The critical region for Behcet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA- B, by association analysis using refined microsatellite mapping

American Journal of Human Genetics

Volumn 64, Issue 5, 1999, Pages 1406-1410

  Ota, Masao ^a   Mizuki, Nobuhisa ^b,c   Katsuyama, Yoshihiko ^a   Tamiya, Gen ^c   Shiina, Takashi ^c   Oka, Akira ^c   Ando, Hitoshi ^d   Kimura, Minoru ^c   Goto, Kaori ^b,c   Ohno, Shigeaki ^b   Inoko, Hidetoshi ^c  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Japanese Red Cross Society   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B ANTIGEN; MICROSATELLITE DNA; HLA ANTIGEN CLASS 1; MHC CLASS I RELATED CHAIN A; MHC CLASS I-RELATED CHAIN A; TUMOR NECROSIS FACTOR ALPHA;

ALLELE; ARTICLE; BEHCET DISEASE; CENTROMERE; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MARKER GENE; PRIORITY JOURNAL; CHROMOSOME MAP; GENE; GENETICS;

BEHCET SYNDROME; CHROMOSOME MAPPING; GENES, MHC CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MICROSATELLITE REPEATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033237816     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302364     Document Type: Article

References (14)

1. Grimaldi M-C, Clayton J, Pontarotti P, Cambon-Thomsen A, Crouau-Roy B (1996) New highly polymorphic microsatellite marker in linkage disequilibrium with HLA-B. Hum Immunol 51:89-94
2. Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (1996) Cell stress regulated human MHC class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci USA 93:12445-12450
3. Groh V, Steinle A, Bauer S, Spies T (1998) Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279:1737-1740
4. Guo SW, Thompson EA (1992) Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 48:361-372
5. Mizuki N, Ando H, Kimura M, Ohno S, Miyata S, Yamazaki M, Tashiro H, et al (1997b) Nucleotide sequence analysis of the HLA class I region spanning the 237-kb segment around the HLA-B and -C genes. Genomics 42:55-66
6. Mizuki N, Ohno S, Ando H, Kimura M, Ishihara M, Miyata S, Nakamura S, et al (1996) HLA-C genotyping in the patients with Behçet disease. Hum Immunol 50:47-53
7. Mizuki N, Ohno S, Sato T, Ishikawa M, Miyata S, Nakamura S, Naruse T, et al (1995) Microsatellite polymorphism located between the TNF and HLA-B genes in Behçet disease. Hum Immunol 43:129-135
8. Mizuki N, Ota M, Kimura M, Ohno S, Ando H, Katsuyama Y, Yamazaki M, et al (1997a) Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behçet disease. Proc Natl Acad Sci USA 94:1298-1303
9. Ohno S, Ohguchi M, Hirose S, Matsuda H, Wakisaka A, Aizawa H (1982) Close association of HLA-Bw51 with Behçet disease. Arch Ophthalmol 100:1455-1458
10. Ota M, Katsuyama Y, Mizuki N, Ando H, Furihata K, Ohno S, Pivetti-Pezzi P, et al (1997) Trinucleotide repeat polymorphism within exon 5 of the MICA gene (MHC class I chain-related gene A): allele frequency data in the nine population groups Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian. Tissue Antigens 49:448-454
11. Raymond M, Rousset F (1995) An exact test for population differentiation. Evolution 49:1280-1283
12. Raymond M, Rousset F (1997) Genepop (version 1.2): population genetics software for exact tests and ecumenicism. J Hered 86:248-249
13. Shiina T, Tamiya G, Oka A, Yamagata T, Yamagata N, Kikkawa E, Goto K, et al (1998) Nucleotide sequencing analysis of the 146-kilobase segment around the IkNL and MICA genes at the centromeric end of the HLA class I region. Genomics 47:372-382
14. Tamiya G, Ota M, Katsuyama Y, Shiina T, Oka A, Makino S, Kimura M, et al (1998) Twenty-six new polymorphic microsatellite markers around the HLA-B, -C and -E loci in the human MHC class I region. Tissue Antigens 51:337-346