress induces vascular endothelial turnover in vivo. Proc. Natl. Acad. Sci. USA 83:2114-17
29. Di Martino E, Mantero S, Inzoli F, Melissano G, Astore D, et al. 1998.Biomechanics of abdominal aortic aneurysm in the presence of endoluminal thrombus: experimental characterization and structure static computational analysis. Eur J. Vasc. Endovasc. Surg. 15:290-99
30. Di Martino ES, Guadagni G, Fumero A, Ballerini G, Spirito R, et al. 2001. Fluid-structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm. Med. Eng. Phys. 23:647-55
31. Di Martino ES, Vorp DA. 2003. Effect of variation in intraluminal thrombus constitutive properties on abdominal aortic aneurysm wall stress. Ann. Biomed. Eng. 31:804-9
32. Dobrin PB. 1978. Mechanical properties of arteries. Physiol. Rev. 58:397-441
33. Egelhoff CJ, Budwig RS, Elringer DF, Khraishi TA, Johansen KH. 1999. Model studies of the flow in abdominal aortic aneurysms during resting and exercise conditions. J. Biomech. 32:1319-29
34. Englund R, Hudson P, Hanel Y, Stanton A. 1998. Expansion rate of small abdominal aortic aneurysms. Aust. NZ. J. Surg. 123:474-84
35. Ferguson GG, Roach MR. 1972. Flow conditions at bifurcations as determined in glass models, with reference to the focal distribution of vascular lesions. In Cardiovascular Fluid Dynamics, ed. DH Bergel, 2:141-56. New York. Academic
36. Fillinger MF, Marra SP, Raghavan ML. 2003. Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter. J. Vasc. Surg. 37:724-32
37. Finol EA, Amon CH. 2001. Blood flow in abdominal aortic aneurysms: pulsatile flow hemodynamics. J. Biomech. Eng. 123:474-84
38. Finol EA, Amon CH. 2002. Flow-induced wall shear stress in abdominal aortic aneurysms: Parts I and II. Comput. Methods Biomech. Biomed. Eng. 5:309-28
39. Finol EA, Amon CH. 2003. Flow dynamics in abdominal aortic aneurysms. Acta Cient. Venez. 54:43-49
40. Finol EA, Keyhani K, Amon CH. 2003. The effect of asymmetry in abdominal aortic aneurysms under physiologically realistic pulsatile flow conditions. J. Biomech. Eng. 125:207-17
41. Foutrakis GN, Yonas H, Sclabassi RJ. 1997. Finite element methods in the simulation and analysis of intracranial blood flow. Neurol. Res. 19:174-86
42. Foutrakis GN, Yonas H, Sclabassi RJ. 1999. Saccular aneurysm formation in curved and bifurcating arteries. Am. J. Neuroradiol. 20:1309-17
43. Fox JL, ed. 1983. Intracranial Aneurysms, Vol. 1. New York: Springer-Verlag
44. Fox JL, Hugh AE. 1996. Location of atheroma: a theory based on boundary layer separation. Br Heart. J. 26:288-99
45. Friedman M, Ehrlich LW. 1984. Numerical simulation of aortic bifurcation flows: the effect of flow divider curvature. J. Biomech. 17:881-89
46. Fukushima T, Matsuzawa T, Homma T. 1989. Visualization and finite element analysis of pulsatile flow in models of the abdominal aortic aneurysm. Biorheology 26:109-30
47. Fung YC. 1993. Biomechanics: Mechanical Properties of Living Tissues. New York: Springer-Verlag
48. Fung YC. 1997. Biomechanics: Circulation. New York. Springer-Verlag
49. Ghorpade A, Baxter BT. 1996. Biochemistry and molecular regulation of matrix macromolecules in abdominal aortic aneurysms. In The Abdominal Aortic Aneurysm: Genetics, Pathophysiology, and Molecular Biology, ed. MD Tilson, CD Boyd. Ann. NY Acad. Sci. 800:138-50
50. Gibbons GH, Dzau VJ. 1994. The emeging concepts of vascular remodeling. N. Engl. J. Med. 330:1431-38
51. Glagov S, Zarins CK, Giddens DG, Ku DN. 1988. Hemodynamics and atherosclerosis, insights and perspectives gained from studies of human arteries. Arch. Pathol. Lab. Med. 112:1018-31
