Thyroid hormone (T3)-modification of polyethyleneglycol (PEG)-polyethyleneimine (PEI) graft copolymers for improved gene delivery to hepatocytes

Biomaterials

Volumn 28, Issue 10, 2007, Pages 1900-1911

  Rudolph, Carsten ^a,b   Sieverling, Nathalie ^c   Schillinger, Ulrike ^d   Lesina, Eugenia ^a   Plank, Christian ^d   Thünemann, Andreas F ^e   Schönberger, Hubert ^d   Rosenecker, Joseph ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c FRAUNHOFER INSTITUTE FOR APPLIED POLYMER RESEARCH   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e Federal Institute for Materials Sciences and Testing   (Germany)

Author keywords

Gene transfer; Liver; Nonviral; PEI; T3; Thyroid hormone

Indexed keywords

DISEASES; DNA; GENE TRANSFER; HORMONES; POLYETHERIMIDES; POLYETHYLENE GLYCOLS;

HEPATOCYTES; LIVER; NONVIRAL; THYROID HORMONES;

GRAFT COPOLYMERS;

COPOLYMER; DEXTRAN; FLUORESCENT DYE; LIOTHYRONINE; MACROGOL; PLASMID DNA; POLYETHYLENEIMINE; THYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA TRANSFECTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SYNTHESIS; DRUG UPTAKE; ENDOSOME; FEMALE; GENE OVEREXPRESSION; GENE TARGETING; GENE TRANSFER; GENE VECTOR; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER PARENCHYMA; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CELLS, CULTURED; DNA; DRUG CARRIERS; FEMALE; GENE TARGETING; HEPATOCYTES; LIVER; MATERIALS TESTING; MICE; MICE, INBRED C57BL; POLYAMINES; POLYETHYLENE GLYCOLS; TISSUE DISTRIBUTION; TRANSFECTION; TRIIODOTHYRONINE;

MUS;

EID: 33846312876     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2006.12.011     Document Type: Article

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