Mechanism by which hyperglycemia plays a role in the setting of acute cardiovascular illness

Reviews in Cardiovascular Medicine

Volumn 7, Issue SUPPL. 2, 2006, Pages

  Zarich, Stuart W ^a,b  

^a BRIDGEPORT HOSPITAL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute coronary syndromes; Diabetes mellitus; Hyperglycemia

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; GLUCOSE PLUS INSULIN PLUS POTASSIUM; INSULIN; PLACEBO; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONTINUOUS INFUSION; CORONARY ARTERY; DIABETES MELLITUS; DRUG DOSE COMPARISON; DRUG MEGADOSE; ENDOTHELIUM LESION; ENERGY TRANSFER; GLUCOSE OXIDATION; GLYCEMIC CONTROL; GLYCOLYSIS; HEART MUSCLE; HEART MUSCLE METABOLISM; HUMAN; HYPERGLYCEMIA; INFLAMMATION; LOW DRUG DOSE; MORBIDITY; MORTALITY; NONHUMAN; OXIDATIVE STRESS; PERCUTANEOUS CORONARY INTERVENTION; RISK ASSESSMENT; SPRAGUE DAWLEY RAT; ST SEGMENT ELEVATION; THROMBOGENESIS;

ACUTE DISEASE; BLOOD GLUCOSE; CARDIOVASCULAR DISEASES; CLINICAL COMPETENCE; DIABETES MELLITUS; GLUCOSE; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INFLAMMATION MEDIATORS; INFUSIONS, PARENTERAL; INSULIN; OXIDATIVE STRESS; PATIENT SELECTION; POTASSIUM;

