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Volumn 23, Issue 2, 2007, Pages 149-158

Current issues in gastrointestinal stromal tumors: Incidence, molecular biology, and contemporary treatment of localized and advanced disease

Author keywords

Gastrointestinal stromal tumor; Imatinib; KIT; Sunitinib; Surgery

Indexed keywords

IMATINIB; PLACEBO; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB; TYROSINE KINASE RECEPTOR;

EID: 33846691775     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32802086d0     Document Type: Review
Times cited : (45)

References (85)
  • 1
    • 0035122393 scopus 로고    scopus 로고
    • Malignant gastrointestinal stromal tumors of the small intestine: A review of 50 cases from a prospective database
    • Crosby JA, Catton CN, Davis A, et al. Malignant gastrointestinal stromal tumors of the small intestine: a review of 50 cases from a prospective database. Ann Surg Oncol 2001; 8:50-59.
    • (2001) Ann Surg Oncol , vol.8 , pp. 50-59
    • Crosby, J.A.1    Catton, C.N.2    Davis, A.3
  • 2
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
    • DeMatteo RP, Lewis JJ, Leung D, et al. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg 2000; 231:51-58.
    • (2000) Ann Surg , vol.231 , pp. 51-58
    • DeMatteo, R.P.1    Lewis, J.J.2    Leung, D.3
  • 4
    • 0033814350 scopus 로고    scopus 로고
    • Biological and clinical review of stromal tumors in the gastrointestinal tract
    • Nishida T, Hirota S. Biological and clinical review of stromal tumors in the gastrointestinal tract. Histol Histopathol 2000; 15:1293-1301.
    • (2000) Histol Histopathol , vol.15 , pp. 1293-1301
    • Nishida, T.1    Hirota, S.2
  • 5
    • 0035142836 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
    • Miettinen M, Lasota J. Gastrointestinal stromal tumors: definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001; 438:1-12.
    • (2001) Virchows Arch , vol.438 , pp. 1-12
    • Miettinen, M.1    Lasota, J.2
  • 6
    • 0036301722 scopus 로고    scopus 로고
    • Diagnosis of gastrointestinal stromal tumors: A consensus approach
    • Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002; 33:459-465.
    • (2002) Hum Pathol , vol.33 , pp. 459-465
    • Fletcher, C.D.1    Berman, J.J.2    Corless, C.3
  • 7
    • 0036769928 scopus 로고    scopus 로고
    • Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease
    • Roberts PJ, Eisenberg B. Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease. Eur J Cancer 2002; 38:S37-S38.
    • (2002) Eur J Cancer , vol.38
    • Roberts, P.J.1    Eisenberg, B.2
  • 8
    • 0344837699 scopus 로고    scopus 로고
    • Response to imatinib mesylate of a gastrointestinal stromal tumor with very low expression of KIT
    • Bauer S, Corless CL, Heinrich MC, et al. Response to imatinib mesylate of a gastrointestinal stromal tumor with very low expression of KIT. Cancer Chemother Pharmacol 2003; 51:261-265.
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 261-265
    • Bauer, S.1    Corless, C.L.2    Heinrich, M.C.3
  • 9
    • 0020514752 scopus 로고
    • Gastric stromal tumors: Reappraisal of histogenesis
    • Mazur MT, Clark HB. Gastric stromal tumors: reappraisal of histogenesis. Am J Surg Pathol 1983; 7:507-519.
    • (1983) Am J Surg Pathol , vol.7 , pp. 507-519
    • Mazur, M.T.1    Clark, H.B.2
  • 10
    • 0036769966 scopus 로고    scopus 로고
    • Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): A review
    • Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer 2002; 38 (Suppl 5):S39-S51.
    • (2002) Eur J Cancer , vol.38 , Issue.SUPPL. 5
    • Miettinen, M.1    Majidi, M.2    Lasota, J.3
  • 11
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 279:577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 12
    • 0037186924 scopus 로고    scopus 로고
    • Imatinib mesylate: A new oral targeted therapy
    • Savage DG, Antman KH. Imatinib mesylate: a new oral targeted therapy. N Engl J Med 2002; 346:683-693.
