Neuropeptide tyrosine and pain

Trends in Pharmacological Sciences

Volumn 28, Issue 2, 2007, Pages 93-102

  Brumovsky, Pablo ^a,b   Shi, Tiejun S ^a   Landry, Marc ^c   Villar, Marcelo J ^b   Hökfelt, Tomas ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSIDAD AUSTRAL   (Argentina)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; GALANIN; MORPHINE; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; OPIATE; SUBSTANCE P;

ANALGESIC ACTIVITY; INFLAMMATION; INTERNEURON; NERVE FIBER; NEUROPATHIC PAIN; NONHUMAN; PAIN; PERIKARYON; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; REVIEW; SPINAL CORD DORSAL HORN; SPINAL GANGLION; UPREGULATION;

ANIMALS; GALANIN; GANGLIA, SPINAL; HUMANS; NEUROPEPTIDE Y; PAIN; POSTERIOR HORN CELLS; SPINAL CORD;

EID: 33846527402     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2006.12.003     Document Type: Review

References (102)

1. Tatemoto K., et al. Neuropeptide Y - a novel brain peptide with structural similarities for peptide YY and pancreatic polypeptide. Nature 296 (1982) 659-660
2. Larhammar D., and Salaneck E. Molecular evolution of NPY receptor subtypes. Neuropeptides 38 (2004) 141-151
3. Grouzmann E. Neuropeptide Y Y2 receptor signalling mechanisms in the human glioblastoma cell line LN319. Peptides 22 (2001) 379-386
4. Sun Q.Q., et al. Neuropeptide Y receptors differentially modulate G-protein-activated inwardly rectifying K+ channels and high-voltage-activated Ca2+ channels in rat thalamic neurons. J. Physiol. 531 (2001) 67-79
5. Silva A.P., et al. Neuropeptide Y and its receptors as potential therapeutic drug targets. Clin. Chim. Acta 326 (2002) 3-25
6. Wang S.J. Activation of neuropeptide Y Y1 receptors inhibits glutamate release through reduction of voltage-dependent Ca2+ entry in the rat cerebral cortex nerve terminals: suppression of this inhibitory effect by the protein kinase C-dependent facilitatory pathway. Neuroscience 134 (2005) 987-1000
7. Eva C. Physiology and gene regulation of the brain NPY Y(1) receptor. Front. Neuroendocrinol. 27 (2006) 308-339
8. 2 receptor-mediated stimulation of mitogen-activated protein kinase activity. Regulatory Peptides (1998) 75-76, 207-213
9. 1 receptor and PLC activation. J. Mol. Cell. Cardiol. 38 (2005) 205-212
10. Colmers W.F., and Bleakman D. Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. 17 (1994) 373-379
11. Smith, P.A. et al. Spinal mechanisms of NPY analgesia. Peptides (in press)
12. Wahlestedt C., et al. Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul. Pept. 13 (1986) 307-318
13. Pickel V.M., et al. Y1 receptors in the nucleus accumbens: ultrastructural localization and association with neuropeptide Y. J. Neurosci. Res. 52 (1998) 54-68
14. St-Pierre J.A., et al. Association of neuropeptide Y Y1 receptors with glutamate-positive and NPY-positive neurons in rat hippocampal cultures. Eur. J. Neurosci. 12 (2000) 1319-1330
15. Naveilhan P., et al. Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor. Nature 409 (2001) 513-517
16. Taiwo O.B., and Taylor B.K. Antihyperalgesic effects of intrathecal neuropeptide Y during inflammation are mediated by Y1 receptors. Pain 96 (2002) 353-363
17. Gibbs J., et al. Neuropeptide Y inhibits capsaicin-sensitive nociceptors via a Y1-receptor-mediated mechanism. Neuroscience 125 (2004) 703-709
18. Hua X.Y., et al. The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship. J. Pharmacol. Exp. Ther. 258 (1991) 243-248
19. Ossipov M.H., et al. Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. J. Neurosci. 22 (2002) 9858-9867
20. Tracey D.J., et al. Peripheral hyperalgesia in experimental neuropathy: exacerbation by neuropeptide Y. Brain Res. 669 (1995) 245-254
21. White D.M. Intrathecal neuropeptide Y exacerbates nerve injury-induced mechanical hyperalgesia. Brain Res. 750 (1997) 141-146
22. Lin Q., et al. Involvement of peripheral neuropeptide Y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin. Neuroscience 123 (2004) 337-347
