Definition of the metabolic syndrome: What's new and what predicts risk?

Metabolic Syndrome and Related Disorders

Volumn 4, Issue 4, 2006, Pages 237-251

  Li, Chaoyang ^a   Ford, Earl S ^a  

^a NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DYSLIPIDEMIA; ETHNIC GROUP; GENDER; GLUCOSE METABOLISM; HUMAN; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; METABOLIC SYNDROME X; MORBIDITY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PREDICTION; PREVALENCE; PRIORITY JOURNAL; PUBLIC HEALTH; REVIEW;

EID: 33846514045     PISSN: 15404196     EISSN: None     Source Type: Journal    
DOI: 10.1089/met.2006.4.237     Document Type: Review

References (95)

1. Zimmet PZ, McCarty DJ, de Courten MP. The global epidemiology of non-insulin-dependent diabetes mellitus and the metabolic syndrome. J Diabetes Complications 1997;11:60-68.
2. Gotto AM Jr, Blackburn GL, Dailey GE III, Garber AJ, Grundy SM, Sobel BE, et al. The metabolic syndrome: A call to action. Coron Artery Dis 2006;17:77-80.
3. Reaven GM. Banting Lecture, 1988: role of insulin resistance in human disease. Diabetes 1988;37:1595-1607.
4. DeFronzo RA. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis. Neth J Med 1997;50:191-197.
5. Kaplan NM. The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 1989;149:1514-1520.
6. Despres JP. The insulin resistance-dyslipidemia syndrome: the most prevalent cause of coronary artery disease? CMAJ 1993;148:1339-1340.
7. Hjermann I. The metabolic cardiovascular syndrome: syndrome X, Reaven's syndrome, insulin resistance syndrome, atherothrombogenic syndrome. J Cardiovasc Pharmacol 1992;20 (Suppl 8):S5-S10.
8. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-553.
9. World Health Organization Department of Noncommunicable Disease Surveillance. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1: diagnosis and classification of diabetes mellitus. Geneva, Switzerland: World Health Organization, 1999.
10. Balkau B, Charles MA. Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med 1999;16:442-443.
11. Executive Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
12. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004;109:433-438.
13. Einhorn D, Reaven GM, Cobin RH, Ford E, Ganda OP, Handelsman Y, et al. American College of Endocrinology position statement on the insulin resistance syndrome. Endocr Pract 2003;9:237-252.
14. Bloomgarden ZT. Definitions of the insulin resistance syndrome: The 1st World Congress on the Insulin Resistance Syndrome. Diabetes Care 2004;27: 824-830.
15. International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. Available at: http://www.idf.org/ webdata/docs/Metabolic_syndrome_definition.pdf. Accessed April 3, 2006.
16. Executive Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
17. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112: 2735-2752.
18. Executive Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
19. Misra A, Wasir JS, Vikram NK. Waist circumference criteria for the diagnosis of abdominal obesity are not applicable uniformly to all populations and ethnic groups. Nutrition 2005;21:969-976.
20. Tan CE, Ma S, Wai D, Chew SK, Tai ES. Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians? Diabetes Care 2004;27:1182-1186.
21. Patel A, Huang KC, Janus ED, Gill T, Neal B, Suriyawongpaisal P, et al. Is a single definition of the metabolic syndrome appropriate? A comparative study of the USA and Asia. Atherosclerosis 2006;184:225-232.
22. Ford ES. Prevalence of the metabolic syndrome in US populations. Endocrinol Metab Clin North Am 2004, 33:333-350.
23. Cameron AJ, Shaw JE, Zimmet PZ. The metabolic syndrome: Prevalence in worldwide populations. Endocrinol Metab Clin North Am 2004;33:351-375.
24. Executive Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
25. Rguibi M, Belahsen R. Metabolic syndrome among Moroccan Sahraoui adult women. Am J Hum Biol 2004;16:598-601.
26. Harzallah F, Alberti H, Ben KF. The metabolic syndrome in an Arab population: A first look at the new International Diabetes Federation criteria. Diabet Med 2006;23:441-444.
27. Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, et al. Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 2005;365: 1398-1405.
