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DOI: 10.1021/jm060683e
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Lynch J.K., Freeman J.C., Judd A.S., Iyengar R.R., Mulhern M., Zhao G., Napier J.J., Wodka D., Brodjian S., Dayton B.D., Falls H.D., Ogiela C., Reilly R.M., Campbell T.J., Polakowski J.S., Hernandez L., Marsh K.C., Shapiro R., Knourek-Segal V., Droz B., Bush E., Brune M., Preusser L.C., Fryer R.M., Reinhart G.A., Houseman K., Diaz G., Mikhail A., Limberis J.T., Sham H.L., Collins C.A., and Kym P.R. J. Med. Chem. (2006) DOI: 10.1021/jm060683e
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33846601600
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note
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Chiralcell O. J., Hex/EtOH/MeOH (50/25/25), 0.8 mL/min, UV 220 nM. Both (-)-12 and (+)-12 were purified to enantiomeric purity within the limits of detection. The elution times for (-)-12 and (+)-12, respectively, are 6.1 and 9.2 min.
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-
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17
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33846647242
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note
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Chiralcell O. J., Hex/EtOH/MeOH (70/15/15), 0.8 mL/min, UV 240 nM. Both (-)-16 and (+)-16 were purified to enantiomeric purity within the limits of detection. The elution times for (-)-16 and (+)-16, respectively, are 7.57 min and 5.43 min.
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18
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24944458852
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See the following reference to 4-aminopiperidin- based MCHR1 antagonists
-
See the following reference to 4-aminopiperidin- based MCHR1 antagonists. Kym P.R., Iyengar R., Souers A.J., Lynch J.K., Judd A.S., Gao J., Freeman J., Mulhern M., Zhao G., Vasudevan A., Wodka D., Blackburn C., Brown J., Che J.L., Cullis C., Lai S.J., LaMarche M., Marsilje T., Roses J., Sells T., Geddes B., Govek E., Patane M., Fry D., Dayton B.D., Brodjian S., Falls D., Brune M., Bush E., Shapiro R., Knourek-Segel V., Fey T., McDowell C., Reinhart G.A., Preusser L.C., Marsh K., Hernandez L., Sham H.L., and Collins C.A. J. Med. Chem. 48 (2005) 5888
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Freeman, J.7
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Zhao, G.9
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Wodka, D.11
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Fry, D.24
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Falls, D.27
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Bush, E.29
Shapiro, R.30
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Fey, T.32
McDowell, C.33
Reinhart, G.A.34
Preusser, L.C.35
Marsh, K.36
Hernandez, L.37
Sham, H.L.38
Collins, C.A.39
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33846575863
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Cross-reactivity assays were performed by CEREP. www.cerep.com.
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