PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 3, 2007, Pages 789-792

  Beghyn, Terence ^a,b   Hounsou, Candide ^a,b   Deprez, Benoit P ^a,b  

^a INSERM   (France)

^b UNIV LILLE   (France)

Author keywords

Cuprous iodide; Epimerisation; N arylation; PDE5; Tadalafil; Tetrahydrobetacarboline

Indexed keywords

NORTADALAFIL; PHOSPHODIESTERASE V INHIBITOR; PYRIMIDINE DERIVATIVE; TADALAFIL; UNCLASSIFIED DRUG; WATER;

ARTICLE; BIODIVERSITY; DRUG DETERMINATION; DRUG STRUCTURE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; CARBOLINES; CATALYSIS; COPPER; ENZYME INHIBITORS; FLUORESCENCE RESONANCE ENERGY TRANSFER; INDICATORS AND REAGENTS; ISOMERISM; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846195093     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.069     Document Type: Article

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9. 4, evaporated to dryness and purified by TLC.
10. 50 values were obtained using the curve fitting software XLfit4.2 (IDBS).
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