메뉴 건너뛰기




Volumn 14, Issue 2, 2007, Pages 276-285

Cancer cachexia: It's time for more clinical trials

Author keywords

Anorexia; Approved therapy; Cancer cachexia; Candidate drugs; Muscle wasting

Indexed keywords

CANNABIS DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; CYTOKINE ANTIBODY; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOCETAXEL; DRONABINOL; ETANERCEPT; FISH OIL; GHRELIN; HORMONE RECEPTOR BLOCKING AGENT; IBUPROFEN; ICOSAPENTAENOIC ACID; INFLIXIMAB; INTERLEUKIN 12; INTERLEUKIN 15; MEGESTROL ACETATE; MELANOCORTIN RECEPTOR ANTAGONIST; MELATONIN; MYOSTATIN; MYOSTATIN ANTIBODY; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; NANDROLONE DECANOATE; OXANDROLONE; PENTOXIFYLLINE; PLACEBO; PROTEIN ANTIBODY; SURAMIN; THALIDOMIDE; UNCLASSIFIED DRUG;

EID: 33846593870     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-006-9179-5     Document Type: Article
Times cited : (62)

References (84)
  • 1
    • 29144513918 scopus 로고    scopus 로고
    • Prevention and treatment of cancer cachexia: New insights into and old problem
    • Muscaritoli M, Bossola M, Aversa Z, et al. Prevention and treatment of cancer cachexia: new insights into and old problem. Eur J Cancer 2006; 42:31-41.
    • (2006) Eur J Cancer , vol.42 , pp. 31-41
    • Muscaritoli, M.1    Bossola, M.2    Aversa, Z.3
  • 3
    • 0028348894 scopus 로고
    • Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer
    • Falconer JS, Fearon KC, Plester CE, et al. Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 1994; 219:325-331.
    • (1994) Ann Surg , vol.219 , pp. 325-331
    • Falconer, J.S.1    Fearon, K.C.2    Plester, C.E.3
  • 4
    • 0242691782 scopus 로고    scopus 로고
    • Cancer anorexia: Clinical implications, pathogenesis, and therapeutic strategies
    • Laviano A, Meguid MM, Rossi Fanelli F. Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies. Lancet Oncol 2003; 4:686-694.
    • (2003) Lancet Oncol , vol.4 , pp. 686-694
    • Laviano, A.1    Meguid, M.M.2    Rossi Fanelli, F.3
  • 5
    • 0022474238 scopus 로고    scopus 로고
    • Energy expenditure in malnourished patients with colorectal cancer
    • Dempsey DT, Knox LS, Mullen JL, et al. Energy expenditure in malnourished patients with colorectal cancer. Arch Surg 1996; 121:789-795.
    • (1996) Arch Surg , vol.121 , pp. 789-795
    • Dempsey, D.T.1    Knox, L.S.2    Mullen, J.L.3
  • 6
    • 0031434277 scopus 로고    scopus 로고
    • Total energy expenditure in patients with non small-cell lung cancer: Results of a validated study using the bicarbonate-urea method
    • Gibney E, Elia M, Jebb SA, et al. Total energy expenditure in patients with non small-cell lung cancer: results of a validated study using the bicarbonate-urea method. Metabolism 1997; 46:1412-1417.
    • (1997) Metabolism , vol.46 , pp. 1412-1417
    • Gibney, E.1    Elia, M.2    Jebb, S.A.3
  • 7
    • 0021249139 scopus 로고
    • Cancer cachexia and protein metabolism
    • Jeevanandam M, Horowitz GD, Lowry SF, et al. Cancer cachexia and protein metabolism. Lancet 1984; 1:1423-1426.
    • (1984) Lancet , vol.1 , pp. 1423-1426
    • Jeevanandam, M.1    Horowitz, G.D.2    Lowry, S.F.3
  • 8
    • 0026909816 scopus 로고
    • The mechanisms and treatment of weight loss in cancer
    • Fearon KCH. The mechanisms and treatment of weight loss in cancer. Proc Nutr Soc 1992; 51:251-265.
    • (1992) Proc Nutr Soc , vol.51 , pp. 251-265
    • Fearon, K.C.H.1
  • 9
    • 0037561931 scopus 로고    scopus 로고
    • The cancer cachectic factor
    • Tisdale MJ. The cancer cachectic factor. Support Care Cancer 2003; 11:73-78.
