Why much of the pathophysiology of preeclampsia-eclampsia must be of an autoimmune nature

American Journal of Obstetrics and Gynecology

Volumn 196, Issue 1, 2007, Pages 5.e1-5.e7

  Gleicher, Norbert ^a  

^a Chicago Center for Human Reproduction   (United States)

Author keywords

allograft; allograft rejection; autoantibodies; autoimmunity; disease exacerbation; eclampsia; graft versus host disease (GVHD); microchimerism; preeclampsia; pregnancy

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; CORTICOSTEROID; EPITOPE; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; PHOSPHOLIPID ANTIBODY; THROMBOCYTE ANTIBODY; THYROID ANTIBODY;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; COMPARATIVE STUDY; DIAGNOSTIC APPROACH ROUTE; DISEASE ASSOCIATION; DONOR LYMPHOCYTE INFUSION; ECLAMPSIA; FERTILIZATION IN VITRO; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GRAFT VERSUS HOST REACTION; HELLP SYNDROME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNOGENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; MOTHER FETUS RELATIONSHIP; PATHOPHYSIOLOGY; PLASMAPHERESIS; PREECLAMPSIA; PREVENTIVE MEDICINE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; TREATMENT INDICATION;

EID: 33846238560     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2006.09.016     Document Type: Article

References (78)

