메뉴 건너뛰기




Volumn 85, Issue 4, 2006, Pages 744-751

Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys

Author keywords

Antalarmin; Cocaine discrimination; Cocaine self administration; CRF1 antagonist; HPA axis

Indexed keywords

ANTALARMIN; COCAINE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

EID: 33846556879     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.11.008     Document Type: Article
Times cited : (18)

References (52)
  • 1
    • 8744304959 scopus 로고    scopus 로고
    • Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotrophin-releasing hormone receptor antagonist in a primate stress paradigm
    • Ayala A.R., Pushkas J., Higley J.D., Ronsaville D., Gold P.W., Chrousos G.P., et al. Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotrophin-releasing hormone receptor antagonist in a primate stress paradigm. J Clin Endocrinol Metab 89 (2004) 5729-5737
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5729-5737
    • Ayala, A.R.1    Pushkas, J.2    Higley, J.D.3    Ronsaville, D.4    Gold, P.W.5    Chrousos, G.P.6
  • 2
    • 28544445676 scopus 로고    scopus 로고
    • Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications
    • Bossert J., Ghitza U., Lu L., Epstein D.H., and Shaham Y. Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications. Eur J Pharmacol 526 (2005) 36-50
    • (2005) Eur J Pharmacol , vol.526 , pp. 36-50
    • Bossert, J.1    Ghitza, U.2    Lu, L.3    Epstein, D.H.4    Shaham, Y.5
  • 3
    • 0032968234 scopus 로고    scopus 로고
    • Effects of response contingent and noncontingent cocaine injection on hypothalamic-pituitary-adrenal activity in rhesus monkeys
    • Broadbear J.H., Winger G., Cicero T.J., and Woods J.H. Effects of response contingent and noncontingent cocaine injection on hypothalamic-pituitary-adrenal activity in rhesus monkeys. J Pharmacol Exp Ther 290 (1999) 393-402
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 393-402
    • Broadbear, J.H.1    Winger, G.2    Cicero, T.J.3    Woods, J.H.4
  • 4
    • 0032994150 scopus 로고    scopus 로고
    • Effects of self-administered cocaine on plasma adrenocorticotropic hormone and cortisol in male rhesus monkeys
    • Broadbear J.H., Winger G., Cicero T.J., and Woods J.H. Effects of self-administered cocaine on plasma adrenocorticotropic hormone and cortisol in male rhesus monkeys. J Pharmacol Exp Ther 289 (1999) 1641-1647
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1641-1647
    • Broadbear, J.H.1    Winger, G.2    Cicero, T.J.3    Woods, J.H.4
  • 5
    • 0032773518 scopus 로고    scopus 로고
    • Cocaine-reinforced responding in rhesus monkeys: Pharmacological attenuation of the hypothalamic-pituitary-adrenal axis response
    • Broadbear J.H., Winger G., and Woods J.H. Cocaine-reinforced responding in rhesus monkeys: Pharmacological attenuation of the hypothalamic-pituitary-adrenal axis response. J Pharmacol Exp Ther 290 (1999) 1347-1355
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 1347-1355
    • Broadbear, J.H.1    Winger, G.2    Woods, J.H.3
  • 6
    • 2442636261 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys
    • Broadbear J.H., Winger G., Rivier J.E., Rice K.C., and Woods J.H. Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys. Neuropsychopharmacology 29 (2004) 1112-1121
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1112-1121
    • Broadbear, J.H.1    Winger, G.2    Rivier, J.E.3    Rice, K.C.4    Woods, J.H.5
  • 7
    • 33646506868 scopus 로고    scopus 로고
    • Recent advances in small molecule antagonists of the corticotropin-releasing factor type-1 receptor - focus on pharmacology and pharmacokinetics
    • Chen C. Recent advances in small molecule antagonists of the corticotropin-releasing factor type-1 receptor - focus on pharmacology and pharmacokinetics. Curr Med Chem 13 (2006) 1261-1282
    • (2006) Curr Med Chem , vol.13 , pp. 1261-1282
    • Chen, C.1
  • 8
