Vascular smooth muscle cell apoptosis induced by 7-ketocholesterol was mediated via Ca2+ and inhibited by the calcium channel blocker nifedipine

Metabolism: Clinical and Experimental

Volumn 56, Issue 3, 2007, Pages 357-362

  Sasaki, Hidehisa ^a   Watanabe, Fusako ^a   Murano, Takeyoshi ^a   Miyashita, Yoh ^a   Shirai, Kohji ^a  

^a Sakura Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 OXOCHOLESTEROL; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CASPASE 3; DNA FRAGMENT; NIFEDIPINE; VERAPAMIL;

APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

APOPTOSIS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CASPASE 3; HUMANS; IN SITU NICK-END LABELING; KETOCHOLESTEROLS; MUSCLE, SMOOTH, VASCULAR; NIFEDIPINE;

EID: 33846784831     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2006.10.017     Document Type: Article

References (30)

1. Blood Pressure Lowering Treatment Trialists Collaboration. Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomized trials. Lancet 355 (2000) 1955-1964
2. Pahor M., Psaty B.M., Williamson J.D., et al. Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomized controlled trials. Lancet 356 (2000) 1949-1954
3. Henry P.D. Calcium antagonist and atherosclerosis. Atherosclerosis 10 (1990) 963-965
4. Pitt B. Diversity of calcium antagonist. Clin Ther 19 (1997) 3-17
5. Khalfi F., Gressier B., Cazin J.C., et al. Verapamil inhibits elastase release and superoxide anion production in human neutrophils. Biol Pharm Bull 21 (1998) 109-112
6. Brown A.J., and Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 142 (1998) 1-28
7. Smith L.L. Review of progress in sterol oxidations: 1987-1995. Lipids 31 (1996) 453-487
8. Sevanian A., Berliner J., and Peterson A.R. Uptake, metabolism and cytotoxicity of isomeric cholesterol-5, 6-epoxides in rabbit aortic endothelial cells. J Lipid Res 32 (1991) 147-155
9. Sevanian A., Hodis H.N., Peterson H., et al. Involvement of cholesterol oxides in the atherogenic action of oxidized LDL. In: Bellomo G., Finardi G., Maggi E., and Rice-Evans C. (Eds). Free radicals, lipoprotein oxidation and atherosclerosis. 1st ed (1995), Eichelieu Press, London (England) 139-161
10. Palladini G., Finardi G., and Bellomo G. Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. Exp Cell Res 223 (1996) 72-82
11. Boissonneault G.A., Hennig B., Oeltgen P.R., et al. Effect of oxysterol-enriched low-density lipoproteins. Ann Nutr Metab 35 (1991) 226-232
12. Boissonneault G.A., Hennig B., and Ouyang C.M. Oxysterols, cholesterol biosynthesis, and vascular endothelial cell monolayer barrier function. Proc Soc Exp Biol Med 196 (1991) 338-343
13. Deckert V., Brunet A., Devynck M.-A., et al. Inhibition by cholesterol oxides of NO release from human vascular endothelial cells. Arterioscler Thromb Vasc Bio 18 (1998) 1054-1060
14. Deckert V., Persegol L., Lagrost L., et al. Inhibition of arterial relaxation among components of human oxidized low-density lipoproteins: cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. Circulation 95 (1997) 723-731
15. Miyashita Y., Shirai K., Ito Y., et al. Cytotoxicity of some oxysterols on human vascular smooth muscle cells was mediated by apoptosis. J Atheroscler Thromb 4 (1997) 73-78
16. Urano Y., Shirai K., Miyashita Y., et al. Vascular smooth muscle cell outgrowth, proliferation, and apoptosis in young and old rats. Atherosclerosis 146 (1999) 101-105
17. Oyama T., Miyashita Y., Shirai K., et al. Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells. J Atheroscler Thromb 9 (2001) 109-113
18. Dimmeler S., Haendeler J., Zeiher A.M., et al. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J Exp Med 185 (1997) 601-607
19. Schönbeck U., Herzberg M., Loppnow H., et al. Human vascular smooth muscle cells express interleukin-1β-converting enzyme (ICE)-like, but inhibit processing of the interleukin-1β-precursor by ICE. J Exp Med 185 (1997) 1287-1294
20. Noda T., Iwakiri R., Fujimoto K., et al. Suppression of apoptosis is responsible for increased thickness of intestinal mucosa in streptozotocin-induced diabetic rats. Metabolism 50 (2001) 259-264
21. Riedl S.J., Renatus M., Salvesen G.S., et al. Mechanism-based inactivation of caspases by the apoptotic suppressor p35. Biochemistry 40 (2001) 13274-13280
22. Liang Y., Yan C., and Schor N.F. Apoptosis in the absence of caspase 3. Oncogene 20 (2001) 6570-6578
23. Piro S., Anello M., Purrello F., et al. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 51 (2002) 1340-1347
24. McConkey D.J., and Orrenius S. The role of calcium in the regulation of apoptosis. J Leukoc Biol 59 (1996) 775-783
25. Thiry M. Highly sensitive immunodetection of DNA on sections with exogenous terminal deoxynucleotidyl transferase and non-isotopic nucleotide analogs. J Histochem Cytochem 40 (1992) 411-419
26. Miyashita Y., Koide N., Oyama T., Itoh Y., and Shirai K. Apoptosis induced by 7-ketocholesterol is enhanced in smooth muscle cells derived from OLETF rats. J Atheroscler Thromb 12 (2005) 92-97
27. Kleinbloesem C.H., Voogd P.J., Breimer D.D., et al. Nifedipine: kinetics and dynamics in healthy subjects. Clin Pharmacol Ther 35 (1984) 742-749
28. Orii Y., Hashizume K., Tanaka T., et al. Investigation of plasma nisoldipine concentrations with a newly developed GM/MS method. Ther Res 19 (1998) 1297-1309
29. Ram C.V. Antiatherosclerotic effects of calcium-channel blockers: therapeutic implications. Cardiology 10 (1999) 77-83
30. Fang L.H., Zhang Y.H., Kim T.J., et al. Inhibitory effects of tetrandrine on the serum- and platelet-derived growth factor-BB-induced proliferation of cell cycle progression DNA synthesis, ERK1/2 activation and c-fos expression. Atherosclerosis 174 (2004) 215-223