1. Dekker G.A., and Sibai B.M. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 179 (1998) 1359-1375
2. Redman C.W.G., Sacks G.P., and Sargent I.L. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 180 (1999) 499-506
3. Roberts J.M., and Cooper D.W. Pathogenesis and genetics of pre-eclampsia. Lancet 357 (2001) 53-56
4. Sibai B., Dekker G., and Kupferminc M. Pre-eclampsia. Lancet 365 (2005) 785-799
5. Broughton Pipkin F. Risk factors for preeclampsia. [Editorial]. N Engl J Med 344 (2001) 925-926
6. Gleicher N., Pratt D., and Dudkiewicz A. What do we really know about autoantibody abnormalities and reproductive failure: a critical review. Autoimmunity 16 (1993) 115-140
7. Kita M., Goulis D.G., and Avramidea A. Post-partum thyroiditis in a Mediterranean population: a prospective study of a large cohort of thyroid antibody positive women at the time of delivery. J Endocrinol Invest 25 (2002) 513-519
8. Ansari A.A., Fett J.D., Carraway R.E., Mayne A.E., Onlamoon N., and Sundstrom J.B. Autoimmune mechanisms as the basis of human peripartum cardiomyopathy. Clin Rev Allergy Immunol 23 (2002) 301-324
9. Report of the National High Blood Pressure Education Program Working Group Report on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 183 (2000) S1-S22
10. Zhang J., Meikle S., and Trumble A. Severe maternal morbidity associated with hypertensive disorders in pregnancy in the United States. Hypertens Pregnancy 22 (2003) 203-212
11. Belogolovkin V., Levine S.R., Fields M.C., and Stone J.L. Postpartum eclampsia complicated by reversible cerebral herniation. Obstet Gynecol 107 (2006) 442-445
12. Elkayam U., Akhter M.W., Singh H., Khan S., Bitar F., Hameed A., and Shotan A. Pregnancy associated cardiomyopathy: clinical characteristics and a comparison between early and late presentation. Circulation 111 (2005) 2050-2055
13. Davidson A., and Diamond B. Autoimmune diseases. N Engl J Med 345 (2001) 340-350
14. Conrad K.P., Miles T.M., and Benyo D.F. Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 40 (1998) 102-111
15. Rappaport V.J., Hirata G., Yap H.K., and Jordan S.C. Anti-vascular endothelial cell antibodies in severe preeclampsia. Am J Obstet Gynecol 162 (1990) 138-145
16. El-Roeiy A., Myers S.A., and Gleicher N. The relationship between autoantibodies and intrauterine growth retardation in hypertensive disorders of pregnancy. Am J Obstet Gynecol 164 (1991) 1253-1261
17. Milliez J., Lelong F., Bayani N., Jannet D., El Medjadji M., Latrous H., Hammami M., and Paniel B.J. The prevalence of autoantibodies during third-trimester pregnancy complicated by hypertension or idiopathic fetal growth retardation. Am J Obstet Gynecol 165 (1991) 51-56
18. 2-glycoprotein I in preeclampsia. Clin Exp Immunol 94 (1993) 196-200
19. Ware Branch D., Mitchell M.D., Miller E., Palinski W., and Witztum J.L. Pre-eclampsia and serum antibodies to oxidized low-density lipoprotein. Lancet 343 (1994) 645-646
20. Dekker G.A., de Vries J.I.P., Doelitzsch P.M., Huijgens P.C., von Blomberg B.M.E., Jakobs C., and van Geijn H.P. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 173 (1995) 1042-1048
21. 2-glycoprotein-I antibodies in preeclampsia. Obstet Gynecol 102 (2003) 294-300
22. Dreyfus M., Hedelin G., Kutnahorsky R., Lehmann M., Viville B., Langer B., Fleury A., M'Barek M., Treisser A., Wiesel M.-L., and Pasquali J.-L. Antiphospholipid antibodies and preeclampsia: a case-control study. Obstet Gynecol 97 (2001) 29-34
23. Sibai B.M. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol 103 (2004) 981-991
24. Mandanas RA. Graft versus host disease. Available at: http://www.emedicine.com/MED/topic926.htm. Updated April 4, 2006.
25. Sawant R.B., and Rajadhyaksha S.B. Plasma exchange for thrombotic thrombocytopenic purpura following hematopoietic stem cell transplantation. J Assoc Physicians India 53 (2005) 981-983
26. Patriarca F., Skert C., Sperotto A., Zaja F., Falleti E., Mestroni R., Kikic F., Calistri E., Fili C., Geromin A., Cerno M., and Fanin R. The development of autoantibodies after allogeneic stem cell transplantation is related with chronic graft-vs-host disease and immune recovery. Exp Hematol 34 (2006) 389-396
27. Blanche P., Dreyfus F., and Sicard D. Polymyositis and chronic graft-versus-host disease: efficacy of intravenous gammaglobulin and methotrexate. Clin Exp Rheumatol 13 (1995) 377-379
28. Martin Jr. J.N., Rose C.H., and Briery C.M. Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticosteroids for mother and child. Am J Obstet Gynecol 195 (2006) 914-934 Epub May 2, 2006
29. Katz V.L., Thorp Jr. J.M., Watson W.J., Fowler L., and Heine R.P. Human immunoglobulin therapy for preeclampsia associated with lupus anticoagulant and anticardiolipin antibody. Obstet Gynecol 76 (1990) 986-988
