Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: Relationship to clinical symptomatology and psychophysical olfactory performance

Schizophrenia Research

Volumn 90, Issue 1-3, 2007, Pages 221-228

  Moberg, Paul J ^a   McGue, Colleen ^a   Kanes, Stephen J ^a   Roalf, David R ^a   Balderston, Catherine C ^a   Gur, Raquel E ^a   Kohler, Christian G ^a   Turetsky, Bruce I ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Family; Genetics; Phenylthiocarbamide; PTC; Schizophrenia; Taste

Indexed keywords

PHENYLTHIOUREA;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; PHENOTYPIC VARIATION; PREVALENCE; PRIORITY JOURNAL; RELATIVE; RISK FACTOR; SCHIZOPHRENIA; SMELLING; SYMPTOMATOLOGY; TASTE;

ADULT; FEMALE; GENES, RECESSIVE; HUMANS; MALE; MIDDLE AGED; PHENYLTHIOUREA; PSYCHIATRIC STATUS RATING SCALES; PSYCHOPHYSICS; REFERENCE VALUES; RISK FACTORS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; SMELL; STATISTICS; TASTE THRESHOLD;

EID: 33846573230     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2006.11.014     Document Type: Article

References (47)

1. APA. Diagnostic and Statistical Manual of Mental Disorders. Fourth edition (1994), American Psychiatric Association, Washington, D.C.
2. Andreasen N.C. Scale for the Assessment of Negative Symptoms (SANS) (1984), University of Iowa, Iowa City, IA
3. Andreasen N.C. The Scale for the Assessment of Positive Symptoms (SAPS) (1984), The University of Iowa, Iowa City, IA
4. Barnicot N.A. Taste deficiency for phenylthiourea in African Negroes and Chinese. Annals of Eugenics 15 (1950) 248-254
5. Bartoshuk L.M., Duffy V.B., and Miller I.J. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiology and Behavior 56 (1994) 1165-1171
6. Blakeslee A.F. Genetics of sensory thresholds: taste for phenyl-thio-carbamide. Proceedings of the National Academy of Sciences of the United States of America 18 (1932) 120-130
7. Bromley S.M., and Doty R.L. Odor recognition memory is better under bilateral than unilateral test conditions. Cortex 31 1 (1995) 25-40
8. Buck L., and Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65 (1991) 175-187
9. Bufe B., Breslin P.A.S., Kuhn C., Reed D.R., Tharp C.D., Slack J.P., Kim U.-K., Drayna D., and Meyerhof W. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Current Biology 15 (2005) 322-327
10. Carpenter W.T., Heinrichs D.W., and Wagman A.M. Deficit and nondeficit forms of schizophrenia: the concept. American Journal of Psychiatry 145 5 (1988) 578-583
11. Constantinidis J. Les marqueurs de chromosomes chez les schizophrènes et la recherche du linkage entre ces caractères et la schizophrenie par la méthode de Penrose. Journal de Genetique Humaine 7 (1958) 189-242
12. Doty R.L., Brugger W.E., Jurs P.C., Orndorff M.A., Synder P.J., and Lowry D. Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiology and Behavior 20 2 (1978) 175-185
13. Doty R.L., Shaman P., and Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiology and Behavior 32 3 (1984) 489-502
14. Doty R.L., Gregor T., and Monroe C. Quantitative assessment of olfactory function in an industrial setting. Journal of Occupational Medicine 28 6 (1986) 457-460
15. Doty R.L., Frye R.E., and Agrawal U. Internal consistency reliability of the fractionated and whole University of Pennsylvania Smell Identification Test. Perception & Psychophysics 45 5 (1989) 381-384
16. Drayna D. Human taste genetics. Annual Review of Genomics and Human Genetics 6 (2005) 217-235
17. Drayna D., Coon H., Kim U.-K., Elsner T., Cromer K., Otterud B., Baird L., Peiffer A.P., and Lepport M. Genetic analysis of a complex trait in the Utah Gentic Reference Project: a major locus for PTC taste ability on chromosome 7q and secondary locus on chromosome 16p. Human Genetics 112 (2003) 567-572
18. Driscol K.A., Perez M., Cukrowicz K.C., Butler M., and Joiner T.E. Associations of phenylthiocarbamide tasting to alcohol problems and family history of alcoholism differ by gender. Psychiatry Research 143 (2006) 21-27
19. Enoch M.A., Harris C.R., and Goldman D. Does a reduced sensitivity to bitter taste increase the risk of becoming nicotine addicted?. Addictive Behaviors 26 (2001) 399-404
20. First M.B., Spitzer R.L., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders, Non-Patient Edition (SCID-NP) (1995), State Psychiatric Institute/Biometrics Research Department, New York
