Molecular basis of perhydrolase activity in serine hydrolases

Angewandte Chemie - International Edition

Volumn 44, Issue 18, 2005, Pages 2742-2746

  Bernhardt, Peter ^a,b   Hult, Karl ^b   Kazlauskas, Romas J ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ALBANOVA UNIVERSITY CENTER   (Sweden)

Author keywords

Enzyme catalysis; Hydrolases; Molecular modeling; Mutagenesis; Peroxides

Indexed keywords

ACYLATION; AMINO ACIDS; CHEMICAL BONDS; ENZYMES; MOLECULAR DYNAMICS; MUTAGENESIS; OXYGEN; SUBSTRATES; YEAST;

ESTERASES; MUTATIONS; PERHYDROLASE ACTIVITY; SERINE HYDROLASES;

ENZYME KINETICS;

ESTER; ESTERASE; HYDROLASE; PERACETIC ACID; SERINE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; HYDROLYSIS; KINETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; PSEUDOMONAS FLUORESCENS; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ESTERASES; ESTERS; HYDROLASES; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PERACETIC ACID; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS FLUORESCENS; RATS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 18844377217     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200463006     Document Type: Article

References (23)

1. P. J. O'Brien, D. Herschlag, Chem. Biol. 1999, 6, R91-R105.
2. U. T. Bornscheuer, R. J. Kazlauskas, Angew. Chem. 2004, 116, 6156-6165;
3. Angew. Chem. Int. Ed. 2004, 43, 6032-6040.
4. F. Björkling, H. Frykman, S. E. Godtfredsen, O. Kirk, Tetrahedron 1992, 48, 4587-4592.
5. M. Picard, J. Gross, E. Lübbert, S. Tölzer, S. Krauss, K.-H. van Pée, A. Berkessel, Angew. Chem. 1997, 109, 1245-1248;
6. Angew. Chem. Int. Ed. Engl. 1997, 36, 1196-1199.
7. I. Pelletier, J. Altenbuchner, R. Mattes, Biochim. Biophys. Acta 1995, 1250, 149-157.
8. K.-H. van Pée, G. Sury, F. Lingens, Biol. Chem. Hoppe-Seyler 1987, 368, 1225-1232.
9. W. Wiesner, K.-H. van Pée, F. Lingens, J. Biol. Chem. 1988, 263, 13725-13732.
10. N. Itoh, T. Kawanami, J.-Q. Liu, T. Dairi, M. Miyakoshi, C. Nitta, Y. Kimoto, Biochim. Biophys. Acta 2001, 1545, 53-66.
11. B. Hofmann, S. Tölzer, I. Pelletier, J. Altenbuchner, K.-H. van Pée, H. J. Hecht, J. Mol. Biol. 1998, 279, 889-900.
12. O. Kirk, L. S. Conrad, Angew. Chem. 1999, 111, 1031-1033;
13. Angew. Chem. Int. Ed. 1999, 38, 977-979.
14. O. Kirk, M. W. Christensen, T. Damhus, S. E. Godtfredsen, Biocatalysis 1994, 11, 65-77.
15. T. D. H. Bugg, Bioorg. Chem. 2004, 33, 367-375.
16. J. D. Cheeseman, A. Tocilj, S. Park, J. D. Schrag, R. J. Kazlauskas, Acta Crystallogr. Sect. D 2004, 60, 1237-1243.
17. I. Pelletier, J. Altenbuchner, Microbiology 1995, 141, 459-468.
18. S. C. Rothman, J. F. Kirsch, J. Mol. Biol. 2003, 327, 593-608.
19. L. P. Hager, D. R. Morris, F. S. Brown, H. J. Eberwein, J. Biol. Chem. 1966, 241, 1769-1777.
20. H. Gutfreund, J. M. Sturtevant, Biochem. J. 1956, 63, 656-661.
21. G. E. Schultz, R. H. Schirmer, Principles of Protein Structure, Springer, New York, 1984, p. 35.
22. A. R. Fersht, J.P Shi, J. Knill-Jones, D. M. Lowe, A. J. Wilkinson, D. M. Blow, P. Brick, P. Carter, M. M. Waye, G. Winter, Nature 1985, 314, 235-238.
23. A. R. Fersht, Biochemistry 1988, 27, 1577-1580.