    • (2002) N Engl J Med , vol.346 , pp. 683-693
    • Savage, D.G.1    Antman, K.H.2
  • 13
    • 0035890740 scopus 로고    scopus 로고
    • KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
    • Rubin BP, Singer S, Tsao C, et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001; 61:8118-8121.
    • (2001) Cancer Res , vol.61 , pp. 8118-8121
    • Rubin, B.P.1    Singer, S.2    Tsao, C.3
  • 14
    • 0037087531 scopus 로고    scopus 로고
    • Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
    • Heinrich MC, Blanke CD, Druker BJ, Corless CL. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 2002; 20:1692-1703.
    • (2002) J Clin Oncol , vol.20 , pp. 1692-1703
    • Heinrich, M.C.1    Blanke, C.D.2    Druker, B.J.3    Corless, C.L.4
  • 16
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003; 21:4342-4349.
    • (2003) J Clin Oncol , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 17
    • 15944379625 scopus 로고    scopus 로고
    • Imatinib and gastrointestinal stromal tumors: Where do we go from here?
    • De Giorgi U, Verweij J. Imatinib and gastrointestinal stromal tumors: where do we go from here? Mol Cancer Ther 2005; 4:495-501.
    • (2005) Mol Cancer Ther , vol.4 , pp. 495-501
    • De Giorgi, U.1    Verweij, J.2
  • 18
    • 1842465615 scopus 로고    scopus 로고
    • Clinicopathologic, phenotypic, and genotypic characteristics of gastrointestinal mesenchymal tumors
    • Emile JF, Theou N, Tabone S, et al. Clinicopathologic, phenotypic, and genotypic characteristics of gastrointestinal mesenchymal tumors. Clin Gastroenterol Hepatol 2004; 2:597-605.
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 597-605
    • Emile, J.F.1    Theou, N.2    Tabone, S.3
  • 19
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003; 299:708-710.
    • (2003) Science , vol.299 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 20
    • 0041971080 scopus 로고    scopus 로고
    • Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
    • Hirota S, Ohashi A, Nishida T, et al. Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. Gastroenterology 2003; 125:660-667.
    • (2003) Gastroenterology , vol.125 , pp. 660-667
    • Hirota, S.1    Ohashi, A.2    Nishida, T.3
  • 21
    • 2142747025 scopus 로고    scopus 로고
    • KIT-negative gastrointestinal stromal tumors: Proof of concept and therapeutic implications
    • Medeiros F, Corless CL, Duensing A, et al. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am J Surg Pathol 2004; 28:889-894.
    • (2004) Am J Surg Pathol , vol.28 , pp. 889-894
    • Medeiros, F.1    Corless, C.L.2    Duensing, A.3
  • 22
    • 23944476156 scopus 로고    scopus 로고
    • Corless CL, Schroeder A, Griffith D, et al. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol 2005; 23:5357-5364. This study is the most definitive analysis of PDGFRA mutations.
    • Corless CL, Schroeder A, Griffith D, et al. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol 2005; 23:5357-5364. This study is the most definitive analysis of PDGFRA mutations.
  • 23
    • 13444270334 scopus 로고    scopus 로고
    • Nilsson B, Bumming P, Meis-Kindblom JM, et al. Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era: a population-based study in western Sweden. Cancer 2005; 103:821-829. A population-based study from a province in Sweden provides information on the true incidence of GISTs.
    • Nilsson B, Bumming P, Meis-Kindblom JM, et al. Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era: a population-based study in western Sweden. Cancer 2005; 103:821-829. A population-based study from a province in Sweden provides information on the true incidence of GISTs.
  • 24
    • 0037572285 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors (GISTs): Definition, occurrence, pathology, differential diagnosis and molecular genetics
    • Miettinen M, Lasota J. Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol 2003; 54:3-24.
    • (2003) Pol J Pathol , vol.54 , pp. 3-24
    • Miettinen, M.1    Lasota, J.2
  • 25
    • 33645291186 scopus 로고    scopus 로고
    • Perez EA, Livingstone AS, Franceschi D, et al. Current incidence and outcomes of gastrointestinal mesenchymal tumors including gastrointestinal stromal tumors. J Am Coll Surg 2006; 202:623-629. This is the first evaluation of the incidence of GIST using the SEER database since the identification of KIT mutations.
