Glucocorticoid receptor expression in the cortex of the neonatal rat brain with and without focal cerebral ischemia

Neonatology

Volumn 91, Issue 1, 2007, Pages 12-19

  Lee, Ben H ^a   Wen, Tong Chun ^a   Rogido, Marta ^a   Sola, Augusto ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain development; Brain injury; Glucocorticosteroid; Rat pups; Receptors; Stroke

Indexed keywords

GLUCOCORTICOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN ISCHEMIA; DOWN REGULATION; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE CELL; NEWBORN; NEWBORN PERIOD; NISSL STAINING; NONHUMAN; ONTOGENY; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BRAIN ISCHEMIA; CEREBRAL CORTEX; FEMALE; IMMUNOHISTOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID;

RATTUS;

EID: 33846532457     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000096966     Document Type: Article

References (31)

1. Lynch JK, Nelson KB: Epidemiology of perinatal stroke. Curr Opin Pediatr 2001;13:499-505.
2. Nelson KB, Lynch JK: Stroke in newborn infants. Lancet Neurol 2004;3:150-158.
3. Lynch JK, Hirtz DG, DeVeber G, Nelson KB: Report of the National Institute of Neurological Disorders and Stroke Workshop on Perinatal and Childhood Stroke. Pediatrics 2002;109:116-123.
4. Golomb MR, MacGregor DL, Domi T, Armstrong DC, McCrindle BW, Mayank S, deVeber GA: Presumed pre- or perinatal arterial ischemic stroke: risk factors and outcomes. Ann Neurol 2001;50:163-168.
5. de Vries LS, Groenendaal F, Eken P, van Haastert IC, Rademaker KJ, Meiners LC: Infarcts in the vascular distribution of the middle cerebral artery in preterm and fullterm infants. Neuropediatrics 1997;28:88-96.
6. Golomb MR, Dick PT, MacGregor DL, Armstrong DC, DeVeber GA: Cranial ultrasonography has a low sensitivity for detecting arterial ischemic stroke in term neonates. J Child Neurol 2003;18:98-103.
7. Bouza H, Rutherford M, Acolet D, Pennock JM, Dubowitz LM: Evolution of early hemiplegic signs in full-term infants with unilateral brain lesions in the neonatal period: a prospective study. Neuropediatrics 1994;25:201-207.
8. O'Shea TM, Kothadia JM, Klinepeter KL, Goldstein DJ, Jackson BG, Weaver RG 3rd, Dillard RG: Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants: outcome of study participants at 1-year adjusted age. Pediatrics 1999;104:15-21.
9. American Academy of Pediatrics, Committee on Fetus and Newborn: Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics 2002;109:330-338.
10. Norris JW: Steroids may have a role in stroke therapy. Stroke 2004;35:228-229.
11. de Courten-Myers GM, Kleinholz M, Wagner KR, Xi G, Myers RE: Efficacious experimental stroke treatment with high-dose methylprednisolone. Stroke 1994;25:487-492.
12. Arquie C, Leroux P, Bodenant C, Laquerriere A, Marpeau L, Marret S: Glucocorticoid treatment in an ischaemic-like excitotoxic model of periventricular leucomalacia in mice. BJOG 2002;109:989-996.
13. Tuor UI, Chumas PD, Del Bigio MR: Prevention of hypoxic-ischemic damage with dexamethasone is dependent on age and not influenced by fasting. Exp Neurol 1995;132:116-122.
14. Tuor UI, Yager JY, Bascaramurty S, Del Bigio MR: Dexamethasone prevents hypoxia/ischemia-induced reductions in cerebral glucose utilization and high-energy phosphate metabolites in immature brain. J Neurochem 1997;69:1954-1963.
15. Tuor UI, Del Bigio MR: Protection against hypoxic-ischemic damage with corticosterone and dexamethasone: inhibition of effect by a glucocorticoid antagonist RU38486. Brain Res 1996;743:258-262.
16. Ballow M, Nelson R: Immunopharmacology: immunomodulation and immunotherapy. JAMA 1997;278:2008-2017.
17. Chan RS, Huey ED, Maecker HL, Cortopassi KM, Howard SA, Iyer AM, McIntosh LJ, Ajilore OA, Brooke SM, Sapolsky RM: Endocrine modulators of necrotic neuron death. Brain Pathol 1996;6:481-491.
18. Alexis MN, Stylianopoulou F, Kitraki E, Sekeris CE: The distribution and properties of the glucocorticoid receptor from rat brain and pituitary. J Biol Chem 1983;258:4710-4714.
19. Morimoto M, Morita N, Ozawa H, Yokoyama K, Kawata M: Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study. Neurosci Res 1996;26:235-269.
20. Kawata M, Yuri K, Ozawa H, Nishi M, Ito T, Hu Z, Lu H, Yoshida M: Steroid hormones and their receptors in the brain. J Steroid Biochem Mol Biol 1998;65:273-280.
21. Wen TC, Rogido M, Gressens P, Sola A: A reproducible experimental model of focal cerebral ischemia in the neonatal rat. Brain Res Brain Res Protoc 2004;13:76-83.
22. Vannucci RC: Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage. Pediatr Res 1990;27:317-326.
23. Dobbing J, Sands J: Comparative aspects of the brain growth spurt. Early Hum Dev 1979;3:79-83.
24. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
25. Clayton CJ, Grosser BI, Stevens W: The ontogeny of corticosterone and dexamethasone receptors in rat brain. Brain Res 1977;134:445-453.
26. Kalinyak JE, Griffin CA, Hamilton RW, Bradshaw JG, Perlman AJ, Hoffman AR: Developmental and hormonal regulation of glucocorticoid receptor messenger RNA in the rat. J Clin Invest 1989;84:1843-1848.
27. McCullers DL, Sullivan PG, Scheff SW, Herman JP: Mifepristone protects CA1 hippocampal neurons following traumatic brain injury in rat. Neuroscience 2001;109:219-230.
28. Sugo N, Hurn PD, Morahan MB, Hattori K, Traystman RJ, DeVries AC: Social stress exacerbates focal cerebral ischemia in mice. Stroke 2002;33:1660-1664.
29. Antonawich FJ, Miller G, Rigsby DC, Davis JN: Regulation of ischemic cell death by glucocorticoids and adrenocorticotropic hormone. Neuroscience 1999;88:319-325.
30. Benesova O, Pavlik A: Perinatal treatment with glucocorticoids and the risk of maldevelopment of the brain. Neuropharmacology 1989;281:89-97.
31. Kitraki E, Kremmyda O, Youlatos D, Alexis MN, Kittas C: Gender-dependent alterations in corticosteroid receptor status and spatial performance following 21 days of restraint stress. Neuroscience 2004;125:47-55.