    • 0032892569 scopus 로고    scopus 로고
    • The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress
    • Deak T., Nguyen K.T., Ehrlich A.L., Watkins L.R., Spencer R.L., Maier S.F., et al. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology 140 (1999) 79-86
    • (1999) Endocrinology , vol.140 , pp. 79-86
    • Deak, T.1    Nguyen, K.T.2    Ehrlich, A.L.3    Watkins, L.R.4    Spencer, R.L.5    Maier, S.F.6
  • 9
    • 0030957932 scopus 로고    scopus 로고
    • Glucocorticoids and behavioral effects of psychostimulants. II: cocaine intravenous self-administration and reinstatement depend on glucocorticoid levels
    • Deroche V., Marinelli M., Le Moal M., and Piazza P.V. Glucocorticoids and behavioral effects of psychostimulants. II: cocaine intravenous self-administration and reinstatement depend on glucocorticoid levels. J Pharmacol Exp Ther 281 (1997) 1401-1407
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 1401-1407
    • Deroche, V.1    Marinelli, M.2    Le Moal, M.3    Piazza, P.V.4
  • 10
    • 0032527895 scopus 로고    scopus 로고
    • The role of corticotropin-releasing factor and corticosterone in stress- and cocaine-induced relapse to cocaine seeking in rats
    • Erb S., Shaham Y., and Stewart J. The role of corticotropin-releasing factor and corticosterone in stress- and cocaine-induced relapse to cocaine seeking in rats. J Neurosci 18 (1998) 5529-5536
    • (1998) J Neurosci , vol.18 , pp. 5529-5536
    • Erb, S.1    Shaham, Y.2    Stewart, J.3
  • 11
    • 0031714333 scopus 로고    scopus 로고
    • Substance misuse and psychiatric comorbidity: an overview of the OPCS national psychiatric morbidity survey
    • Farrell M., Howes S., Taylor C., Lewis G., Jenkins R., Bebbington P., et al. Substance misuse and psychiatric comorbidity: an overview of the OPCS national psychiatric morbidity survey. Addict Behav 23 (1998) 909-918
    • (1998) Addict Behav , vol.23 , pp. 909-918
    • Farrell, M.1    Howes, S.2    Taylor, C.3    Lewis, G.4    Jenkins, R.5    Bebbington, P.6
  • 12
    • 33846485227 scopus 로고    scopus 로고
    • Ghitza, UE, Gray, SM, Epstein, DH, Rice, K, Shaham, Y. The anxiogenic drug Yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors. Neuropsychopharmacology, in press.
  • 13
    • 0030835433 scopus 로고    scopus 로고
    • A neuroendocrine role in cocaine reinforcement
    • Goeders N.E. A neuroendocrine role in cocaine reinforcement. Psychoneuroendocrinology 22 (1997) 237-259
    • (1997) Psychoneuroendocrinology , vol.22 , pp. 237-259
    • Goeders, N.E.1
  • 14
    • 0036264336 scopus 로고    scopus 로고
    • Stress and cocaine addiction
    • Goeders N.E. Stress and cocaine addiction. J Pharmacol Exp Ther 301 (2002) 785-789
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 785-789
    • Goeders, N.E.1
  • 15
    • 0036135147 scopus 로고    scopus 로고
    • The HPA axis and cocaine reinforcement
    • Goeders N.E. The HPA axis and cocaine reinforcement. Psychoneuroendocrinology 27 (2002) 13-33
    • (2002) Psychoneuroendocrinology , vol.27 , pp. 13-33
    • Goeders, N.E.1
  • 16
    • 0033802193 scopus 로고    scopus 로고
    • Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats
    • Goeders N.E., and Guerin G.F. Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats. Neuropsychopharmacology 23 (2000) 577-586
    • (2000) Neuropsychopharmacology , vol.23 , pp. 577-586
    • Goeders, N.E.1    Guerin, G.F.2
  • 17
    • 0029860765 scopus 로고    scopus 로고
    • Role for corticosterone in intravenous cocaine self-administration in rats
    • Goeders N.E., and Guerin G.F. Role for corticosterone in intravenous cocaine self-administration in rats. Neuroendocrinology 64 (1996) 337-348
    • (1996) Neuroendocrinology , vol.64 , pp. 337-348
    • Goeders, N.E.1    Guerin, G.F.2
  • 18
    • 0023680751 scopus 로고
    • Clinical and biomedical manifestations of depression: relationship to the neurobiology of stress (Part I)