28. Ko GT, Cockram CS, Chow CC, Yeung V, Chan WB, So WY, et al. High prevalence of metabolic syndrome in Hong Kong Chinese - comparison of three diagnostic criteria. Diabetes Res Clin Pract 2005;69:160-168.
29. Ko GT, Cockram CS, Chow CC, Yeung VT, Chan WB, So WY, et al. Metabolic syndrome by the International Diabetes Federation definition in Hong Kong Chinese. Diabetes Res Clin Pract 2006;73:58-64.
30. Thomas GN, Ho SY, Janus ED, Lam KS, Hedley AJ, Lam TH. The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III): Prevalence of the metabolic syndrome in a Chinese population. Diabetes Res Clin Pract 2005;67:251-257.
31. Gupta R, Deedwania PC, Gupta A, Rastogi S, Panwar RB, Kothari K. Prevalence of metabolic syndrome in an Indian urban population. Int J Cardiol 2004;97:257-261.
32. Azizi F, Salehi P, Etemadi A, Zahedi-Ast S. Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study. Diabetes Res Clin Pract 2003;61:29-37.
33. Park HS, Oh SW, Cho SI, Choi WH, Kim YS. The metabolic syndrome and associated lifestyle factors among South Korean adults. Int J Epidemiol 2004;33: 328-336.
34. Park HS, Lee SY, Kim SM, Han JH, Kim DJ. Prevalence of the metabolic syndrome among Korean adults according to the criteria of the International Diabetes Federation. Diabetes Care 2006;29:933-934.
35. Chuang SY, Chen CH, Chou P. Prevalence of metabolic syndrome in a large health check-up population in Taiwan. J Chin Med Assoc 2004;67:611-620.
36. Adams RJ, Appleton S, Wilson DH, Taylor AW, Dal GE, Chittleborough C, et al. Population comparison of two clinical approaches to the metabolic syndrome: Implications of the new International Diabetes Federation consensus definition. Diabetes Care 2005;28:2777-2779.
37. Hu G, Qiao Q, Tuomilehto J, Balkau B, Borch-Johnsen K, Pyorala. K. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med 2004;164:1066-1076.
38. Athyros VG, Ganotakis ES, Elisaf M, Mikhailidis DP. The prevalence of the metabolic syndrome using the National Cholesterol Educational Program and International Diabetes Federation definitions. Curr Med Res Opin 2005;21:1157-1159.
39. Jorgensen ME, Bjerregaard P, Gyntelberg F, Borch-Johnsen K. Prevalence of the metabolic syndrome among the Inuit in Greenland: A comparison between two proposed definitions. Diabet Med 2004;21: 1237-1242.
40. Hidvegi T, Hetyesi K, Biro L, Jermendy G. Screening for metabolic syndrome in hypertensive and/or obese subjects registered in primary health care in Hungary Med Sci Monit 2003;9:CR328-CR334.
41. Villegas R, Perrv IJ, Creagh D, Hinchion R, O'Halloran D. Prevalence of the metabolic syndrome in middle-aged men and women. Diabetes Care 2003;26: 3198-3199.
42. Sattar N, Gaw A, Scherbakova O, Ford I, O'Reilly DS, Haffner SM, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 2003;108: 414-419.
43. Sanisoglu SY, Oktenli C, Hasimi A, Yokusoglu M, Ugurlu M. Prevalence of metabolic syndrome-related disorders in a large adult population in Turkey. BMC Public Health 2006;6:92.
44. Pollex RL, Hanley AJ, Zinman B, Harris SB, Khan HM, Hegele RA. Metabolic syndrome in aboriginal Canadians: Prevalence and genetic associations. Atherosclerosis 2006;184:121-129.
45. Ford ES. Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care 2005;28:2745-2749.
46. Aguilar-Salinas CA, Rojas R, Gomez-Perez FJ, Garcia E, Valles V, Rios-Torres JM, et al. Prevalence and characteristics of early-onset type 2 diabetes in Mexico. Am J Med 2002;113:569-574.
47. Florez H, Silva E, Fernandez V, Ryder E, Sulbaran T, Campos G, et al. Prevalence and risk factors associated with the metabolic syndrome and dyslipidemia in white, black, Amerindian and mixed Hispanics in Zulia State, Venezuela. Diabetes Res Clin Pract 2005; 69:63-77.
48. Gupta A, Gupta R, Sarna M, Rastogi S, Gupta VP, Kothari K. Prevalence of diabetes, impaired fasting glucose and insulin resistance syndrome in an urban Indian population. Diabetes Res Clin Pract 2003;61: 69-76.
49. Ford ES, Giles WH. A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care 2003;26:575-581.
50. Ford ES, Mokdad AH, Giles WH. Trends in waist circumference among U.S. adults. Obes Res 2003;11: 1223-1231.
51. Whincup PH, Gilg JA, Donald AE, Katterhorn M, Oliver C, Cook DG, et al. Arterial distensibility in adolescents: The influence of adiposity, the metabolic syndrome, and classic risk factors. Circulation 2005;112:1789-1797.
