Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22

Immunogenetics

Volumn 59, Issue 2, 2007, Pages 99-108

  Kikuchi, Tomoki ^a,c   Naruse, Taeko K ^b   Onizuka, Makoto ^c   Li, Suyun ^c   Kimura, Tetsuaki ^c   Oka, Akira ^c   Morishima, Yasuo ^d   Kulski, Jerzy K ^c,e   Ichimiya, Shingo ^a   Sato, Noriyuki ^a   Inoko, Hidetoshi ^c  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Tokyo Medical and Dental University ^*  (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d AICHI CANCER CENTER HOSPITAL   (Japan)

^e MURDOCH UNIVERSITY   (Australia)

Author keywords

Acute GVHD; Bone marrow transplantation; Chromosome 22; Microsatellite; Non HLA

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; ETOPOSIDE; HLA ANTIGEN; MELPHALAN; METHOTREXATE; PREDNISOLONE; TACROLIMUS;

ACUTE GRAFT REJECTION; ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; BONE MARROW TRANSPLANTATION; CHROMOSOME 22; CHROMOSOME ARM; CHRONIC MYELOID LEUKEMIA; FEMALE; GENE FREQUENCY; GENE LOCATION; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; GENOTYPE; GRAFT RECIPIENT; HLA MATCHING; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; ORGAN DONOR; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCREENING TEST;

ACUTE DISEASE; ADOLESCENT; ADULT; ALLELES; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 22; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY TESTING; HUMANS; INFANT; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; RETROSPECTIVE STUDIES; TISSUE DONORS;

EID: 33846390689     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00251-006-0186-2     Document Type: Article

References (49)

