The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors

Journal of Experimental Medicine

Volumn 192, Issue 1, 2000, Pages 1-9

  Chen, Qijun ^a   Heddini, Andreas ^a   Barragan, Antonio ^a   Fernandez, Victor ^a   Pearce, S Frieda A ^b   Wahlgren, Mats ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Cytoadherence; Ligand; Malaria; Rosetting; Sequestration

Indexed keywords

BLOOD GROUP A ANTIGEN; CD31 ANTIGEN; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; IMMUNOGLOBULIN M; LIGAND; MEMBRANE PROTEIN; RECEPTOR PROTEIN;

ARTICLE; BINDING AFFINITY; CELL ADHESION; CONTROLLED STUDY; ERYTHROCYTE; MALARIA; NONHUMAN; PERIPHERAL CIRCULATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN BINDING;

ABO BLOOD-GROUP SYSTEM; ANIMALS; ANTIGENS, CD31; ANTIGENS, CD36; BINDING SITES; CELL ADHESION; CHO CELLS; CRICETINAE; ERYTHROCYTE MEMBRANE; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERCELLULAR ADHESION MOLECULE-1; L CELLS (CELL LINE); MICE; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0034600909     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.1.1     Document Type: Article

References (34)

1. Miller, L.H., M.F. Good, and G. Milon. 1994. Malaria pathogenesis. Science. 264:1878-1883.
2. Barnwell, J.W., A.S. Asch, R.L. Nachman, M. Yamaya, M. Aikawa, and P. Ingravallo. 1989. A human 88-kD membrane glucoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes J. Clin. Invest. 84:77-87.
3. Berendt, A.R., D.L. Simmons, J. Tansey, C.I. Newbold, and K. Marsh. 1989. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature. 341:57-59.
4. Robert, C., B. Pouvelle, P. Meyer, K. Muanza, H. Fujioka, M. Aikawa, A. Scherf, and J. Gysin. 1995. Chondroitin-4-sulfate (proteoglycan), a receptor for Plasmodium falciparum-erythrocyte adhesion. Res. Immunol. 146:383-393.
5. Rogerson, S.J., C.S. Chaiyaroj, K. Ng, J.C. Reeder, and G.V. Brown. 1995. Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes. J. Exp. Med. 182:15-20.
6. Newbold, I.C., P. Warn, G. Black, A. Berendt, A. Craig, B. Snow, M. Msobo, N. Peshu, and K. Marsh. 1997. Receptor-specific adhesion and clinical disease in Plasmodium falciparum. Am. J. Trop. Med. Hyg. 57:389-398.
7. Treutiger, C.J., A. Heddini, V. Fernandez, W.A. Muller, and M. Wahlgren. 1997. PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes. Nat. Med. 3:1405-1408.
8. Carlson, J., and M. Wahlgren. 1992. Plasmodium falciparum erythrocyte rosetting is mediated by promiscuous lectin-like interactions. J. Exp. Med. 176:1311-1317.
9. Handunnetti, S.M., M.R. Schravendijk, T. Hasler, J.W. Barnwell, D.E. Greenwalt, and R.J. Howard. 1992. Involvement of CD36 on erythrocytes as a rosetting receptor for Plasmodium falciparum-infected erythrocytes. Blood. 80:2097-2104.
10. Rowe, A.J., J.M. Moulds, C.I. Newbold, and L.H. Miller. 1997. P. falciparum rosetting is mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature. 388:292-295.
11. Scholander, C., C.J. Treutiger, K. Hultenby, and M. Wahlgren. 1996. Novel fibrillar structure confers adhesive property to malaria-infected erythrocytes. Nat. Med. 2:204-208.
12. Chen, Q., A. Barragan, V. Fernandez, A. Sundström, M. Schlichtherle, A. Sahlén, J. Carlson, S. Datta, and M. Wahlgren. 1998. Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum. J. Exp. Med. 187:15-23.
13. Barragan, A., D. Spillmann, M. Wahlgren, and J. Carlson. 1999. Erythrocyte glycans as Plasmodium falciparum rosetting receptors: molecular background of strain specific rosette disruption by glycosaminoglycans and sulfated glycoconjugates. Exp. Parasitol. 91:133-143.
14. Carlson, J., H. Helmby, A.V.S. Hill, D. Brewster, B.M. Greenwood, and M. Wahlgren. 1990. Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies. Lancet. 336:1457-1460.
15. Treutiger, C.J., I. Hedlund, H. Helmby, J. Carlson, A. Jepson, P. Twumasi, D. Kwiatkowski, B.M. Greenwood, and M. Wahlgren. 1992. Rosette formation in Plasmodium falciparum isolates and anti-rosette activity of sera from Gambians with cerebral or uncomplicated malaria. Am. J. Trop. Med. Hyg. 46:503-510.