52. Lambert M, Paradis G, O'Loughlin J, Delvin EE, Hanley JA, Levy E. Insulin resistance syndrome in a representative sample of children and adolescents from Quebec, Canada. Int J Obes Relat Metab Disord 2004;28:833-841.
53. Braunschweig CL, Gomez S, Liang H, Tomey K, Doerfler B, Wang Y, et al. Obesity and risk factors for the metabolic syndrome among low-income, urban, African American schoolchildren: The rule rather than the exception? Am J Clin Nutr 2005;81:970-975.
54. Chen W, Srinivasan SR, Li S, Xu J, Berenson GS. Metabolic syndrome variables at low levels in childhood are beneficially associated with adulthood cardiovascular risk: The Bogalusa Heart Study Diabetes Care 2005;28:126-131.
55. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: Findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med 2003;157:821-827.
56. Weitzman M, Cook S, Auinger P, Florin TA, Daniels S, Nguyen M, et al. Tobacco smoke exposure is associated with the metabolic syndrome in adolescents. Circulation 2005;112:862-869.
57. Wideman RF Jr, Hooge DM, Cummings KR. Dietary sodium bicarbonate, cool temperatures, and feed withdrawal: impact on arterial and venous blood-gas values in broilers. Poult Sci 2003;82:560-570.
58. Atabek ME, Pirgon O, Kurtoglu S. Prevalence of metabolic syndrome in obese Turkish children and adolescents. Diabetes Res Clin Pract 2006;72:315-321.
59. Butte NF, Comuzzie AG, Cole SA, Mehta NR, Cai G, Tejero M, et al. Quantitative genetic analysis of the metabolic syndrome in Hispanic children. Pediatr Res 2005;58:1243-1248.
60. Golley RK, Magarey AM, Steinbeck KS, Baur LA, Daniels LA. Comparison of metabolic syndrome prevalence using six different definitions in overweight pre-pubertal children enrolled in a weight management study. Int J Obes (Lond) 2006;30:853-860.
61. Papadopoulou-Alataki E, Papadopoulou-Legbelou K, Doukas L, Karatzidou K, Pavlitou-Tsiontsi A, Pagkalos E. Clinical and biochemical manifestations of syndrome X in obese children. Eur J Pediatr 2004; 163:573-579.
62. Torok K, Szelenyi Z, Porszasz J, Molnar D. Low physical performance in obese adolescent boys with metabolic syndrome. Int J Obes Relat Metab Disord 2001;25:966-970.
63. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: Association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 2005;115:290-296.
64. Cruz ML, Weigensberg MJ, Huang IT, Ball G, Shaibi GQ, Goran MI. The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab 2004;89:108-113.
65. da Silva RC, Miranda WL, Chacra AR, Dib SA. Metabolic syndrome and insulin resistance in normal glucose tolerant brazilian adolescents with family history of type 2 diabetes. Diabetes Care 2005;28: 716-718.
66. Coviello AD, Legro RS, Dunaif A. Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J Clin Endocrinol Metab 2006;91: 492-497.
67. Goodman E, Daniels SR, Morrison JA, Huang B, Dolan LM. Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. J Pediatr 2004;145:445-451.
68. Vikram NK, Misra A, Pandey RM, Luthra K, Wasir JS, Dhingra V. Heterogeneous phenotypes of insulin resistance and its implications for defining metabolic syndrome in Asian Indian adolescents. Atherosclerosis 2006;186:193-199.
69. Rodriguez-Moran M, Salazar-Vazquez B, Violante R, Guerrero-Romero F. Metabolic syndrome among children and adolescents aged 10-18 years. Diabetes Care 2004;27:2516-2517.
70. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002;288:2709-2716.
71. Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: A summary of the evidence. Diabetes Care 2005;28:1769-1778.
72. Eberly LE, Prineas R, Cohen JD, Vazquez G, Zhi X, Neaten JD, et al. Metabolic syndrome: Risk factor distribution and 18-year mortality in the multiple risk factor intervention trial. Diabetes Care 2006; 29:123-130.
73. Tanko LB, Bagger YZ, Qin G, Alexandersen P, Larsen PJ, Christiansen C. Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women. Circulation 2005; 111:1883-1890.
74. Wilson PW, D'Agostino RB, Parise H, Sullivan L, Meigs JB. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 2005;112:3066-3072.
75. Guzder RN, Gatling W, Mullee MA, Byrne CD. Impact of metabolic syndrome criteria on cardiovascular disease risk in people with newly diagnosed type 2 diabetes. Diabetologia 2006;49:49-55.
