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Volumn 46, Issue 3, 2007, Pages 400-404

Substrate modulation of the activity of an artificial nanoesterase made of peptide-functionalized gold nanoparticles

Author keywords

Artificial proteins; Gold; Hydrolysis; Nanoparticles; Peptides

Indexed keywords

AMINO ACIDS; CATALYSTS; ESTERS; GOLD; HYDROLYSIS; NANOSTRUCTURED MATERIALS; SUBSTRATES;

EID: 33846431991     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200602581     Document Type: Article
Times cited : (104)

References (32)
  • 4
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    • Angew. Chem. Int. Ed. 2004, 43, 6165-6169.
    • (2004) Chem. Int. Ed , vol.43 , pp. 6165-6169
    • Angew1
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    • Angew. Chem. Int. Ed. 1998, 37, 2755-2794.
    • (1998) Chem. Int. Ed , vol.37 , pp. 2755-2794
    • Angew1
  • 19
    • 33846422196 scopus 로고    scopus 로고
    • The sequences of the four peptides not discussed in the text were as follows: Leu-Gly-Tyr-Ala-Ala-Lys-Phe-Arg-Gly-His-Gly-Arg-OH, Ala-Gly-Ala-Gly-Gly-Lys-Phe-His-Ala-Arg-Ala-Arg-OH, Leu-Gly-Tyr-His-Ala-Lys-Phe- Arg-Ala-Gly-Gly-Arg-OH, and Leu-His-Tyr-Lys-Ala-Arg-Phe-Arg-Ala-Gly-Gly-Gly-OH
    • The sequences of the four peptides not discussed in the text were as follows: Leu-Gly-Tyr-Ala-Ala-Lys-Phe-Arg-Gly-His-Gly-Arg-OH, Ala-Gly-Ala-Gly-Gly-Lys-Phe-His-Ala-Arg-Ala-Arg-OH, Leu-Gly-Tyr-His-Ala-Lys-Phe- Arg-Ala-Gly-Gly-Arg-OH, and Leu-His-Tyr-Lys-Ala-Arg-Phe-Arg-Ala-Gly-Gly-Gly-OH.
  • 25
    • 33846449710 scopus 로고    scopus 로고
    • 0 is the rate constant for the spontaneous hydrolysis of the substrate, and [catalyst] is the nominal concentration of peptide 1 on the monolayer. Since we are far from full binding of the substrate to the monolayer, we may consider the catalytic process like a bimolecular one.
    • 0 is the rate constant for the spontaneous hydrolysis of the substrate, and [catalyst] is the nominal concentration of peptide 1 on the monolayer. Since we are far from full binding of the substrate to the monolayer, we may consider the catalytic process like a bimolecular one.
  • 26
    • 33846446267 scopus 로고    scopus 로고
    • Under these experimental conditions, there is no evidence of deacylation of Tyr, either for the nanoparticle or the peptide
    • Under these experimental conditions, there is no evidence of deacylation of Tyr, either for the nanoparticle or the peptide.
  • 27
    • 33846426670 scopus 로고    scopus 로고
    • The ΔA value (and hence the p-nitrophenolate released) during the burst increases along with the substrate concentration, but it is less than the catalyst concentration because full saturation of the catalyst was not obtained, even at the highest substrate concentration used.
    • The ΔA value (and hence the p-nitrophenolate released) during the burst increases along with the substrate concentration, but it is less than the catalyst concentration because full saturation of the catalyst was not obtained, even at the highest substrate concentration used.
  • 29
    • 28444450129 scopus 로고    scopus 로고
    • Recent data from our laboratory indicate that not only the substrate but also the size of the nanoparticles may alter the hydrophobicity of the monolayer covering a gold nanoparticle; see: V. Lucarini, P. Franchi, G. F. Pedulli, C. Gentilini, S. Polizzi, P. Pengo, P. Scrimin, L. Pasquato, J. Am. Chem. Soc. 2005, 127, 16 384-16 385
    • Recent data from our laboratory indicate that not only the substrate but also the size of the nanoparticles may alter the hydrophobicity of the monolayer covering a gold nanoparticle; see: V. Lucarini, P. Franchi, G. F. Pedulli, C. Gentilini, S. Polizzi, P. Pengo, P. Scrimin, L. Pasquato, J. Am. Chem. Soc. 2005, 127, 16 384-16 385.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.