23. Son S.J., et al. Activation of transcription factor c-jun in dorsal root ganglia induces VIP and NPY upregulation and contributes to the pathogenesis of neuropathic pain. Exp. Neurol. (2006). http://www.sciencedirect.com/ 10.1016/j.expneurol.2006.09.020 (www.sciencedirect.com)
24. 2 receptors. Br. J. Pharmacol. (in press)
25. Xu I.S., et al. The effect of intrathecal selective agonists of Y1 and Y2 neuropeptide Y receptors on the flexor reflex in normal and axotomized rats. Brain Res. 833 (1999) 251-257
26. Brumovsky P., et al. The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord. Neuroscience 138 (2006) 1361-1376
27. Shi T.J., et al. Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers. Neuroscience 140 (2006) 293-304
28. Brumovsky P., et al. Neuropeptide Y2 receptor protein is present in peptidergic and nonpeptidergic primary sensory neurons of the mouse. J. Comp. Neurol. 489 (2005) 328-348
29. Brumovsky P.R., et al. NPY Y1 receptors are present in axonal processes of DRG neurons. Exp. Neurol. 174 (2002) 1-10
30. Abdulla F.A., and Smith P.A. Nerve injury increases an excitatory action of neuropeptide Y and Y2-agonists on dorsal root ganglion neurons. Neuroscience 89 (1999) 43-60
31. Miyakawa A., et al. Action of neuropeptide Y on nociceptive transmission in substantia gelatinosa of the adult rat spinal dorsal horn. Neuroscience 134 (2005) 595-604
32. Moran T.D., et al. Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation. J. Neurophysiol. 92 (2004) 3266-3275
33. Tatemoto K., et al. Galanin - a novel biologically active peptide from porcine intestine. FEBS Lett. 164 (1983) 124-128
34. Liu H.X., and Hokfelt T. The participation of galanin in pain processing at the spinal level. Trends Pharmacol. Sci. 23 (2002) 468-474
35. Gibson S.J., et al. The distribution and origin of a novel brain peptide, neuropeptide Y, in the spinal cord of several mammals. J. Comp. Neurol. 227 (1984) 78-91
36. Corness J., et al. Influence of leukemia inhibitory factor on galanin/GMAP and neuropeptide Y expression in mouse primary sensory neurons after axotomy. Exp. Brain Res. 112 (1996) 79-88
37. Zhang X., et al. Effect of peripheral nerve cut on neuropeptides in dorsal root ganglia and the spinal cord of monkey with special reference to galanin. J. Neurocytol. 22 (1993) 342-381
38. Zhang X., et al. Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 729-734
39. Zhang X., et al. Localization of neuropeptide Y Y1 receptors in the rat nervous system with special reference to somatic receptors on small dorsal root ganglion neurons. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 11738-11742
40. Shi T.J., et al. Effect of peripheral axotomy on dorsal root ganglion neuron phenotype and autonomy behaviour in neuropeptide Y-deficient mice. Regul. Pept. 75-76 (1998) 161-173
41. Zhang X., et al. The neuropeptide Y Y1 receptor is a somatic receptor on dorsal root ganglion neurons and a postsynaptic receptor on somatostatin dorsal horn neurons. Eur. J. Neurosci. 11 (1999) 2211-2225
42. Parker M.S., et al. Differences in cation sensitivity of ligand binding to Y1 and Y2 subtype of neuropeptide Y receptor of rat brain. Eur. J. Pharmacol. 318 (1996) 193-200
43. Parker, S.L. et al. (2006) Mammalian Y2 neuropeptide Y (NPY) receptors show two populations in ligand binding and responses to agonists and antagonists. Soc for Neurosci, 36th Annual Meeting, 14-18 Oct, Atlanta, USA
44. Rowan S., et al. Evidence that neuropeptide Y is present in GABAergic neurons in the superficial dorsal horn of the rat spinal cord. Neuroscience 53 (1993) 537-545
45. Holets V.R., et al. Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase or galanin and their efferent projections to the spinal cord, cerebral cortex and hypothalamus. Neuroscience 24 (1988) 893-906
46. Willis Jr. W.D., and Coggeshall R.E. Primary afferent neurons and the spinal dorsal horn. Sensory Mechanisms of the Spinal Cord (2004), Plenum Press
47. Bennett G.J. Animal models of pain. In: Kruger L. (Ed). Methods in Pain Research (2001), CRC Press 67-92
48. Wakisaka S., et al. Increased neuropeptide Y (NPY)-like immunoreactivity in rat sensory neurons following peripheral axotomy. Neurosci. Lett. 124 (1991) 200-203