    • (2003) Support Care Cancer , vol.11 , pp. 73-78
    • Tisdale, M.J.1
  • 10
    • 0032101680 scopus 로고    scopus 로고
    • Purification and characterization of a tumor lipid-mobilizing factor
    • Todorov PT, Mc Devitt TM, Meyer DJ, et al. Purification and characterization of a tumor lipid-mobilizing factor. Cancer Res 1998; 58:2353-2358.
    • (1998) Cancer Res , vol.58 , pp. 2353-2358
    • Todorov, P.T.1    Mc Devitt, T.M.2    Meyer, D.J.3
  • 11
    • 0032100584 scopus 로고    scopus 로고
    • Biological evaluation of a lipid mobilizing factor isolated from the urine cancer patients
    • Hirai K, Hussey HJ, Barber MD, et al. Biological evaluation of a lipid mobilizing factor isolated from the urine cancer patients. Cancer Res 1998; 58:2359-2365.
    • (1998) Cancer Res , vol.58 , pp. 2359-2365
    • Hirai, K.1    Hussey, H.J.2    Barber, M.D.3
  • 12
    • 0032913372 scopus 로고    scopus 로고
    • Catabolism of adipose tissue by a tumor-produced lipid mobilising factor
    • Khan S, Tisdale M. Catabolism of adipose tissue by a tumor-produced lipid mobilising factor. Int J Cancer 1999; 29:444-447.
    • (1999) Int J Cancer , vol.29 , pp. 444-447
    • Khan, S.1    Tisdale, M.2
  • 13
    • 1642397296 scopus 로고    scopus 로고
    • Mechanisms of skeletal muscle depletion in wasting syndromes: Role of ATP-ubiquitin-dependent proteolysis
    • Costelli P, Baccino FM. Mechanisms of skeletal muscle depletion in wasting syndromes: role of ATP-ubiquitin-dependent proteolysis. Curr Opin Clin Nutr Metab Care 2003; 6:407-412.
    • (2003) Curr Opin Clin Nutr Metab Care , vol.6 , pp. 407-412
    • Costelli, P.1    Baccino, F.M.2
  • 14
    • 84979796479 scopus 로고    scopus 로고
    • 2+-dependent proteolysis in skeletal muscle and heart in cancer cachexia
    • 2+-dependent proteolysis in skeletal muscle and heart in cancer cachexia. Br J Cancer 2001; 84:946-950.
    • (2001) Br J Cancer , vol.84 , pp. 946-950
    • Costelli, P.1    Tullio, R.D.2    Baccino, F.M.3
  • 15
    • 0036382762 scopus 로고    scopus 로고
    • 2+-dependent proteolytic systems in the muscle of tumour-bearing rats
    • 2+-dependent proteolytic systems in the muscle of tumour-bearing rats. Cytokine 2002; 19:1-5.
    • (2002) Cytokine , vol.19 , pp. 1-5
    • Costelli, P.1    Bossola, M.2    Muscaritoli, M.3
  • 17
    • 85047694453 scopus 로고    scopus 로고
    • Increased muscle proteasome activity correlates whit disease severity in gastric cancer patients
    • Bossola M, Muscaritoli M, Costelli P, et al. Increased muscle proteasome activity correlates whit disease severity in gastric cancer patients. Ann Surg 2003; 237:384-389.
    • (2003) Ann Surg , vol.237 , pp. 384-389
    • Bossola, M.1    Muscaritoli, M.2    Costelli, P.3
  • 18
    • 0035941020 scopus 로고    scopus 로고
    • Identification of ubiquitin ligases required for skeletal muscle atrophy
    • Bodine SC, Latres E, Baumhueter S, et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 2001; 294:1704-1708.
    • (2001) Science , vol.294 , pp. 1704-1708
    • Bodine, S.C.1    Latres, E.2    Baumhueter, S.3
  • 19
    • 0347285363 scopus 로고    scopus 로고
    • Multiple types of skeletal muscle atrophy involve a common program of changes in genes expression
    • Lecker SH, Jagoe T, Gilbert M, et al. Multiple types of skeletal muscle atrophy involve a common program of changes in genes expression. FASEB J 2004; 18:39-51.
    • (2004) FASEB J , vol.18 , pp. 39-51
    • Lecker, S.H.1    Jagoe, T.2    Gilbert, M.3
  • 20
    • 0034730251 scopus 로고    scopus 로고
    • NF-kappaB-induced loss of MyoD messenger RNA: Possible role in muscle decay and cachexia
    • Guttridge DC, Mayo MW, Madrid LV, et al. NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 2000; 289:2363-2366.
