A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis

Bioscience, Biotechnology and Biochemistry

Volumn 71, Issue 1, 2007, Pages 234-237

  Hirayasu, Hirofumi ^a   Yoshikawa, Yumiko ^a   Tsuzuki, Satoshi ^a   Fushiki, Tohru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Cytotoxic T lymphocytes; Dextran sulfate sodium; Granzyme A; Pancreatic secretory trypsin inhibitor; Ulcerative colitis

Indexed keywords

GRANZYME A;

GENES; GENETIC ENGINEERING; GROWTH KINETICS; HORMONES; METABOLISM;

ENZYME KINETICS;

ALPHA CHEMOKINE; CASPASE 3; CXCL1 PROTEIN, RAT; DEXTRAN SULFATE; GRANZYME; TRYPTASE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; LYMPHOCYTE; MALE; METABOLISM; RAT; SPRAGUE DAWLEY RAT; ULCERATIVE COLITIS;

ANIMALS; CASPASE 3; CELLS, CULTURED; CHEMOKINES, CXC; COLITIS, ULCERATIVE; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GRANZYMES; LYMPHOCYTES; MALE; RATS; RATS, SPRAGUE-DAWLEY; TRYPTASES;

RATTUS;

EID: 33846533653     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.60354     Document Type: Article

References (14)

1. Kam, C. M., Hudig, D., and Powers, J. C., Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors. Biochim. Biophys. Acta, 1477, 307-323 (2000).
2. Muller, S., Lory, J., Corazza, N., Griffiths, G. M., Z'graggen, K., Mazzucchelli, L., Kappeler, A., and Mueller, C., Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease. Am. J. Pathol., 152, 261-268 (1998).
3. Hansen, K. K., Sherman, P. M., Cellars, L., Andrade-Gordon, P., Pan, Z., Baruch, A., Wallace, J. L., Hollenberg, M. D., and Vergnolle, N., A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proc. Natl. Acad. Sci. USA, 102, 8363-8368 (2005).
4. Gaudio, E., Taddei, G., Vetuschi, A., Sferra, R., Frieri, G., Ricciardi, G., and Caprilli, R., Dextran sulfate sodium (DSS) colitis in rats: clinical, structural, and ultrastructural aspects. Dig. Dis. Sci., 44, 1458-1475 (1999).
5. 2 in protection against mucosal damage. Digestion, 63, 73-80 (2001).
6. Tsuzuki, S., Kokado, Y., Satomi, S., Yamasaki, Y., Hirayasu, H., Iwanaga, T., and Fushiki, T., Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A. Biochem. J., 372, 227-233 (2003).
7. Yamanishi, R., Kotera, J., Fushiki, T., Soneda, T., Saitoh, T., Oomori, T., Satoh, T., and Sugimoto, E., A specific binding of the cholecystokinin- releasing peptide (monitor peptide) to isolated rat small-intestinal cells. Biochem. J., 291, 57-63 (1993).
8. Hirayasu, H., Yoshikawa, Y., Tsuzuki, S., and Fushiki, T., Sulfated polysaccharides derived from dietary seaweeds increase the esterase activity of a lymphocyte tryptase, granzyme A. J. Nutr. Sci. Vitaminol., 51, 475-477 (2005).
9. Blackmon, D. L., Watson, A. J., and Montrose, M. H., Assay of apical membrane enzymes based on fluorogenic substrates. Anal. Biochem., 200, 352-358 (1992).
10. Baggioline, M., Dewald, B., and Moser, B., Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol., 55, 97-179 (1994).
11. van der Woude, C. J., Moshage, H., Homan, M., Kleibeuker, J. H., Jansen, P. L., and van Dekken, H., Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis. J. Clin. Pathol., 58, 811-814 (2005).
12. Gerhard, R., and Tilo, A., Cytokines in inflammatory bowel disease. World J. Surg., 22, 382-389 (1998).
13. Janas, M. L., Groves, P., Kienzle, N., and Kelso, A., IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferation. J. Immunol., 175, 8003-8010 (2005).
14. DeBlaker-Hohe, D. F., Yamauchi, A., Yu, C. R., Horvath-Arcidiacono, J. A., and Bloom, E. T., IL-12 synergizes with IL-2 to induce lymphokine-activated cytotoxicity and perforin and granzyme gene expression in fresh human NK cells. Cell Immunol., 165, 33-43 (1995).