Power of genome-wide linkage disequilibrium testing by using microsatellite markers

Journal of Human Genetics

Volumn 48, Issue 9, 2003, Pages 487-491

  Ohashi, Jun ^a,b   Tokunaga, Katsushi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

2 statistic; Case control study; Correction of significance level; Low frequency disease variant; One step stepwise mutation model; Recombination; Single nucleotide polymorphism

Indexed keywords

MICROSATELLITE DNA;

ALLELE; ARTICLE; CALCULATION; CASE CONTROL STUDY; ERROR; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC ANALYSIS; GENETIC MARKER; GENETIC MODEL; GENETIC VARIABILITY; HUMAN; HUMAN GENOME; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; CASE-CONTROL STUDIES; CHROMOSOME MAPPING; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; LINKAGE DISEQUILIBRIUM; MICROSATELLITE REPEATS; MODELS, GENETIC; MODELS, STATISTICAL; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 0142119390     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-003-0058-7     Document Type: Article

References (7)

1. Chapman NH, Wijsman EM (1998) Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility. Am J Hum Genet 63:1872-1885
2. Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES (2001) High-resolution haplotype structure in the human genome. Nat Genet 29: 229-232
3. Farrall M, Weeks DE (1998) Mutational mechanisms for generating microsatellite allele-frequency distributions: an analysis of 4,558 markers. Am J Hum Genet 62:1260-1262
4. Ohashi J, Tokunaga K (2001) Power of genome wide association studies of complex disease genes: statistical limitation of indirect approaches using SNP markers. J Hum Genet 46:478-482
5. Ohashi J, Tokunaga K (2002) The expected power of genome-wide linkage disequilibrium testing using single nucleotide polymorphism markers for detecting a low-frequency disease variant. Ann Hum Genet 66:297-306
6. Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K (2003) CD36 polymorphism is associated with protection from cerebral malaria. Am J Hum Genet 72:364-374
7. Xiong M, Jin L (1999) Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods. Am J Hum Genet 64:629-640