    • Perez EA, Livingstone AS, Franceschi D, et al. Current incidence and outcomes of gastrointestinal mesenchymal tumors including gastrointestinal stromal tumors. J Am Coll Surg 2006; 202:623-629. This is the first evaluation of the incidence of GIST using the SEER database since the identification of KIT mutations.
  • 26
    • 0013383136 scopus 로고    scopus 로고
    • Incidence, prevalence, phenotype, and biologic spectrum of gastrointestinal stroma tumors (GIST): A population-based study [abstract]
    • Kindblom LG, Meis-Kindblom JM, Blumming P, et al. Incidence, prevalence, phenotype, and biologic spectrum of gastrointestinal stroma tumors (GIST): a population-based study [abstract]. Ann Oncol 2003; 13:157.
    • (2003) Ann Oncol , vol.13 , pp. 157
    • Kindblom, L.G.1    Meis-Kindblom, J.M.2    Blumming, P.3
  • 27
    • 25444448316 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in Iceland, 1990-2003: The Icelandic GIST study, a population-based incidence and pathologic risk stratification study
    • A population-based study reviewing all potential cases in Iceland provides information on the true incidence of GISTs
    • Tryggvason G, Gislason HG, Magnusson MK, Jonasson JG. Gastrointestinal stromal tumors in Iceland, 1990-2003: the Icelandic GIST study, a population-based incidence and pathologic risk stratification study. Int J Cancer 2005; 117:289-293. A population-based study reviewing all potential cases in Iceland provides information on the true incidence of GISTs.
    • (2005) Int J Cancer , vol.117 , pp. 289-293
    • Tryggvason, G.1    Gislason, H.G.2    Magnusson, M.K.3    Jonasson, J.G.4
  • 28
    • 0035425217 scopus 로고    scopus 로고
    • Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa
    • Beghini A, Tibiletti MG, Roversi G, et al. Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. Cancer 2001; 92:657-662.
    • (2001) Cancer , vol.92 , pp. 657-662
    • Beghini, A.1    Tibiletti, M.G.2    Roversi, G.3
  • 29
    • 0036499042 scopus 로고    scopus 로고
    • Familial paraganglioma and gastric stromal sarcoma: A new syndrome distinct from the Carney triad
    • Carney JA, Stratakis CA. Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney triad. Am J Med Genet 2002; 108:132-139.
    • (2002) Am J Med Genet , vol.108 , pp. 132-139
    • Carney, J.A.1    Stratakis, C.A.2
  • 30
    • 0036240932 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene
    • Hirota S, Nishida T, Isozaki K, et al. Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene. Gastroenterology 2002; 122:1493-1499.
    • (2002) Gastroenterology , vol.122 , pp. 1493-1499
    • Hirota, S.1    Nishida, T.2    Isozaki, K.3
  • 31
    • 0033678402 scopus 로고    scopus 로고
    • Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors
    • Isozaki K, Terris B, Belghiti J, et al. Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. Am J Pathol 2000; 157:1581-1585.
    • (2000) Am J Pathol , vol.157 , pp. 1581-1585
    • Isozaki, K.1    Terris, B.2    Belghiti, J.3
  • 32
    • 21044439344 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumor syndrome: Phenotypic and molecular features in a kindred
    • Additional data on familial cases of GIST are discussed here
    • Li FP, Fletcher JA, Heinrich MC, et al. Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred. J Clin Oncol 2005; 23:2735-2743. Additional data on familial cases of GIST are discussed here.
    • (2005) J Clin Oncol , vol.23 , pp. 2735-2743
    • Li, F.P.1    Fletcher, J.A.2    Heinrich, M.C.3
  • 33
    • 0035174752 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumor with hyperpigmentation: Association with a germline mutation of the c-kit gene
    • Maeyama H, Hidaka E, Ota H, et al. Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene. Gastroenterology 2001; 120:210-215.
    • (2001) Gastroenterology , vol.120 , pp. 210-215
    • Maeyama, H.1    Hidaka, E.2    Ota, H.3
  • 34
    • 0031848146 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
    • Nishida T, Hirota S, Taniguchi M, et al. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet 1998; 19: 323-324.