    • (2000) Science , vol.289 , pp. 2363-2366
    • Guttridge, D.C.1    Mayo, M.W.2    Madrid, L.V.3
  • 21
    • 19344368263 scopus 로고    scopus 로고
    • Skeletal muscle wasting in tumour-bearing rats is associated with MyoD down-regulation
    • Costelli P, Muscaritoli M, Bossola M, et al. Skeletal muscle wasting in tumour-bearing rats is associated with MyoD down-regulation. Int J Oncol 2005; 26:1663-1668.
    • (2005) Int J Oncol , vol.26 , pp. 1663-1668
    • Costelli, P.1    Muscaritoli, M.2    Bossola, M.3
  • 22
    • 0030818314 scopus 로고    scopus 로고
    • Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle
    • Kambadur R, Sharma M, Smith TP, Bass JJ. Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res 1997; 7:910-916.
    • (1997) Genome Res , vol.7 , pp. 910-916
    • Kambadur, R.1    Sharma, M.2    Smith, T.P.3    Bass, J.J.4
  • 23
    • 0030840359 scopus 로고    scopus 로고
    • Double muscling in cattle due to mutations in the myostatin gene
    • McPherron AC, Lee SJ. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA 1997; 94:12457-12461.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12457-12461
    • McPherron, A.C.1    Lee, S.J.2
  • 24
    • 0031928214 scopus 로고    scopus 로고
    • A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice
    • Szabo G, Dallmann G, Muller G, et al. A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice. Mamm Genome 1998; 9:671-672.
    • (1998) Mamm Genome , vol.9 , pp. 671-672
    • Szabo, G.1    Dallmann, G.2    Muller, G.3
  • 25
    • 0041802726 scopus 로고    scopus 로고
    • Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression
    • Ma K, Mallidis C, Bhasin S, et al. Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiol Endocrinol Metab 2003; 285:E363-E371.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Ma, K.1    Mallidis, C.2    Bhasin, S.3
  • 26
    • 0037165983 scopus 로고    scopus 로고
    • Induction of cachexia in mice by systemically administered myostatin
    • Zimmers TA, Davies MV, Koniaris LG, et al. Induction of cachexia in mice by systemically administered myostatin. Science 2002; 296:1486-1488.
    • (2002) Science , vol.296 , pp. 1486-1488
    • Zimmers, T.A.1    Davies, M.V.2    Koniaris, L.G.3
  • 27
    • 0141768237 scopus 로고    scopus 로고
    • Myostatin negatively regulates satellite cell activation and self-renewal
    • McCroskery S, Thomas M, Maxwell L, et al. Myostatin negatively regulates satellite cell activation and self-renewal. J Cell Biol 2003; 162:1135-1147.
    • (2003) J Cell Biol , vol.162 , pp. 1135-1147
    • McCroskery, S.1    Thomas, M.2    Maxwell, L.3
  • 28
    • 0037147210 scopus 로고    scopus 로고
    • Myostatin inhibits myoblast differentiation by down-regulating MyoD expression
    • Langley B, Thomas M, Bishop A, et al. Myostatin inhibits myoblast differentiation by down-regulating MyoD expression. J Biol Chem 2002; 277:49831-49840.
    • (2002) J Biol Chem , vol.277 , pp. 49831-49840
    • Langley, B.1    Thomas, M.2    Bishop, A.3
  • 30
    • 1642634608 scopus 로고    scopus 로고
    • Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome
    • Lopez AP, Roque Figuls M, Cuchi GU, et al. Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome. J Pain Sympt Manag 2004; 27:360-369.
    • (2004) J Pain Sympt Manag , vol.27 , pp. 360-369
    • Lopez, A.P.1    Roque Figuls, M.2    Cuchi, G.U.3
  • 32
    • 16444382105 scopus 로고    scopus 로고
    • Endocannabinoids and food intake: Newborn suckling and appetite regulation in adulthood
    • Fide E, Bregman T, Kirkham TC, et al. Endocannabinoids and food intake: newborn suckling and appetite regulation in adulthood. Exp Biol Med 2005; 230:225-234.
    • (2005) Exp Biol Med , vol.230 , pp. 225-234
    • Fide, E.1    Bregman, T.2    Kirkham, T.C.3
  • 33
    • 0037080279 scopus 로고    scopus 로고
    • Dronabinol versus combination therapy for cancer-associated anorexia: A North Central Cancer Treatment study
    • Jatoi A, Windschiltl HE, Loprinzi CL, et al. Dronabinol versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment study. J Cin Oncol 2002; 20:567-573.
