Adenosine attenuates in vivo myocardial stunning with minimal effects on cardiac energetics

Basic Research in Cardiology

Volumn 93, Issue 4, 1998, Pages 303-312

  Lasley, R D ^a   Zhou, Z ^b   Hegge, J O ^b   Bunger R ^c   Mentzer Jr , R M ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Adenosine; Myocardial phosphorylation potential; Myocardial stunning; Pig

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE REPERFUSION; HEART VENTRICLE FUNCTION; MALE; NONHUMAN; STUNNED HEART MUSCLE; SWINE;

ADENOSINE; ANIMALS; CARDIOVASCULAR AGENTS; FEMALE; HEART; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIAL STUNNING; MYOCARDIUM; PHOSPHATES; PHOSPHOCREATINE; PHOSPHORYLATION; SWINE;

EID: 0031710669     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950050099     Document Type: Article

References (32)

1. Allard JR, Conhaim RL, Vlahakes GJ, O'Neill MJ, Hoffmann JIE (1981) Rapidfreezing transmural cardiac biopsy drill. Am J Physiol 240: H126-H132
2. Angello DA, Headrick JP, Coddington NM, Berne RM (1991) Adenosine antagonism decreases metabolic but not functional recovery from ischemia. Am J Physiol 260: H193-H200
3. Auchampach JA, Rizvi A, Qiu Y, Tang XL, Maldonado C, Teschner S, Bolli R (1997) Selective activation of A, adenosine receptors with N6-(3-iodobenzyl) adenosine5'-N-methyluronamide protects against myocardial stunning and infarction with hemodynamic changes in conscious rabbits. Circ Res 80: 800-809
4. Bergmeyer HU (1974) Methods of Enzymatic Analysis. New York San Francisco London, Verlag Chemie Weinheim, Academic Press, Inc.
5. Bradamante S, Dejong JW, Piccini F (1993) Intracellular magnesium homeostasis is involved in the functional recovery of preconditioned rat heart. Biochem Biophys Res Comm 196: 872-878
6. Bünger R, Mallat RT, Hartman DA (1989) Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and post-ischemic isolated working heart. Near-complete prevention of reperfusion contractile failure. Eur J Biochem 180: 221-233
7. Bünger R, Mukohara N, Kang YH, Mallet RT (1991) Combined glyceraldehyde-3-phosphate dehydrogenase/phosphoglycerate kinase in catecholamine-stimulated guinea-pig cardiac muscle. Comparison with mass-action ratio of creatine kinase. Eur J Biochem 202: 913-921
8. + handling during low-flow ischemia in perfused guinea pig heart. Drug Dev Res 31: 254 (Abstract)
9. Bünger R, Soboll S (1986) Cytosolic adenylates and adenosine release in perfused working heart. Comparison of whole tissue with cytosolic non-aqueous fractionation analyses. Eur J Biochem 159: 203-13
10. Dornheim TA, Hoffman A, Van Wylen DG, Mentzer RM Jr (1991) Enhanced interstitial fluid adenosine attenuates myocardial stunning. Surgery 110: 136-145
11. Finegan B, Lopaschuk GD, Gandhi M, Clanachan AS (1996) Inhibition of glycolysis and enhanced mechanical function of working rat hearts as a result of adenosine A(1) receptor stimulation during reperfusion following ischaemia. British J Pharmacol 18: 355-363
12. Fiolet JW, Baartscheer A, Schumacher CA, Coronel R, ter Welle HF (1984) The change of the free energy of ATP hydrolysis during global ischemia and anoxia in the rat heart. Its possible role in the regulation of transsarcolemmal sodium and potassium gradients. J Mol Cell Cardiol 16: 1023-1036
