Prostaglandin E receptor EP4 antagonist suppresses osteolysis due to bone metastasis of mouse malignant melanoma cells

FEBS Letters

Volumn 581, Issue 3, 2007, Pages 565-571

  Takita, Morichika ^a   Inada, Masaki ^a   Maruyama, Takayuki ^b   Miyaura, Chisato ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Bone metastasis of cancer; Bone resorption; EP4 receptor; Malignant melanoma; Prostaglandin E

Indexed keywords

AE 3 208; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; OSTEOCLAST DIFFERENTIATION FACTOR; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E4 RECEPTOR; PROSTAGLANDIN E4 RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DESTRUCTION; BONE MARROW CELL; BONE METASTASIS; COCULTURE; CONTROLLED STUDY; DRUG EFFICACY; FEMUR; MALE; MELANOMA; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL;

ANIMALS; BONE DENSITY; BONE NEOPLASMS; CELL DIVISION; DINOPROSTONE; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NAPHTHALENES; OSTEOCLASTS; OSTEOLYSIS; PHENYLBUTYRATES; RECEPTORS, PROSTAGLANDIN E;

MUS;

EID: 33846427739     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.01.005     Document Type: Article

References (25)

1. Guise T.A., Yin J.J., Taylor S.D., Kumagai Y., Dallas M., Boyce B.F., Yoneda T., and Mundy G.R. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J. Clin. Invest. 98 (1996) 1544-1549
2. Powell G.J., Southby J., Danks J.A., Stillwell R.G., Hayman J.A., Henderson M.A., Bennett R.C., and Martin T.J. Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res. 51 (1991) 3059-3061
3. Ohshiba T., Miyaura C., Inada M., and Ito A. Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis. Br. J. Cancer 88 (2003) 1318-1326
4. Ushikubi F., Hirata M., and Narumiya S. Molecular biology of prostanoid receptors; an overview. J. Lipid. Med. Cell Signal. 12 (1995) 343-359
5. Coleman R.A., Grix S.P., Head S.A., Louttit J.B., Mallett A., and Sheldrick R.L. A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins 47 (1994) 151-168
6. Sugimoto Y., Namba T., Shigemoto R., Negishi M., Ichikawa A., and Narumiya S. Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. Am. J. Physiol. 266 (1994) F823-F828
7. Suda M., Tanaka K., Natsui K., Usui T., Tanaka I., Fukushima M., Shigeno C., Konishi J., Narumiya S., Ichikawa A., and Nakao N. Prostaglandin E receptor subtypes in mouse osteoblastic cell line. Endocrinology 137 (1996) 1698-1705
8. Suzawa T., Miyaura C., Inada M., Maruyama T., Sugimoto Y., Ushikubi F., Ichikawa A., Narumiya S., and Suda T. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: An analysis using specific agonists for the respective EPs. Endocrinology 141 (2000) 1554-1559
9. Miyaura C., Inada M., Suzawa T., Sugimoto Y., Ushikubi F., Ichikawa A., Narumiya S., and Suda T. Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice. J. Biol. Chem. 275 (2000) 19819-19823
10. {up triangle, open}716knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87 (1996) 803-809
11. {up triangle, open}716 knockout mice. Nat. Med. 7 (2001) 1048-1051
12. Ristimaki A., Sivula A., Lundin J., Lundin M., Salminen T., Haglund C., Joensuu H., and Isola J. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res. 62 (2002) 632-635
13. Elder D.J., and Paraskeva C. COX-2 inhibitors for colorectal cancer. Nat. Med. 4 (1998) 392-393
14. Sales K.J., Katz A.A., Howard B., Soeters R.P., Millar R.P., and Jabbour H.N. Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin E receptors, and angiogenic factors by cyclooxygenase-1. Cancer Res. 62 (2002) 424-432
15. Ma X., Kundu N., Rifat S., Walser T., and Fulton A.M. Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. Cancer Res. 66 (2006) 2923-2927
16. Ono K., Akatsu T., Murakami T., Kitamura R., Yamamoto M., Shinomiya N., Rokutanda M., Sasaki T., Amizuka N., Ozawa H., Nagata N., and Kugai N. Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. J. Bone Miner. Res. 17 (2002) 774-781
17. Kabashima K., Saji T., Murata T., Nagamachi M., Matsuoka T., Segi E., Tsuboi K., Sugimoto Y., Kobayashi T., Miyachi Y., Ichikawa A., and Narumiya S. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J. Clin. Invest. 109 (2002) 883-893
18. Miyaura C., Inada M., Matsumoto C., Ohshiba T., Uozumi N., Shimizu T., and Ito A. An essential role of cytosolic phospholipase A2α in prostaglandin E2-mediated bone resorption associated with inflammation. J. Exp. Med. 197 (2003) 1303-1310
19. Miyaura C., Kusano K., Masuzawa T., Chaki O., Onoe Y., Aoyagi M., Sasaki T., Tamura T., Koishihara Y., Ohsugi Y., and Suda T. Endogenous bone-resorbing factors in estrogen deficiency: cooperative effects of IL-1 and IL-6. J. Bone Miner. Res. 10 (1995) 1365-1373
20. 2 production by osteoblast plays a critical rule in LPS-induced bone loss associated with inflammation. J. Immunol. 177 (2006) 1879-1885
21. Xia S., Lu Y., Wang J., He C., Hong S., Serhan C.N., and Kang J.X. Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc. Natl. Acad. Sci. USA 103 (2006) 12499-12504
22. Perez M., Migliaccio S., Taranta A., Festuccia C., Orru L., Brama M., Bologna M., Faraggiana T., Baron R., and Teti A. Melanoma cells stimulate osteoclastogenesis, c-Src expression and osteoblast cytokines. Eur. J. Cancer 37 (2001) 629-640
23. Ohshiba T., Miyaura C., and Ito A. Role of prostaglandin E produced by osteoblasts in osteolysis due to bone metastasis. Biochem. Biophys. Res. Commun. 300 (2003) 957-964
24. Gupta S., Adhami V.M., Subbarayan M., MacLennan G.T., Lewin J.S., Hafeli U.O., Fu P., and Mukhtar H. Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 64 (2004) 3334-3343
25. Amano H., Hayashi I., Endo H., Kitasato H., Yamashina S., Maruyama T., Kobayashi M., Satoh K., Narita M., Sugimoto Y., Murata T., Yoshimura H., Narumiya S., and Majima M. Host prostaglandin E2-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J. Exp. Med. 197 (2003) 221-232