    • (2002) J Cin Oncol , vol.20 , pp. 567-573
    • Jatoi, A.1    Windschiltl, H.E.2    Loprinzi, C.L.3
  • 34
  • 35
    • 17144438040 scopus 로고    scopus 로고
    • Protein and energy supplementation in elderly people at risk of malnutrition
    • CD003288
    • Milne AC, Potter J, Avenell A. Protein and energy supplementation in elderly people at risk of malnutrition. Cochrane database Syst Rev 2002; 3:CD003288.
    • (2002) Cochrane database Syst Rev , pp. 3
    • Milne, A.C.1    Potter, J.2    Avenell, A.3
  • 36
    • 0033912417 scopus 로고    scopus 로고
    • Are oral nutritional supplements of benefits in patients in the community? Findings from a systematic review
    • Stratton RJ, Elia M. Are oral nutritional supplements of benefits in patients in the community? Findings from a systematic review. Curr Opin Clin Nutr Metab Care 2000; 3:311-315.
    • (2000) Curr Opin Clin Nutr Metab Care , vol.3 , pp. 311-315
    • Stratton, R.J.1    Elia, M.2
  • 37
    • 0036846542 scopus 로고    scopus 로고
    • Rationale and indications for preoperative feeding of malnourished surgical cancer patients
    • Bozzetti F. Rationale and indications for preoperative feeding of malnourished surgical cancer patients. Nutrition 2002; 18:953-959.
    • (2002) Nutrition , vol.18 , pp. 953-959
    • Bozzetti, F.1
  • 38
    • 85026172882 scopus 로고    scopus 로고
    • parenteral nutrition
    • American Gastroenterological Association Medical position statement
    • American Gastroenterological Association Medical position statement: parenteral nutrition. Gastroeneterology 2001; 121:966-969.
    • (2001) Gastroeneterology , vol.121 , pp. 966-969
  • 39
    • 33846634834 scopus 로고    scopus 로고
    • American Society for Parenteral and Enteral Nutrition Board of Directors Guidelines for the use of parenteral and enteral nutrition in adult pediatric patients. JPEN J Parenter Enteral Nutr 2002; 26:SA1-S138
    • American Society for Parenteral and Enteral Nutrition Board of Directors Guidelines for the use of parenteral and enteral nutrition in adult pediatric patients. JPEN J Parenter Enteral Nutr 2002; 26:SA1-S138.
  • 40
    • 33744513119 scopus 로고    scopus 로고
    • ESPEN guidelines on enteral nutrition: Non-surgical oncology
    • May 11; Epub ahead of print
    • Arends J, Bodoky G, Bozzetti F, et al. ESPEN guidelines on enteral nutrition: non-surgical oncology. Clin Nutr 2006, May 11; Epub ahead of print.
    • (2006) Clin Nutr
    • Arends, J.1    Bodoky, G.2    Bozzetti, F.3
  • 41
    • 27644576866 scopus 로고    scopus 로고
    • Pareneteral nutrition in advanced cancer: Indications and clinical practice guidelines
    • Mirhosseini N, Fainsinger RL, Baracos V. Pareneteral nutrition in advanced cancer: indications and clinical practice guidelines. J Pall Med 2005; 8:914-918.
    • (2005) J Pall Med , vol.8 , pp. 914-918
    • Mirhosseini, N.1    Fainsinger, R.L.2    Baracos, V.3
  • 42
    • 1942530864 scopus 로고    scopus 로고
    • Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: Effects on survival, metabolism, and function
    • Lundholm K, Daneryd P, Bosaeus I, Komer Ulla, Lindholm E. Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: effects on survival, metabolism, and function. Cancer 2004; 100:1967-1977.
    • (2004) Cancer , vol.100 , pp. 1967-1977
    • Lundholm, K.1    Daneryd, P.2    Bosaeus, I.3    Ulla, K.4    Lindholm, E.5
  • 43
    • 0037376816 scopus 로고    scopus 로고
    • Enteral nutritional support of the patient with cancer
    • Schattner M. Enteral nutritional support of the patient with cancer. J Clin Gastroenterol 2003; 36:297-302.
    • (2003) J Clin Gastroenterol , vol.36 , pp. 297-302
    • Schattner, M.1
  • 44
    • 0032907404 scopus 로고    scopus 로고
    • Artificial nutrition in cancer patients: Which route, what composition?
