-
2
-
-
0003484310
-
-
FDA. Food and Drug Administration, Center for Drug Evaluation and Research: Washington, DC
-
FDA. Guidance for Industry: Bioanalytical Method Validation. Food and Drug Administration, Center for Drug Evaluation and Research: Washington, DC, 2001.
-
(2001)
Guidance for Industry: Bioanalytical Method Validation
-
-
-
3
-
-
0036647071
-
Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration
-
Giri SN, Wang Q, Xie Y, Lango J, Morin D, Margolin SB and Buckpitt AR. Pharmacokinetics; and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration. Biopharmaceutics and Drug Disposition 2002; 23: 203-211.
-
(2002)
Biopharmaceutics and Drug Disposition
, vol.23
, pp. 203-211
-
-
Giri, S.N.1
Wang, Q.2
Xie, Y.3
Lango, J.4
Morin, D.5
Margolin, S.B.6
Buckpitt, A.R.7
-
4
-
-
0035718790
-
Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis
-
Hewitson TD, Kelynack KJ, Tait MG, Martic M, Jones CL, Margolin SB and Becker GJ. Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis. Journal of Nephrology 2001; 14: 453-460.
-
(2001)
Journal of Nephrology
, vol.14
, pp. 453-460
-
-
Hewitson, T.D.1
Kelynack, K.J.2
Tait, M.G.3
Martic, M.4
Jones, C.L.5
Margolin, S.B.6
Becker, G.J.7
-
5
-
-
0029318974
-
Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters
-
Iyer SN, Wild JS, Schiedt MJ, Hyde DM, Margolin SB and Giri SN. Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters. Journal of Laboratory and Clinical Medicine 1995; 125: 779-785.
-
(1995)
Journal of Laboratory and Clinical Medicine
, vol.125
, pp. 779-785
-
-
Iyer, S.N.1
Wild, J.S.2
Schiedt, M.J.3
Hyde, D.M.4
Margolin, S.B.5
Giri, S.N.6
-
6
-
-
0031914475
-
Lung fibrosis is ameliorated by pirfenidone fed in diet after the second dose in a three-dose bleomycin-hamster model
-
Iyer SN, Margolin SB, Hyde DM and Giri SN. Lung fibrosis is ameliorated by pirfenidone fed in diet after the second dose in a three-dose bleomycin-hamster model. Experimental Lung Research 1998; 24: 119-132.
-
(1998)
Experimental Lung Research
, vol.24
, pp. 119-132
-
-
Iyer, S.N.1
Margolin, S.B.2
Hyde, D.M.3
Giri, S.N.4
-
7
-
-
7044249281
-
Pirfenidone protects endotoxin-induced liver injury after hepatic ischemia in rats
-
Kaibori M, Yanagida H, Uchida Y, Yokoigawa N, Kwon AH, Okumura T and Kamiyama Y. Pirfenidone protects endotoxin-induced liver injury after hepatic ischemia in rats. Transplantation Proceedings 2004; 36: 1973-1974.
-
(2004)
Transplantation Proceedings
, vol.36
, pp. 1973-1974
-
-
Kaibori, M.1
Yanagida, H.2
Uchida, Y.3
Yokoigawa, N.4
Kwon, A.H.5
Okumura, T.6
Kamiyama, Y.7
-
8
-
-
0031820998
-
Pirfenidone induces intercellular adhesion molecule-1 (ICAM-1) down-regulation on cultured human synovial fibroblasts
-
Kaneko M, Inoue H, Nakazawa R, Azuma N, Suzuki M, Yamauchi S, Margolin SB, Tsubota K and Saito I. Pirfenidone induces intercellular adhesion molecule-1 (ICAM-1) down-regulation on cultured human synovial fibroblasts. Clinical and Experimental Immunology 1998; 113: 72-76.
-
(1998)
Clinical and Experimental Immunology
, vol.113
, pp. 72-76
-
-
Kaneko, M.1
Inoue, H.2
Nakazawa, R.3
Azuma, N.4
Suzuki, M.5
Yamauchi, S.6
Margolin, S.B.7
Tsubota, K.8
Saito, I.9
-
9
-
-
0031557123
-
Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice
-
Kehrer JP and Margolin SB. Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicology Letters 1997; 90: 125-132.