52. Greenwald SE, Berry CL. 2000. Improving vascular grafts: the importance of mechanical and hemodynamic properties. J. Pathol. 190:292-99
53. Hademenos GJ. 1995. The physics of cerebral aneurysms. Phys. Today 48:24-30
54. Helmlinger G, Geiger RV, Schreck S, Nerem RM. 1991. Effects of pulsatile flow on cultured vascular endothelial cell morphology. J. Biomech. Eng. 113:123-31
55. Juvela S. 2000. Risk factor for multiple intracranial aneurysms. Stroke 31(2):392-97
56. Juvela S, Poussa Y, Porras M. 2001. Factors affecting formation and growth of intracranial aneurysms. A long-term follow-up study. Stroke 32(2):485-91
57. Kawaguti M, Hamano A. 1980. Numerical study on bifurcating flow of a viscous fluid. Pulsatile flow. J. Phys. Soc. Jpn. 49(2):817-24
58. Kayembe KNT, Sasahara M, Hazama F. 1984. Cerebral aneurysms and variations in the Circle of Willis. Stroke 15(5):846-50
59. Kissane JM. 1985. Anderson's Pathology. St. Louis: Mosby
60. Krex D, Schackert HK, Schackert G. 2001. Genesis of cerebral aneurysms-an update. Acta Neurochir 143:429-49
61. Ku DN, Giddens DP, Zarins CK, Glagov S. 1985. Pulsatile flow and athersclerosia in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stresses. Atheriosclerosis 5:293-302
62. Lakatta EG, Mitchell JH, Pomerance A, Rowe G. 1987. Human aging: changes in structure and functions. J. Am. Coll. Cardiol. 10:A42-47
63. Law MR, Morris J, Wald NJ. 1994. Screening for abdominal aortic aneurysms. J. Med. Screen. 1:110-16
64. Lee AJ, Fowkes FG, Carson MN, Leng GC, Allan PL. 1997. Smoking, atherosclerosis and risk of abdominal aortic aneurysm. Eur Heart J. 18:545-46
65. Lee RMKW. 1995. Morphology of cerebral arteries. Pbarmacol. Ther. 66:149-73
66. Lei M, Kleinstreuer DP, Zarins CK, Glagov S. 1995. Pulsatile flow and atherosclerosis in the human carotid bifurcation: positive correlation between plaque location and low oscillating stress. Atherosclerosis 5:293-302
67. Levy BI. 1999. Mechanics of the large artery vascular wall. Pathol. Biol. 47:634-40
68. Li Z, Kleinstreuer C. 2005. A new wall stress equation for aneurysm-rupture prediction. Ann. Biomed. Eng. 33:209-13
69. Liepsch D, Moravec S. 1984. Pulsatile flow of non-Newtonian fluid in distensible models of human arteries. Biorheology 21:571-86
70. Ling SC, Atabek HB. 1988. A numerical study of flow in curved tubes simulating coronary arteries. J. Biomech. 21:927-37
71. Lopez-Candales A, Holmes D, Liao S, Scott M, Wickline SA, Thompson RW. 1997. Decrease vascular smooth muscle cell density in median degeneration of human abdominal aortic aneurysms. Am. J. Pathol. 150:3:993-1007
72. MacSweeney ST, Ellis M, Worrell PC, Greenhalgh RM, Powell JT. 1994. Smoking and growth rate of small abdominal aortic aneurysms. Lancet 344:651-52
73. MacSweeney ST, Young G, Greenhalgh RM, Powell JT. 1992. Mechanical properties of the abdominal aorta. Br. J. Surg. 79:1281-84
74. Malek M, Alper SL, Izumo S. 1999. Hemodynamic shear stress and its role in atherosclerosis. JAMA 282:2035-42
75. Malinauskas RA, Sarraf P, Barber KM, Truskey GA. 1998. Association between secondary flow in models of the aorto-celiac junction and subendothelial macrophages in the normal rabbit. Atherosclerosis 140:121-34
76. McDonald DA. 1974. Blood Flow in Arteries. London: Edward Arnold. 2nd ed.
77. McVeigh GE, Hamilton PK, Morgan DR. 2002. Evaluation of mechanical arterial properties: clinical, experimental and therapeutic aspects. Clin. Sci. 102:51-67.
