The effect of an adenosine and lidocaine intravenous infusion on myocardial high-energy phosphates and pH during regional ischemia in the rat model in vivo

Canadian Journal of Physiology and Pharmacology

Volumn 84, Issue 8-9, 2006, Pages 903-912

  Canyon, Sarah J ^a   Dobson, Geoffrey P ^a  

^a JAMES COOK UNIVERSITY   (Australia)

Author keywords

31P NMR; Adenosine; ATP; Heart; Ischemia; Lidocaine; Metabolism; PCr; pH

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; LIDOCAINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DOSE RESPONSE; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART RATE; HEART VENTRICLE FIBRILLATION; HEMODYNAMICS; HIGH ENERGY PHOSPHATE; IN VIVO STUDY; MEAN ARTERIAL PRESSURE; NONHUMAN; OVERALL SURVIVAL; PH MEASUREMENT; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CARDIOTONIC AGENTS; DRUG COMBINATIONS; HEART; HEART VENTRICLES; HYDROGEN-ION CONCENTRATION; INFUSIONS, INTRAVENOUS; LIDOCAINE; MODELS, ANIMAL; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PHOSPHOCREATINE; RATS;

EID: 33846391241     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y06-035     Document Type: Article

References (44)

1. Allen, D.G., Cairns, S.P., Turvey, S.E., and Lee, J.A. 1993. Intracellular calcium and myocardial function during ischemia. Adv. Exp. Med. Biol. 346: 19-29. PMID:8184757.
2. + exchange inhibitors: potential mechanisms of action. Basic Res. Cardiol. 96: 306-311. doi:10.1007/s003950170037. PMID:11518185.
3. Balnave, C.D., and Vaughan-Jones, R.D. 2000. Effect of intracellular pH on spontaneous Ca2+ sparks in rat ventricular myocytes. J. Physiol. 528: 25-37. doi:10.1111/j.1469-7793.2000.00025.x. PMID:11018103.
4. Braunwald, E., and Kloner, R.A. 1982. The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation, 66: 1146-1149. PMID:6754130.
5. Canyon, S.J., and Dobson, G.P. 2004. Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat. Am. J. Physiol. Heart Circ. Physiol. 287: H1286-H1295. doi:10.1152/ajpheart. 00273.2004. PMID:15317678.
6. Canyon, S.J., and Dobson, G.P. 2005. Pretreatment with an Adenosine A1 receptor agonist and lidocaine: a possible alternative to myocardial preconditioning. J. Thorac. Cardiovasc. Surg. 130: 371-377. doi:10.1016/j.jtcvs.2004.12.052. PMID:16077401.
7. Carmeliet, E. 1999. Cardiac ionic channels and acute ischemia: from channels to arrhythmias. Physiol. Rev. 79: 917-1017. PMID:10390520.
8. (2+) concentration and rate adaptation of the cardiac action potential. Cell Calcium, 35: 557-573. doi:10.1016/j.ceca.2004.01.010. PMID:15110146.
9. Cimponeriu, A., Starmer, C.F., and Bezerianos, A. 2001. A theoretical analysis of acute ischemia and infarction using ECG reconstruction on a 2-D model of myocardium. IEEE Trans. Biomed. Eng. 48: 41-54. doi:10.1109/10.900247. PMID:11235590.
10. Dobson, G.P. 2004. Organ arrest, protection and preservation: natural hibernation to cardiac surgery: a review. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 139: 469-485. PMID:15544969.
11. Dobson, G.P., and Jones, M.W. 2004. Adenosine and Lignocaine: a new concept in non-depolarising surgical arrest, protection and preservation. J. Thorac. Cardiovasc. Surg. 127: 794-805. doi:10. 1016/S0022-5223(03)01192- 9. PMID:15001909.
12. Dobson, G.P., Hitchins, S., and Teague, W.E.J. 2002. Thermodynamics of the pyruvate kinase reaction and the reversal of glycolysis in heart and skeletal muscle. J. Biol. Chem. 277: 27176-27182. doi:10.1074/jbc. M111422200. PMID:11986306.
