The 5-hydroxytryptamine1A receptor agonist, (+)-8-hydroxy-2-(di- n-propylamino)-tetralin, increases cardiac output and renal perfusion in rats subjected to hypovolemic shock

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 2, 2007, Pages 811-818

  Tiniakov, Ruslan ^a   Osei Owusu, Patrick ^b   Scrogin, Karie E ^a,c  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Pharmacology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ADRENALIN; SEROTONIN 1A AGONIST; SODIUM CHLORIDE; CARBON DIOXIDE; NORADRENALIN; SEROTONIN 1A RECEPTOR; SEROTONIN AGONIST;

ACID BASE BALANCE; ACIDOSIS; ANIMAL EXPERIMENT; ARTICLE; ASCENDING AORTA; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; HEART HEMODYNAMICS; HEART OUTPUT; HEMORRHAGIC HYPOTENSION; HEMORRHAGIC SHOCK; HYPOVOLEMIC SHOCK; KIDNEY BLOOD FLOW; KIDNEY PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR RESISTANCE; VASOCONSTRICTION; ANIMAL; BLOOD; DRUG POTENTIATION; HEART RATE; ILIAC BONE; KIDNEY CIRCULATION; PATHOPHYSIOLOGY; SHOCK; SPRAGUE DAWLEY RAT; VASCULARIZATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BLOOD PRESSURE; CARBON DIOXIDE; CARDIAC OUTPUT; EPINEPHRINE; HEART RATE; ILIUM; MALE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RENAL CIRCULATION; SEROTONIN AGONISTS; SHOCK;

EID: 33846428061     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.114355     Document Type: Article

References (44)