78. Merillon JP, Motte G, Masquet C, Azancot I, Aumont MC, et al. 1982. Changes in the physical properties of the arterial system with age and in permanent arterial hypertension: their interpretation. Cardiovasc. Res. 16:646-56
79. Morris L, Delassus P, Walsh M, McGloughlin T. 2004. A mathematical model to predict the in vivo pulsatile drag forces acting on bifurcated stent grafts used in endovascular treatment of abdominal aortic aneurysms (AAA). J. Biomech. 37:1087-95
80. Nader-Sepahi A, Casimiro M, Sen J, Kitchen ND. 2004. Is aspect ratio a reliable predictor for intracranial aneurysm rupture? Neurosurgery 54(6):1343-48
81. Nagel T, Resnick N, Dewey CF, Gimbrone MA. 1999. Vascular endothelial. cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors. Arterioscl. Thromb. Vasc. Biol. 19:1825-34
82. Nichols WW, O'Rourke MF. 1990. McDonald's Blood Flow in Arteries. Theoretic, Experimental and Clinical Principles. London: Edward Arnold
83. O'Rourke MY. 1982. Arterial Function in Health and Disease. Edinburgh: Churchill Livingstone
84. O'Rourke MF. 1990. Arterial stiffness, systolic blood pressure and logical treatment of hypertension. Hypertension 15:339-47
85. Oshima M, Torii R, Kobayashi T, Taniguchi N, Takagi K. 2001. Finite element simulation of blood flow in the cerebral artery. Comp. Methods Appl. Mech. Eng. 191:661-71
86. Peattie RA, Riehle TJ, Bluth EI. 2004. Pulsatile flow in fusiform models of abdominal aortic aneurysms: flow fields, velocity patterns and flow-induced wall stresses. ASME J. Biomech. Eng. 126:438-46
87. Peattie RA, Schrader T, Bluth EI, Comstock CE. 1994. Development of turbulence in steady flow through models of abdominal aortic aneurysms. J. Ultrasound Med. 13:467-72
88. Pedersen E, Sung H, Burlson A, Yoganathan A. 1993. Two-dimensional velocity measurements in a pulsatile flow model of the normal abdominal aortic simulating different hemodynamic conditions. J. Biomech. 26:1237-47
89. Perktold K. 1986. On the paths of fluid particles in an axisymmetrical aneurysm. J. Biomech. 20(3):311-17
90. Perktold K, Florian H, Hilbert D. 1987. Analysis of pulsatile blood flow: a carotid siphon model. J. Biomech. Eng. 9:46-53
91. Perktold K, Kenner T, Hilbert D, Spork B, Florian H. 1988. Numerical blood flow analysis: arterial bifurcation with a saccular aneurysm. Basic Res. Cardiol. 83:24-31
92. Perktold K, Peter RO, Resch M. 1989. Pulsatile non-Newtonian blood flow simulation through a bifurcation with an aneurysm. Biorheology 26:1011-30
93. Perktold K, Rappitesch G. 1995. Computer simulation of local blood flow and vessel mechanics in a compliant carotid artery bifurcation model. J. Biomech. 28:845-56
94. Pokrovskii AV, Dan VN, Zlatovchen AM, Il'in SA. 2003. The impact of cardiac status and arterial hypertension on the results of surgical treatment of patients over 70 years with abdominal aortic aneurysms. Angiol. Sosud. Khir. 9:71-76
95. Raghavan ML, Fillinger M, Marra SP, Naegelein BP, Kennedy FE. 2005. Automated methodology for determination of stress distribution in human abdominal aortic aneurysm. ASME J. Biomech. Eng. 127:868-70
96. Raghavan ML, Vorp DA. 2000. Toward a biomechanical tool to evaluate rapture potential of abdominal aortic aneurysm: identification of a finite strain constitutive model and evaluation of its applicability. J. Biomech. 33:475-82
