Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of α1-adrenergic receptors after severe hemorrhage

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 3, 2004, Pages 1132-1140

  Osei Owusu, Patrick ^a   Scrogin, Karie E ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BUSPIRONE; HEXAMETHONIUM CHLORIDE; PRAZOSIN; SEROTONIN 1A AGONIST;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD PRESSURE; BRADYCARDIA; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; GANGLION BLOCK; HEART RATE; HYPOTENSION; HYPOVOLEMIA; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SYMPATHETIC NERVE; TACHYCARDIA; VASOCONSTRICTION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BLOOD PRESSURE; BUSPIRONE; DISEASE MODELS, ANIMAL; HEMORRHAGE; MALE; PRESSORECEPTORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; SEROTONIN AGONISTS; SYMPATHETIC NERVOUS SYSTEM;

EID: 2442659028     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.064626     Document Type: Article

References (39)

1. Albert PR, Lembo P, Storring JM, Charest A, and Saucier C (1996) The 5-HT1A receptor: signaling, desensitization and gene transcription. Neuropsychopharmacology 14:19-25.
2. Andronati S, Sava V, Makan S, and Kolodeev G (1999) Synthesis of 3-aryl-1-[(4-phenyl-1-piperazinyl)butyl]indazole derivatives and their affinity to 5-HT1A serotonin and dopamine D1 receptors. Pharmazie 54:99-101.
3. Bago M, Sprtel BM, and Dean C (1999) Modulation of sympathetic nerve activity by microinjection of the 5-HT1A receptor agonist 8-OH-DPAT into the rostroventrolateral medulla. J Auton Nerv Syst 76:127-134.
4. Barr AJ, Brass LF, and Manning DR (1997) Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor. G protein coupling. J Biol Chem 272:2223-2229.
5. Barr AJ and Manning DR (1997) Agonist-independent activation of Gz by the 5-hydroxytryptamine1A receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists. J Biol Chem 272:32979-32987.
6. Blier P, Seletti B, Gilbert F, Young SN, and Benkelfat C (2002) Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology 27:301-308.
7. Bobker DH and Williams JT (1989) Serotonin agonists inhibit synaptic potentials in the rat locus ceruleus in vitro via 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors. J Pharmacol Exp Ther 250:37-43.
8. Bradley E, Law A, Bell D, and Johnson CD (2003) Effects of varying impulse number on cotransmitter contributions to sympathetic vasoconstriction in rat tail artery. Am J Physiol 284:H2007-H2014.
9. Castillo C, Bobadilla RA, Ibarra M, Castillo EF, and Hong E (1995) A comparative study of the effects of some 5-HT1A receptor agonists on the blood pressure of pithed rats. Arch Med Res 26:251-255.
10. Castillo C, Ibarra M, Marquez JA, Villalobos-Molina R, and Hong E (1993) Pharmacological evidence for interactions between 5-HT1A receptor agonists and subtypes of alpha 1-adrenoceptors on rabbit aorta. Eur J Pharmacol 241:141-148.
11. Davis JO and Freeman RH (1976) Mechanisms regulating renin release. Physiol Rev 56:1-56.
12. Elam R, Bergmann F, and Feuerstein G (1985) The use of antiserotonergic agents for the treatment of acute hemorrhagic shock of cats. Eur J Pharmacol 107:275-278.
13. Evans RG, Hayes IP, and Ludbrook J (1992) Does the haemodynamic response to acute central hypovolaemia depend on the rate of fall of cardiac output? Clin Exp Pharmacol Physiol 19:657-661.
14. Greenway CV and Lawson AE (1966) The effects of adrenaline and noradrenaline on venous return and regional blood flows in the anaesthetized cat with special reference to intestinal blood flow. J Physiol (Lond) 186:579-595.
15. Guarini S, Tagliavini S, Bazzani C, Ferrari W, and Bertolini A (1990) Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective. Crit Care Med 18:862-865.
16. Hasser EM and Schadt JC (1992) Sympathoinhibition and its reversal by naloxone during hemorrhage. Am J Physiol 262:R444-R451.