    • Bozzetti F, Gavazzi C, Mariani L, et al. Artificial nutrition in cancer patients: which route, what composition? World J Surg 1999; 23:577-583.
    • (1999) World J Surg , vol.23 , pp. 577-583
    • Bozzetti, F.1    Gavazzi, C.2    Mariani, L.3
  • 45
    • 0031935183 scopus 로고    scopus 로고
    • Parenteral versus enteral nutrition in cancer patients: Indications and practice
    • Mercadante S. Parenteral versus enteral nutrition in cancer patients: indications and practice. Support Care Cancer 1998; 6:85-93.
    • (1998) Support Care Cancer , vol.6 , pp. 85-93
    • Mercadante, S.1
  • 46
    • 0035328839 scopus 로고    scopus 로고
    • Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid
    • Whitehouse AS, Smith HJ, Drake JL, et al. Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid. Cancer Res 2001; 61:3604-3609.
    • (2001) Cancer Res , vol.61 , pp. 3604-3609
    • Whitehouse, A.S.1    Smith, H.J.2    Drake, J.L.3
  • 47
    • 0033918233 scopus 로고    scopus 로고
    • Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer
    • Wigmore SJ, Barber MD, Ross JA. Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer. Nutr Cancer 2000; 36:177-184.
    • (2000) Nutr Cancer , vol.36 , pp. 177-184
    • Wigmore, S.J.1    Barber, M.D.2    Ross, J.A.3
  • 48
    • 0141869044 scopus 로고    scopus 로고
    • Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: A randomised double blind trial
    • Fearon KC, von Meyenfeldt MF, Moses AG, et al. Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut 2003; 52:1479-1486.
    • (2003) Gut , vol.52 , pp. 1479-1486
    • Fearon, K.C.1    von Meyenfeldt, M.F.2    Moses, A.G.3
  • 49
    • 1942424855 scopus 로고    scopus 로고
    • Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids
    • Moses AWG, Slater C, Preston T, et al. Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. Br J Cancer 2004; 90:996-1002.
    • (2004) Br J Cancer , vol.90 , pp. 996-1002
    • Moses, A.W.G.1    Slater, C.2    Preston, T.3
  • 50
    • 2942706075 scopus 로고    scopus 로고
    • An eicosapentaenoic acid supplement versus megestrol acetate versus both patients with cancer-associated wasting: A north central cancer treatment group and national cancer institute of Canada collaborative efforts
    • Jatoi A, Kendrith R, Loprinzi CL, et al. An eicosapentaenoic acid supplement versus megestrol acetate versus both patients with cancer-associated wasting: a north central cancer treatment group and national cancer institute of Canada collaborative efforts. J Clin Oncol 2004; 22:2469-2476.
    • (2004) J Clin Oncol , vol.22 , pp. 2469-2476
    • Jatoi, A.1    Kendrith, R.2    Loprinzi, C.L.3
  • 51
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci 2005; 8:571-578.
    • (2005) Nat Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 52
    • 19944421460 scopus 로고    scopus 로고
    • MC4 receptor antagonists: A potential treatment for cachexia
    • Foster AC, Chen C, Markison S, Marks DL. MC4 receptor antagonists: a potential treatment for cachexia. IDrugs 2005; 8:314-319.
    • (2005) IDrugs , vol.8 , pp. 314-319
    • Foster, A.C.1    Chen, C.2    Markison, S.3    Marks, D.L.4
  • 53
    • 18844432794 scopus 로고    scopus 로고
    • The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist
    • Markison S, Foster AC, Chen C, et al. The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist. Endocrinology 2005; 146:2766-2773.
    • (2005) Endocrinology , vol.146 , pp. 2766-2773
    • Markison, S.1    Foster, A.C.2    Chen, C.3
  • 54
    • 33645889660 scopus 로고    scopus 로고
    • Peripheral administration of a melanocortin4-receptor inverse agonist prevents loss of a lean body mass in tumor-bearing mice
    • Jan 25; Epub ahead of print
    • Nicholson JR, Kohler G, Schaerer F, et al. Peripheral administration of a melanocortin4-receptor inverse agonist prevents loss of a lean body mass in tumor-bearing mice. J Pharmacol Exp Ther 2006, Jan 25; Epub ahead of print.
    • (2006) J Pharmacol Exp Ther
    • Nicholson, J.R.1    Kohler, G.2    Schaerer, F.3
  • 55
    • 0035216623 scopus 로고    scopus 로고
    • Ghrelin enhances appetite and increases food intake in humans
    • Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Endocrinol Metab 2001; 86:5992-5995.