49. Mark M.A., et al. Spontaneous release of immunoreactive neuropeptide Y from the central terminals of large diameter primary afferents of rats with peripheral nerve injury. Neuroscience 83 (1998) 581-589
50. Zhang X., et al. Effect of peripheral axotomy on expression of neuropeptide Y receptor mRNA in rat lumbar dorsal root ganglia. Eur. J. Neurosci. 6 (1994) 43-57
51. Landry M., et al. Effect of axotomy on expression of NPY, galanin, and NPY Y1 and Y2 receptors in dorsal root ganglia and the superior cervical ganglion studied with double-labeling in situ hybridization and immunohistochemistry. Exp. Neurol. 162 (2000) 361-384
52. Brumovsky P.R., et al. Effect of a graded single constriction of the rat sciatic nerve on pain behavior and expression of immunoreactive NPY and NPY Y1 receptor in DRG neurons and spinal cord. Brain Res. 1006 (2004) 87-99
53. Kar S., and Quirion R. Quantitative autoradiographic localization of [125I]neuropeptide Y receptor binding sites in rat spinal cord and the effects of neonatal capsaicin, dorsal rhizotomy and peripheral axotomy. Brain Res. 574 (1992) 333-337
54. Zhang X., et al. Neuropeptide Y and galanin binding sites in rat and monkey lumbar dorsal root ganglia and spinal cord and effect of peripheral axotomy. Eur. J. Neurosci. 7 (1995) 367-380
55. Wakisaka S., et al. Effects of peripheral nerve injuries and tissue inflammation on the levels of neuropeptide Y-like immunoreactivity in rat primary afferent neurons. Brain Res. 598 (1992) 349-352
56. Ji R.R., et al. Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation. J. Neurosci. 14 (1994) 6423-6434
57. Dubner R., and Ruda M.A. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15 (1992) 96-103
58. Lundberg J.M., et al. Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol. Scand. 116 (1982) 477-480
59. Cavadas C., et al. Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 10497-10502
60. Bodnar R.J. Effects of opioid peptides on peripheral stimulation and 'stress'-induced analgesia in animals. Crit. Rev. Neurobiol. 6 (1990) 39-49
61. Huang L.Y., and Neher E. Ca(2+)-dependent exocytosis in the somata of dorsal root ganglion neurons. Neuron 17 (1996) 135-145
62. Ulrich-Lai Y.M., et al. Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from rat trigeminal ganglion: evidence for intraganglionic neurotransmission. Pain 91 (2001) 219-226
63. Amir R., and Devor M. Chemically mediated cross-excitation in rat dorsal root ganglia. J. Neurosci. 16 (1996) 4733-4741
64. Abdulla F.A., and Smith P.A. Axotomy- and autotomy-induced changes in Ca2+ and K+ channel currents of rat dorsal root ganglion neurons. J. Neurophysiol. 85 (2001) 644-658
65. Duggan A.W., et al. Microinjection of neuropeptide Y into the superficial dorsal horn reduces stimulus-evoked release of immunoreactive substance P in the anaesthetized cat. Neuroscience 44 (1991) 733-740
66. Giuliani S., et al. Prejunctional modulatory action of neuropeptide Y on peripheral terminals of capsaicin-sensitive sensory nerves. Br. J. Pharmacol. 98 (1989) 407-412
67. Hiruma H., et al. Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells. J. Physiol. 543 (2002) 85-97
68. Mantyh P.W. Neurobiology of substance P and the NK1 receptor. J. Clin. Psychiatry 63 Suppl. 11 (2002) 6-10
69. Seybold V.S., et al. Calcitonin gene-related peptide regulates expression of neurokinin1 receptors by rat spinal neurons. J. Neurosci. 23 (2003) 1816-1824
70. Todd A.J., et al. The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn. Eur. J. Neurosci. 17 (2003) 13-27
71. Polgár E., et al. GABAergic neurons that contain neuropeptide Y selectively target cells with the neurokinin 1 receptor in laminae III and IV of the rat spinal cord. J. Neurosci. 19 (1999) 2637-2646
72. Mantyh P.W., et al. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science 268 (1995) 1629-1632
73. Todd A.J., et al. Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem. Eur. J. Neurosci. 12 (2000) 689-700
