Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury

Pediatric Critical Care Medicine

Volumn 8, Issue 1, 2007, Pages 1-9

  Natale, JoAnne E ^a,f   Guerguerian, Anne Marie ^c   Joseph, Jill G ^b   McCarter, Robert ^b   Shao, Cheng ^b   Slomine, Beth ^d   Christensen, James ^e   Johnston, Michael V ^d   Shaffner, Donald H ^e  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Children; Hemodynamics; Magnesium sulfate; QT interval; Traumatic brain injury

Indexed keywords

MAGNESIUM SULFATE; PLACEBO;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; ADULT; ARTICLE; BRAIN PERFUSION; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; EMERGENCY HEALTH SERVICE; FEASIBILITY STUDY; FEMALE; GLASGOW COMA SCALE; HEART CONDUCTION; HEART RATE; HEMODYNAMICS; HUMAN; INFANT; INFORMED CONSENT; INJURY; INTRACRANIAL PRESSURE; MAGNESIUM BLOOD LEVEL; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; MULTICENTER STUDY; NEUROPROTECTION; PILOT STUDY; PRIORITY JOURNAL; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCREENING; TRAUMATIC BRAIN INJURY;

ADOLESCENT; BLOOD PRESSURE; BRAIN INJURIES; CEREBROVASCULAR CIRCULATION; CHILD; CHILD, PRESCHOOL; DATA INTERPRETATION, STATISTICAL; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; FEASIBILITY STUDIES; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; INFUSIONS, INTRAVENOUS; INTRACRANIAL PRESSURE; MAGNESIUM SULFATE; MALE; NEUROPROTECTIVE AGENTS; PATIENT SELECTION; PILOT PROJECTS; PLACEBOS; SAFETY; TIME FACTORS;

EID: 33846471042     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pcc.0000256620.55512.5f     Document Type: Article

References (33)

1. Langlois JA, Rutland-Brown W, Thomas KE (Eds): 2004 Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations, and Deaths. Atlanta, GA. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, 2006.
2. Ewing-Cobbs L, Fletcher JM, Levin HS, et al: Longitudinal neuropsychological outcome in infants and preschoolers with traumatic brain injury. J Int Neuropsychol Soc 1997; 3:581-591
3. Thakker JC, Splaingard M, Zhu J, et al: Survival and functional outcome of children requiring endotracheal intubation during therapy for severe traumatic brain injury. Crit Care Med 1997; 25:1396-1401
4. Narayan RK, Michel ME, Ansell B, et al: Clinical trials in head injury. J Neurotrauma 2002; 19:503-557
5. Zhang L, Rzigalinski BA, Ellis EF, et al: Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neurons. Science 1996; 274:1921-1923
6. Boet R, Mee E: Magnesium sulfate in the management of patients with Fisher Grade 3 subarachnoid hemorrhage: A pilot study. Neurosurgery 2000; 47:602-606
7. Wang T, Wang J, Cottrell JE, et al: Small physiologic changes in calcium and magnesium alter excitability and burst firing of CA1 pyramidal cells in rat hippocampal slices. J Neurosurg Anesthesiol 2004; 16:201-209
8. Regan RF, Guo Y: Magnesium deprivation decreases cellular reduced glutathione and causes oxidative neuronal death in murine cortical cultures. Brain Res 2001; 890:177-183
9. Ustun ME, Gurbilek M, Ak A, et al: Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma. Intensive Care Med 2001; 27:264-268
10. Vink R, McIntosh TK, Demediuk P, et al: Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma. J Biol Chem 1988; 263:757-761
11. Fromm L, Heath DL, Vink R, et al: Magnesium attenuates post-traumatic depression/ anxiety following diffuse traumatic brain injury in rats. J Am Coll Nutr 2004; 23: 529S-533S
12. Heath DL, Vink R: Improved motor outcome in response to magnesium therapy received up to 24 hours after traumatic diffuse axonal brain injury in rats. J Neurosurg 1999; 90:504-509
13. Muir JK, Raghupathi R, Emery DL, et al: Postinjury magnesium treatment attenuates traumatic brain injury-induced cortical induction of p53 mRNA in rats. Exp Neurol 1999; 159:584-593
14. Vink R, O'Connor CA, Nimmo AJ, et al: Magnesium attenuates persistent functional deficits following diffuse traumatic brain injury in rats. Neurosci Lett 2003; 336:41-44
15. Muir KW, Lees KR, Ford I, et al: Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): Randomised controlled trial. Lancet 2004; 363:439-445
16. Saver JL, Kidwell C, Eckstein M, et al: Pre-hospital neuroprotective therapy for acute stroke: Results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial. Stroke 2004; 35:e106-e108
17. van den Bergh WM, Algra A, van Kooten F, et al: Magnesium sulfate in aneurysmal subarachnoid hemorrhage: A randomized controlled trial. Stroke 2005; 36:1011-1015
18. Veyna RS, Seyfried D, Burke DG, et al: Magnesium sulfate therapy after aneurysmal subarachnoid hemorrhage. J Neurosurg 2002; 96:510-514
19. Caldwell PH, Butow PN, Craig JC: Parents' attitudes to children's participation in randomized controlled trials. J Pediatr 2003; 142:554-559
20. Heath DL, Vink R: Subdural hematoma following traumatic brain injury causes a secondary decline in brain free magnesium concentration. J Neurotrauma 2001; 18:465-469
21. Altura BT, Shirey TL, Young CC, et al: Characterization of a new ion selective electrode for ionized magnesium in whole blood, plasma, serum, and aqueous samples. Scand J Clin Lab Invest Suppl 1994; 217:21-36
22. Sorteberg W, Lindegaard KF, Rootwelt K, et al: Blood velocity and regional blood flow in defined cerebral artery systems. Acta Neurochir (Wien) 1989; 97:47-52
23. Muizelaar JP, Ward JD, Marmarou A, et al: Cerebral blood flow and metabolism in severely head-injured children. Part 2: Autoregulation. J Neurosurg 1989; 71:72-76
24. Mendez DR, Corbett R, Macias C, et al: Total and ionized plasma magnesium concentrations in children after traumatic brain injury. Pediatr Res 2005; 57:347-352
25. Heinen M, Hall MJ, Boudreault MA, et al: National trends in injury hospitalizations, 1979-2001. Hyattsville, MD, National Center for Health Statistics, 2005, pp 53-54
26. Sankar P: Communication and miscommunication in informed consent to research. Med Anthropol Q 2004; 18:429-446
27. Natale JE, Joseph JG, Pretzlaff R, et al: Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses. Developmental Neuroscience 2006; 28:276-290
28. Zeger SL, Liang KY: Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986; 42:121-130
29. Fukui S, Katoh H, Tsuzuki N, et al: Multivariate analysis of risk factors for QT prolongation following subarachnoid hemorrhage. Crit Care 2003; 7:R7-R12
30. van den Bergh WM, Algra A, Rinkel GJ: Electrocardiographic abnormalities and serum magnesium in patients with subarachnoid hemorrhage. Stroke 2004; 35:644-648
31. Cheung RT, Hachinski V: The insula and cerebrogenic sudden death. Arch Neurol 2000; 57:1685-1688
32. Oppenheimer SM, Cechetto DF, Hachinski VC: Cerebrogenic cardiac arrhythmias. Cerebral electrocardiographic influences and their role in sudden death. Arch Neurol 1990; 47:513-519
33. Ozdemir D, Ozdemir N, Unal N, et al: QTc dispersion in children with severe head trauma. Pediatr Emerg Care 2005; 21: 658-661