1. Abecasis GR, Noguchi E, Heinzmann A, Traherne JA, Bhattacharyya S, Leaves NI, Anderson GG, Zhang Y, Lench NJ, Carey A, Cardon LR, Moffatt MF, Cookson WO (2001) Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet 68:191-197
2. Assink JJ, de Backer E, ten Brink JB, Kohno T, de Jong PT, Bergen AA, Meire F (2000) Sorsby fundus dystrophy without a mutation in the TIMP-3 gene. Br J Ophthalmol 84:682-686
3. Berkovic SF, Serratosa JM, Phillips HA, Xiong L, Andermann E, Diaz-Otero F, Gomez-Garre P, Martin M, Fernandez-Bullido Y, Andermann F, Lopes-Cendes I, Dubeau F, Desbiens R, Scheffer IE, Wallace RH, Mulley JC, Pandolfo M (2004) Familial partial epilepsy with variable foci: clinical features and linkage to chromosome 22q12. Epilepsia 45:1054-1060
4. Black III JL, Lennon VA (1999) Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications. Mayo Clin Proc 74:357-361
5. Brouard S, Berberat PO, Tobiasch E, Seldon MP, Bach FH, Soares MP (2002) Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis. J Biol Chem 277:17950-17961
6. Chao NJ (2004) Minors come of age: Minor histocompatibility antigens and graft-versus-host disease. Biol Blood Marrow Transplant 10:215-223
7. Charron D (2003) Immunogenomics of hematopoietic stem cell transplantation. Transfus Clin Biol 10:156-158
8. Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA (2000) Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408:936-943
9. Cullup H, Dickinson AM, Cavet J, Jackson GH, Middleton PG (2003) Polymorphisms of interleukin-1 alpha constitute independent risk factors for chronic graft-versus-host disease after allogeneic bone marrow transplantation. Br J Haematol 122:778-787
10. DeLisi LE, Shaw SH, Crow TJ, Shields G, Smith AB, Larach VW, Wellman N, Loftus J, Nanthakumar B, Razi K, Stewart J, Comazzi M, Vita A, Heffner T, Sherrington R (2002) A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder. Am J Psychiatry 159:803-812
11. Dickinson AM, Charron D (2005) Non-HLA immunogenetics in hematopoietic stem cell transplantation. Curr Opin Immunol 17:517-525
12. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S (1999) The DNA sequence of human chromosome 22. Nature 402:489-495
13. Falkenburg JH, van de Corput L, Marijt EW, Willemze R (2003) Minor histocompatibility antigens in human stem cell transplantation. Exp Hematol 31:743-751
14. Gerbitz A, Ewing P, Wilke A, Schubert T, Eissner G, Dietl B, Andreesen R, Cooke KR, Holler E (2004) Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 10:461-472
15. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 18:295-304
16. Gubarev MI, Jenkin JC, Leppert MF, Buchanan GS, Otterud BE, Guilbert DA, Beatty PG (1996) Localization to chromosome 22 of a gene encoding a human minor histocompatibility antigen. J Immunol 157:5448-5454
17. Hartman SE, Bertone P, Nath AK, Royce TE, Gerstein M, Weissman S, Snyder M (2005) Global changes in STAT target selection and transcription regulation upon interferon treatments. Genes Dev 19:2953-2968
18. Jacobelli J, Chmura SA, Buxton DB, Davis MM, Krummel MF (2004) A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol 5:531-538
19. Kallianpur AR (2005) Genomic screening and complications of hematopoietic stem cell transplantation: has the time come? Bone Marrow Transplant 35:1-16
20. Kanari Y, Clerici M, Abe H, Kawabata H, Trabattoni D, Caputo SL, Mazzotta F, Fujisawa H, Niwa A, Ishihara C, Takei YA, Miyazawa M (2005) Genotypes at chromosome 22q12-13 are associated with HIV-1-exposed but uninfected status in Italians. Aids 19:1015-1024
21. Karabon L, Wysoczanska B, Bogunia-Kubik K, Suchnicki K, Lange A (2005) IL-6 and IL-10 promoter gene polymorphisms of patients and donors of allogeneic sibling hematopoietic stem cell transplants associate with the risk of acute graft-versus-host disease. Hum Immunol 66:700-710
22. Keicho N, Ohashi J, Tamiya G, Nakata K, Taguchi Y, Azuma A, Ohishi N, Emi M, Park MH, Inoko H, Tokunaga K, Kudoh S (2000) Fine localization of a major disease-susceptibility locus for diffuse panbronchiolitis. Am J Hum Genet 66:501-507
23. S, Kawata H, Katsuyama Y, Ota M, Morishima Y, Mano S, Kulski JK, Naruse KT, Inoko H (2004) Association of polymorphic MHC microsatellites with GVHD, survival, and leukemia relapse in unrelated hematopoietic stem cell transplant donor/recipient pairs matched at five HLA loci. Tissue Antigens 63:362-368
24. Liguori M, Cittadella R, Manna I, Valentino P, La Russa A, Serra P, Trojano M, Messina D, Ruscica F, Andreoli V, Romeo N, Livrea P, Quattrone A (2004) Association between Synapsin III gene promoter polymorphisms and multiple sclerosis. J Neurol 251:165-170
25. Malmberg KJ, Schaffer M, Ringden O, Remberger M, Ljunggren HG (2005) KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation. Mol Immunol 42:531-534
