A high throughput screening approach to identify Isocitrate lyase inhibitors from traditional Chinese medicine sources

Drug Development Research

Volumn 67, Issue 10, 2006, Pages 818-823

  Bai, Bing ^a   Xie, Jian Ping ^a,c   Yan, Ju Fang ^b   Wang, Hong Hai ^c   Hu, Chang A ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b Sichuan Institute of Chinese Materia Medica   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

High throughput screen; Inhibitors; Isocitrate lyase; Mycobacterium tuberculosis; Traditional Chinese medicines

Indexed keywords

ENZYME INHIBITOR; GLYOXYLIC ACID; ISOCITRATE LYASE; PHENYLHYDRAZONE DERIVATIVE;

ARTICLE; CHINESE MEDICINE; COLORIMETRY; DOSE RESPONSE; DRUG DETERMINATION; ENZYME ASSAY; ENZYME MECHANISM; ENZYME PURIFICATION; HIGH THROUGHPUT SCREENING; IC 50; ILLICIUM VERUM; MYCOBACTERIUM TUBERCULOSIS; PROTEIN EXPRESSION; SIGNAL NOISE RATIO; TUBERCULOSIS;

EID: 33846440518     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20152     Document Type: Article

References (23)

1. Bentrup KHZ, Miczak A, Swenson DL, Russell DG. 1999. Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis. J Bacteriol 181:7161-7167.
2. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE III, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
3. Dixon GH, Kornberg HL. 1959 Assay methods for key enzymes of the glyoxylate cycle. Proc Biochem Soc 72:3.
4. Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidaman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs WRJR, Venter JC, Fraser CM. 2002. Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol 184:5479-5490.
5. Gong X, Sucher NJ. 2002. Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development. Phytomedicine 9:478-484.
6. Hatfull GF, Jacobs WRJR. 2002. Molecular genetics of mycobacteria. Washington, DC: ASM Press. p 316.
7. Kelly BG, Wall DM, Boland CA, Meijer WG. 2002. Isocitrate lyase of the facultative intracellular pathogen Rhodococcus equi. Microbiology 148:793-798.
8. Lin XT. 2001. The choiceness of proved recipe for tuberculosis. Guang Zhou: Guangdong Science and Technology Press, p 106-200.
9. Liu YH, Sun YL. 2004. China traditional Chinese Medicine (TCM) Patent Database. World Patent Information 26:91-96.
10. Lorenz MC, Fink GR. 2001. The glyoxylate cycle is required for fungal virulence. Nature 412:83-86.
11. Lorenz MC, Fink GR. 2002. Life and death in a macrophage: role of the glyoxylate cycle in virulence. Eukaryot Cell 1:657-662.
12. Matsuoka M, Ueda Y, Aiba S. 1980. Role and control of isocitrate lyase in Candida lipolytica. J Bacteriol 144:692-697.
13. McKinney JD, Bentrup KHZ, Munoz-Elias EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR, Russell DG. 2000. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 406:735-738.
14. Patwardhan B, Warudel D, Pushpangadan P, Bhatt N. 2005. Ayurveda and traditional Chinese medicine: a comparative overview. eCAM 2:465-473.
15. Smith I. 2003. Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev 16:463-496.
16. State Chinese Medicine Administration Bureau. 1999. Chinese Ben Cao. Shanghai: Shanghai Science and Technology Press, p 925-928.
17. Tripathi RP, Tewari N, Dwivedi N, Tiwari VK. 2005. Fighting tuberculosis: an old disease with new challenges. Med Res Rev 25:93-131.
18. Wang M, Qian HM, Su JD. 2003. Antipyretic and analgesic effects of Rhizoma Zingiberis alcoholic extract and its in-vitro antibacterial actions. Trad Chin Drug Res Clin Pharmacol 5: 299-301.
19. Wang Q, Jiang L, Wen QB. 2005. Advances in studies on Illicium verum. China Condiment 5:18-22.
20. Wang ZX, Brämer CO, Steinbüchel A. 2003. The glyoxylate bypass of Ralstonia eutropha FEMS. Microbiol Lett 228:63-71.
21. Watanabe S, Yamaoka N, Takada Y, Fukunaga N. 2002. The cold-inducible icl gene encoding thermolabile isocitrate lyase of a psychrophilic bacterium, Colwellia maris. Microbiology 148: 2579-2589.
22. WHO. 2005. Global tuberculosis control: surveillance, planning, financing. Geneva: World Health Organization.
23. Zhang JH, Cheung TD, Oldenburg KR. 1999. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 4:67-73.