A nerve growth factor-induced retrograde survival signal mediated by mechanisms downstream of TrkA

Neuropharmacology

Volumn 52, Issue 2, 2007, Pages 270-278

  Mok, Sue A ^a   Campenot, Robert B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

G 6976; K252a; Nerve growth factor; Neuronal apoptosis; Neuronal survival; TrkA

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; K 252A; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; PROTEIN TYROSINE KINASE A;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; INNERVATION; NERVE ENDING; NERVE FIBER; NERVE MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; RETROGRADE NERVE FIBER TRANSPORT; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL;

ANIMALS; ANIMALS, NEWBORN; AXONS; BLOTTING, WESTERN; CARBAZOLES; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; INDOLES; NERVE GROWTH FACTOR; NEURONS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKA; SERINE; SIGNAL TRANSDUCTION; SUPERIOR CERVICAL GANGLION; TYROSINE;

EID: 33846278287     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.07.032     Document Type: Article

References (36)

1. Behrens M.M., Strasser U., and Choi D.W. Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. J. Neurochem. 72 (1999) 919-924
2. Bhattacharyya A., Watson F.L., Pomeroy S.L., Zhang Y.Z., Stiles C.D., and Segal R.A. High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J. Neurobiol. 51 (2002) 302-312
3. Borasio G.D. Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons. Neurosci. Lett. 108 (1990) 207-212
4. Campenot R.B. Development of sympathetic neurons in compartmentalized cultures. Il Local control of neurite growth by nerve growth factor. Dev. Biol. 93 (1982) 1-12
5. Campenot R.B., and MacInnis B.L. Retrograde transport of neurotrophins: fact and function. J. Neurobiol. 58 (2004) 217-229
6. Campenot R.B., and Martin G. Construction and Use of Compartmented Cultures for Studies of Cell Biology of Neurons (2001), Humana Press, Totowa, NJ
7. Cheng B., Barger S.W., and Mattson M.P. Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose. J. Neurochem. 62 (1994) 1319-1329
8. Delcroix J.D., Valletta J.S., Wu C., Hunt S.J., Kowal A.S., and Mobley W.C. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 39 (2003) 69-84
9. Dikic I., Batzer A.G., Blaikie P., Obermeier A., Ullrich A., Schlessinger J., and Margolis B. Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain. J. Biol. Chem. 270 (1995) 15125-15129
10. Ehlers M.D., Kaplan D.R., Price D.L., and Koliatsos V.E. NGF-stimulated retrograde transport of trkA in the mammalian nervous system. J. Cell Biol. 130 (1995) 149-156
11. Ginty D.D., and Segal R.A. Retrograde neurotrophin signaling: Trk-ing along the axon. Curr. Opin. Neurobiol. 12 (2002) 268-274
12. Glicksman M.A., Forbes M.E., Prantner J.E., and Neff N.T. K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures. J. Neurochem. 64 (1995) 1502-1512
13. Hendry I.A. The effect of the retrograde axonal transport of nerve growth factor on the morphology of adrenergic neurones. Brain Res. 134 (1977) 213-223
14. Hendry I.A., Stockel K., Thoenen H., and Iversen L.L. The retrograde axonal transport of nerve growth factor. Brain Res. 68 (1974) 103-121
15. Howe C.L., and Mobley W.C. Signaling endosome hypothesis: A cellular mechanism for long distance communication. J. Neurobiol. 58 (2004) 207-216
16. Howe C.L., and Mobley W.C. Long-distance retrograde neurotrophic signaling. Curr. Opin. Neurobiol. 15 (2005) 40-48
17. Johnson Jr. E.M., Andres R.Y., and Bradshaw R.A. Characterization of the retrograde transport of nerve growth factor (NGF) using high specific activity [125I]NGF. Brain Res. 150 (1978) 319-331
18. Kaplan D.R., Martin-Zanca D., and Parada L.F. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350 (1991) 158-160
19. Kuruvilla R., Ye H., and Ginty D.D. Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron 27 (2000) 499-512
20. MacInnis, B.L., 2003. NGF retrograde signaling and axon degeneration. Thesis (PhD), University of Alberta.
21. MacInnis B.L., and Campenot R.B. Retrograde support of neuronal survival without retrograde transport of nerve growth factor. Science 295 (2002) 1536-1539
22. MacInnis B.L., Senger D.L., and Campenot R.B. Spatial requirements for TrkA kinase activity in the support of neuronal survival and axon growth in rat sympathetic neurons. Neuropharmacology 45 (2003) 995-1010
23. Martiny-Baron G., Kazanietz M.G., Mischak H., Blumberg P.M., Kochs G., Hug H., Marme D., and Schachtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J. Biol. Chem. 268 (1993) 9194-9197
24. Neet K.E., and Campenot R.B. Receptor binding, internalization, and retrograde transport of neurotrophic factors. Cell. Mol. Life Sci. 58 (2001) 1021-1035
25. Pan J., Zhang Q.G., and Zhang G.Y. The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. Neuroscience 131 (2005) 147-159
26. Riccio A., Pierchala B.A., Ciarallo C.L., and Ginty D.D. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. Science 277 (1997) 1097-1100
27. Riccio A., Ahn S., Davenport C.M., Blendy J.A., and Ginty D.D. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286 (1999) 2358-2361
28. Roux P.P., Dorval G., Boudreau M., Angers-Loustau A., Morris S.J., Makkerh J., and Barker P.A. K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J. Biol. Chem. 277 (2002) 49473-49480
29. Senger D.L., and Campenot R.B. Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures. J. Cell Biol. 138 (1997) 411-421
30. Stockel K., Paravicini U., and Thoenen H. Specificity of the retrograde axonal transport of nerve growth factor. Brain Res. 76 (1974) 413-421
31. Stoeckel K., Guroff G., Schwab M., and Thoenen H. The significance of retrograde axonal transport for the accumulation of systemically administered nerve growth factor (NGF) in the rat superior cervical ganglion. Brain Res. 109 (1976) 271-284
32. Tsui-Pierchala B.A., and Ginty D.D. Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons. J. Neurosci. 19 (1999) 8207-8218
33. Ure D.R., and Campenot R.B. Leukemia inhibitory factor and nerve growth factor are retrogradely transported and processed by cultured rat sympathetic neurons. Dev. Biol. 162 (1994) 339-347
34. Ye H., Kuruvilla R., Zweifel L.S., and Ginty D.D. Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons. Neuron 39 (2003) 57-68
35. Yoon S.O., Soltoff S.P., and Chao M.V. A dominant role of the juxtamembrane region of the TrkA nerve growth factor receptor during neuronal cell differentiation. J. Biol. Chem. 272 (1997) 23231-23238
36. Zweifel L.S., Kuruvilla R., and Ginty D.D. Functions and mechanisms of retrograde neurotrophin signalling. Nat. Rev. Neurosci. 6 (2005) 615-625