26. Martone R, Euskirchen G, Bertone P, Hartman S, Royce TE, Luscombe NM, Rinn JL, Nelson FK, Miller P, Gerstein M, Weissman S, Snyder M (2003) Distribution of NF-kappaB-binding sites across human chromosome 22. Proc Natl Acad Sci USA 100:12247-12252
27. McDermid HE, Morrow BE (2002) Genomic disorders on 22q11. Am J Hum Genet 70:1077-1088
28. Mendoza-Londono R, Lammer E, Watson R, Harper J, Hatamochi A, Hatamochi-Hayashi S, Napierala D, Hermanns P, Collins S, Roa BB, Hedge MR, Wakui K, Nguyen D, Stockton DW, Lee B (2005) Characterization of a new syndrome that associates craniosynostosis, delayed fontanel closure, parietal foramina, imperforate anus, and skin eruption: CDAGS. Am J Hum Genet 77:161-168
29. Morishima Y, Sasazuki T, Inoko H, Juji T, Akaza T, Yamamoto K, Ishikawa Y, Kato S, Sao H, Sakamaki H, Kawa K, Hamajima N, Asano S, Kodera Y (2002) The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood 99:4200-4206
30. Mullighan C, Heatley S, Doherty K, Szabo F, Grigg A, Hughes T, Schwarer A, Szer J, Tait B, To B, Bardy P (2004) Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation. Transplantation 77:587-596
31. Nordlander A, Uzunel M, Mattsson J, Remberger M (2002) The TNFd4 allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplantation. Br J Haematol 119:1133-1136
32. Ohashi J, Tokunaga K (2003) Power of genome-wide linkage disequilibrium testing by using microsatellite markers. J Hum Genet 48:487-491
33. Oka A, Tamiya G, Tomizawa M, Ota M, Katsuyama Y, Makino S, Shiina T, Yoshitome M, Iizuka M, Sasao Y, Iwashita K, Kawakubo Y, Sugai J, Ozawa A, Ohkido M, Kimura M, Bahram S, Inoko H (1999) Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. Hum Mol Genet 8:2165-2170
34. Ota M, Mizuki N, Katsuyama Y, Tamiya G, Shiina T, Oka A, Ando H, Kimura M, Goto K, Ohno S, Inoko H (1999) The critical region for Behcet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping. Am J Hum Genet 64:1406-1410
35. Pfitzner E, Kliem S, Baus D, Litterst CM (2004) The role of STATs in inflammation and Inflammatory diseases. Curr Pharm Des 10:2839-2850
36. Rey M, Vicente-Manzanares M, Viedma F, Yanez-Mo M, Urzainqui A, Barreiro O, Vazquez J, Sanchez-Madrid F (2002) Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes. J Immunol 169:5410-5414
37. Routes JM, Ryan S, Morris K, Takaki R, Cerwenka A, Lanier LL (2005) Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection. J Exp Med 202:1477-1482
38. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posat S, Rogaia D, Frassoni F, Aversa F, Martelli MF, Velardi A (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295:2097-2100
39. Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, Inoko H, Yoshida T, Kimura A, Akaza T, Kamikawaji N, Kodera Y, Takaku F (1998) Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N Engl JMed 339:1177-1185
40. Seri M, Cusano R, Gangarossa S, Caridi G, Bordo D, Lo Nigro C, Ghiggeri GM, Ravazzolo R, Savino M, Del Vecchio M, d'Apolito M, Iolascon A, Zelante LL, Savoia A, Balduini CL, Noris P, Magrini U, Belletti S, Heath KE, Babcock M (2000) Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium. Nat Genet 26:103-105
41. Sostak P, Padovan CS, Yousry TA, Ledderose G, Kolb HJ, Straube A (2003) Prospective evaluation of neurological complications after allogeneic bone marrow transplantation. Neurology 60:842-848
42. Stambolian D, Ibay G, Reider L, Dana D, Moy C, Schlifka M, Holmes T, Ciner E, Bailey-Wilson JE (2004) Genomewide linkage scan for myopia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 22q12. Am J Hum Genet 75:448-459
43. Tamiya G, Shinya M, Imanishi T, Ikuta T, Makino S, Okamoto K, Furugaki K, Matsumoto T, Mano S, Ando S, Nozaki Y, Yukawa W, Nakashige R, Yamaguchi D, Ishibashi H, Yonekura M, Nakami Y, Takayama S, Endo T, Saruwatari T (2005) Whole genome association study of rheumatoid arthritis using 27 039 microsatellites. Hum Mol Genet 14:2305-2321
44. Thomas ED, Storb R, Clift RA, Fefer A, Johnson L, Neiman PE, Lerner KG, Glucksberg H, Buckner CD (1975) Bone-marrow transplantation (second of two parts). N Engl J Med 292:895-902
45. Vo N, Goodman RH (2001) CREB-binding protein and p300 in transcriptional regulation. J Biol Chem 276:13505-13508
46. Willis D, Moore AR, Frederick R, Willoughby DA (1996) Heme oxygenase: a novel target for the modulation of the inflammatory response. Nat Med 2:87-90
47. Witt C, Moghaddam PH, van der Meer R, Trimboli F, Ottinger H, Christiansen F, Giphart M (1999) Matching for TNF microsatellites is strongly associated with matching for other non-HLA MHC sequences in unrelated bone marrow donor-recipient pairs. Hum Immunol 60:862-866
48. Yamakami M, Yokosawa H (2004) Tom1 (target of Myb 1) is a novel negative regulator of interleukin-1- and tumor necrosis factor-induced signaling pathways. Biol Pharm Bull 27:564-566
49. Zapata C, Rodriguez S, Visedo G, Sacristan F (2001) Spectrum of nonrandom associations between microsatellite loci on human chromosome 11p15. Genetics 158:1235-1251