16. Ringwald, P., J.P. Lepers, J. Le Bras, C. Rakotomalala, M. Rabodonirina, J.P. Vuillez, M. Razanamparany, F. Peyron, and J. Roux. 1992. Parasite virulence factors during falciparum malaria: rosetting, cytoadherence, and modulation of cytoadherence by cytokines. Infect. Immun. 61:5198-5204.
17. Rowe, A.J., J. Obeiro, C.I. Newbold, and K. Marsh. 1995. Plasmodium falciparum rosetting is associated with malaria severity in Kenya. Inject. Immun. 63:2323-2326.
18. Udomsangpetch, R., B.J. Taylor, S. Looareesuwan, N.J. White, J.F. Elliott, and M. Ho. 1996. Receptor specificity of clinical Plasmodium falciparum isolates: non-adherence to cell-bound E-selectin and vascular cell adhesion molecule-1. Blood. 88:2754-2760.
19. Fernandez, V., C.J. Treutiger, G.B. Nash, and M. Wahlgren. 1998. Multiple adhesive phenotypes linked to rosetting-binding of erythrocytes in Plasmodium falciparum malaria. Infect. Immun. 66:2969-2975.
20. Howard, R.J. 1988. Malarial proteins at the membrane of Plasmodium falciparum-infected erythrocytes and their involvement in cytoadherence to endothelial cells. Prog. Allergy. 41: 98-147.
21. Su, X.Z., V.M. Heatwole, S.P. Wertheimer, F. Guinet, J.A. Herrfeldt, D.S. Peterson, J.A. Ravetch, and T.E. Wellems. 1995. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell. 82:89-99.
22. Baruch, D.I., J.A. Gormley, C. Ma, R.J. Howard, and B.L. Pasloske. 1996. Plasmodium falciparum erythrocyte membrane protein 1 is a parasitized erythrocyte receptor for adherence to CD36, thrombospondin, and intracellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA. 93:3497-3502.
23. Baruch, D.I., B.L. Pasloske, H.B. Singh, X. Bi, C. Ma, M. Feldman, T.F. Taraschi, and R.J. Howard. 1995. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell. 82:77-87.
24. Baruch, D.I., C. Ma, H.B. Singh, X. Bi, B.L. Pasloske, and R.J. Howard. 1997. Identification of a region of PfEMP1 that mediates adherence of Plasmodium falciparum infected erythrocytes to CD36: conserved function with variant sequence. Blood. 90:3766-3775.
25. Udomsangpetch, R., B. Wåhlin, J. Carlson, K. Berzins, M. Torii, M. Aikawa, P. Perlmann, and M. Wahlgren. 1989. Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes. J. Exp. Med. 169:1835-1840.
26. Pearce, S.F., P. Roy, A.C. Nicholson, D.P. Hajjar, M. Febbraio, and P.L. Silverstein. 1998. Recombinant glutathione S-transferase/CD36 fusion proteins define an oxidized low density lipoprotein-binding domain. J. Biol. Chem. 273: 34875-34881.
27. Chen, Q., V. Fernandez, A. Sundström, M. Schlichtherle, S. Datta, P. Hagblom, and M. Wahlgren. 1998. Developmental selection of var gene expression in Plasmodium falciparum. Nature. 394:392-395.
28. Duksin, D., and W.C. Mahoney. 1982. Relationship of the structure and biological activity of the natural homologues of tunicamycin. J. Biol. Chem. 257:3105-3109.
29. Cohen, G.H., W.C. Wilcox, D.L. Sodora, D. Long, J.Z. Levin, and R.J. Eisenberg. 1988. Expression of herpes simplex virus type 1 glycoprotein D deletion mutants in mammalian cells. J. Virol. 62:1932-1940.
30. Chitnis, C.E., and L.H. Miller. 1994. Identification of the erythrocyte binding domains of Plasmodium vivax and and Plasmodium knowlesi proteins involved in erythrocyte invasion. J. Exp. Med. 180:497-506.
31. Cardin, A.D., and H.J.R. Weintraub. 1989. Molecular modeling of protein-glycosammoglycan interactions. Arteriosclerosis. 9:21-32.
32. Fernandez, V., M. Hommel, Q. Chen, P. Hagblom, and M. Wahlgren. 1999. Small, clonally variant antigens expressed on the surface of the Plasmodium falciparum-infected erythrocyte are encoded by the rif gene family and are the target of human immune responses. J. Exp. Med. 190:1393-1404.
33. Fisher, P.R., and P. Boone. 1993. Severe malaria associated with blood group. Am. J. Trop. Med. Hyg. 58:122-123.
34. Udomsangpetch, R., J. Todd, J. Carlson, and B.M. Greenwood. 1993. The effects of haemoglobin genotype and of ABO blood group on the formation of rosettes by Plasmodium falciparum infected red blood cells. Am. J. Trop. Med. Hyg. 48: 149-153.