76. Reinhard W, Holmer SR, Fischer M, Gloeckner C, Hubauer U, Baessler A, et al. Association of the metabolic syndrome with early coronary disease in families with frequent myocardial infarction. Am J Cardiol 2006;97:964-967.
77. Nigam A, Bourassa MG, Fortier A, Guertin MC, Tardif JC. The metabolic syndrome and its components and the long-term risk of death in patients with coronary heart disease. Am Heart J 2006;151:514-521.
78. Wallenfeldt K, Hulthe J, Fagerberg B. The metabolic syndrome in middle-aged men according to different definitions and related changes in carotid artery intima-media thickness (IMT) during 3 years of follow-up. J Intern Med 2005;258:28-37.
79. Dekker JM, Girman C, Rhodes T, Nijpels G, Stehouwer CD, Bouter LM, et al. Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study. Circulation 2005;112:666-673.
80. Saely CH, Koch L, Schmid F, Marte T, Aczel S, Langer P, et al. Adult Treatment Panel III 2001 but not International Diabetes Federation 2005 criteria of the metabolic syndrome predict clinical cardiovascular events in subjects who underwent coronary angiography. Diabetes Care 2006;29:901-907.
81. Sone H, Tanaka S, Ishibashi S, Yamasaki Y, Oikawa S, Ito H, et al. The new worldwide definition of metabolic syndrome is not a better diagnostic predictor of cardiovascular disease in Japanese diabetic patients than the existing definitions: Additional analysis from the Japan Diabetes Complications Study. Diabetes Care 2006;29:145-147.
82. Skilton MR, Moulin P, Serusclat A, Nony P, Bonnet F. A comparison of the NCEP-ATPIII, IDF and AHA/NHLBI metabolic syndrome definitions with relation to early carotid atherosclerosis in subjects with hypercholesterolemia or at risk of CVD: Evidence for sex-specific differences. Atherosclerosis 2006 (in press).
83. Lawlor DA, Smith GD, Ebrahim S. Does the new International Diabetes Federation definition of the metabolic syndrome predict CHD any more strongly than older definitions? Findings from the British Women's Heart and Health Study. Diabetologia 2006;49:41-48.
84. Wannamethee SG, Shaper AG, Lennon L, Morris RW. Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus. Arch Intern Med 2005; 165:2644-2650.
85. Najarian RM, Sullivan LM, Kannel WB, Wilson PW, D'Agostino RB, Wolf PA. Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke: The Framingham Offspring Study. Arch Intern Med 2006;166:106-111.
86. Kurl S, Laukkanen JA, Niskanen L, Laaksonen D, Sivenius J, Nyyssonen K, et al. Metabolic syndrome and the risk of stroke in middle-aged men. Stroke 2006;37:806-811.
87. Milionis HJ, Rizos E, Goudevenos J, Seferiadis K, Mikhailidis DP, Elisaf MS. Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects. Stroke 2005; 36:1372-1376.
88. Koren-Morag N, Goldbourt U, Tanne D. Relation between the metabolic syndrome and ischernic stroke or transient ischemic attack: A prospective cohort study in patients with atherosclerotic cardiovascular disease. Stroke 2005;36:1366-1371.
89. Kwon HM, Kim BJ, Lee SH, Choi SH, Oh BH, Yoon BW. Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people. Stroke 2006;37:466-470.
90. Hanley AJ, Karter AJ, Williams K, Festa A, D'Agostino RB Jr, Wagenknecht LE, et al. Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: The Insulin Resistance Atherosclerosis Study. Circulation 2005;112:3713-3721.
91. Kida Y, Sato T. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2006;144:379-380.
92. Tanaka H, Shiohira Y, Uezu Y, Higa A, Iseki K. Metabolic syndrome and chronic kidney disease in Okinawa, Japan. Kidney Int 2006;69:369-374.
93. Laukkanen JA, Laaksonen DE, Niskanen L, Pukkala E, Hakkarainen A, Salonen JT. Metabolic syndrome and the risk of prostate cancer in Finnish men: A population-based study. Cancer Epidemiol Biomarkers Prev 2004;13:1646-1650.
94. Morita T, Tabata S, Mineshita M, Mizoue T, Moore MA, Kono S. The metabolic syndrome is associated with increased risk of colorectal adenoma development: The Self-Defense Forces Health Study. Asian Pac J Cancer Prev 2005;6:485-489.
95. Pasanisi P, Berrino F, De PM, Venturelli E, Mastroianni A, Panico S. Metabolic syndrome as a prognostic factor for breast cancer recurrences. Int J Cancer 2006;119:236-238.