21. First M.B., Gibbon M., Spitzer R.L., and Williams J.B.W. Structured Clinical Interview for DSM-IV - Patient Edition (SCID-P, Version 2.0) (1996), New York State Psychiatric Institute, New York
22. First M.B., Spitzer R.L., Williams J.B.W., and Benjamin L.S. Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) (1997), American Psychiatric Press, Washington, DC
23. Fox A.L. Taste blindness. Science 73 (1931) 14
24. Freire-Maia N., Karam E.J., and Mehl H. PTC sensitivity among psychiatric patients. Acta Genetica et Statistica Medica 18 (1968) 31-37
25. Gainetdinov R.R., Premont R.T., Bohn L.M., Lefkowitz R.J., and Caron M.G. Desensitization of G protein-coupled receptors and neuronal functions. Annual Review of Neuroscience 27 (2004) 107-144
26. Gould T.J., Bizily S.P., Tokarczyk J., Kelly M.P., Siegel S.J., Kanes S.J., and Abel T. Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gsα. Neuropsychopharmacology 29 (2004) 494-501
27. Guo S.-W., and Reed D.R. The genetics of phenylthiocarbamide perception. Annals of Human Biology 28 2 (2001) 111-142
28. Gur R.E., Mozley P.D., Shtasel D.L., Cannon T.D., Gallacher F., Turetsky B., Grossman R., and Gur R.C. Clinical subtypes of schizophrenia: differences in brain and CSF volume. American Journal of Psychiatry 151 3 (1994) 343-350
29. Joiner T., and Perez M. Phenylthiocarbamide tasting and family history of depression, revisited: low rates of depression in families of supertasters. Psychiatry Research 126 (2004) 83-87
30. Kim U.-K., Jorgenson E., Coon H., Leppert M., Risch N., and Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299 (2003) 1221-1225
31. Lawless H.T., Antinone M.J., Ledford R.A., and Johnston M. Olfactory responsiveness to diacetyl. Journal of Sensory Studies 9 (1994) 47-56
32. Mattes R.D. 6-n-propylthiouracil taster status: dietary modifier, marker, or misleader?. In: Prescott J., and Tepper B.J. (Eds). Genetic Variation in Taste Sensitivity (2004), Marcel Dekker, Inc., New York 229-250
33. Moberg P.J., Agrin R., Gur R.E., Gur R.C., Turetsky B.I., and Doty R.L. Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology 21 (1999) 325-340
34. Moberg P.J., Roalf D.R., Balderston C.C., Kanes S.J., Gur R.E., and Turetsky B.I. Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree relatives. American Journal of Psychiatry 162 (2005) 788-790
35. Monteleone P., Di Lieto A., Martiadis V., Bartoli L., and Maj M. Correlations between negative symptoms and peripheral G protein levels in mononuclear leukocytes of deficit and nondeficit schizophrenics. European Archives of Psychiatry and Clinical Neuroscience 252 5 (2002) 214-218
36. Mourant A., Kopec A., and Domaniewski-Sobezak K. The Distribution of the Human Blood Groups and Other Polymorphisms (1976), Oxford University Press, Oxford, UK
37. Overall M., and Gorham D.R. The Brief Psychiatric Rating Scale. Journal of Operational Psychiatry 11 (1980) 48-64
38. Pal S.K., Sharma K., Pathak A., Sawhney I.M., and Prabhakar S. Possible relationship between phenylthiocarbamide taste sensitivity and epilepsy. Neurology India 52 (2004) 206-209
39. Reed D.R. Gene mapping for taste related phenotypes in humans and mice. Appetite 35 (2000) 189-190
40. Ronnett G.V., and Moon C. G proteins and olfactory signal transduction. Annual Review of Physiology 64 (2002) 189-222
41. Schlosberg A., and Baruch I. Phenylthiocarbamide (PTC) tasting in paranoid and nonparanoid schizophrenic patients. Perceptual and Motor Skills 74 (1992) 383-386
42. Schreiber G., and Avissar S. G proteins as a biochemical tool for diagnosing and monitoring treatments of mental disorders. The Israel Medical Association Journal 2 86-91 (2000)
43. Schreiber G., and Avissar S. Application of G-proteins in the molecular diagnosis of psychiatric disorders. Expert Review of Molecular Diagnostics 3 1 (2003) 69-80
44. Sidhu A., and Niznik H.B. Coupling of dopamine receptor subtypes to multiple and diverse G proteins. International Journal of Developmental Neuroscience 18 (2000) 669-677
45. Snyder L.H. Inherited taste deficiency. Science 74 (1931) 151-152
46. Whittemore P. Phenylthiocarbamide (PTC) tasting, genetics, and depression. Journal of Clinical Psychology 46 (1990) 262-272
47. Yackinous C., and Guinard J.X. Relation between PROP taster status and fat perception, touch, and olfaction. Physiology and Behavior 72 (2001) 427-437