Glucocorticoid receptor transcriptional isoforms and resistance in multiple myeloma cells

Molecular Cancer Therapeutics

Volumn 5, Issue 12, 2006, Pages 3062-3070

  Sánchez Vega, Beatriz ^a   Krett, Nancy ^b   Rosen, Steven T ^b   Gandhi, Varsha ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; NUCLEAR RECEPTOR COACTIVATOR 2;

ARTICLE; DNA EXTRACTION; EXON; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METHYLATION; MOLECULAR CLONING; MULTIPLE MYELOMA; MUTATIONAL ANALYSIS; MYELOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RNA EXTRACTION;

CELL LINE, TUMOR; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOCORTICOIDS; HUMANS; MULTIPLE MYELOMA; PROMOTER REGIONS (GENETICS); PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33846187629     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0344     Document Type: Article

References (46)

1. Greenstein S, Ghias K, Krett NL, Rosen ST. Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies. Clin Cancer Res 2002;8:1681-94.
2. Hsu SC, DeFranco DB. Selectivity of cell cycle regulation of glucocorticoid receptor function. J Biol Chem 1995;270:3359-64.
3. Lim-Tio SS, Keightley MC, Fuller PJ. Determinants of specificity of transactivation by the mineralocorticoid or glucocorticoid receptor. Endocrinology 1997;138:2537-43.
4. Moalli PA, Rosen ST. Glucocorticoid receptors and resistance to glucocorticoids in hematologic malignancies. Leuk Lymphoma 1994;15: 363-74.
5. Hala M, Hartmann BL, Bock G, Geley S, Kotler R. Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines. Int J Cancer 1996;68:663-8,
6. Thompson EB, Harmon JM. Glucocorticoid receptors and glucocorticoid resistance in human leukemia in vivo and in vitro. Adv Exp Med Biol 1986;196:111-27.
7. Kino T, Stauber RH, Resau JH, Pavlakis GN, Chrousos GP. Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking. J Clin Endocrinol Metab 2001;86:5600-8.
8. Hillmann AG, Ramdas J, Multanen K, Norman MR, Harmon JM. Glucocorticoid receptor gene mutations in leukemic cells acquired in vitro and in vivo. Cancer Res 2000;60:2056-62.
9. Iacobelli S, Marchetti P, De Rossi G, Mandelli F, Gentiioni N. Glucocorticoid receptors predict response to combination chemotherapy in patients with acute lymphoblastic leukemia. Oncology 1987;44:13-6.
10. Mastrangelo R, Malandrino R, Riccardi R, Longo P, Ranelletti FO, Iacobelli S. Clinical implications of glucocorticoid receptor studies in childhood acute lymphoblastic leukemia. Blood 1980;56:1036-40.
11. Pui CH, Dahl GV, Rivera G, Murphy SB, Costlow ME. The relationship of blast cell glucocorticoid receptor levels to response to single-agent steroid trial and remission response in children with acute lymphoblastic leukemia. Leuk Res 1984;8:579-85.
12. Giguere V, Hollenberg SM, Rosenfeld MG, Evans RM. Functional domains of the human glucocorticoid receptor. Cell 1986;46:645-52.
13. Weinberger C, Hollenberg SM, Rosenfeld MG, Evans RM. Domain structure of human glucocorticoid receptor and its relationship to the v-erb-a oncogene product. Nature 1985;318:670-2.
14. Wright AP, Zilliacus J, McEwan IJ, et al. Structure and function of the glucocorticoid receptor. J Steroid Biochem Mol Biol 1993;47:11-9.
15. Tao Y, Williams-Skipp C, Scheinman RI. Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-κB and induction of apoptosis. J Biol Chem 2001;276:2329-32.
16. Miesfeld R, Godowski PJ, Maler BA, Yamamoto KR. Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation. Science 1987;236:423-7.
17. Dahlman-Wright K, Wright AP, Gustafsson JA. Determinants of high-affinity DNA binding by the glucocorticoid receptor: evaluation of receptor domains outside the DNA-binding domain. Biochemistry 1992; 31:9040-4.
18. Bledsoe RK, Montana VG, Stanley TB, et al. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell 2002;110: 93-105.
19. Hollenberg SM, Giguere V, Segui P, Evans RM. Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell 1987;49:39-46.