13. Fralix TA, Murphy E, London RE, Steenbergen C (1993) Protective effects of adenosine in the perfused rat heart: changes in metabolism and intracellular ion homeostasis. Am J Physiol 264: C986-C994
14. Lasley RD, Konyn PJ, Hegge JO, Mentzer RM Jr (1995) The effects of ischemic and adenosine preconditioning on interstitial fluid adenosine and myocardial infarct size. Am J Physiol 269: H1460-H1466
15. 1 receptor mechanism. Am J Physiol 263: H1460-H1465
16. Lasley RD, Mentzer RM Jr (1993) Adenosine increases lactate release and delays onset of contracture during global low flow ischaemia. Cardiovasc Res 27: 96-101
17. 1 receptor mediated protection of the globally ischemic isolated rat heart. J Mol Cell Cardiol 22: 39-47
18. Mallet RT, Bünger R (1993) Metabolic protection of post-ischemic phosphorylation potential and ventricular performance. Adv Exp Med Biol 346: 233-41
19. Marcovitz PM, Aisen AM, Fencil LE, Swanson SD, Buda AJ (1992) Metabolic effects of adenosine on regional myocardial ischemia by phosphorus 31 nuclear magnetic resonance spectroscopy. Am Heart J 124: 1205-1212
20. Mentzer RM Jr, Bünger R, Lasley RD (1993) Adenosine enhanced preservation of myocardial function and energetics. Possible involvement of the adenosine A1 receptor system. Cardiovasc Res 27: 28-35
21. Miyamae M, Fujiwara H, Kida M, Yokota R, Tanaka M, Katsuragawa M, Hasegawa K, Ohura M, Koga K, Yabuuchi Y (1993) Preconditioning improves energy metabolism during reperfusion but does not attenuate myocardial stunning in porcine hearts. Circulation 88: 223-234
22. Neely JR, Grotyohann LW (1984) Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts. Circ Res 55: 816-24
23. Randhawa MPS Jr, Lasley RD, Mentzer RM Jr (1995) Salutary effects of exogenous adenosine on canine myocardial stunning in vivo. J Thorac Cardiovasc Surg 110: 63-74
24. Schulze K, Bünger R, Schultheiss H-P (1994) Adenosine A1-receptor stimulation does not enhance phosphorylation potential in postischemic guinea pig myocardium. Drug Develop Res 31: 319 (Abstract)
25. Sekili S, Jeroudi MO, Tang XL, Zughaib M, Sun JZ, Bolli R (1995) Effect of adenosine on myocardial ,stunning' in the dog. Circ Res 76: 82-94
26. Sommers KE, Ohkado A, Simplaceanu E, Koretsky AP, Ho C, del Nido PJ (1992) The role of magnesium in postischemic cardiac dysfunction. Surgery 112: 159-165
27. Van Wylen DGL, Willis J, Sodhi J, Weiss RJ, Lasley RD, Mentzer RM (1990) Cardiac microdialysis to estimate interstitial adenosine and coronary blood flow. Am J Physiol 258: H1642-H1649
28. Veech RL, Lawson JW, Cornell NW, Krebs HA (1979) Cytosolic phosphorylation potential. J Biol Chem 254: 6538-6547
29. 1 receptor-mediated cardioprotection in stunned canine myocardium. Circulation 88: 235-44
30. Yokota R, Fujiwara H, Miyamae M, Tanaka M, Yamasaki K, Itoh S, Koga K, Yabuuchi Y, Sasayama S (1995) Transient adenosine infusion before ischemia and reperfusion protects against metabolic damage in pig hearts. Am J Physiol 268: H1149-H1157
31. Zhou Z, Lasley RD, Hegge JO, B̈nger R, Mentzer RM Jr (1995) Myocardial stunning: A therapeutic conundrum. J Thorac Cardiovasc Surg 110: 1391-1401
32. Zughaib ME, Abd-Elfattah AS, Jeroudi MO, Sun JZ, Sekili S, Tang XL, Bolli R (1993) Augmentation of endogenous adenosine attenuates myocardial 'stunning' independently of coronary flow or hemo-dynamic effects. Circulation 88: 2359-2369