13. Dobson, G.P., Yamamoto, E., and Hochachka, P.W. 1986. Phosphofructokinase control in muscle: nature and reversal of pH-dependent ATP inhibition. Am. J. Physiol. 250: R71-R76. PMID:2934994.
14. Force, T., Kuida, K., Namchuk, M., Parang, K., and Kyriakis, J.M. 2004. Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease. Circulation, 109: 1196-1205. doi:10.1161/01.CIR. 0000118538.21306.A9. PMID:15023894.
15. Fralix, T.A., Murphy, E., London, R.E., and Steenbergen, C. 1993. Protective effects of adenosine in the perfused rat heart: changes in metabolism and intracellular ion homeostasis. Am. J. Physiol. 264: C986-C994. PMID:8476025.
16. Fryer, R.M., Auchampach, J.A., and Gross, G.J. 2002. Therapeutic receptor targets of ischemic preconditioning. Cardiovasc. Res. 55: 520-525. doi:10.1016/S0008-6363(02)00316-4. PMID:12160948.
17. Gettes, L.S. 1986. Effect of ischemia on cardiac electrophysiology. In The heart and the cardiovascular system: scientific foundations. Vol. 2. Edited by H.A. Fozzard, R.B. Jennings, E. Haber, A.M. Katz, and H.E. Morgan. Raven Press, New York, pp. 1317-1341.
18. Graham, R.M., Frazier, D.P., Thompson, J.W., Haliko, S., Li, H., Wasserlauf, B.J., et al. 2004. A unique pathway of cardiac myocyte death caused by hypoxia-acidosis. J. Exp. Biol. 207: 3189-3200. doi:10.1242/jeb.01109. PMID:15299040.
19. Grove, T.H., Ackerman, J.J.H., Radda, G.K., and Bore, P.J. 1980. Analysis of rat heart in vivo by phosphorus nuclear magnetic resonance. Proc. Natl. Acad. Sci. U.S.A. 77: 299-302. doi:10. 1073/pnas.77.1.299. PMID:6928622.
20. Himmelreich, U., and Dobson, G.P. 2000. Detection and quantification of free cytosolic phosphate and other phosphorus compounds in the beating mouse heart in situ. NMR Biomed. 13: 467-473. doi:10.1002/nbm.664. PMID:11252032.
21. 31P NMR quantitation of phosphorus metabolites ion rat heart and skeletal muscle in vivo. Am. J. Physiol. Heart Circ. Physiol. 281: H882-H887. PMID:11454594.
22. Janier, M.F., Vanoverschelde, J.L., and Bergmann, S.R. 1993. Adenosine protects ischemic and reperfused myocardium by receptor-mediated mechanisms. Am. J. Physiol. 264: H163-H170. PMID:8430842.
23. Janse, M.J. 2003. A brief history of sudden cardiac death and its therapy. Pharmacol. Ther. 100: 89-99. doi:10.1016/S0163-7258(03)00104-9. PMID:14550507.
24. Janse, M.J. 2004. Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. Cardiovasc. Res. 61: 208-217. doi:10.1016/j.cardiores.2003.11.018. PMID:14736537.
25. Jeffrey, P.M., Storey, C.J., Nunnally, R.L., and Malloy, C.R. 1989. Efffect of ischemia on NMR detection of phosphorylated metabolites in intact rat heart. Biochemistry, 28: 5323-5326. doi:10. 1021/bi00439a003. PMID:2775710.
26. Jennings, R.B., Reimer, K.A., and Steenbergen, C. 1985. Myocardial ischemia and reperfusion: role of calcium. In Control and manipulation of calcium movement. Edited by J.R. Paratt. Raven Press, New York.
27. Kleiber, A.G., and Oetliker, H. 1991. Cellular aspects of early contractile failure in ischemia. In The heart and the cardiovascular system: scientific foundations. Vol. 2. Edited by H.A. Fozzard, R.B. Jennings, E. Haber, A.M. Katz, and H.E. Morgan. Raven Press, New York. pp. 1975-1996.