    • (1998) Nat Genet , vol.19 , pp. 323-324
    • Nishida, T.1    Hirota, S.2    Taniguchi, M.3
  • 35
    • 12144286747 scopus 로고    scopus 로고
    • Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia
    • Robson ME, Glogowski E, Sommer G, et al. Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia. Clin Cancer Res 2004; 10:1250-1254.
    • (2004) Clin Cancer Res , vol.10 , pp. 1250-1254
    • Robson, M.E.1    Glogowski, E.2    Sommer, G.3
  • 36
    • 25144443610 scopus 로고    scopus 로고
    • Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors
    • This study summarizes GIST tumor biology, and specifically provides a clear summary of familial cases
    • Shinomura Y, Kinoshita K, Tsutsui S, Hirota S. Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors. J Gastroenterol 2005; 40:775-780. This study summarizes GIST tumor biology, and specifically provides a clear summary of familial cases.
    • (2005) J Gastroenterol , vol.40 , pp. 775-780
    • Shinomura, Y.1    Kinoshita, K.2    Tsutsui, S.3    Hirota, S.4
  • 37
    • 33644752349 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in patients with neurofibromatosis 1: A clinicopathologic and molecular genetic study of 45 cases
    • This is a thorough analysis of familial GISTs
    • Miettinen M, Fetsch JF, Sobin LH, Lasota J. Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases. Am J Surg Pathol 2006; 30:90-96. This is a thorough analysis of familial GISTs.
    • (2006) Am J Surg Pathol , vol.30 , pp. 90-96
    • Miettinen, M.1    Fetsch, J.F.2    Sobin, L.H.3    Lasota, J.4
  • 38
    • 0030960182 scopus 로고    scopus 로고
    • Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population
    • Zoller ME, Rembeck B, Oden A, et al. Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population. Cancer 1997; 79:2125-2131.
    • (1997) Cancer , vol.79 , pp. 2125-2131
    • Zoller, M.E.1    Rembeck, B.2    Oden, A.3
  • 39
    • 19544389327 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of neurofibromatosis type I (von Recklinghausen's disease)
    • Takazawa Y, Sakurai S, Sakuma Y, et al. Gastrointestinal stromal tumors of neurofibromatosis type I (von Recklinghausen's disease). Am J Surg Pathol 2005; 29:755-763.
    • (2005) Am J Surg Pathol , vol.29 , pp. 755-763
    • Takazawa, Y.1    Sakurai, S.2    Sakuma, Y.3
  • 40
    • 0346025449 scopus 로고    scopus 로고
    • Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients
    • Kinoshita K, Hirota S, Isozaki K, et al. Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients. J Pathol 2004; 202:80-85.
    • (2004) J Pathol , vol.202 , pp. 80-85
    • Kinoshita, K.1    Hirota, S.2    Isozaki, K.3
  • 41
    • 0032955439 scopus 로고    scopus 로고
    • Prognosis of gastrointestinal smooth-muscle (stromal) tumors: Dependence on anatomic site
    • Emory TS, Sobin LH, Lukes L, et al. Prognosis of gastrointestinal smooth-muscle (stromal) tumors: dependence on anatomic site. Am J Surg Pathol 1999; 23:82-87.
    • (1999) Am J Surg Pathol , vol.23 , pp. 82-87
    • Emory, T.S.1    Sobin, L.H.2    Lukes, L.3
  • 43
    • 20944443259 scopus 로고    scopus 로고
    • Blay JY, Bonvalot S, Casali P, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann Oncol 2005; 16:566-578. The consensus statement addresses some of the controversies in GIST management and provides the level of evidence-behind recommendations.
    • Blay JY, Bonvalot S, Casali P, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann Oncol 2005; 16:566-578. The consensus statement addresses some of the controversies in GIST management and provides the level of evidence-behind recommendations.
  • 44
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347:472-480.
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 45
    • 1842451619 scopus 로고    scopus 로고
    • The role of 18F-FDG PET in staging and early prediction of response to therapy of recurrent gastrointestinal stromal tumors
    • Gayed I, Vu T, Iyer R, et al. The role of 18F-FDG PET in staging and early prediction of response to therapy of recurrent gastrointestinal stromal tumors. J Nucl Med 2004; 45:17-21.
