Controlled release of huperzine A from biodegradable microspheres: In vitro and in vivo studies

International Journal of Pharmaceutics

Volumn 330, Issue 1-2, 2007, Pages 1-5

  Gao, Ping ^a   Xu, Hui ^a   Ding, Pingtian ^a   Gao, Qizhen ^b   Sun, Jingyi ^a   Chen, Dawei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Biodegradable microspheres; Controlled release; Huperzine A; Poly(d,l lactide co glycolide)

Indexed keywords

HUPERZINE A; MICROSPHERE; POLYGLACTIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; BRAIN CORTEX; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BLOOD LEVEL; DRUG STABILITY; EMULSION; IN VITRO STUDY; IN VIVO CULTURE; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; LACTIC ACID; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR; SESQUITERPENES;

EID: 33846239393     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.08.030     Document Type: Article

References (16)

1. Anderson J.M., and Shive M.S. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv. Drug Deliv. Rev. 28 (1997) 5-24
2. Chen L., Apte R.N., and Cohen S. Characterization of PLG microspheres for the controlled delivery of IL-1α for tumor immunotherapy. J. Control. Release 43 (1997) 261-272
3. Cummings J.L., and Mendez M.F. Alzheimer's disease: cognitive and behavioral pharmacotherapy. Conn. Med. 61 (1997) 543-552
4. Gao P., Ding P.T., Xu H., Yuan Z.T., Chen D.W., Wei J., and Chen D. In vitro and in vivo characterization of huperzine A loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid). Chem. Pharm. Bull. 54 1 (2006) 89-93
5. Giacobini E., and Becker R. Development of drugs for Alzheimer therapy: a decade of progress. In: Giacobini E., and Becker R. (Eds). Alzheimer Disease: Therapeutic Strategies (1994), Birkhäuser, Boston, MA 1-7
6. Heya T., Okada H., Tanigawara Y., Ogawa Y., and Toguchi H. Effects of counteranion of TRH and loading amount on control of TRH release from copoly(dl-lactic/glycolic acid) microspheres prepared by an in-water drying method. Int. J. Pharm. 69 (1991) 69-75
7. Liang Y.Q., and Tang X.C. Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats. Neurosci. Lett. 361 (2004) 56-59
8. Liu F.I., Kuo J.H., Sung K.C., and Hu O.Y.P. Biodegradable polymeric microspheres for nalbuphine prodrug controlled delivery in vitro characterization and in vivo pharmacokinetics studies. Int. J. Pharm. 257 (2003) 23-31
9. Ogawa Y., Yamamoto M., Takada S., Okada H., and Shimamoto T. Controlled-release of leuprolide acetate from polylactic acid or copoly (lactic/glycolic) acid microcapsules: influence of molecular weight and copolymer ratio of polymer. Chem. Pharm. Bull. 36 (1988) 1502-1507
10. Okada H. One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate. Adv. Drug Deliv. Rev. 28 (1997) 43-70
11. Okada H., Doken Y., Ogawa Y., and Toguchi H. Preparation of 3-month Depot injectable microspheres of leuprorelin acetate using biodegradable polymers. Pharm. Res. 11 (1994) 1143-1147
12. Okada H., Yamamoto M., Heya T., Inoue Y., Kamei S., Ogawa Y., and Toguchi H. Drug delivery using biodegradable microspheres. J. Control. Release 28 (1994) 121-129
13. Park T.G., Lee H.Y., and Nam Y.S. A new preparation method for protein loaded poly(d,l-lactic-co-glycolic acid) microspheres and protein release mechanism study. J. Control. Release 55 (1998) 181-191
14. Parnetti L., Senin U., and Mecocci P. Cognitive enhancement therapy for Alzheimer's disease. The way forward. Drugs 53 (1997) 752-768
15. Roullin V.G., Deverre J.R., Lemaire L., Hindre F., Venier-Julienne M.C., Vienet R., and Benoit J.P. Anti-cancer drug diffusion within living rat brain tissue an experimental study using [3H] (6)-5-fluorouracil-loaded PLG microspheres. Eur. J. Pharm. Biopharm. 53 (2002) 293-299
16. Tabata Y., and Ikada Y. Phagocytosis of polymer microspheres by macrophages. Adv. Polym. Sci. 94 (1990) 107-141