    • (2001) J Endocrinol Metab , vol.86 , pp. 5992-5995
    • Wren, A.M.1    Seal, L.J.2    Cohen, M.A.3
  • 56
    • 32544448074 scopus 로고    scopus 로고
    • Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers
    • Druce MR, Neary NM, Small CJ, et al. Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers. Int J Obes 2006; 30:293-296.
    • (2006) Int J Obes , vol.30 , pp. 293-296
    • Druce, M.R.1    Neary, N.M.2    Small, C.J.3
  • 57
    • 2942670638 scopus 로고    scopus 로고
    • Ghrelin increases energy intake in cancer patients with impaired appetite: Acute, randomized, placebo-controlled trial
    • Neary NM, Small CJ, Wren AM, et al. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrin Metab 2004; 89:2832-2836.
    • (2004) J Clin Endocrin Metab , vol.89 , pp. 2832-2836
    • Neary, N.M.1    Small, C.J.2    Wren, A.M.3
  • 58
    • 0344915169 scopus 로고    scopus 로고
    • Manipulation of the ubiquitin-proteasome pathway in cachexia: Pentoxifylline suppresses the activation of the 20S and 26S proteasomes in muscles from tumour bearing rats
    • Combaret L, Ralliere C, Taillandier D, et al. Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of the 20S and 26S proteasomes in muscles from tumour bearing rats. Mol Biol Rep 1999; 26:95-101.
    • (1999) Mol Biol Rep , vol.26 , pp. 95-101
    • Combaret, L.1    Ralliere, C.2    Taillandier, D.3
  • 59
    • 0033857366 scopus 로고    scopus 로고
    • Potential novel uses of thalidomide: Focus on palliative care
    • Peuckmann V, Fisch M, Bruera E. Potential novel uses of thalidomide: focus on palliative care. Drugs 2000; 60:273-292.
    • (2000) Drugs , vol.60 , pp. 273-292
    • Peuckmann, V.1    Fisch, M.2    Bruera, E.3
  • 60
    • 1942428953 scopus 로고    scopus 로고
    • Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia
    • Lundholm K, Daneryd P, Korner U, et al. Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. Int J Oncol 2004; 24:505-512.
    • (2004) Int J Oncol , vol.24 , pp. 505-512
    • Lundholm, K.1    Daneryd, P.2    Korner, U.3
  • 61
    • 1342344552 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase by celecoxib reverses tumour-2 induced wasting
    • Davis TW, Zweifel BS, O'Neal JM, et al. Inhibition of cyclooxygenase by celecoxib reverses tumour-2 induced wasting. J Pharmacol Exp Ther 2004; 308:929-934.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 929-934
    • Davis, T.W.1    Zweifel, B.S.2    O'Neal, J.M.3
  • 62
    • 0242580671 scopus 로고    scopus 로고
    • Effects of simvastatin administration in an experimental model of cancer cachexia
    • Muscaritoli M, Costelli P, Bossola M, et al. Effects of simvastatin administration in an experimental model of cancer cachexia. Nutrition 2003; 19:936-940.
    • (2003) Nutrition , vol.19 , pp. 936-940
    • Muscaritoli, M.1    Costelli, P.2    Bossola, M.3
  • 63
    • 0027488473 scopus 로고
    • Suramin interfers with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo
    • Strassmann G, Fong M, Freter CE, et al. Suramin interfers with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. J Clin Invest 1993; 92:2152-2159.
    • (1993) J Clin Invest , vol.92 , pp. 2152-2159
    • Strassmann, G.1    Fong, M.2    Freter, C.E.3
  • 64
    • 0029910826 scopus 로고    scopus 로고
    • Murine interleukin-12 prevents the development of cancer cachexia in a murine model
    • Mori K, Fujimoto-Ouchi K, Ishikawa T, et al. Murine interleukin-12 prevents the development of cancer cachexia in a murine model. Int J Cancer 1996; 67:849-855.
    • (1996) Int J Cancer , vol.67 , pp. 849-855
    • Mori, K.1    Fujimoto-Ouchi, K.2    Ishikawa, T.3
  • 65
    • 0029098563 scopus 로고
    • Interleukin-15: A novel anabolic cytokine for skeletal muscle
    • Quinn LS, Haugk KL, Grabstein KH. Interleukin-15: a novel anabolic cytokine for skeletal muscle. Endocrinology 1995; 136:3669-3672.