    • (2004) J Nucl Med , vol.45 , pp. 17-21
    • Gayed, I.1    Vu, T.2    Iyer, R.3
  • 47
    • 0035949177 scopus 로고    scopus 로고
    • Fine-needle aspiration biopsy diagnosis of gastrointestinal stromal tumors using morphology, immunocytochemistry, and mutational analysis of c-kit
    • Rader AE, Avery A, Wait CL, et al. Fine-needle aspiration biopsy diagnosis of gastrointestinal stromal tumors using morphology, immunocytochemistry, and mutational analysis of c-kit. Cancer 2001; 93:269-275.
    • (2001) Cancer , vol.93 , pp. 269-275
    • Rader, A.E.1    Avery, A.2    Wait, C.L.3
  • 48
    • 24944536236 scopus 로고    scopus 로고
    • Martin J, Poveda A, Llombart-Bosch A, et al. Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS). J Clin Oncol 2005; 23:6190-6198. The prognostic value of specific KIT mutations is presented.
    • Martin J, Poveda A, Llombart-Bosch A, et al. Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS). J Clin Oncol 2005; 23:6190-6198. The prognostic value of specific KIT mutations is presented.
  • 49
    • 0037106370 scopus 로고    scopus 로고
    • Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors
    • Singer S, Rubin BP, Lux ML, et al. Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors. J Clin Oncol 2002; 20:3898-3905.
    • (2002) J Clin Oncol , vol.20 , pp. 3898-3905
    • Singer, S.1    Rubin, B.P.2    Lux, M.L.3
  • 50
    • 0037841463 scopus 로고    scopus 로고
    • Prognostic assessment of gastrointestinal stromal tumor
    • Yan H, Marchettini P, Acherman YI, et al. Prognostic assessment of gastrointestinal stromal tumor. Am J Clin Oncol 2003; 26:221-228.
    • (2003) Am J Clin Oncol , vol.26 , pp. 221-228
    • Yan, H.1    Marchettini, P.2    Acherman, Y.I.3
  • 51
    • 0032408616 scopus 로고    scopus 로고
    • KIT mutation portends poor prognosis in gastrointestinal stromal/smooth muscle tumors
    • Ernst SI, Hubbs AE, Przygodzki RM, et al. KIT mutation portends poor prognosis in gastrointestinal stromal/smooth muscle tumors. Lab Invest 1998; 78:1633-1636.
    • (1998) Lab Invest , vol.78 , pp. 1633-1636
    • Ernst, S.I.1    Hubbs, A.E.2    Przygodzki, R.M.3
  • 52
    • 0032953812 scopus 로고    scopus 로고
    • Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
    • Lasota J, Jasinski M, Sarlomo-Rikala M, Miettinen M. Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas. Am J Pathol 1999; 154:53-60.
    • (1999) Am J Pathol , vol.154 , pp. 53-60
    • Lasota, J.1    Jasinski, M.2    Sarlomo-Rikala, M.3    Miettinen, M.4
  • 53
    • 0033652255 scopus 로고    scopus 로고
    • Analysis of KIT mutation and protein expression in fine needle aspirates of gastrointestinal stromal/smooth muscle tumors
    • Li SQ, O'Leary TJ, Sobin LH, et al. Analysis of KIT mutation and protein expression in fine needle aspirates of gastrointestinal stromal/smooth muscle tumors. Acta Cytol 2000; 44:981-986.
    • (2000) Acta Cytol , vol.44 , pp. 981-986
    • Li, S.Q.1    O'Leary, T.J.2    Sobin, L.H.3
  • 54
    • 0033199890 scopus 로고    scopus 로고
    • Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
    • Taniguchi M, Nishida T, Hirota S, et al. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors. Cancer Res 1999; 59:4297-4300.
    • (1999) Cancer Res , vol.59 , pp. 4297-4300
    • Taniguchi, M.1    Nishida, T.2    Hirota, S.3
  • 55
    • 0036846345 scopus 로고    scopus 로고
    • Management of malignant gastrointestinal stromal tumours
    • Joensuu H, Fletcher C, Dimitrijevic S, et al. Management of malignant gastrointestinal stromal tumours. Lancet Oncol 2002; 3:655-664.
