F-18 labelled N,N-bis-haloethylamino-phenylsulfoxides - A new class of compounds for the imaging of hypoxic tissue

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 49, Issue 12, 2006, Pages 1089-1103

  Falzon, Cheryl L ^a,b,c   Ackermann, Uwe ^b,c   Spratt, Neil ^c,d   Tochon Danguy, Henri J ^b,c   White, Jonathon ^a   Howells, David ^c,d   Scott, Andrew M ^b,c,e  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTIN HEALTH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^e LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

Hypoxia; PET; Radiolabelling; Stroke

Indexed keywords

HALOGEN EXCHANGE; HYPOXIA; HYPOXIC TISSUES; IN-VIVO; PHENYLSULFOXIDE; RADIOCHEMICAL YIELD; RADIOLABELLING; SPECIFIC ACTIVITY; STROKE; SYNTHESISED;

TISSUE;

ANILINE DERIVATIVE; DIMETHYL SULFOXIDE; FLUORINE 18; N (2 CHLOROETHYL) N (2 FLUOROETHYL (4 METHYLSULFINYL ANILINE; N (2 CHLOROETHYL) N (2 FLUOROETHYL [4 (4 NITROPHENYLSULFINYL)] ANILINE; N,N BIS CHLOROETHYLAMINO PHENYLSULFOXIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; STROKE;

EID: 33846444767     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1129     Document Type: Article

References (20)

1. Brizel DM, Dodge RK, Clough RW, Dewhirst MW. Radiother Oncol 1999; 53: 113-117.
2. Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Harts WH, Broder GJ. Int J Radiat Oncol Biol Phys 1988; 14: 831-838.
3. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Nature 1996; 379: 88-91.
4. Lawrentschuk N, Poon AMT, Foo SS, Putra LGJ, Murone C, Davis ID, Bolton DM, Scott AM. BJU Int 2005; 96(4): 540-546.
5. Foo SS, Abbott DF, Lawrentschuk N, Scott AM. Mol Imaging Biol 2004; 6(5): 291-305.
6. Hossman KA. Ann Neurol 1994; 36: 557-565.
7. Lewis JS, Welch MJ. Q J Nucl Med 2001; 45: 138-188.
8. Markus R, Donnan GA, Kazui S, Read S, Hirano T, Scott AM, O'Keefe GJ, Tochon-Danguy HJ, Sachinidis JI, Reutens DC. Neuroimage 2002; 16: 425-433.
9. Brady F, Luthra KS, Brown GD, Osman S, Aboagye E, Saleem A, Price PM. Curr Pharm Des 2001; 7(18): 1863-1892.
10. Nunn A, Lindner K, Strauss HW. Eur J Nucl Med 1995; 22: 265-280.
11. Franko AJ. Int J Radiat Oncol Biol Phys 1986; 12: 1195-1202.
12. Read SJ, Hirano T, Abbott DF, Markus R, Sachinidis JI, Tochon-Danguy HJ, Chan JG, Egan GF, Scott AM, Bladin CF, McKay WJ, Donnan GA. Ann Neurol 2000; 48: 228-235.
13. Kwon CH, Blanco DR, Baturay N. J Med Chem 1992; 35: 2137-2139.
14. Sun ZY, Botros E, Su AD, Kim Y, Wang E, Baturay NZ, Kwon CH. J Med Chem 2000; 43: 4160-4168.
15. Davis PJ, Guenthner LE. Xenobiotica 1985; 15: 845-847.
16. Duggan DE, Hooke KF, Noll RM, Hucker HB, Van Arman CC. Biochem Pharmacol 1978; 27: 2311-2320.
17. Lemaire C, Plenevaux A, Del Fiore G, Aerts J, Luxen A. J Label Compd Radiopharm 1995; 37: 723.
18. Saita K, Chen M, Spratt NJ, Porritt MJ, Libratore GT, Read SJ, Levi CR, Donnan GA, Ackermann U, Tochon-Danguy HJ, Sachinidis JI, Howells DW. Stroke 2004; 35: 975-980.
19. Tochon-Danguy HJ, Sachinidis JI, Chan F, Chan JG, Hall C, Cher L, Stylli S, Hill J, Kaye A, Scott AM. Nucl Med Biol 2000; 29: 191-197.
20. Schmid-Elsaesser R, Zausinger S, Hungerhuber E, Baethmann A, Reulen HJ, Garcia JH. Stroke 1998; 29(10): 2162-2170.