17. Kellum JA and Pinsky MR (2002) Use of vasopressor agents in critically ill patients. Curr Opin Crit Care 8:236-241.
18. Laubie M, Drouillat M, Dabire H, Cherqui C, and Schmitt H (1989) Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (±)8-OH-DPAT in anaesthetized dogs. Eur J Pharmacol 160:385-394.
19. Martel MJ, MacKinnon KJ, Arsenault MY, Bartellas E, Klein MC, Lane CA, Sprague AE, and Wilson AK (2002) Hemorrhagic shock. J Obstet Gynaecol Can 24:504-520.
20. Mazzoni MC, Borgstrom P, Arfors KE, and Intaglietta M (1988) Dynamic fluid redistribution in hyperosmotic resuscitation of hypovolemic hemorrhage. Am J Physiol 255:H629-H637.
21. McCall RB, Romero AG, Bienkowski MJ, Harris DW, McGuire JC, Piercey MF, Shuck ME, Smith MW, Svensson KA, and Schreur PJ (1994) Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J Pharmacol Exp Ther 271:875-883.
22. Nilsson H (1985) Adrenergic nervous control of resistance and capacitance vessels. Studies on isolated blood vessels from the rat. Acta Physiol Scand Suppl 541:1-34.
23. Nosjean A and Guyenet PG (1991) Role of ventrolateral medulla in sympatholytic effect of 8-OHDPAT in rats. Am J Physiol 260:R600-R609.
24. Ogawa Y, Takenaka T, Onodera S, Tobise K, Takeda A, Hirayama T, Morita K, and Kikuchi K (1995) Comparison of 5-hydroxytryptamine-induced contraction of rat pulmonary artery to that of aorta in vitro. Jpn Circ J 59:89-97.
25. Pang CC and Tabrizchi R (1986) The effects of noradrenaline, B-HT 920, methoxamine, angiotensin II and vasopressin on mean circulatory filling pressure in conscious rats. Br J Pharmacol 89:389-394.
26. Peroutka SJ (1985) Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors. Biol Psychiatry 20:971-979.
27. Protais P, Lesourd M, and Comoy E (1998) Similar pharmacological properties of 8-OH-DPAT and alnespirone (S 20499) at dopamine receptors: comparison with buspirone. Eur J Pharmacol 352:179-187.
28. Rocha e Silva, Velasco IT, Nogueira da Silva RI, Oliveira MA, Negraes GA, and Oliveira MA (1987) Hyperosmotic sodium salts reverse severe hemorrhagic shock: other solutes do not. Am J Physiol 253:H751-H762.
29. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, and Pons PT (1995) Epidemiology of trauma deaths: a reassessment. J Trauma 38:185-193.
30. Scrogin KE (2003) 5-HT1A receptor agonist 8-OH-DPAT acts in the hindbrain to reverse the sympatholytic response to severe hemorrhage. Am J Physiol 284: R782-R791.
31. Scrogin KE, Johnson AK, and Brooks VL (2000) Methysergide delays the decompensatory responses to severe hemorrhage by activating 5-HT(1A) receptors. Am J Physiol 279:R1776-R1786.
32. Scrogin KE, McKeogh DF, and Brooks VL (2002) Is osmolality a long-term regulator of renal sympathetic nerve activity in conscious water-deprived rats? Am J Physiol 282:R560-R568.
33. Seki K, Aibiki M, and Ogura S (1997) 3.5% hypertonic saline produces sympathetic activation in hemorrhaged rabbits. J Auton Nerv Syst 64:49-56.
34. Sethy VH and Francis JW (1988) Pharmacokinetics of buspirone as determined by ex vivo (3H)-DPAT binding. Life Sci 42:1045-1048.
35. Suzuki S and Hashiba K (1986) The mechanism of the control of renin release by beta-adrenergic receptors. Jpn Heart J 27:871-880.
36. Takasu A, Norio H, Gotoh Y, Sakamoto T, and Okada Y (2003) Effect of induced-hypothermia on short-term survival after volume-controlled hemorrhage in pigs. Resuscitation 56:319-328.
37. Takasu A, Norio H, Sakamoto T, and Okada Y (2002) Mild hypothermia prolongs the survival time during uncontrolled hemorrhagic shock in rats. Resuscitation 54: 303-309.
38. Vicentic A, Li Q, Battaglia G, and Van de Kar LD (1998) WAY-100635 inhibits 8-OH-DPAT-stimulated oxytocin, ACTH and corticosterone, but not prolactin secretion. Eur J Pharmacol 346:261-266.
39. Yocca FD (1990) Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. J Clin Psychopharmacol 10:6S-12S.