    • (1995) Endocrinology , vol.136 , pp. 3669-3672
    • Quinn, L.S.1    Haugk, K.L.2    Grabstein, K.H.3
  • 66
    • 0028787659 scopus 로고
    • Pentoxiphylline for treatment of cancer anorexia and cachexia? A randomised, double-bind, placebo-controlled trial
    • Goldberg RM, Loprinzi CL, Maillard JA, et al. Pentoxiphylline for treatment of cancer anorexia and cachexia? A randomised, double-bind, placebo-controlled trial. J Clin Oncol 1995; 13:2856-2859.
    • (1995) J Clin Oncol , vol.13 , pp. 2856-2859
    • Goldberg, R.M.1    Loprinzi, C.L.2    Maillard, J.A.3
  • 67
    • 0032771855 scopus 로고    scopus 로고
    • Thalidomide in patients with cachexia due to terminal cancer: Preliminary report
    • Bruera E, Neumann CM, Pituskin E, Calder K, Ball G, Hanson J. Thalidomide in patients with cachexia due to terminal cancer: preliminary report. Ann Oncology 1999; 10:857-859.
    • (1999) Ann Oncology , vol.10 , pp. 857-859
    • Bruera, E.1    Neumann, C.M.2    Pituskin, E.3    Calder, K.4    Ball, G.5    Hanson, J.6
  • 68
    • 0345269703 scopus 로고    scopus 로고
    • Oesophageal cancer and cachexia: The effect of short term treatment with thalidomide on weight loss and lean body mass
    • Khan ZH, Simpson EJ, Cole AT, et al. Oesophageal cancer and cachexia: the effect of short term treatment with thalidomide on weight loss and lean body mass. Aliment Pharmacol Ther 2003; 17:677-683.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 677-683
    • Khan, Z.H.1    Simpson, E.J.2    Cole, A.T.3
  • 69
    • 15444379633 scopus 로고    scopus 로고
    • Thalidomide in the treatment of cancer cachexia: A randomised placebo controlled trial
    • Gordon JN, Trebble TM, Ellis RD, et al. Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. Gut 2005; 54:540-545.
    • (2005) Gut , vol.54 , pp. 540-545
    • Gordon, J.N.1    Trebble, T.M.2    Ellis, R.D.3
  • 70
    • 0031021914 scopus 로고    scopus 로고
    • Melatonin in humans
    • Brzezinski A. Melatonin in humans. N Engl J Med 1997; 336:186-195.
    • (1997) N Engl J Med , vol.336 , pp. 186-195
    • Brzezinski, A.1
  • 71
    • 0030056686 scopus 로고    scopus 로고
    • Is there a role for melatonin in treatment of neoplastic cachexia?
    • Lissoni P, Paolorossi F, Tancini G, et al. Is there a role for melatonin in treatment of neoplastic cachexia?. Eur J Cancer 1996; 32:340-1343.
    • (1996) Eur J Cancer , vol.32 , pp. 340-1343
    • Lissoni, P.1    Paolorossi, F.2    Tancini, G.3
  • 72
    • 13844299005 scopus 로고    scopus 로고
    • Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: A randomised pilot study
    • Pearson C, Glimelius B, Ronnelid J, et al. Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomised pilot study. Nutrition 2005; 21:170-178.
    • (2005) Nutrition , vol.21 , pp. 170-178
    • Pearson, C.1    Glimelius, B.2    Ronnelid, J.3
  • 73
    • 0030851124 scopus 로고    scopus 로고
    • A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients
    • Mc Millan DC, OGorman P, Fearon KC, et al. A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients. Br J cancer 1997; 76:788-790.
    • (1997) Br J cancer , vol.76 , pp. 788-790
    • Mc Millan, D.C.1    OGorman, P.2    Fearon, K.C.3
  • 74
    • 18044399645 scopus 로고    scopus 로고
    • Clinical significance of weight loss in cancer patients: Rationale for the use of anabolic agents in the treatment of cancer-related cachexia
    • Langer CJ, Hoffman JP, Ottery FD, et al. Clinical significance of weight loss in cancer patients: rationale for the use of anabolic agents in the treatment of cancer-related cachexia. Nutrition 2001; 17(Suppl):S1-S20.
    • (2001) Nutrition , vol.17 , Issue.SUPPL.
    • Langer, C.J.1    Hoffman, J.P.2    Ottery, F.D.3
  • 75
    • 0034012929 scopus 로고    scopus 로고
    • Androgens and the control of skeletal muscle protein synthesis
    • Sheffield Moore M. Androgens and the control of skeletal muscle protein synthesis. Ann Med 2000; 32:181-186.
