No apoptosis is induced in rat cortical neurons exposed to GSM phone fields

Bioelectromagnetics

Volumn 28, Issue 2, 2007, Pages 115-121

  Joubert, Vanessa ^a   Leveque, Philippe ^b   Cueille, Marylene ^b   Bourthoumieu, Sylvie ^a   Yardin, Catherine ^a  

^a LIMOGES UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF LIMOGES   (France)

Author keywords

Apoptosis; Electromagnetic field; Flow cytometry; GSM; Rat cortical neurons

Indexed keywords

CELL CULTURE; ELECTROMAGNETIC FIELDS; FLOW CYTOMETRY; NEURONS; RATS;

APOPTOSIS RATES; CORTEXES; CULTURED NEURONS; EMBRYONICS; EXPOSED TO; IN-VITRO; MOBILE COMMUNICATION PHONE; NEURONAL APOPTOSIS; RADIOFREQUENCY ELECTROMAGNETIC FIELD; RAT CORTICAL NEURONS;

CELL DEATH;

4',6 DIAMIDINO 2 PHENYLINDOLE; CASPASE 3; DNA; PROPIDIUM IODIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL LABELING; CELL LINE; CONTROLLED STUDY; ELECTROMAGNETIC FIELD; EMBRYO; ENZYME ACTIVITY; ENZYME ASSAY; FLOW CYTOMETRY; FLUOROMETRY; IN VITRO STUDY; MOBILE PHONE; NERVE CELL CULTURE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIOFREQUENCY; RAT;

RATTUS; RATTUS NORVEGICUS;

EID: 33846675220     PISSN: 01978462     EISSN: 1521186X     Source Type: Journal    
DOI: 10.1002/bem.20274     Document Type: Article

References (24)