28. Lasley, R.D., Zhou, Z., Hegge, J.O., Bunger, R., and Mentzer, R.M., Jr. 1998. Adenosine attenuates in vivo myocardial stunning with minimal effects on cardiac energetics. Basic Res. Cardiol. 93: 303-312. doi:10.1007/ s003950050099. PMID:9782373.
29. Lundmark, J.A., Trueblood, N., Wang, L.F., Ramasamy, R., and Schaefer, S. 1999. Repetitive acidosis protects the ischemic heart: implications for mechanisms in preconditioned hearts. J. Mol. Cell. Cardiol. 31: 907-917. doi:10.1006/jmcc.1998.0931. PMID:10329217.
30. Matsumura, N., Matsumura, H., and Abiko, Y. 1987. Effect of lidocaine on the myocardial acidosis induced by coronary artery occlusion in dogs. J. Pharmacol. Exp. Ther. 242: 1114-1119. PMID:3656111.
31. McCully, J.D., and Levitsky, S. 2003. Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection. Arch. Biochem. Biophys. 420: 237-245. doi:10.1016/j.abb. 2003.06.003. PMID:14654062.
32. Peart, J.N., and Gross, G.J. 2003. Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross talk between receptors. Am. J. Physiol. Heart Circ. Physiol. 285: H81-H89. PMID:12637353.
33. Reimer, K.A., and Jennings, R.B. 1991. Myocardial ischaemia, hypoxia and infarction. In The heart and cardiovascular system. Edited by H.A. Fozzard, R.B. Jennings, E. Haber, A.M. Katz, and H.E. Morgan. Raven Press, New York. pp. 1875-1974.
34. Robergs, R.A., Ghiasvand, F., and Parker, D. 2004. Biochemistry of exercise-induced metabolic acidosis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287: R502-R516. PMID:15308499.
35. Roden, D.M. 1994. Risks and benefits of antiarrhythmic therapy. N. Engl. J. Med. 331:785-791. doi:10.1056/NEJM199409223311207. PMID:8065408.
36. Rooke, G.A., and Feigl, E.O. 1982. Work as a correlate of canine left ventricular oxygen consumption, and the problem of catecholamine oxygen wasting. Circ. Res. 50: 273-286. PMID:6120048.
37. Schaefer, S., Carr, L.J., Prussel, E., and Ramasamy, R. 1995. Effects of glycogen depletion on ischemic injury in isolated rat hearts: insights into preconditioning. Am. J. Physiol. 268: H935-H944. PMID:7900892.
38. Shaw, R.M., and Rudy, Y. 1997. Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc. Res. 35: 256-272. doi:10.1016/S0008- 6363(97)00093-X. PMID:9349389.
39. + during myocardial ischemia: consequences for post-ischemic recovery. J. Mol. Cell. Cardiol. 29: 85-96. doi:10.1006/jmcc.1996.0254. PMID:9040024.
40. Vinten-Johansen, J. 2004. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc. Res. 61: 481-497. doi:10.1016/j.cardiores.2003.10.011. PMID:14962479.
41. Vinten-Johansen, J., Thourani, V.H., Ronson, R.S., Jordan, J.E., Zhao, Z.Q., Nakamura, M., et al. 1999. Broad-spectrum cardioprotection with adenosine. Ann. Thorac. Surg. 68: 1942-1948. doi:10.1016/S0003-4975(99)01018-8. PMID:10585108.
42. Wendland, M.F., Saeed, M., Kondo, C., Derugin, N., and Higgins, C.B. 1993. Effect of lidocaine on acute regional myocardial ischemia and reperfusion in the cat. An in-vivo 31P magnetic-resonance spectroscopy study. Invest. Radiol. 28: 619-628. PMID:8344812.
43. Wernly, J.A. 2004. Ischemia, reperfusion, and the role of surgery in the treatment of cardiogenic shock secondary to acute myocardial infarction: an interpretative review. J. Surg. Res. 117: 6-21. doi:10.1016/j.jss.2003. 12.024. PMID:15013709.
44. Yellon, D.M., and Dana, A. 2000. The preconditioning phenomenon: a tool fo the scientist or clinical reality. Circ. Res. 87: 543-550. PMID:11009558.