EID: 33846408329     PISSN: 15306550     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Stamler J, Vaccaro O, Neaton JD, Wentworth D, for the Multiple Risk Factor Intervention Trial Research Group. Diabetes, other risk factors and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Invention Trial. Diabetes Care. 1993;16:434-444.
2. Mak KH, Moliterno DJ, Gragner CB, et al., for the GUSTO-I Investigators. Influence of diabetes mellitus on clinical outcome in the thrombolytic era of acute myocardial infarction. J Am Coll Cardiol. 1997;30:171-179.
3. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;355:773-778.
4. Cruikshank N. Coronary thrombosis and myocardial infarction, with glycosuria. BMJ. 1931; 1:618-619.
5. Wahab NN, Cowden EA, Pearce NJ, et al. Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era? J Am Coll Cardiol. 2002;40:1748-1754.
6. Malmberg K, Norhammar A, Wedel H, Ryden L. Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the diabetes and insulin-glucose infusion in acute myocardial infarction (DIGAMI) study. Circulation. 1999;99:2626-2632.
7. Cao JJ, Hudson M, Jankowski M, et al. Relation of chronic and acute glycemic control on mortality in acute myocardial infarction with diabetes mellitus. Am J Cardiol. 2005;96:183-186.
8. Stranders I, Diamant M, van Gelder R, et al. Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus. Arch Intern Med. 2004;164:982-988.
9. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449-461.
10. Falciglia M, Alessio D, Freyberg R, et al. Prevalence of hyperglycemia and cardiovascular disease in critically ill patients with diabetes. Diabetes. 2005;54:A255.
11. Garber A, Moghissi E, Bransome E, et al. American College of Endocrinology Consensus Development Conference of Inpatient Diabetes and Metabolic Control. Endo Pract. 2004; 10(suppl 2):4-9.
12. Kosiborod M, Rathore S, Inzucchi S, et al. Admission glucose and mortality in elderly patients hospitalized with acute myocardial infarction: implications for patients with and without recognized diabetes. Circulation. 2005; 111:3078-3086.
13. Malmberg K. Prospective randomized study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ. 1997;34:187-220.
14. Opie L. Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction: relation to myocardial ischemia and infarct size. Am J. Cardiol. 1979;43:801-809.
15. Barzilay JI, Spiekerman CF, Wahl PW, et al. Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men. The Rancho Bernardo Study. Diabetes Care. 1998;21:1236-1239.
16. Norhammar A, Tenerz A, Nilsson G, et al. Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. Lancet. 2002:359:2140-2144.
17. Zeller M, Steg PG, Ravisy J, et al. Prevalence and impact of metabolic syndrome on hospital outcomes in acute myocardial infarction. Arch Intern Med. 2005;165:1192-1198.
18. Young LH, Renfu Y, Russell R, et al. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation. 1997;95:415-422.
19. Russell RR III, Yin R, Caplan MJ, et al. Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo. Circulation. 1998;98:2180-2186.
20. Sodi-Pallares D, Testelli MR, Fishleder BL, et al. Effects of an intravenous infusion of a potassium-insulin-glucose solution on the electrocardiographic signs of myocardial infarction: a preliminary clinical report. Am J Cardiol. 1962:9:166-181.
21. Fath-Ordoubadi F, Beatt KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials. Circulation. 1997;96: 1152-1156.
22. Van den Berghe G, Wouters P, Weekers F. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345:1359-1367.
23. Malmberg K, Ryden L. Results of the DIGAMI 2 study. 40th Annual Meeting of the European Association for the Study of Diabetes. Munich, Germany: September 5-9, 2004.
24. CREATE-ECLA Trial Group Investigators. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction. The CREATE-ECLA Randomized Controlled Trial. JAMA. 2005; 293:437-444.
25. van der Horst IC, Timmer JR, Ottervanger JP, et al. Glucose-insulin-potassium and reperfusion in acute myocardial infarction: rationale and design of the Glucose-Insulin-Potassium Study-2 (GIPS-2). Am Heart J. 2005;149:585-591.
26. Stanley Jr AW, Prather JW. Glucose-insulin-potassium, patient mortality and the acute myocardial infarction: results from a prospective randomised study. Circulation. 1978;57:61.
27. Rogers WJ, Stanley Jr AW, Breinig JB, et al. Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin potassium infusion. Am Heart J. 1976;92:441-454.
28. van der Horst IC, Zijlstra F, van't Hof AW, et al. Glucose-insulin potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: the glucose-insulin-potassium study: a randomized trial. J Am Coll Cardiol. 2003;42:784-791.
29. Diaz R, Paolasso EA, Piegas LS, et al. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiologicos Latinoamerica) collaborative group. Circulation. 1998;98:2227-2234.
30. Malmberg K, Ryden L, Efendic S, et al. Randomized trial of insulin glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol. 1995;26:57-65.
31. Mittra B. Potassium, glucose, and insulin in treatment of myocardial infarction. Lancet. 1965;2:607-609.
32. Pentecost BL, Mayne NM, Lamb P. Controlled trial of intravenous glucose, potassium, and insulin in acute myocardial infarction. Lancet. 1968;1:946-948.
33. Medical Research Council Working Party on the Treatment of Myocardial Infarction. Potassium, glucose, and insulin treatment for acute myocardial infarction. Lancet. 1968;2:1355-1360.
34. Pilcher J, Etishamudin M, Exon P, et al. Potassium, glucose and insulin in myocardial infarction. Lancet. 1967;1:1109.
35. Hjermann I. A controlled study of peroral glucose, insulin and potassium treatment in myocardial infarction. Acta Med Scand. 1971;190: 213-218.
36. Ceremuzynski L, Budaj A, Czepiel A, et al. Low-dose glucoseinsulin-potassium is ineffective in acute myocardial infarction: results of a randomized multicenter Pol-GIK trial. Cardiovasc Drugs Ther. 1999;13:191-200.
37. Srinivasan M, Herrero P, McGill J, et al. The effects of plasma insulin and glucose on myocardial blood flow in patients with type 1 diabetes mellitus. J Am Coll Cardiol. 2005;46:42-48.
38. Scogamiglio R, Negut C, Vigili S, et al. Post-prandial myocardial perfusion in healthy subjects and in type 2 diabetic patients. Circulation. 2005;112:179-184.
39. Wang P, Lloyd S, Chatham J. Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart. Circulation. 2005;111:2006-2072.
40. Yellon DM, Baxter GF. Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distinct dream or near reality? Heart. 2000;83:381-387.
41. Chaudhuri A, Janicke D, Wilson MF, et al. Antiinflammatory and pro-fibrinolytic effect of insulin in acute ST-elevation myocardial infarction. Circulation. 2004;109:849-854.
42. Brownlee M. The pathophysiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54:1615-1625.
43. Rask-Madsen C, Dominguez H, Ihelmann N, et al. Tumor necrosis factor-α inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation. 2003;108:1815-1821.
44. Esposito K, Nappo F, Marfella R et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002;106:2067-2072.
45. Marfella R, Siniscalchi M, Esposito K, et al. Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome. Diabetes Care. 2003;26:3129-3135.
46. Mohanty P, Ghanim H, Hamouda W, et al. Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes. J Clin Endocrinol Metab. 2000;85:2970-2973.
47. Kawano H, Motoyama T, Hirashima O, et al. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol. 1999;34: 146-154.
48. Ceriello A, Taboga C, Tonutti L, et al. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short and long term simvastatin treatment. Circulation. 2002;106:1211-1218.
49. de Jonge R, Serne E, Ijerman R, et al. Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation. 2004;109:2529-2535.
50. Prior J, Quinones M, Hernandez-Pampaloni M, et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation. 2005;111: 2291-2298.
51. Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295:1681-1687.
52. Brownlee M, Hirsch I. Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic complications. JAMA. 2006;295:1707-1708.
53. Timmer J, Ottervanger J, de Boer M, et al. Hyperglycemia is an important predictor of impaired coronary flow before reperfusion therapy in ST segment elevation myocardial infarction. J Am Coll Cardiol. 2005;45:999-1002.
54. Prasad A, Stone GW, Stuckey TD, et al. Impact of diabetes mellitus on myocardial perfusion after primary angioplasty in patients with acute myocardial infarction. J Am Coll Cardiol. 2005; 45:508-514.
55. Iwakura K, Ito H, Ikushima M, et al. Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction. J Am Coll Cardiol. 2003;41:1-7.
56. Carr M. Diabetes mellitus: a hypercoaguable state. J Diabetes Comp. 2001;15:44-54.
57. Yamagishi S, Edelstein D, Du X, Brownlee M. Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction. Diabetes. 2001;50: 1491-1494.
58. Rao A, Chouhan V, Chen X, et al. Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men. Diabetes. 1999;48:1156-1161.
59. Anand S, Yi Q, Gerstein H, et al. Relationship of metabolic syndrome and fibrinolytic function to cardiovascular disease. Circulation. 2003;108: 420-1245.
60. Ishihara M, Inoue I, Kawagoe T, et al. Diabetes mellitus prevents ischemic preconditioning in patients with a first acute anterior wall myocardial infarction. J Am Coll Cardiol. 2001;38:1007-1011.