97. Raghavan ML, Vorp DA, Federle MP, Makaroun MS, Webster MW. 2000. Wall stress distribution on three-dimensionally reconstructed models of human abdominal aortic aneurysm. J. Vascular Surg. 31(4):760-69
98. Reilly JM, Tilson MD. 1989. Incidence and etiology of abdominal aortic aneurysms. In Abdominal Aortic Aneurysm, ed. GE Pierce, pp. 689-898. Philadelphia: Saunders
99. Rucker RB, Tinker D. 1977. Structure and metabolism of arterial elastin. Int. Rev. Exp. Pathol. 17:1-41
100. Salsac AV. 2005. Changes in the hemodynamic stresses occurring during the enlargement of abdominal aortic aneurysms. PhD thesis. Univ. Calif., San Diego
101. Salsac AV, Sparks SR, Chomaz JM, Lasheras JC. 2006. Evolution of the wall shear stresses during the progressive enlargement of symmetric abdominal aortic aneurysms. J. Fluid Mech. 560:19-51
102. Salsac AV, Sparks SR, Lasheras JC. 2004. Changes in pressure and wall tension occurring during the enlargement of abdominal aortic aneurysms. J. Vasc. Surg. 18(1):14-21
103. Scherer P. 1973. Flow in axisymmetrical glass model aneurysms. J. Biomech. 6:695-700
104. Schrader T, Peattie RA, Bluth EI, Comstock CE. 1992. A qualitative investigation of turbulence in flow through a model abdominal aortic aneurysm. Invest. Radiol. 27:515-19
105. Shipkowitz T, Rodgers VGJ, Frazin LJ, Chandran KB. 2000. Numerical study on the effect of secondary flow in the human aorta on local shear stresses in abdominal aortic branches. J. Biomech. 33:717-28
106. Singh Y, Bønaa KH, Jacobsen BK, Bjørk L, Solberg S. 2001. Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study. Am. J. Epidemiol. 154:236-44
107. Soliman E. 2001. Cerebral aneurysm. eMed. J. 2(9)
108. Steiger HJ, Liepsch DW, Poll A, Reulen HJ. 1988a. Hemodynamic stress in terminal saccular aneurysms: a laser-Doppler study. Heart Vessels 4:162-69
109. Steiger HJ, Poll A, Liepsch D, Reulen HJ. 1987a. Basic flow structure in saccular aneurysms: a flow visualization study. Heart Vessels 3:55-65
110. Steiger HJ, Poll A, Liepsch D, Reulen HJ. 1987b. Haemodynamic stress in lateral saccular aneurysms. An experimental study. Acta Neurochir. 86:98-105
111. Steiger HJ, Poll A, Liepsch DW, Reulen HJ. 1988b. Haemodynamic stress in terminal aneurysms. Acta Neurochir 93:18-23
112. Steinman DA, Vorp DA, Ethier CR. 2003. Computational modeling of arterial biomechanics: Insights into pathogenesis and treatment of vascular disease. J. Vasc. Surg 37:1118-28
113. Stringfellow MM, Lawrence PE, Stringfellow RG. 1987. The influence of aorta-aneurysms geometry upon stress in aneurysms wall. J. Surg. Res. 42:425-33
114. Szilagyi DE. 1982. Clinical diagnosis of intact and ruptured abdominal aortic aneurysms. In Aneurysms, Diagnosis and Treatment, ed. JJ Bergan, JS Yao, pp. 205-16. New York. Grane & Stratton
115. Taylor TW, Porter JM. 1987. Basis data related to clinical decision-making in abdominal aortic aneurysms. Ann. Vasc. Surg. 1:502-4
116. Taylor TW, Yamaguchi T. 1994. Three-dimensional simulation of blood flow in an abdominal aortic aneurysm - steady and unsteady flow cases. J. Biomech. Eng. 116:89-97