30. Martin Jr. J.N., Files J.C., Blake P.G., Norman P.H., Martin R.W., Hess L.W., Morrison J.C., and Wiser W.L. Plasma exchange for preeclampsia. I. Postpartum use for persistently severe preeclampsia-eclampsia with HELLP syndrome. Am J Obstet Gynecol 162 (1990) 126-137
31. Adachi H., Takakuwa K., Mitsui T., Ishii K., Tamura M., and Tanaka K. Results of immunotherapy for patients with unexplained secondary recurrent abortions. Clin Immunol 106 (2003) 175-180
32. Steck T., Westphal E., and Wurfel W. Maternal immunization by husband's leukocytes for repeated fetal death associated with mild pre-eclampsia: case report with successful outcome. Arch Gynecol Obstet 252 (1992) 103-107
33. Huff C.A., Fuchs E.J., Smith B.D., Blackford A., Garrett-Mayer E., Brodsky R.A., Flinn I.W., Ambinder R.F., Borrello I.M., Matsui W.H., Vogelsang G.B., Griffin C.A., Luznik L., and Jones R.J. Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions. Biol Blood Marrow Transplant 12 (2006) 414-421
34. Feeney J.G., Tovey L.A., and Scott J.S. Influence of previous blood transfusion on incidence of pre-eclampsia. Lancet 1 (1977) 874-875
35. Van Twuyver E., Mooijaart R.J.D., tenBerge I.J.M., van der Horst A.R., Wilmink J.M., Kast W.M., Melief C.J.M., and de Waal L.P. Pretransplantation blood transfusion revisited. N Engl J Med 325 (1991) 1210-1213
36. Kamradt T., and Mitchison N.A. Tolerance and autoimmunity. N Engl J Med 344 (2001) 655-664
37. Perruche S., Marandin A., Kleinclauss F., Angonin R., Fresnay S., Baron M.H., Tiberghien P., and Saas P. Association of mixed hematopoietic chimerism with elevated circulating autoantibodies and chronic graft-versus-host disease occurrence. Transplantation 81 (2006) 573-582
38. Hess A., Thoburn C., Chen W., and Horwitz L. Autoreactive T-cell subset in acute and chronic syngeneic graft-versus-host disease. Transplant Proc 33 (2001) 1754-1756
39. Parkman R. Chronic graft-versus-host disease. Curr Opin Hematol 5 (1998) 22-25
40. Wucherpfennig K.W. Structural basis for molecular mimicry. J Autoimmun 16 (2001) 293-302
41. Rose N.R., and Mackay I.R. Molecular mimicry: a critical look at exemplary instances in human disease. Cell Mol Life Sci 57 (2000) 542-551
42. Tough D.F., Borrow P., and Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272 (1996) 1947-1950
43. Horwitz M.S., Bradley L.M., Harbertson J., Krahl T., Lee J., and Sarvetnick N. Diabetes induced coxsackievirus: initiation by bystander damage and not molecular mimicry. Nat Med 4 (1998) 781-785
44. Hartwell E.A., and American Society of Clinical Pathologists. Use of Rh immune globulin: ASCP practice parameter. Am J Clin Pathol 110 (1998) 281-292
45. Nelson J.L., Hughes K.A., Smith A.G., Nisperos B.B., Branchaud A.M., and Hansen J.A. Maternal-fetal disparity in HLA class II alloantigens and the pregnancy-induced amelioration of rheumatoid arthritis. N Engl J Med 329 (1993) 466-471
46. Sedlacek D., Ulcova-Gallova Z., Milichovska L., Novakova P., and Rokyta Z. Seven antiphospholipid antibodies in HIV-positive patients: correlation with clinical outcome and laboratory findings. Am J Reprod Immunol 50 (2003) 439-443
47. Gomez-Puerta J.A., Cervera R., Espinosa G., Aguilo S., Bucciarelli S., Ramos-Casals M., Ingelmo M., Asherson R.A., and Font J. Antiphospholipid antibodies associated with malignancies: clinical and pathological characteristics of 120 patients. Semin Arthritis Rheum 35 (2006) 322-332
48. Burrows R.F., Hunter D.J., Andrew M., and Kelton J.G. A prospective study investigating the mechanism of thrombocytopenia in preeclampsia. Obstet Gynecol 70 (1987) 334-338
49. Gleicher N. Some thoughts on the reproductive autoimmune failure syndrome (RAFS) and the Th-1 versus Th-2 immune responses. Am J Reprod Immunol 48 (2002) 252-254
50. Crane I.J., and Forrester J.V. Th1 and Th2 lymphocytes in autoimmune disease. Crit Rev Immunol 25 (2005) 75-102
51. Brix T.H., Kyvik K.O., Christensen K., and Hegedus L. Evidence for a major role of heredity in Grave's disease: a population-based study of two Danish twin cohorts. J Clin Endocrinol Metab 86 (2001) 930-934
52. Klein J., and Sato A. The HLA system. Second of two parts. N Engl J Med 343 (2000) 782-786 [Erratum in: N Engl J Med 2000;343:1504]
53. Takakuwa K., Honda K., Ishii K., Hataya I., Yasuda M., and Tanaka K. Studies on the HLA-DRB1 genotype in Japanese women with severe pre-eclampsia positive and negative for anticardiolipin antibody using polymerase chain reaction-restriction fragment length polymorphism method. Hum Reprod 14 (1999) 2980-2986
54. Arngrimsson R., Connor J.M., Geirsson R.T., Brennecke S., and Cooper D.W. Is genetic susceptibility for pre-eclampsia and eclampsia associated with implantation failure and fetal demise?. Lancet 343 (1994) 1643-1645