1. Belyaev LY, Hillert L, Protopopova M, Tamm C, Malmgren LOG, Persson BRR, Selivanova G, Harms-Ringdahl M. 2005. 915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons. Bioelectromagnetics 26:173-184.
2. Capri M, Scarcella E, Bianchi E, Fumelli C, Mesirca P, Agostini C, Remondini D, Schuderer J, Kuster N, Franceschi C, Bersani F. 2004a. 1800 MHz radiofrequency (mobile phones, different Global System for Mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors. Int J Radiat Biol 80:389-397.
3. Capri M, Scarcella E, Fumelli C, Bianchi E, Salvioli S, Mesirca P, Agostini C, Antolini A, Schiavoni A, Castellani G, Bersani F, Franceschi C. 2004b. In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: Studies of proliferation, apoptosis and mitochondrial membrane potential. Radiat Res 162:211-218.
4. Caraglia M, Marra M, Mancinelli F, D'Ambrosio G, Massa R, Giordano A, Budillon A, Abbruzzese A, Bismuto E. 2005. Electromagnetic fields at mobile phone frequency induce apoptosis and inactivation of the multi-chaperone complex in human epidermoid cancer cells. J Cell Physiol 204:539-548.
5. Czyz J, Guan K, Zeng Q, Nikolova T, Meister A, Schönborn F, Schuderer J, Kuster N, Wobus AM. 2004. High frequency electromagnetic fields (GSM signals) affect gene expression levels in tumor suppressor p53-deficient embryonic stem cells. Bioelectromagnetics 25:296-307.
6. Diem E, Schwarz C, Adlkofer F, Jahn O, Rüdiger H. 2005. Non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro. Mutat Res 583:178-183.
7. Hook GJ, Zhang P, Lagroye I, Li L, Higashikubo R, Moros EG, Straube WL, Pickard WJ, Baty JD, Roti Roti JL. 2004. Measurement of DNA damage and apoptosis in Molt-4 cells in vitro exposure to radiofrequency radiation. Radiat Res 161:193-200.
8. Joubert V, Leveque P, Rametti A, Collin A, Bourthoumieu S, Yardin C. 2006. Microwave exposure of neuronal cells in vitro: Study of apoptosis. Int J Radiat Biol 82:267-275.
9. Kerr JFR, Wyllie AH, Currie AR. 1972. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257.
10. Koh JY, Wie MB, Gwag BJ, Sensi SL, Canzoniero LMT, Demaro J, Csernansky C, Choi DW. 1995. Staurosporine-induced neuronal apoptosis. Exp Neurol 135:153-159.
11. Lagroye I, Anane R, Wettring BA, Moros EG, Straube WL, Laregina M, Niehoff M, Pickard WF, Baty J, Roti Roti JL. 2004a. Measurement of DNA damage after acute exposure to pulsed-wave 2450 MHz microwaves in rat brain cells by two alkaline comet assay methods. Int J Radiat Biol 80:11-20.
12. Lagroye I, Hook GJ, Wettring BA, Baty JD, Moros EG, Straube WL, Roti Roti JL. 2004b. Measurements of alkali-labile DNA damage and protein-DNA crosslinks after 2450 MHz microwave and low-dose gamma irradiation in vitro. Radiat Res 161:201-214.
13. Laval L, Leveque P Jecko B. 2000. A new in vitro exposure device for the mobile frequency of 900 MHz. Bioelectromagnetics 21:255-263.
14. Li L, Bisht KS, Lagroye I, Zhang P, Straube WL, Moros EG, Roti Roti JL. 2001. Measurement of DNA damage in mammalian cells exposed in vitro to radiofrequency fields at SARs of 3-5 W/kg. Radiat Res 156:328-332.
15. Maeda K, Maeda T, Qi Y 2004. In vitro and in vivo induction of human LoVo cells into apoptotic process by non-invasive microwave treatment: A potentially novel approach for physical therapy of human colorectal cancer. Oncol Rep 11:771-775.
16. Malyapa RS, Ahern EW, Straube WL, Moros EG, Pickard WF, Roti Roti JL. 1997. Measurement of DNA damage after exposure to electromagnetic radiation in the cellular phone communication frequency band (835.62 and 847.74 MHz). Radiat Res 148:618-627.
17. Marinelli F, La Sala D, Cicciotti G, Cattini L, Trimarchi C, Putti S, Zamparelli A, Giuliani L, Tomassetti G, Cinti C. 2004. Exposure to 900 MHz electromagnetic field induces an unbalance between pro-apoptotic and pro-survival signals in T-lymphoblastoid leukemia CCRF-CEM cells. J Cell Physiol 198:324-332.
18. Markkanen A, Penttinen P, Naarala J, Pelkonen J, Sihvonen AP, Juutilainen J. 2004. Apoptosis induced by ultraviolet radiation is enhanced by amplitude modulated radiofrequency radiation in mutant yeast cells. Bioelectromagnetics 25:127-133.
19. Merola P, Marino C, Lovisolo GA, Pinto R, Laconi C, Negroni A. 2006. Proliferation and apoptosis in a neuroblastoma cell line exposed to 900 MHz modulated radiofrequency field. Bioelectromagnetics 27:164-171.
20. Nicholson DW, Thornberry NA. 1997. Caspases: Killer proteases. Trends Biochem Sci 22:299-306.
21. Peinnequin A, Piriou A, Mathieu JL, Dabouis V, Sebbah C, Malabiau R, Debouzy JC. 2000. Non-thermal effects of continuous 2.45 GHz microwaves on Fas-induced apoptosis in human Jurkat T-cell line. Bioelectrochemistry 51:157-161.
22. Phillips JL, Ivaschuk O, Ishida-Jones T, Jones RA, Campbell-Beachler M, Haggren W. 1998. DNA damage in Molt-4 T-lymphoblastoid cells exposed to cellular telephone radiofrequency fields in vitro. Bioelectrochem Bioenerg 45:103-110.
23. Schuderer J, Spät D, Samaras T, Oesch W, Kuster N. 2004. In vitro exposure systems for RF exposures at 900 MHz. IEEE Trans Microw Theory Tech 52:2067-2075.
24. Zeni O, Romano M, Perrotta A, Lioi MB, Barbieri R, d'Ambrosio G, Massa R, Scarfi MR. 2005. Evaluation of genotoxic effects in human peripheral blood leukocytes following an acute in vitro exposure to 900 MHz radiofrequency fields. Bioelectromagnetics 26:258-265.