117. Thompson RW, Liao S, Curci JA. 1997. Vascular smooth muscle cell apoptosis in abdominal aortic aneurysms. Coron. Artery Dis. 8:623-31
118. Thubrikar MJ, Labrosse M, Robicsek F, Al-Soudi J, Fowler B. 2001. Mechanical properties of abdominal aortic aneurysm wall. J. Med. Eng. Technol. 25:133-42
119. Ting T, Brin KP, Lin SJ, Wang SP, Chang MS, et al. 1986. Arterial hemodynamics in human hypertension. J. Clin. Invest. 78:1462-71
120. Traub O, Berk BC. 1998. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb. Vasc. Biol. 18:677-85
121. Ujiie H, Tachibana H, Hiramatsu O, Hazel AL, Matsumoto T, et al. 1999. Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms. Neurosurgery 45(1):119-30
122. Viswanath N, Rodkiewicz CM, Zajac S. 1997. On the abdominal aortic aneurysms: pulsatile state considerations. Med. Eng. Phys. 19:343-51
123. Vito RP, Dixon SA. 2003. Blood vessel constitutive models - 1995-2002. Annu. Rev. Biomed. Eng. 5:413-39
124. Vorp DA, Vande Geest JP. 2005. Biomechanical determinants of abdominal aortic aneurysm rupture. Arterioscler Thromb. Vasc. Biol. 2 5:1558-66
125. Wang DH, Makaroun M, Webster MW, Vorp DA. 2001. Mechanical properties and microstructure of intraluminal thrombus from abdominal aortic aneurysm. ASME J. Biomech. Eng. 123:536-39
126. Wanhainen A, Bergqvist B, Boman Y, Nilsson TK, Rutegard J. 2005. Risk factors associated with abdominal aortic aneurysm: A population-based study with historical and current data. J. Vasc. Surg. 41:390-96
127. Wilmink ABM, Quick CRG, Hubbard CSF, Day NE. 2000. The association between connective tissue laxity and the risk of an abdominal aortic aneurysm. Eur. J. Endovasc. Surg. 20:290-95
128. Wolters BJBM, Rutten MCM, Schurink GWH, Kose U, de Hart J, van de Vosse FN. 2005. A patient-specific computational model of fluid-structure interaction in abdominal aortic aneurysms. Med. Eng. Phys. 27:871-83
129. Wurzinger LJ, Blasherg P, Schmid-Schonbein H. 1985. Towards a concept of thrombosis in accelerated flow: rheology, fluid dynamics, and biochemistry. Biorheology 22:437-49
130. Yip TH, Yu SCM. 2001. Cyclic transition to turbulence in rigid abdominal aortic aneurysm models. Fluid Dyn. Res. 29:81-113
131. Yip TH, Ya SCM. 2003. Cyclic flow characteristics in an idealized asymmetric abdominal aortic aneurysm model. Proc. Inst. Mech. Eng. H 217(H1):27-39
132. Yu SCM. 2000. Steady and pulsatile flow characteristics in Abdominal Aortic Aneurysm models using Particle Image Velocimetry. Int. J. Heat Fluid Flow. 21:74-83
133. Yu SCM, Chan WK, Ng BTH, Chua LP. 1999. A numerical investigation on the steady and pulsatile flow characteristics in axi-symmetric abdominal aortic aneurysm models with some experimental evaluation. J. Med. Eng. Technol. 23:228-39
134. Yu SCM, Zhao JB. 1999. A steady flow analysis on the stented and nonstented sidewall aneurysm models. Med. Eng. Phys. 21:133-41
135. Yu SCM, Zhao JB. 2000. A particle image velocimetry study on the pulsatile flow characteristics in straight tubes with an asymmetric bulge. Proc. Inst. Mech. Eng. C 214:655-71
136. Zhac, Y, Chen BP, Miao H, Yuan S, Li YS, et al. 2002. Improved significance test for DNA microarray data: temporal effects of shear stress on endothelial genes. Physiol. Genomics 12:1-11