-
(1997)
Toxicology Letters
, vol.90
, pp. 125-132
-
-
Kehrer, J.P.1
Margolin, S.B.2
-
10
-
-
24644510860
-
Pirfenidone inhibits inflammatory responses and ameliorates allograft injury in a rat lung transplant model
-
Liu H, Drew P, Cheng Y and Visner GA. Pirfenidone inhibits inflammatory responses and ameliorates allograft injury in a rat lung transplant model. Journal of Thoracic and Cardiovascular Surgery 2005; 130: 852-858.
-
(2005)
Journal of Thoracic and Cardiovascular Surgery
, vol.130
, pp. 852-858
-
-
Liu, H.1
Drew, P.2
Cheng, Y.3
Visner, G.A.4
-
11
-
-
0034946204
-
Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats
-
Miric G, Dallemagne C, Endre Z, Margolin S, Taylor SM and Brown L. Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. British Journal of Pharmacology 2001; 133: 687-694.
-
(2001)
British Journal of Pharmacology
, vol.133
, pp. 687-694
-
-
Miric, G.1
Dallemagne, C.2
Endre, Z.3
Margolin, S.4
Taylor, S.M.5
Brown, L.6
-
12
-
-
0033600396
-
Pirfenidone in idiopathic pulmonary fibrosis
-
Nicod LP. Pirfenidone in idiopathic pulmonary fibrosis. Lancet 1999; 354: 268-269.
-
(1999)
Lancet
, vol.354
, pp. 268-269
-
-
Nicod, L.P.1
-
13
-
-
0031834709
-
Pirfenidone improves renal function and fibrosis in the post-obstructed kidney
-
Shimizu T, Kuroda T, Hata S, Fukagawa M, Margolin SB and Kurokawa K. Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. Kidney International 1998; 54: 99-109.
-
(1998)
Kidney International
, vol.54
, pp. 99-109
-
-
Shimizu, T.1
Kuroda, T.2
Hata, S.3
Fukagawa, M.4
Margolin, S.B.5
Kurokawa, K.6
-
14
-
-
0034953519
-
Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats
-
Tada S, Nakamuta M, Enjoji M, Sugimoto R, Iwamoto H, Kato M, Nakashima Y and Nawata H. Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Clinical and Experimental Pharmacology and Physiology 2001; 28: 522-527.
-
(2001)
Clinical and Experimental Pharmacology and Physiology
, vol.28
, pp. 522-527
-
-
Tada, S.1
Nakamuta, M.2
Enjoji, M.3
Sugimoto, R.4
Iwamoto, H.5
Kato, M.6
Nakashima, Y.7
Nawata, H.8
-
15
-
-
0030976513
-
Pharmacokinetics of an antifibrotic agent, pirfenidone, in haemodialysis patients
-
Taniyama M, Ohbayashi S, Narita M, Nakazawa R, Hasegawa S, Azuma N, Teraoka S, Ota K, Yamauchi S and Margolin SB. Pharmacokinetics of an antifibrotic agent, pirfenidone, in haemodialysis patients. European Journal of Clinical Pharmacology 1997; 52: 77-78.
-
(1997)
European Journal of Clinical Pharmacology
, vol.52
, pp. 77-78
-
-
Taniyama, M.1
Ohbayashi, S.2
Narita, M.3
Nakazawa, R.4
Hasegawa, S.5
Azuma, N.6
Teraoka, S.7
Ota, K.8
Yamauchi, S.9
Margolin, S.B.10
-
16
-
-
0346059343
-
Pirfenidone prevents endotoxin-induced liver injury after partial hepatectomy in rats
-
Tsuchiya H, Kaibori M, Yanagida H, Yokoigawa N, Kwon AH, Okumura T and Kamiyama Y. Pirfenidone prevents endotoxin-induced liver injury after partial hepatectomy in rats. Journal Hepatology 2004; 40: 94-101.
-
(2004)
Journal Hepatology
, vol.40
, pp. 94-101
-
-
Tsuchiya, H.1
Kaibori, M.2
Yanagida, H.3
Yokoigawa, N.4
Kwon, A.H.5
Okumura, T.6
Kamiyama, Y.7
-
17
-
-
0034747862
-
Pirfenidone for chronic progressive multiple sclerosis
-
Walker JE and Margolin SB. Pirfenidone for chronic progressive multiple sclerosis. Multiple Sclerosis 2001; 7: 305-312.
-
(2001)
Multiple Sclerosis
, vol.7
, pp. 305-312
-
-
Walker, J.E.1
Margolin, S.B.2
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