Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall

European Journal of Medicinal Chemistry

Volumn 42, Issue 1, 2007, Pages 54-63

  Gobec, Stanislav ^a   Plantan, Ivan ^a   Mravljak, Janez ^a   Švajger, Urban ^a   Wilson, Rosalind A ^b   Besra, Gurdyal S ^b   Soares, Sousana L ^c   Appelberg, Rui ^c   Kikelj, Danijel ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Antigen 85C; Antituberculosis agents; Phosphonate inhibitors; Tuberculosis

Indexed keywords

(1,3 DIOXO 1,3 DIHYDRO 2H ISOINDOL 2 YL)METHYLETHYLHEPTYLPHOSPHONATE; 2 BUTANOL; 4 (PHTHALIMIDO)BUTANOL; ANTIGEN 85C; ANTIGEN 85C INHIBITOR; BACTERIAL ENZYME; BENZYL ALCOHOL; ETHYL 3 PHENOXYBENZYLBUTYLPHOSPHONATE; MYCOLIC ACID; N (OMEGA HYDROXYALKYL)PHTHALIMIDE; PHENETHYL ALCOHOL; PHOSPHONIC ACID DERIVATIVE; PHTHALIMIDE DERIVATIVE; TRANSFERASE; TREHALOSE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIUM CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; IC 50; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MYCOBACTERIUM AVIUM; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY;

ACYLTRANSFERASES; ANTIGENS, BACTERIAL; ANTITUBERCULAR AGENTS; CELL WALL; DRUG DESIGN; MYCOBACTERIUM AVIUM; PHOSPHONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846690975     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.08.007     Document Type: Article

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