74. Kato G., et al. Electrophysiological mapping of the nociceptive inputs to the substantia gelatinosa in rat horizontal spinal cord slices. J. Physiol. 560 (2004) 303-315
75. Wang C.C., et al. Ascending projections from the area around the spinal cord central canal: A Phaseolus vulgaris leucoagglutinin study in rats. J. Comp. Neurol. 415 (1999) 341-367
76. Gibbs J.L., et al. Attenuation of capsaicin-evoked mechanical allodynia by peripheral neuropeptide Y Y1 receptors. Pain 124 (2006) 167-174
77. Dimitrijevic M., et al. Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). J. Neuroimmunol. 129 (2002) 35-42
78. Wiesenfeld-Hallin Z., and Xu X.J. Neuropeptides in neuropathic and inflammatory pain with special emphasis on cholecystokinin and galanin. Eur. J. Pharmacol. 429 (2001) 49-59
79. Ch'ng J.L.C., et al. Distribution of galanin immunoreactivity in the central nervous system and the responses of galanin-containing neuronal pathway to injury. Neuroscience 16 (1985) 343-354
80. Skofitsch G., and Jacobowitz D.M. Immunohistochemical mapping of galanin-like neurons in the rat central nervous system. Peptides 6 (1985) 509-546
81. Kerekes N., et al. Galanin increases membrane excitability and enhances Ca(2+) currents in adult, acutely dissociated dorsal root ganglion neurons. Eur. J. Neurosci. 18 (2003) 2957-2966
82. Simmons D.R., et al. Galanin is contained in GABAergic neurons in the rat spinal dorsal horn. Neurosci. Lett. 187 (1995) 119-122
83. Brumovsky P., et al. Differential distribution and regulation of galanin receptors-1 and -2 in the rat lumbar spinal cord. Brain Res. 1085 (2006) 111-120
84. Landry M., et al. Galanin receptor 1 is expressed in a subpopulation of glutamatergic interneurons in the dorsal horn of the rat spinal cord. J. Comp. Neurol. 499 (2006) 391-403
85. Xu X.J., et al. The effects of intrathecal neuropeptide Y on the spinal nociceptive flexor reflex in rats with intact sciatic nerves and after peripheral axotomy. Neuroscience 63 (1994) 817-826
86. Liu H.X., et al. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 9960-9964
87. Hua X.Y., et al. Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization?. Neuropeptides 39 (2005) 211-216
88. Hua X.Y., et al. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J. Pharmacol. Exp. Ther. 308 (2004) 574-582
89. Blakeman K.H., et al. Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors. Neuroscience 117 (2003) 221-227
90. Holmes F.E., et al. Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6180-6185
91. Hygge-Blakeman K., et al. Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury. Brain Res. 1025 (2004) 152-158
92. Sapunar D., et al. Effect of peripheral axotomy on pain-related behavior and dorsal root ganglion neurons excitability in NPY transgenic rats. Brain Res. 1063 (2005) 48-58
93. Stacey B.R. Management of peripheral neuropathic pain. Am. J. Phys. Med. Rehabil. 84 Suppl. 3 (2005) S4-S16
94. Eisenberg, E et al. (2006) Opioids for neuropathic pain. Cochrane Database Syst. Rev. 3, CD006146
95. Back S.K. Loss of spinal μ-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy. Pain 123 (2006) 117-126
96. In: Fuxe K., and Agnati L.F. (Eds). Volume Transmission in the Brain (1991), Raven Press
97. Wang H., et al. Transganglionic transport and binding of the isolectin B4 from Griffonia simplicifolia I in rat primary sensory neurons. Neuroscience 62 (1994) 539-551
98. Bergman E., et al. Neuropeptides, nitric oxide synthase and GAP-43 in B4-binding and RT97 immunoreactive primary sensory neurons: normal distribution pattern and changes after peripheral nerve transection and aging. Brain Res. 832 (1999) 63-83
99. McMahon S.B., and Priestley J.V. Nociceptor plasticity. In: Hunt S.P., and Koltzenburg M. (Eds). The Neurobiology of Pain (2004), OUP
100. Zwick M., et al. Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse. J. Neurosci. 22 (2002) 4057-4065
101. Brumovsky P. Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse. Exp. Neurol. 200 (2006) 153-165
102. Shi T.J., et al. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurons development and pain behavior. Eur. J. Neurosci. 23 (2006) 627-636