    • (2000) Ann Med , vol.32 , pp. 181-186
    • Sheffield Moore, M.1
  • 76
    • 0242720533 scopus 로고    scopus 로고
    • Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid
    • Demling RH, DeSanti L. Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid. Burns 2003; 29:793-797.
    • (2003) Burns , vol.29 , pp. 793-797
    • Demling, R.H.1    DeSanti, L.2
  • 77
    • 0036838939 scopus 로고    scopus 로고
    • Body cell mass repletion and improved quality of life in HIV-infected individuals receiving oxandrolone
    • Earthman CP, Reid PM, Harper IT, et al. Body cell mass repletion and improved quality of life in HIV-infected individuals receiving oxandrolone. JPEN J Parenteral Enteral Nutr 2002; 26:357-365.
    • (2002) JPEN J Parenteral Enteral Nutr , vol.26 , pp. 357-365
    • Earthman, C.P.1    Reid, P.M.2    Harper, I.T.3
  • 78
    • 0242721245 scopus 로고    scopus 로고
    • A role for anabolic steroids in therehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial
    • Creutzberg EC, Wouters EF, Mostert R, et al. A role for anabolic steroids in therehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial. Chest 2003; 104:1733-1742.
    • (2003) Chest , vol.104 , pp. 1733-1742
    • Creutzberg, E.C.1    Wouters, E.F.2    Mostert, R.3
  • 79
    • 0022593172 scopus 로고
    • Influence of nandrolone decanoate on weight loss in advanced non-small cell lung cancer
    • Chlebowski RT, Herrold J, Ali I, et al. Influence of nandrolone decanoate on weight loss in advanced non-small cell lung cancer. Cancer 1986; 58:183-186.
    • (1986) Cancer , vol.58 , pp. 183-186
    • Chlebowski, R.T.1    Herrold, J.2    Ali, I.3
  • 80
    • 4143059779 scopus 로고    scopus 로고
    • Ongoing placebo-controlled study of oxandrolone in cancer-related weight loss
    • Tchekmedyian S, Fesen M, Price LM, et al. Ongoing placebo-controlled study of oxandrolone in cancer-related weight loss. Int J Radiat Oncol Biol Phys 2003; 57(Suppl):S283-S284.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , Issue.SUPPL.
    • Tchekmedyian, S.1    Fesen, M.2    Price, L.M.3
  • 81
    • 0037191752 scopus 로고    scopus 로고
    • Functional improvement of dystrophic muscle by myostatin blockade
    • Bogdanovich S, Krag TOB, Barton ER, et al. Functional improvement of dystrophic muscle by myostatin blockade. Nature 2002; 420:418-421.
    • (2002) Nature , vol.420 , pp. 418-421
    • Bogdanovich, S.1    Krag, T.O.B.2    Barton, E.R.3
  • 82
    • 0036895736 scopus 로고    scopus 로고
    • Loss of myostatin attenuates severity of muscular dystrophy in mdx mice
    • Wagner KR, McPherron AC, Winik N, et al. Loss of myostatin attenuates severity of muscular dystrophy in mdx mice. Ann Neurol 2002; 52:832-836.
    • (2002) Ann Neurol , vol.52 , pp. 832-836
    • Wagner, K.R.1    McPherron, A.C.2    Winik, N.3
  • 83
    • 12144268598 scopus 로고    scopus 로고
    • A pilot study on safety and pharmacokinetics of infliximab for the cancer anorexia/weight loss syndrome in non-small-cell lung cancer patients
    • Jatoi A, Jett JR, Sloan J, et al. A pilot study on safety and pharmacokinetics of infliximab for the cancer anorexia/weight loss syndrome in non-small-cell lung cancer patients. Support Care Cancer 2004; 12:859-863.
    • (2004) Support Care Cancer , vol.12 , pp. 859-863
    • Jatoi, A.1    Jett, J.R.2    Sloan, J.3
  • 84
    • 33646382887 scopus 로고    scopus 로고
    • Assessment of tumor necrosis factor-alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients
    • Monk JP, Phillips G, Waite R, et al. Assessment of tumor necrosis factor-alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients. J Clin Oncol 2006; 24:1852-1859.
    • (2006) J Clin Oncol , vol.24 , pp. 1852-1859
    • Monk, J.P.1    Phillips, G.2    Waite, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.