    • Gold P.W., Goodwin F.K., and Chrousos G.P. Clinical and biomedical manifestations of depression: relationship to the neurobiology of stress (Part I). N Engl J Med 319 (1988) 348-353
    • (1988) N Engl J Med , vol.319 , pp. 348-353
    • Gold, P.W.1    Goodwin, F.K.2    Chrousos, G.P.3
  • 19
    • 0023759468 scopus 로고
    • Clinical and biomedical manifestations of depression: relationship to the neurobiology of stress (Part II)
    • Gold P.W., Goodwin F.K., and Chrousos G.P. Clinical and biomedical manifestations of depression: relationship to the neurobiology of stress (Part II). N Engl J Med 319 (1988) 413-420
    • (1988) N Engl J Med , vol.319 , pp. 413-420
    • Gold, P.W.1    Goodwin, F.K.2    Chrousos, G.P.3
  • 20
    • 0038407615 scopus 로고    scopus 로고
    • Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists
    • Grammatopoulos D.K., and Chrousos G.P. Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists. Trends Endocrinol Metab 13 (2002) 436-444
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 436-444
    • Grammatopoulos, D.K.1    Chrousos, G.P.2
  • 21
    • 12944262399 scopus 로고    scopus 로고
    • Oral administration of a corticotrophin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates
    • Habib K.E., Weld K.P., Rice K.C., Pushkas J., Champoux M., Listwak S., et al. Oral administration of a corticotrophin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc Natl Acad Sci U S A 97 (2000) 6079-6084
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6079-6084
    • Habib, K.E.1    Weld, K.P.2    Rice, K.C.3    Pushkas, J.4    Champoux, M.5    Listwak, S.6
  • 22
    • 12344335160 scopus 로고    scopus 로고
    • Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving
    • Heidbreder C.A., and Hagan J.J. Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. Curr Opin Pharmacol 5 (2005) 107-118
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 107-118
    • Heidbreder, C.A.1    Hagan, J.J.2
  • 23
    • 0037284475 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone modulators and depression
    • Holsboer F. Corticotropin-releasing hormone modulators and depression. Curr Opin Investig Drugs 4 (2003) 46-50
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 46-50
    • Holsboer, F.1
  • 24
    • 0033797445 scopus 로고    scopus 로고
    • The corticosteroid receptor hypothesis of depression
    • Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23 (2000) 477-501
    • (2000) Neuropsychopharmacology , vol.23 , pp. 477-501
    • Holsboer, F.1
  • 25
    • 0037844639 scopus 로고    scopus 로고
    • Non-peptidic CRF1 receptor antagonists for the treatment of anxiety, depression and stress disorders
    • Kehne J., and De Lombaert S. Non-peptidic CRF1 receptor antagonists for the treatment of anxiety, depression and stress disorders. Curr Drug Targets CNS Neurol Disord 1 (2002) 467-493
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.1 , pp. 467-493
    • Kehne, J.1    De Lombaert, S.2
  • 26
    • 0033232472 scopus 로고    scopus 로고
    • Corticotropin-releasing factor, norepinephrine, and stress
    • Koob G.F. Corticotropin-releasing factor, norepinephrine, and stress. Biol Psychiatry 46 (1999) 1167-1180
    • (1999) Biol Psychiatry , vol.46 , pp. 1167-1180
    • Koob, G.F.1
  • 29
    • 0037345745 scopus 로고    scopus 로고
    • Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes
    • Lu L., Liu Z., Huang M., and Zhang Z. Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes. J Neurochem 84 (2003) 1378-1386
    • (2003) J Neurochem , vol.84 , pp. 1378-1386
    • Lu, L.1    Liu, Z.2    Huang, M.3    Zhang, Z.4
  • 30
    • 33846537019 scopus 로고    scopus 로고
    • Mantsch, JR, Katz, ES. Elevation of glucocorticoids is necessary but not sufficient for the escalation of cocaine self-administration by chronic electric footshock stress in rats. Neuropsychopharmacology in press.
