Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys

Biological Chemistry

Volumn 388, Issue 1, 2007, Pages 25-36

  Curtidor, Hernando ^a   Torres, Mary Helena ^a   Alba, Martha Patricia ^a   Patarroyo, Manuel E ^a  

^a UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

Binding; Malaria; Peptide; PfEMP 1; Plasmodium

Indexed keywords

ERYTHROCYTE MEMBRANE PROTEIN 1; GLUTAMYLGLYCYLGLUTAMINYLSERYLISOLEUCYLTHREONYLGLUTAMINYLASPARTYL TYROSYLPROLYLLYSYLTYROSYLGLUTAMINYLALANYLTHREONYLTYROSYLGLYCYLASPARTYLSERYL PROLINE; GLUTAMYLSERYLALANYLLYSYLHISTIDYLLYSYLASPARTYLPHENYLALANYLARGINYL ISOLEUCYLGLYCYLLYSYLASPARTYLVALYLTYROSYLASPARTYLMETHIONYLVALYLLYSYLGLUTAMIC ACID; GLUTAMYLSERYLALANYLLYSYLHISTIDYLLYSYLPHENYLALANYLASPARTYLARGINYL ISOLEUCYLGLYCYLLYSYLASPARTYLVALYLTYROSYLASPARTYLMETHIONYLVALYLLYSYLGLUTAMIC ACID; GLUTAMYLSERYLALANYLLYSYLHISTIDYLLYSYLPHENYLALANYLASPARTYLARGINYLISOL EUCYLGLYCYLLYSYLASPARTYLASPARTYLTYROSYLASPARTYLMETHIONYLVALYLMETHIONYLGLUTAMIC ACID; GLUTAMYLSERYLALANYLLYSYLHISTIDYLMETHIONYLPHENYLALANYLASPARTYL ARGINYLISOLEUCYLGLYCYLLYSYLASPARTYLVALYLTYROSYLASPARTYLLYSYLVALYLLYSYLGLUTAMIC ACID; GLUTAMYLSERYLALANYLLYSYLHISTIDYLMETHIONYLPHENYLALANYLASPARTYLARGINYL ISOLEUCYLGLYCYLLYSYLASPARTYLVALYLTYROSYLASPARTYLMETHIONYLVALYLLYSYLGLUTAMIC ACID; GLYCYLALANYLCYSTEINYLALANYLPROLYLTYROSYLARGINYLARGINYLLEUCYL HISTIDYLVALYLCYSTEINYLASPARTYLGLUTAMINYLASPARAGINYLLEUCYLGLUTAMYLGLUTAMINYL ISOLEUCYLGLUTAMIC ACID; GLYCYLGLUTAMYLARGINYLTHREONYLLYSYLGLYCYLTYROSYLCYSTEINYLARGINYL CYSTEINYLASPARAGINYLASPARTYLASPARTYLGLUTAMINYLVALYLPROLYLTHREONYLTYROSYL GLUTAMYLASPARTIC ACID; HLA DR ANTIGEN; LEUCYLLYSYLTHREONYLISOLEUCYLGLUTAMYLGLYCYLLYSYLISOLEUCYLTYROSYL GLUTAMYLLYSYLLEUCYLASPARAGINYLGLYCYLALANYLGLUTAMYLALANYLARGINYLTYROSYLGLYCINE; LYSYLHISTIDYLLYSYLPHENYLALANYLASPARTYLARGINYLISOLEUCYLGLYCYLLYSYL ASPARTYLVALYLTYROSYLASPARTYLMETHIONYLVALYLLYSYLGLUTAMIC ACID; LYSYLHISTIDYLLYSYLPHENYLALANYLASPARTYLPHENYLALANYLISOLEUCYLGLYCYL LYSYLISOLEUCYLVALYLTYROSYLASPARTYLMETHIONYLVALYLLYSYLGLUTAMYLARGININE; LYSYLPHENYLALANYLASPARTYLARGINYLISOLEUCYLGLYCYLLYSYLASPARTYLVALYL TYROSYLASPARTYLMETHIONYLVALYLLYSYLGLUTAMIC ACID; MEMBRANE PROTEIN; METHIONYLVALYLGLUTAMYLLEUCYLALANYLLYSYLMETHIONYLGLYCYLPROLYLLYSYL GLUTAMYLALANYLALANYLGLYCYLGLYCYLASPARTYLASPARTYLISOLEUCYLGLUTAMYLASPARTIC ACID; TYROSYLARGINYLALANYLLYSYLGLUTAMYLARGINYLGLYCYLLYSYLGLYCYLLEUCYL GLUTAMINYLGLYCYLARGINYLLEUCYLSERYLGLUTAMYLALANYLLYSYLPHENYLALANYLGLUTAMYLLYSINE; TYROSYLASPARAGINYLLYSYLLYSYLISOLEUCYLLYSYLASPARTYLVALYLLYSYLARGINYL ASPARAGINYLCYSTEINYLARGINYLGLYCYLLYSYLASPARTYLLYSYLGLUTAMYLASPARTYLLYSYL ASPARTI C ACID; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; HUMORAL IMMUNITY; IMMUNOGENICITY; MALARIA FALCIPARUM; MONKEY; MULTIPLE CYCLE TREATMENT; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTECTION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; VACCINATION;

AMINO ACID SEQUENCE; ANIMALS; AOTIDAE; BINDING SITES; BLOTTING, WESTERN; ERYTHROCYTES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA VACCINES; MALARIA, FALCIPARUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; TUMOR CELLS, CULTURED;

PLASMODIUM FALCIPARUM;

EID: 33846130572     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2007.003     Document Type: Article

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