20. Godowski PJ, Rusconi S, Miesfeld R, Yamamoto KR. Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 1987;325:365-8.
21. Yudt MR, Cidlowski JA. The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene, Mol Endocrinol 2002;16:1719-26.
22. Breslin ME, Geng CD, Vedeckis WV. Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol Endocrinol 2001;15:1381-95.
23. Kofler R. The molecular basis of glucocorticoid-induced apoptosis of lymphoblastic leukemia cells. Histochem Cell Biol 2000;114:1-7.
24. Chen F, Watson CS, Gametchu B. Association of the glucocorticoid receptor alternatively-spliced transcript 1A with the presence of the high molecular weight membrane glucocorticoid receptor in mouse lymphoma cells. J Cell Biochem 1999;74:430-46.
25. Diba F, Watson CS, Gametchu B. 5′ UTR sequences of the glucocorticoid receptor 1A transcript encode a peptide associated with translational regulation of the glucocorticoid receptor. J Cell Biochem 2001;81:149-61.
26. Bamberger CM, Bamberger AM, de Castro M, Chrousos GP. Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 1995;96:2435-41.
27. Hollenberg SM, Weinberger C, Ong ES, et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 1985;318:635-41.
28. Moalli PA, Pillay S, Krett NL, Rosen ST. Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells. Cancer Res 1993;53:3877-9.
29. Rivers C, Levy A, Hancock J, Lightman S, Norman M. Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing. J Clin Endocrinol Metab 1999;84:4283-6.
30. Goldman-Leikin RE, Salwen HR, Herst CV, et al. Characterization of a novel myeloma cell line, MM. 1. J Lab Clin Med 1989; 113:335-45.
31. Moalli PA, Pillay S, Weiner D, Leikin R, Rosen ST. A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA. Blood 1992;79:213-22.
32. Antonini SR, Latronico AC, Elias LL, et al. Glucocorticoid receptor gene polymorphisms in ACTH-secreting pituitary tumours. Clin Endocrinol (Oxf) 2002;57:657-62.
33. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000;132:365-86.
34. Pedersen KB, Vedeckis WV. Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. Biochemistry 2003;42:10978-90.
35. Chauhan D, Pandey P, Hideshima T, et al. Shp2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. J Biol Chem 2000;275:27845-50.
36. Chauhan D, Auclair D, Robinson EK, et al. Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays. Oncogene 2002;21:1346-58.
37. Gametchu B, Chen F, Sackey F, Powell C, Watson CS. Plasma membrane-resident glucocorticoid receptors in rodent lymphoma and human leukemia models. Steroids 1999;64:107-19.
38. Costlow ME, Pui CH, Dahl GV. Glucocorticoid receptors in childhood acute lymphocytic leukemia. Cancer Res 1982;42:4801-6.
39. Quddus FF, Leventhal BG, Boyett JM, Pullen DJ, Crist WM, Borowitz MJ. Glucocorticoid receptors in immunological subtypes of childhood acute lymphocytic leukemia cells: a pediatric oncology group study. Cancer Res 1985;45:6482-6.
40. Gandhi V, Sanchez-Vega B. Mechanism of glucocorticoid action and resistance in multiple myelonna. In: Cancer drug resistance. Totowa (NJ): Humana Press, Inc.; 2006. p. 435-58.
41. Ramdas J, Liu W, Harmon JM. Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells. Cancer Res 1999;59:1378-85.
42. Charmandari E, Raji A, Kino T, et al. A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity. J Clin Endocrinol Metab 2005;90:3696-705.
43. Oakley RH, Webster JC, Sar M, Parker CR, Jr., Cidlowski JA. Expression and subcellular distribution of the β-isoform of the human glucocorticoid receptor. Endocrinology 1997;138:5028-36.
44. Gagliardo R, Vignola AM, Mathieu M. Is there a role for glucocorticoid receptor β in asthma? Respir Res 2001;2:1-4.
45. Krett NL, Pillay S, Moalli PA, Greipp PR, Rosen ST. A variant glucocorticoid receptor messenger RNA is expressed in multiple myeloma patients. Cancer Res 1995; 55:2727-9.
46. de Lange P, Segeren CM, Koper JW, et al. Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells. Cancer Res 2001;61:3937-41.