  • 31
    • 0033917937 scopus 로고    scopus 로고
    • Effects of cocaine self-administration on plasma corticosterone and prolactin in rats
    • Mantsch J.R., Schlussman S.D., Ho A., and Kreek M.J. Effects of cocaine self-administration on plasma corticosterone and prolactin in rats. J Pharmacol Exp Ther 294 (2000) 239-247
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 239-247
    • Mantsch, J.R.1    Schlussman, S.D.2    Ho, A.3    Kreek, M.J.4
  • 32
    • 0036460690 scopus 로고    scopus 로고
    • Interaction between glucocorticoid hormones, stress and psychostimulant drugs
    • Marinelli M., and Piazza P.V. Interaction between glucocorticoid hormones, stress and psychostimulant drugs. Eur J Neurosci 16 (2002) 387-394
    • (2002) Eur J Neurosci , vol.16 , pp. 387-394
    • Marinelli, M.1    Piazza, P.V.2
  • 33
    • 0000328731 scopus 로고    scopus 로고
    • Cocaine, hormones and behavior: clinical and preclinical studies
    • Pfaff D.W., Arnold A.P., Etgen A.M., Fahrbach S.E., and Rubin R.T. (Eds), Academic Press, New York
    • Mello N.K., and Mendelson J.H. Cocaine, hormones and behavior: clinical and preclinical studies. In: Pfaff D.W., Arnold A.P., Etgen A.M., Fahrbach S.E., and Rubin R.T. (Eds). Hormones, Brain and Behavior (2002), Academic Press, New York 665-745
    • (2002) Hormones, Brain and Behavior , pp. 665-745
    • Mello, N.K.1    Mendelson, J.H.2
  • 34
    • 0032437428 scopus 로고    scopus 로고
    • Effects of kappa opioid agonists on cocaine- and food-maintained responding by rhesus monkeys
    • Mello N.K., and Negus S.S. Effects of kappa opioid agonists on cocaine- and food-maintained responding by rhesus monkeys. J Pharmacol Exp Ther 286 (1998) 812-824
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 812-824
    • Mello, N.K.1    Negus, S.S.2
  • 36
    • 0026471411 scopus 로고
    • Human studies on the biological basis of reinforcement: a neuroendocrine perspective
    • O'Brien C.P., and Jaffe J.H. (Eds), Raven Press, Ltd., New York
    • Mendelson J.H., Mello N.K., Teoh S.K., Lukas S.E., Phipps W., Ellingboe J., et al. Human studies on the biological basis of reinforcement: a neuroendocrine perspective. In: O'Brien C.P., and Jaffe J.H. (Eds). Addictive States (1992), Raven Press, Ltd., New York 131-155
    • (1992) Addictive States , pp. 131-155
    • Mendelson, J.H.1    Mello, N.K.2    Teoh, S.K.3    Lukas, S.E.4    Phipps, W.5    Ellingboe, J.6
  • 39
    • 0026332080 scopus 로고
    • Physiology and pharmacology of corticotropin-releasing factor
    • Owens M.J., and Nemeroff C.B. Physiology and pharmacology of corticotropin-releasing factor. Pharmacological Rev 143 (1991) 425-473
    • (1991) Pharmacological Rev , vol.143 , pp. 425-473
    • Owens, M.J.1    Nemeroff, C.B.2
  • 40
    • 0032699523 scopus 로고    scopus 로고
    • Corticotropin-releasing factor antagonists in affective disorders
    • Owens M.J., and Nemeroff C.B. Corticotropin-releasing factor antagonists in affective disorders. Expert Opin Investig Drugs 8 (1999) 1849-1858
    • (1999) Expert Opin Investig Drugs , vol.8 , pp. 1849-1858
    • Owens, M.J.1    Nemeroff, C.B.2
  • 41
    • 0029890381 scopus 로고    scopus 로고
    • Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons
    • Piazza P.V., and LeMoal M. Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Ann Rev Pharmacol Toxicol 36 (1996) 359-378
    • (1996) Ann Rev Pharmacol Toxicol , vol.36 , pp. 359-378
    • Piazza, P.V.1    LeMoal, M.2
  • 42
    • 0037359880 scopus 로고    scopus 로고
    • The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review
    • Seymour P.A., Schmidt A.W., and Schulz D.W. The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review. CNS Drug Rev 9 (2003) 57-96
    • (2003) CNS Drug Rev , vol.9 , pp. 57-96
    • Seymour, P.A.1    Schmidt, A.W.2    Schulz, D.W.3
  • 43
