Neurolysosomal pathology in human prosaposin deficiency suggests essential neurotrophic function of prosaposin

Acta Neuropathologica

Volumn 113, Issue 2, 2007, Pages 163-175

  Sikora, Jakub ^a   Harzer, Klaus ^b   Elleder, Milan ^a  

^a Charles University in Prague and General University Hospital in Prague   (Czech Republic)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cortical neuronal survival crisis; Cross correlation function; Neurolysosomal disorder; Prosaposin deficiency; Ubiquitination

Indexed keywords

CERAMIDE; GALACTOSYLCERAMIDE; GLOBOTRIAOSYLCERAMIDE; GLUCOSYLCERAMIDE; GLYCOSPHINGOLIPID; LACTOSYLCERAMIDE; NEUROTROPHIC FACTOR; PROSAPOSIN; SULFATIDE;

ADULT; AGED; ARTICLE; ASTROCYTE; AUTOPSY; BRAIN CORTEX; BRAIN NERVE CELL; CASE REPORT; CELL LOSS; CELL POPULATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONFOCAL MICROSCOPY; CORRELATION ANALYSIS; ENDOSOME; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID STORAGE; LYSOSOME; LYSOSOME STORAGE DISEASE; MICROGLIA; PERIPHERAL NERVOUS SYSTEM; PHAGOCYTOSIS; PRIORITY JOURNAL; PROSAPOSIN DEFICIENCY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; AUTOPSY; CELL ADHESION MOLECULES, NEURONAL; CEREBRAL CORTEX; CHILD; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOSPHINGOLIPIDS; HUMANS; INFANT, NEWBORN; LYSOSOMAL STORAGE DISEASES; LYSOSOMES; MALE; NEURONS; SAPOSINS; UBIQUITIN;

EID: 33846557978     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-006-0148-7     Document Type: Article

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