    • (2002) Lancet Oncol , vol.3 , pp. 655-664
    • Joensuu, H.1    Fletcher, C.2    Dimitrijevic, S.3
  • 56
    • 10744224969 scopus 로고    scopus 로고
    • Is there a role for surgery in patients with 'unresectable' cKIT+ gastrointestinal stromal tumors treated with imatinib mesylate?
    • Scaife CL, Hunt KK, Patel SR, et al. Is there a role for surgery in patients with 'unresectable' cKIT+ gastrointestinal stromal tumors treated with imatinib mesylate? Am J Surg 2003; 186:665-669.
    • (2003) Am J Surg , vol.186 , pp. 665-669
    • Scaife, C.L.1    Hunt, K.K.2    Patel, S.R.3
  • 57
    • 0036081738 scopus 로고    scopus 로고
    • Diagnosis of gastrointestinal stromal tumors: A consensus approach
    • Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Int J Surg Pathol 2002; 10:81-89.
    • (2002) Int J Surg Pathol , vol.10 , pp. 81-89
    • Fletcher, C.D.1    Berman, J.J.2    Corless, C.3
  • 58
    • 33646033112 scopus 로고    scopus 로고
    • Otani Y, Furukawa T, Yoshida M, et al. Operative indications for relatively small (2-5 cm) gastrointestinal stromal tumor of the stomach based on analysis of 60 operated cases. Surgery 2006; 139:484-492. Favorable outcomes after laparoscopic resection of gastric GISTs are presented in this Japanese study.
    • Otani Y, Furukawa T, Yoshida M, et al. Operative indications for relatively small (2-5 cm) gastrointestinal stromal tumor of the stomach based on analysis of 60 operated cases. Surgery 2006; 139:484-492. Favorable outcomes after laparoscopic resection of gastric GISTs are presented in this Japanese study.
  • 60
    • 30544445224 scopus 로고    scopus 로고
    • Surgical management of small gastrointestinal stromal tumors of the stomach
    • Iwahashi M, Takifuji K, Ojima T, et al. Surgical management of small gastrointestinal stromal tumors of the stomach. World J Surg 2006; 30:28-35.
    • (2006) World J Surg , vol.30 , pp. 28-35
    • Iwahashi, M.1    Takifuji, K.2    Ojima, T.3
  • 61
    • 84879133032 scopus 로고    scopus 로고
    • NCCN task force report: Optimal management of patients with gastrointestinal stromal tumor (GIST): expansion and update of NCCN clinical practice guidelines
    • Demetri GD, Benjamin R, Blanke CD, et al. NCCN task force report: optimal management of patients with gastrointestinal stromal tumor (GIST): expansion and update of NCCN clinical practice guidelines. J Natl Compr Cancer Netw 2004; 2 (Suppl 1):S1-S26.
    • (2004) J Natl Compr Cancer Netw , vol.2 , Issue.SUPPL. 1
    • Demetri, G.D.1    Benjamin, R.2    Blanke, C.D.3
  • 62
    • 23844466658 scopus 로고    scopus 로고
    • Laparoscopic surgery for GIST: Too soon to decide
    • Otani Y, Kitajima M. Laparoscopic surgery for GIST: too soon to decide. Gastric Cancer 2005; 8:135-136.
    • (2005) Gastric Cancer , vol.8 , pp. 135-136
    • Otani, Y.1    Kitajima, M.2
  • 63
    • 0142056211 scopus 로고    scopus 로고
    • Outcome and long term results of surgical resection for gastrointestinal stromal tumors (GIST)
    • Besana-Ciani I, Boni L, Dionigi G, et al. Outcome and long term results of surgical resection for gastrointestinal stromal tumors (GIST). Scand J Surg 2003; 92:195-199.
    • (2003) Scand J Surg , vol.92 , pp. 195-199
    • Besana-Ciani, I.1    Boni, L.2    Dionigi, G.3
  • 64
    • 0141670409 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of the stomach: A ten-year surgical experience
    • Carboni F, Carlini M, Scardamaglia F, et al. Gastrointestinal stromal tumors of the stomach: a ten-year surgical experience. J Exp Clin Cancer Res 2003; 22:379-384.