    • 0030900836 scopus 로고    scopus 로고
    • Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats
    • Shaham Y., Funk D., Erb S., Brown T.J., Walker C.D., and Stewart J. Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. J Neurosci 17 (1997) 2605-2614
    • (1997) J Neurosci , vol.17 , pp. 2605-2614
    • Shaham, Y.1    Funk, D.2    Erb, S.3    Brown, T.J.4    Walker, C.D.5    Stewart, J.6
  • 44
    • 0031960095 scopus 로고    scopus 로고
    • CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats
    • Shaham Y., Erb S., Leung S., Buczek Y., and Stewart J. CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats. Psychopharmacology (Berl) 137 (1998) 184-190
    • (1998) Psychopharmacology (Berl) , vol.137 , pp. 184-190
    • Shaham, Y.1    Erb, S.2    Leung, S.3    Buczek, Y.4    Stewart, J.5
  • 45
    • 0033850835 scopus 로고    scopus 로고
    • Stress-induced relapse to heroin and cocaine seeking in rats: a review
    • Shaham Y., Erb S., and Stewart J. Stress-induced relapse to heroin and cocaine seeking in rats: a review. Brain Res Rev 33 (2000) 13-33
    • (2000) Brain Res Rev , vol.33 , pp. 13-33
    • Shaham, Y.1    Erb, S.2    Stewart, J.3
  • 46
    • 0035211708 scopus 로고    scopus 로고
    • How does stress increase risk of drug abuse and relapse?
    • Sinha R. How does stress increase risk of drug abuse and relapse?. Psychopharmacology 158 (2001) 343-359
    • (2001) Psychopharmacology , vol.158 , pp. 343-359
    • Sinha, R.1
  • 47
    • 33644753922 scopus 로고    scopus 로고
    • Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes
    • Sinha R., Garcia M., Paliwal P., Kreek M.J., and Rounsaville B.J. Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch Gen Psychatry 63 (2006) 324-331
    • (2006) Arch Gen Psychatry , vol.63 , pp. 324-331
    • Sinha, R.1    Garcia, M.2    Paliwal, P.3    Kreek, M.J.4    Rounsaville, B.J.5
  • 48
    • 11144275200 scopus 로고    scopus 로고
    • 1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats
    • 1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology 30 (2005) 90-98
    • (2005) Neuropsychopharmacology , vol.30 , pp. 90-98
    • Stinus, L.1    Cador, M.2    Zorrilla, E.P.3    Koob, G.F.4
  • 49
    • 0034884209 scopus 로고    scopus 로고
    • Drug abuse and mental illness: progress in understanding comorbidity
    • Volkow N.D. Drug abuse and mental illness: progress in understanding comorbidity. Am J Psychiatry 158 (2001) 1181-1183
    • (2001) Am J Psychiatry , vol.158 , pp. 1181-1183
    • Volkow, N.D.1
  • 50
    • 20044391431 scopus 로고    scopus 로고
    • Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor; a role in stress-induced relapse to drug seeking
    • Wang B., Shaham Y., Zitzman Y., Azari S., Wise R.A., and You Z.B. Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor; a role in stress-induced relapse to drug seeking. J Neurosci 25 (2005) 5389-5396
    • (2005) J Neurosci , vol.25 , pp. 5389-5396
    • Wang, B.1    Shaham, Y.2    Zitzman, Y.3    Azari, S.4    Wise, R.A.5    You, Z.B.6
  • 51
    • 0030445812 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation
    • Webster E.L., Lewis D.B., Torpy D.J., Zachman E.K., Rice K.C., and Chrousos G.P. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 137 (1996) 5747-5750
    • (1996) Endocrinology , vol.137 , pp. 5747-5750
    • Webster, E.L.1    Lewis, D.B.2    Torpy, D.J.3    Zachman, E.K.4    Rice, K.C.5    Chrousos, G.P.6
  • 52
    • 0037131064 scopus 로고    scopus 로고
    • Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
    • Zorrilla E.P., Valdez G.R., Nozulak J., Koob G.F., and Markou A. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res 952 (2002) 188-199
    • (2002) Brain Res , vol.952 , pp. 188-199
    • Zorrilla, E.P.1    Valdez, G.R.2    Nozulak, J.3    Koob, G.F.4    Markou, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.