55. Esplin M.S., Fausett M.B., Fraser A., Kerber R., Mineau G., Carrillo J., and Varner M.W. Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med 344 (2001) 867-872
56. Wolfberg A.J., Lee-Parritz A., Peller A.J., and Lieberman E.S. Association of rheumatologic disease with preeclampsia. Obstet Gynecol 103 (2004) 1190-1193 [Erratum in: Obstet Gynecol 2005;105:222]
57. Egerman R.S., Ramsey R.D., Kao L.W., Bringman J.J., Bush A.J., and Wan J.Y. Hypertensive disease in pregnancies complicated by systemic lupus erythematosus. Am J Obstet Gynecol 193 (2005) 1676-1679
58. Clark D.A., Blois S., Kandil J., Handjiski B., Manuel J., and Arck P.C. Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans. Am J Reprod Immunol 54 (2005) 203-216
59. Starzl T.E., Demetris A.J., Murase N., Ildstad S., Ricordi C., and Trucco M. Cell migration, microchimerism, and graft acceptance. Lancet 339 (1992) 1579-1582
60. Bianchi D.W., Zickwolf G.K., Weil G.J., Sylvester S., and DeMaria M.A. Male fetal progenitor cells persist in maternal blood for as long as 27 years post-partum. Proc Natl Acad Sci USA 93 (1996) 705-708
61. Nelson J.L. Microchimerism and autoimmune disease. N Engl J Med 338 (1998) 1224-1225
62. Lo Y.M.D., Leung T.N., Tein M.S.C., Sargent I.L., Zhang J., Lau T.K., Haines C.J., and Redman C.W.G. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin Chem 45 (1999) 184-188
63. Magann E.F., Martin Jr. J.N., Isaacs J.D., Perry Jr. K.G., Martin R.W., and Meydrech E.F. Immediate postpartum curettage: accelerated recovery from severe preeclampsia. Obstet Gynecol 81 (1993) 502-506
64. Einarsson J.I., Sangi-Haghpeykar H., and Gardner M.O. Sperm exposure and development of preeclampsia. Am J Obstet Gynecol 188 (2003) 1241-1243
65. Wang J.X., Knottnerus A.-M., Schuit G., Norman R.J., Chan A., and Dekker G.A. Surgically obtained sperm, and risk of gestational hypertension and pre-eclampsia. Lancet 359 (2002) 673-674
66. Lynch A., McDuffie Jr. R., Murphy J., Faber K., and Orleans M. Preeclampsia in multiple gestation: the role of assisted reproductive technologies. Obstet Gynecol 99 (2002) 445-451
67. Wiggins D., and Main E. Outcomes of pregnancies achieved by donor egg in vitro fertilization: a comparison with standard in vitro fertilization pregnancies. Am J Obstet Gynecol 192 (2005) 2002-2006 discussion 2006-8
68. Salha O., Sharma V., Dada T., Nugent D., Rutherford A.J., Tomlinson A.J., Philips S., Allgar V., and Walker J.J. The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod 14 (1999) 2268-2273
69. Kishore R., Agarwal S., Halder A., Das V., Shukla B.R., and Agarwal S.S. HLA sharing, anti-paternal cytotoxic antibodies and MLR blocking factors in women with recurrent spontaneous abortion. J Obstet Gynaecol Res 22 (1996) 177-183
70. Kiyokawa Y., and Yoneyama Y. Relationship between adenosine and T-helper 1/ T-helper 2 balance in hyperemesis gravidarum. Clin Chim Acta 370 (2006) 137-142 Epub Feb 28, 2006
71. Gleicher N. Autoantibodies and pregnancy loss. Lancet 343 (1994) 747-748
72. Akpek G., Chinratanalab W., Lee L.A., Torbenson M., Hallick J.P., Anders V., and Vogelsang G.B. Gastrointestinal involvement in chronic graft-versus-host disease: a clinicopathologic study. Biol Blood Marrow Transplant 9 (2003) 46-51
73. Wimalasundera R.C., Larbalestier N., Smith J.H., de Ruiter A., Thom S.A.McG., Hughes A.D., Poulter N., Regan L., and Taylor G.P. Pre-eclampsia, antiretroviral therapy, and immune reconstitution. Lancet 360 (2002) 1152-1154
74. Skupski D.W., Nelson S., Kowalik A., Polaneczky M., Smith-Levitin M., Hutson J.M., and Rosenwaks Z. Multiple gestation from in vitro fertilization: successful implantation alone is not associated with subsequent preeclampsia. Am J Obstet Gynecol 175 (1996) 1029-1032
75. Ingelfinger J.R. Agonistic autoantibodies and rejection of renal allografts. [Editorial]. N Engl J Med 352 (2005) 617-619
76. Shanklin D.R., and Sibai B.M. Ultrastructural aspects of preeclampsia. I. Placental bed and uterine boundary vessels. Am J Obstet Gynecol 161 (1989) 735-741
77. Ringden O., Uzunel M., Rasmusson I., Remberger M., Sundberg B., Lonnies H., Marschall H.U., Dlugosz A., Szakos A., Hassan Z., Omazic B., Aschan J., Barkholt L., and Le Blanc K. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 27 (2006) 1390-1397
78. Griffith L.M., Pavletic S.Z., Tyndall A., Gratwohl A., Furst D.E., Forman S.J., and Nash R.A. Target populations in allogeneic hematopoietic cell transplantation for autoimmune diseases-a workshop accompanying: cellular therapy for treatment of autoimmune diseases, basic science and clinical studies, including new developments in hematopoietic and mesenchymal stem cell therapy. Biol Blood Marrow Transplant 12 (2006) 688-690