    • (2003) J Exp Clin Cancer Res , vol.22 , pp. 379-384
    • Carboni, F.1    Carlini, M.2    Scardamaglia, F.3
  • 65
    • 0037342143 scopus 로고    scopus 로고
    • Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumours
    • Langer C, Gunawan B, Schuler P, et al. Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumours. Br J Surg 2003; 90:332-339.
    • (2003) Br J Surg , vol.90 , pp. 332-339
    • Langer, C.1    Gunawan, B.2    Schuler, P.3
  • 66
    • 0035044154 scopus 로고    scopus 로고
    • The effect of surgery and grade on outcome of gastrointestinal stromal tumors
    • Pierie JP, Choudry U, Muzikansky A, et al. The effect of surgery and grade on outcome of gastrointestinal stromal tumors. Arch Surg 2001; 136:383-389.
    • (2001) Arch Surg , vol.136 , pp. 383-389
    • Pierie, J.P.1    Choudry, U.2    Muzikansky, A.3
  • 67
    • 10744226681 scopus 로고    scopus 로고
    • Surgical treatment of gastrointestinal stromal tumors in the imatinib (STI-571) era
    • discussion 665-666
    • Wu PC, Langerman A, Ryan CW, et al. Surgical treatment of gastrointestinal stromal tumors in the imatinib (STI-571) era. Surgery 2003; 134:656-665; discussion 665-666.
    • (2003) Surgery , vol.134 , pp. 656-665
    • Wu, P.C.1    Langerman, A.2    Ryan, C.W.3
  • 68
    • 1842863425 scopus 로고    scopus 로고
    • Evaluation of gastrointestinal stromal tumors for recurrence rates and patterns of long-term follow-up
    • discussion 191-192
    • Samiian L, Weaver M, Velanovich V. Evaluation of gastrointestinal stromal tumors for recurrence rates and patterns of long-term follow-up. Am Surg 2004; 70:187-191; discussion 191-192.
    • (2004) Am Surg , vol.70 , pp. 187-191
    • Samiian, L.1    Weaver, M.2    Velanovich, V.3
  • 69
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344:1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 70
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 71
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 2000; 96:925-932.
    • (2000) Blood , vol.96 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3
  • 72
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
    • Joensuu H, Roberts PJ, Sarlomo-Rikala M, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001; 344:1052-1056.
    • (2001) N Engl J Med , vol.344 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3
  • 73
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
    • van Oosterom AT, Judson I, Verweij J, et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 2001; 358:1421-1423.
    • (2001) Lancet , vol.358 , pp. 1421-1423
    • van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 74
    • 0242691170 scopus 로고    scopus 로고
    • Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results [abstract]
    • Benjamin RS, Rankin C, Fletcher CD, et al. Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results [abstract]. Proc Am Soc Clin Oncol 2003; 22:814a.
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Benjamin, R.S.1    Rankin, C.2    Fletcher, C.D.3
  • 75
    • 4544227216 scopus 로고    scopus 로고
    • Dose effect of imatinib (IM) in patients with metastatis GIST: Phase III Sarcoma Group Study S0033
    • Rankin C, Von Mehren M, Blanke C, et al. Dose effect of imatinib (IM) in patients with metastatis GIST: Phase III Sarcoma Group Study S0033. Proc Am Soc Clin Oncol 2004; 23:815a.
    • (2004) Proc Am Soc Clin Oncol , vol.23
    • Rankin, C.1    Von Mehren, M.2    Blanke, C.3
  • 76
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij J, Casali PG, Zalcberg J, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet 2004; 364:1127-1134.
    • (2004) Lancet , vol.364 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 77
    • 24944529613 scopus 로고    scopus 로고
    • Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study
    • Data on imatinib resistance are discussed
    • Van Glabbeke M, Verweij J, Casali PG, et al. Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study. J Clin Oncol 2005; 23:5795-5804. Data on imatinib resistance are discussed.
    • (2005) J Clin Oncol , vol.23 , pp. 5795-5804
    • Van Glabbeke, M.1    Verweij, J.2    Casali, P.G.3
  • 78
    • 27244444216 scopus 로고    scopus 로고
    • Interruption of imatinib (IM) in GIST patients with advanced disease: Updated results of the prospective French Sarcoma Group randomized phase III trial on survival and quality of life
    • The consequences of imatinib interruption in the treatment of patients with advanced GIST are presented
    • Le Cesne A, Perol D, Ray-Coquard I, et al. Interruption of imatinib (IM) in GIST patients with advanced disease: updated results of the prospective French Sarcoma Group randomized phase III trial on survival and quality of life. J Clin Oncol 2005; 23:823s. The consequences of imatinib interruption in the treatment of patients with advanced GIST are presented.
