Higher Numbers of Blood CD14+ Cells before Starting Conditioning Regimen Correlate with Greater Risk of Acute Graft-versus-Host Disease in Allogeneic Stem Cell Transplantation from Related Donors

Biology of Blood and Marrow Transplantation

Volumn 13, Issue 2, 2007, Pages 228-234

  Arpinati, Mario ^a   Chirumbolo, Gabriella ^a   Saunthararajah, Yogen ^b   Stanzani, Marta ^a   Bonifazi, Francesca ^a   Bandini, Giuseppe ^a   Baccarani, Michele ^a   Rondelli, Damiano ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Antigen presenting cell; Dendritic cell; Graft versus host disease; Hematopoietic stem cell transplantation; Monocyte

Indexed keywords

BUSULFAN; CD14 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; FLUDARABINE; HLA ANTIGEN; MELPHALAN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THIOTEPA; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ANTIGEN PRESENTING CELL; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BONE MARROW CELL; CELL COUNT; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CORRELATION ANALYSIS; DENDRITIC CELL; DONOR; DRUG USE; FEMALE; FLOW CYTOMETRY; GRAFT RECIPIENT; HLA MATCHING; HODGKIN DISEASE; HOST CELL; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MULTIPLE MYELOMA; MULTIVARIATE ANALYSIS; MYELOABLATIVE CONDITIONING; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; PATHOPHYSIOLOGY; PLASMA CELL; REDUCED INTENSITY CONDITIONING; RISK ASSESSMENT; SEX DIFFERENCE; TREATMENT OUTCOME; UNIVARIATE ANALYSIS; WHOLE BODY RADIATION;

ADULT; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD14; DENDRITIC CELLS; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; MONOCYTES; STATISTICS, NONPARAMETRIC; TRANSPLANTATION CONDITIONING;

EID: 33846334073     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2006.10.004     Document Type: Article

References (24)

1. Liu Y.J., Kanzler H., Soumelis V., et al. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol 2 (2001) 585-589
2. Banchereau J., Briere F., Caux C., et al. Immunobiology of dendritic cells. Annu Rev Immunol 18 (2000) 767-811
3. Arpinati M., Chirumbolo G., Urbini B., et al. Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation. Transplant Immunol 11 (2003) 345-356
4. Randolph G.J., Inaba K., Robbiani D.F., et al. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11 (1999) 753-761
5. Devetten M.P., and Vose J.M. Graft-versus-host disease: how to translate new insights into new therapeutic strategies. Biol Blood Marrow Transplant 10 (2004) 815-825
6. Shlomchick W.D. Antigen presentation in graft-vs-host disease. Exp Hematol 31 (2003) 1187-1197
7. Ruggeri L., Capanni M., Urbani E., et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295 (2002) 2097-2100
8. Shlomchick W.D., Couzens M.S., Tang C.B., et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science 285 (1999) 412-415
9. Duffner U.A., Maeda Y., Cooke K.R., et al. Host dendritic cells are sufficient to initiate acute graft-versus-host disease. J Immunol 172 (2004) 7393-7398
10. Arpinati M., Chirumbolo G., Urbini B., et al. Acute GVHD and steroid treatment impair myeloid and plasmacytoid dendritic cell reconstitution after allogeneic PBSC. Biol Blood Marrow Transplant 10 (2004) 106-115
11. Reddy V., Iturraspe J.A., Tzolas A.C., et al. Low dendritic cell count after allogeneic hematopoietic stem cell transplantation predicts relapse, death, and acute graft-versus-host disease. Blood 103 (2004) 4330-4335
12. Vakkila J., Thomson A.W., Hovi L., et al. Circulating dendritic cell subset levels after allogeneic stem cell transplantation in children correlate with time posttransplant and severity of acute graft-versus-host disease. Bone Marrow Transplant 35 (2005) 501-507
13. Klangsinsirikul P., Carter G.I., Byrne J.L., et al. Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution. Blood 99 (2002) 2586-2591
14. Roake J., Rao A., Morris P., et al. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med 18 (1995) 2237-2247
15. Hill G.R., Teshima T., Gerbitz A., et al. Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. J Clin Invest 104 (1999) 459-467
16. Panoskaltsis-Mortari A., Strieter R.M., Hermanson J.R., et al. Induction of monocyte- and T-cell-attracting chemokines in the lung during the generation of idiopathic pneumonia syndrome following allogeneic murine bone marrow transplantation. Blood 96 (2000) 834-839
17. Hildebrandt G.C., Duffner U.A., Olkiewicz K.M., et al. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood 103 (2004) 2417-2426
18. Fowler D.H., Foley J., Whit-Shan Hou J., et al. Clinical "cytokine storm" as revealed by monocyte intracellular flow cytometry: correlation of tumor necrosis factor alpha with severe gut graft-versus-host disease. Clin Gastroenterol Hepatol 2 (2004) 237-245
19. Mohty M., Blaise D., Faucher C., et al. Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation. Blood 106 (2005) 4407-4411
20. Aufferman-Gretzinger S., Lossos I.S., Vayntrub T.A., et al. Rapid establishment of dendritic cell chimerism in allogeneic hematopoietic cell transplant recipients. Blood 99 (2002) 1442-14448
21. Fang L., Fehse B., Engel M., et al. Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells. Transplantation 79 (2005) 369-371
22. Tanaka J., Mielcarek M., and Torok-Storb B. Impaired induction of the CD28-responsive complex in granulocyte colony-stimulating factor mobilized CD4 T cells. Blood 91 (1998) 347-352
23. Franzke A., Piao W., Lauber J., et al. G-CSF as an immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases. Blood 102 (2003) 734-739
24. + immature DCs [abstract]. Blood 104 (2004) 3451