Hypertonicity prevents lipopolysaccharide-stimulated CD11b/CD18 expression in human neutrophils in vitro: Role for p38 inhibition

Journal of Trauma - Injury, Infection and Critical Care

Volumn 46, Issue 5, 1999, Pages 794-799

  Rizoli, Sandro B ^a   Kapus, Andras ^a   Parodo, Jean ^a   Rotstein, Ori D ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Hypertonicity; Lipopolysaccharide; MAPKp38

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HYPERTONIC SOLUTION; MITOGEN ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ADULT RESPIRATORY DISTRESS SYNDROME; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; CONFERENCE PAPER; FLUID THERAPY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LEUKOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESUSCITATION; SALINITY; SIGNAL TRANSDUCTION; TISSUE INJURY;

EID: 0032915028     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-199905000-00006     Document Type: Conference Paper

References (20)

1. Rizoli SB, Kapus A, Fan J, Li YH, Marshall JC, Rotstein OD. Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock. J Immunol. 1998;161:6288-6296.
2. Nick JA, Avdi NJ, Gerwins P, Johnson GL, Worthen GS. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J Immunol. 1996; 156:4867-4875.
3. Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 1992;69:11-25.
4. Kishimoto TK, Rothlein R. Integrins, ICAMs, and selectins: role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites. Adv Pharmacol. 1994; 25:117-153.
5. Vedder NB, Harlan JM. Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium. J Clin Invest. 1988;81:676-682.
6. Vedder NB, Fouty BW, Winn RK, Harlan JM, Rice CL. Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock. Surgery. 1989; 106:509-516.
7. Mileski WJ, Winn RK, Vedder NB, Pohlman TH, Harlan JM, Rice CL. Inhibition of the CD18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates. Surgery. 1990;108:206-212.
8. 2-integrin CD18 in the local accumulation of neutrophils in pulmonary and cutaneous inflammation in the rabbit. Am J Respir Cell Mol Biol. 1994;10:391-398.
9. Qin L, Quinlan WM, Doyle NA, et al. The roles of CD11/ CD18 and ICAM-1 in acute Pseudomonas aeruginosa-induced pneumonia in mice. J Immunol, 1996;157:5016-5021.
10. Wade CE, Kramer GC, Grady JJ, Fabian TC, Younes RN. Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies. Surgery. 1997;122:609-616.
11. Shires GT, Barber AE, Illner HP. Current status of resuscitation: solutions including hypertonic saline. Adv Surg. 1995;28:133-170.
12. Mattox KL, Maningas PA, Moore EE. Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension: the USA multicenter trial. Ann Surg. 1991; 213:482-491.
13. Coimbra R, Hoyt DB, Junger WG, et al. Hypertonic saline resuscitation decreases susceptibility to sepsis after hemorrhagic shock. J Trauma. 1997;42:602-606.
14. Junger WG, Coimbra R, Liu FC, et al. Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock. 1997;8:235-241.
15. Angle N, Hoyt DB. Coimbra R, et al. Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock. Shock. 1998; 9:164-170.
16. Junger WG, Hoyt DB, Davis RJ, et al. Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest. 1998;101:2768-2779.
17. Rosengren S, Henson PM, Worthen GS. Migration-associated volume changes in neutrophils facilitate the migratory process in vitro. Am J Physiol. 1994;267:C1623-C1632.
18. Kuchkina NV, Orlov SN, Pokudin NI, Chuchalin AG. Volume-dependent regulation of the respiratory burst of activated human neutrophils. Experientia. 1993;49:995-997.
19. Hampton MB, Chambers ST, Vissers MCM, Winterbourn CC. Bacterial killing by neutrophils in hypertonic environments. J Infect Dis. 1994;169:839-846.
20. Sheikh S, Gratzer WB, Pinder JC, Nash GB. Actin polymerisation regulates integrin-mediated adhesion as well as rigidity of neutrophils. Biochem Biophys Res Commun 1997;238:910-915.