    • (2005) J Clin Oncol , vol.23
    • Le Cesne, A.1    Perol, D.2    Ray-Coquard, I.3
  • 79
    • 27244439258 scopus 로고    scopus 로고
    • van der Zwan SM, DeMatteo RP. Gastrointestinal stromal tumor: 5 years later. Cancer 2005; 104:1781-1788. This comprehensive review summarizes some key developments in GIST therapy.
    • van der Zwan SM, DeMatteo RP. Gastrointestinal stromal tumor: 5 years later. Cancer 2005; 104:1781-1788. This comprehensive review summarizes some key developments in GIST therapy.
  • 80
    • 23844448447 scopus 로고    scopus 로고
    • Correlation of target kinase genotype with clinical activity of imatinib mesylate in patients with metastatic GI stromal tumors (GISTs) expressing KIT (KIT+) [abstract]
    • 3s
    • Heinrich MC, Shoemaker JS, Corless CL, et al. Correlation of target kinase genotype with clinical activity of imatinib mesylate in patients with metastatic GI stromal tumors (GISTs) expressing KIT (KIT+) [abstract]. Proc Am Soc Clin Oncol 2005; 23:3s.
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Heinrich, M.C.1    Shoemaker, J.S.2    Corless, C.L.3
  • 81
    • 33746401591 scopus 로고    scopus 로고
    • Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006; 42:1093-1103. A correlation between KIT mutation and response to imatinib dose is presented.
    • Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006; 42:1093-1103. A correlation between KIT mutation and response to imatinib dose is presented.
  • 82
    • 28244448020 scopus 로고    scopus 로고
    • Effects of cessation of imatinib mesylate (IM) therapy in patients (pts) with IM-refractory gastrointestinal stromal tumors (GIST) as visualized by FDG-PET scanning [abstract]
    • van den Abbeele AD, Badawi RD, Manola J. Effects of cessation of imatinib mesylate (IM) therapy in patients (pts) with IM-refractory gastrointestinal stromal tumors (GIST) as visualized by FDG-PET scanning [abstract]. Proc Am Soc Clin Oncol 2004; 23:198.
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 198
    • van den Abbeele, A.D.1    Badawi, R.D.2    Manola, J.3
  • 83
    • 33645601681 scopus 로고    scopus 로고
    • Does pattern of metastases and early measurable changes after treatment predict therapy effect in gastrointestinal stromal tumors (GIST) on STI571 (imatinib). Chicago, Illinois: RSNA
    • Janicek M, Boston M, Potter A, et al. Does pattern of metastases and early measurable changes after treatment predict therapy effect in gastrointestinal stromal tumors (GIST) on STI571 (imatinib). Chicago, Illinois: RSNA Scientific Program; 2002. p. 583.
    • (2002) Scientific Program , pp. 583
    • Janicek, M.1    Boston, M.2    Potter, A.3
  • 84
    • 2342561799 scopus 로고    scopus 로고
    • Antoch G, Kanja J, Bauer S, et al. Comparison of PET, CT, and dual-modality PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumors. J Nucl Med 2004; 45:357-365.
    • Antoch G, Kanja J, Bauer S, et al. Comparison of PET, CT, and dual-modality PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumors. J Nucl Med 2004; 45:357-365.
  • 85
    • 0346626793 scopus 로고    scopus 로고
    • Monitoring treatment effects of STI-571 on gastrointestinal stromal tumors (GIST) with CT and PET: A quantitative analysis. Chicago, Illinois: RSNA
    • Choi H, Faria S, Benjamin R, et al. Monitoring treatment effects of STI-571 on gastrointestinal stromal tumors (GIST) with CT and PET: a quantitative analysis. Chicago, Illinois: RSNA Scientific Program; 2002. p. 583.
    • (2002) Scientific Program , pp. 583
    • Choi, H.1    Faria, S.2    Benjamin, R.3


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