Results of immunotherapy for patients with unexplained secondary recurrent abortions

Clinical Immunology

Volumn 106, Issue 3, 2003, Pages 175-180

  Adachi, Hiroshi ^a   Takakuwa, Koichi ^a   Mitsui, Takuya ^a   Ishii, Keisuke ^a   Tamura, Masaki ^a   Tanaka, Kenichi ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

Immunotherapy; MLR blocking antibodies; Secondary habitual abortion

Indexed keywords

ANTIBODY; CYTOKINE; MIXED LYMPHOCYTE CULTURE REACTION BLOCKING ANTIBODY; RECOMBINANT INTERLEUKIN 2; UNCLASSIFIED DRUG;

ADULT; ANTIBODY DETECTION; ARTICLE; ASSAY; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MALE; MIXED LYMPHOCYTE CULTURE; MONOCYTE; PREGNANCY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RECURRENT ABORTION; SPOUSE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; VACCINATION;

EID: 0037360520     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6616(02)00044-X     Document Type: Article

References (20)

1. Beer A.E., Quebbeman J.R., Ayers J.W.T., Haines R.F. Major histocompatibility complex antigens, maternal and paternal immune responses, and chronic habitual abortions in humans. Am. J. Obstet. Gynecol. 141:1981;987-999.
2. Taylor C., Faulk W.P. Prevention of recurrent abortion with leucocyte transfusions. Lancet. ii:1981;68-70.
3. Mowbray J.F., Gibbings C., Liddell H., Reginald P.W., Underwood J.L., Beard R.W. Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells. Lancet. i:1985;941-943.
4. Johnson P.M., Barnes R.M.R., Risk J.M., Molloy C.M., Woodrow J.C. Immunogenetic studies of recurrent spontaneous abortions in humans. Exp. Clin. Immunogenet. 2:1985;77-83.
5. Unander A.M., Lindholm A. Transfusion of leucocyte-rich erythrocyte concentrates a successful treatment in selected cases of habitual abortion . Am. J. Obstet. Gynecol. 154:1986;516-520.
6. Gatenby P.A., Cameron K., Simes R.J., Adelstein S., Bennett M.J., Jansen R.P.S., Shearman R.P., Stewart G.J., Whittle M., Doran T.J. Treatment of recurrent spontaneous abortion by immunization with paternal lymphocytes results of a controlled trial . Am. J. Reprod. Immunol. 29:1993;88-94.
7. Takakuwa K., Kanazawa K., Takeuchi S. Production of blocking antibodies by vaccination with husband's lymphocytes in unexplained recurrent aborters the role in successful pregnancies . Am. J. Reprod. Immunol. Microbiol. 10:1986;1-9.
8. Takakuwa K., Goto S., Hasegawa I., Ueda H., Kanazawa K., Takeuchi S., Tanaka K. Result of immunotherapy on patients with unexplained recurrent abortion a beneficial treatment for patients with negative blocking antibodies . Am. J. Reprod. Immunol. 23:1990;37-41.
9. Takakuwa K., Higashino M., Yasuda M., Ishii S., Ueda H., Asano K., Kazama Y., Tanaka K. Is an additional vaccination necessary for a successful second pregnancy in unexplained recurrent aborters who were successfully immunized with their husband's lymphocytes before the first pregnancy. Am. J. Reprod. Immunol. 29:1993;39-44.
10. Worldwide collaborative observational study and metaanalysis on allogeneic leucocyte immunotherapy for recurrent spontaneous abortions. Am. J. Reprod. Immunol. 32:1994;55-72.
11. Carp H.J.A., Toder V., Torchinsky A., Portuguese S., Lipitz S., Gazit E., Mashiach S. Allogeneic leukocyte immunization after five or more miscarrages. Hum. Reprod. 12:1997;250-255.
12. Park M.I., Edwin S.S., Scott J.R., Branch D.W. Interpretation of blocking activity in maternal serum depends on the equation used for calculation of mixed lymphocyte culture results. Clin. Exp. Immunol. 82:1990;363-368.
13. Ramhorst R., Agriello E., Zittermann S., Pando M., Larriba J., Irigoyen M., Cortelezzi M., Auge L., Lombardi E., Etchepareborda J.J., Cotreras Ortiz C., Fainboim L. Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion? Am. J. Reprod. Immunol. 44:2000;129-135.
14. Ober C., Karrison T., Odem R.R., Barnes R.B., Branch D.W., Stephenson M.D., Baron B., Walker M.A., Scott J.R., Schreiber J.R. Mononuclear-cell immunization in prevention of recurrent miscarriages a randomised trial . Lancet. 354:1999;365-369.
15. Hassold T.G. A cytogenetic study of repeated spontaneous abortion. Am. J. Hum. Genet. 32:1980;723-730.
16. Wegmann T.G. Placental immunotrophism maternal T cell enhance placental growth and function . Am. J. Reprod. Immunol. Microbiol. 15:1987;67-69.
17. Lin H., Mosmann T.R., Guilbert L., Tuntipopipat S., Wegmann T.G. Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J. Immunol. 151:1993;4562-4573.
18. Marzi M., Vigano A., Trabattoni D., Villa M.L., Salvaggio A., Clerici E., Clerici M. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin. Exp. Immunol. 106:1996;127-133.
19. Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol. Today. 18:1997;478-482.
20. Wegmann T.G., Lin H., Guilbert L., Mosmann T.R. Bidirectional cytokine interactions in the maternal-fetal relationship is successful pregnancy a TH2 phenomenon? Immunol. Today. 14:1993;353-356.