1. Al-Omar Azzawi S and Shirley DG (1984) Renal blood flow and its distribution following haemorrhage in the rat: the role of vasopressin. J Physiol (Lond) 346:171-179.
2. Albanese J, Leone M, Garnier F, Bourgoin A, Antonini F, and Martin C (2004) Renal effects of norepinephrine in septic and nonseptic patients. Chest 126:534-539.
3. Bagdy G, Calogero AE, Murphy DL, and Szemeredi K (1989a) Serotonin agonists cause parallel activation of the sympathoadrenomedullary system and the hypothalamo-pituitary-adrenocortical axis in conscious rats. Endocrinology 125:2664-2669.
4. Bagdy G, Szemeredi K, and Murphy DL (1989b) Marked increases in plasma catecholamine concentrations precede hypotension and bradycardia caused by 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in conscious rats. J Pharm Pharmacol 41:270-272.
5. Blaisdell FW (1989) The reperfusion syndrome. Microcirc Endothelium Lymphatics 5:127-141.
6. 7 receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha2 adrenergic receptors. Neuroscience 124:901-911.
7. Cronin RE, Erickson AM, de Torrente A, McDonald KM, and Schrier RW (1978) Norepinephrine-induced acute renal failure: a reversible ischemic model of acute renal failure. Kidney Int 14:187-190.
8. Curtis MB, Bednarski RM, and Majors L (1989) Cardiovascular effects of vasopressors in halothane-anesthetized dogs before and after hemorrhage. Am J Vet Res 50:1859-1865.
9. Duanmu Z, Scislo T, and Dunbar JC (1999) Glycemic modulation of insulin/IGF-1 mediated skeletal muscle blood flow following sympathetic denervation in normal rats. Clin Exp Hypertens 21:1239-1255.
10. Duncker DJ, Haitsma DB, Van der Geest IE, Stubenitsky R, Van Meegen, Man in't V, and Verdouw PD (1997) Systemic, pulmonary and coronary haemodynamic actions of the novel dopamine receptor agonist in awake pigs at rest and during treadmill exercise Z1046. Br J Pharmacol 120:1101-1113.
11. 1A-adrenoceptors. Eur J Pharmacol 202:33-44.
12. Gupta RK, Babbar R, and Fahim M (2005) Effect of ionophore monensin on anaesthetized dogs in hemorrhagic hypotension. Vascul Pharmacol 42:69-75.
13. Hamed AT, Ginos JZ, Ekas RD Jr, Jandhyala BS, and Lokhandwala MF (1983) Renal hemodynamics in hemorrhagic hypotension: studies on the effects of preand postjunctional dopamine receptor agonists. J Cardiovasc Pharmacol 5:207-212.
14. Hayes MA, Yau EH, Hinds CJ, and Watson JD (1992) Symmetrical peripheral gangrene: association with noradrenaline administration. Intensive Care Med 18:433-436.
15. 7 receptors to induce hypothermia in rodents. Eur J Pharmacol 487:125-132.
16. Koyama S, Fujita T, Shibamoto T, Matsuda Y, Hayashi T Jr, Saeki Y, Kawamoto M, and Yamaguchi Y (1993) Relative contribution of renal nerve and adrenal gland to renal vascular tone during prolonged canine hemorrhagic hypotension. Circ Shock 39:269-274.
17. Kreis DJ and Baue AE (1984a) Shock: an overview, in Clinical Management of Shock (Kreis DJ and Baue AE eds) pp 38-107, University Park Press, Baltimore.
18. Kreis DJ and Baue AE (1984b) Hemorrhagic shock and trauma, in Clinical Management of Shock (Kreis DJ and Baue AE eds) pp 109-132, University Park Press, Baltimore.
19. Levy ML, Rabb CH, Zelman V, and Giannotta SL (1993) Cardiac performance enhancement from dobutamine in patients refractory to hypervolemic therapy for cerebral vasospasm. J Neurosurg 79:494-499.
20. Meier-Hellmann A, Reinhart K, Bredle DL, Specht M, Spies CD, and Hannemann L (1997) Epinephrine impairs splanchnic perfusion in septic shock. Crit Care Med 25:399-404.
21. Mills LC and Moyer JH (1960) The effects of various catecholamines on specific vascular hemodynamics in hypotensive and normotensive subjects. Am J Cardiol 5:652-659.
22. Mills LC, Moyer JH, and Handley CA (1960) Effects of various sympathicomimetic drugs on renal hemodynamics in normotensive and hypotensive dogs. Am J Physiol 198:1279-1283.
23. 1-adrenergic receptors after severe hemorrhage. J Pharmacol Exp Ther 309:1132-1140.
24. 1A receptor agonist-mediated sympathoexcitation following hypotensive hemorrhage. Am J Physiol 290:R1337-R1344.
25. Ramage AG (2001) Central cardiovascular regulation and 5-hydroxytryptamine receptors. Brain Res Bull 56:425-439.
26. Ramage AG, Clement ME, and McCall RB (1992) 8-OH-DPAT-induced inhibition of renal sympathetic nerve activity and serotonin neuronal firing. Eur J Pharmacol 219:165-167.
27. 2-adrenoceptor agonists in anaesthetized cats. Br J Pharmacol 98:1157-1164.
28. Ramage AG, Wouters W, and Bevan P (1988) Evidence that the novel antihypertensive agent, flesinoxan, causes differential sympathoinhibition and also increases vagal tone by a central action. Eur J Pharmacol 151:373-379.
29. Rump LC, Schwertfeger E, Schaible U, Schuster MJ, Frankenschmidt A, and Schollmeyer P (1993a) Dopamine receptor modulation of noradrenaline release by carmoxirole in human cortical kidney slices. Eur J Clin Pharmacol 44 (Suppl 1):S47-S49.
30. Rump LC, Schwertfeger E, Schuster MJ, Schaible U, Frankenschmidt A, and Schollmeyer PJ (1993b) Dopamine DA2-receptor activation inhibits noradrenaline release in human kidney slices. Kidney Int 43:197-204.
31. 1A receptor agonist 8-OH-DPAT acts in the hindbrain to reverse the sympatholytic response to severe hemorrhage. Am J Physiol 284:R782-R791.
32. 1A receptors. Am J Physiol 279:R1776-R1786.
33. Scrogin KE and Ruszaj A (2006) 5-HT1A receptor agonist administration differentially affects respiratory and hemodynamic responses to hypotensive hemorrhage. J Neurochem 96 (Suppl 1):PTW05-4.
34. Secher NH, Perko G, Madsen P, and Jonsson F (1994) Treatment of hypovolaemic shock: monitoring central blood volume, in Blood Loss and Shock (Secher NH, Pawelczyk J, and Ludbrook J eds) pp 165-172, Edward Arnold, London.
35. Segal JM, Phang PT, and Walley KR (1992) Low-dose dopamine hastens onset of gut ischemia in a porcine model of hemorrhagic shock. J Appl Physiol 73:1159-1164.
36. 3H-DPAT binding. Life Sci 42:1045-1048.
37. Simchon S, Fan FC, Chen RY, Kim S, and Chien S (1985) Effects of experimental hypotension on hemodynamics and renin secretion rate. Circ Shock 15:27-36.
38. Szabo B, Crass D, and Starke K (1992) Effect of the dopamine D2 receptor agonist quinpirole on renal sympathetic nerve activity and renal norepinephrine spillover in anesthetized rabbits. J Pharmacol Exp Ther 263:806-815.
39. Tabrizchi R (1998) Cardiovascular effects of noradrenaline in hypovolemic haemorrhage: role of inducible nitric oxide synthase. Eur J Pharmacol 361:227-234.
40. Teng YD, Bingaman M, Taveira-DaSilva AM, Pace PP, Gillis RA, and Wrathall JR (2003) Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. J Neurosci 23:4182-4189.
41. Tiniakov R and Scrogin KE (2006) The serotonin 5-hydroxytryptaphan1A receptor agonist, (+)8-hydroxy-2-(di-n-propylamino)-tetralin, stimulates sympatheticdependent increases in venous tone during hypovolemic shock. J Pharmacol Exp Ther 319:776-782.
42. Verbeuren TJ (1993) Vasodilator effect of tertatolol in isolated perfused rat kidneys: involvement of endothelial 5-HT1A receptors. Cardiology 83 (Suppl 1):5-9.
43. Verbeuren TJ, Mennecier P, and Laubie M (1991) 5-Hydroxytryptamine- induced vasodilatation in the isolated perfused rat kidney: are endothelial 5-HT1A receptors involved? Eur J Pharmacol 201:17-27.
44. Yu H, Liu Y, Malmberg A, Mohell N, Hacksell U, and Lewander T (1996) Differential serotoninergic and dopaminergic activities of the (R)- and the (S)-enantiomers of 2-(di-n-propylamino)tetralin. Eur J Pharmacol 303:151-162.